Hassan Saei
@hassansaei.bsky.social
Postdoctoral researcher @ Imagine Institute in Paris
Hereditary disease | genetics and genomics | bioinformatics & big data analysis
https://hassansaei.github.io
Hereditary disease | genetics and genomics | bioinformatics & big data analysis
https://hassansaei.github.io
I recently developed a FIJI macro 💻 to support our internal need and decided to share it with the wider community, especially those working regularly with microscopy data. The macro is freely available on my GitHub and can be downloaded via Zenodo (link in the comments!)
November 15, 2025 at 1:14 PM
I recently developed a FIJI macro 💻 to support our internal need and decided to share it with the wider community, especially those working regularly with microscopy data. The macro is freely available on my GitHub and can be downloaded via Zenodo (link in the comments!)
Reposted by Hassan Saei
I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
Mouse Alport podocytes are susceptible to AAV9 transduction in vivo
Alport syndrome features a defective glomerular basement membrane (GBM) due to variants
in COL4A3, COL4A4, and COL4A5. The most severe forms, which lack the GBM’s collagen
α3α4α5(IV) network, progress...
kidney-international.org
November 4, 2025 at 4:11 PM
I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...
Reposted by Hassan Saei
Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...
Collagen IV in Gould syndrome and Alport syndrome
Nature Reviews Nephrology - In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and...
www.nature.com
July 31, 2025 at 2:44 PM
Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...
Excited to be in Basal for BaCell3D!!
Enjoyed discussing with brilliant people working on disease modeling using organoids.
#BaCell3D #organoid #Alport #kidney
@bacell3d.bsky.social
Enjoyed discussing with brilliant people working on disease modeling using organoids.
#BaCell3D #organoid #Alport #kidney
@bacell3d.bsky.social
June 24, 2025 at 10:11 PM
Excited to be in Basal for BaCell3D!!
Enjoyed discussing with brilliant people working on disease modeling using organoids.
#BaCell3D #organoid #Alport #kidney
@bacell3d.bsky.social
Enjoyed discussing with brilliant people working on disease modeling using organoids.
#BaCell3D #organoid #Alport #kidney
@bacell3d.bsky.social
Reposted by Hassan Saei
@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!
June 23, 2025 at 11:25 AM
@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!
🚨 Our new preprint is out!
We developed kidney organoid models of X-linked Alport syndrome carrying deep-intronic variants. Through in-depth characterization, we demonstrate their potential as a robust platform for individualized splice-switching therapy development. #Alport #ASO
@hkd-l.bsky.social
We developed kidney organoid models of X-linked Alport syndrome carrying deep-intronic variants. Through in-depth characterization, we demonstrate their potential as a robust platform for individualized splice-switching therapy development. #Alport #ASO
@hkd-l.bsky.social
Therapeutic splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of X-linked Alport syndrome https://www.biorxiv.org/content/10.1101/2025.06.10.658776v1
June 16, 2025 at 8:22 PM
🚨 Our new preprint is out!
We developed kidney organoid models of X-linked Alport syndrome carrying deep-intronic variants. Through in-depth characterization, we demonstrate their potential as a robust platform for individualized splice-switching therapy development. #Alport #ASO
@hkd-l.bsky.social
We developed kidney organoid models of X-linked Alport syndrome carrying deep-intronic variants. Through in-depth characterization, we demonstrate their potential as a robust platform for individualized splice-switching therapy development. #Alport #ASO
@hkd-l.bsky.social
🚨Check out our latest paper in AJKD! We highlighted the importance of unbiased and large-scale genetic testing in ADTKD-MUC1.
Using VNtyper, we identified de novo cases and ADTKD was not initially suspected in ~40% of positive cases in our cohort.
#ADTKD #MUC1 #VNtyper
Using VNtyper, we identified de novo cases and ADTKD was not initially suspected in ~40% of positive cases in our cohort.
#ADTKD #MUC1 #VNtyper
Phenotypic Heterogeneity of ADTKD-MUC1 Diagnosed Using VNtyper, a Novel Genetic Technique
https://bit.ly/4glVIxd
#ADTKD #CKD
https://bit.ly/4glVIxd
#ADTKD #CKD
February 6, 2025 at 9:49 PM
Reposted by Hassan Saei
Last publication from the HKD-lab...
Special congratulations to Jessica and @hassansaei.bsky.social as well as to all collaborators!
#kidney #ADTKD #MUC1
www.sciencedirect.com/science/arti...
Special congratulations to Jessica and @hassansaei.bsky.social as well as to all collaborators!
#kidney #ADTKD #MUC1
www.sciencedirect.com/science/arti...
Phenotypic Heterogeneity of ADTKD-MUC1 Diagnosed Using VNtyper, a Novel Genetic Technique
Molecular diagnosis of autosomal dominant tubulointerstitial kidney disease (ADTKD) due to variants in the MUC1 gene has long been challenging since v…
www.sciencedirect.com
January 24, 2025 at 9:23 AM
Last publication from the HKD-lab...
Special congratulations to Jessica and @hassansaei.bsky.social as well as to all collaborators!
#kidney #ADTKD #MUC1
www.sciencedirect.com/science/arti...
Special congratulations to Jessica and @hassansaei.bsky.social as well as to all collaborators!
#kidney #ADTKD #MUC1
www.sciencedirect.com/science/arti...
I am immensely proud to be one of the 2024 Pasteur PhD graduates and deeply grateful to the Pasteur Network for organizing such an unforgettable event.
Explore the Highlights of the Institut Pasteur 2024 PhD Graduation Ceremony! 🎓✨
The day was filled with unforgettable moments, from inspiring speeches to joyful celebrations. A huge congratulations again to our graduates!
Dive into the photos & videos of the ceremony 👉 bit.ly/2024PhDCerem...
The day was filled with unforgettable moments, from inspiring speeches to joyful celebrations. A huge congratulations again to our graduates!
Dive into the photos & videos of the ceremony 👉 bit.ly/2024PhDCerem...
January 23, 2025 at 12:04 PM
I am immensely proud to be one of the 2024 Pasteur PhD graduates and deeply grateful to the Pasteur Network for organizing such an unforgettable event.