WRGordonlab-UMN
@wrgordonlab.bsky.social
WRGordonlab at UMN. Cell surface mechanobiology. Protein-DNA bioconjugation via HUH-tags. #gordonlabpuns.
July 1…. Notch your average day. 11 year anniversary of the lab. 11th PhD student graduating this week. Promoted to full professor. 4 year DGS term is OVER! Feeling lucky despite all of the chaos. #gordonlabpuns
July 1, 2025 at 10:16 PM
July 1…. Notch your average day. 11 year anniversary of the lab. 11th PhD student graduating this week. Promoted to full professor. 4 year DGS term is OVER! Feeling lucky despite all of the chaos. #gordonlabpuns
Reposted by WRGordonlab-UMN
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression
The conserved atypical cadherin fat (ft) controls cellular processes such as growth, planar cell polarity, and mitochondrial function, in organisms ranging from fruit flies to mammals. Working at the ...
doi.org
May 10, 2025 at 11:27 AM
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
Ok bringing up an old debate- I am writing my R35 second renewal, and it’s hard to squeeze it all in 6 pages. Both margins justified saves me 6 lines but my husband claims it’s hard to read. So: left- or both- margins justified for grants????? Please help!
May 5, 2025 at 2:40 PM
Ok bringing up an old debate- I am writing my R35 second renewal, and it’s hard to squeeze it all in 6 pages. Both margins justified saves me 6 lines but my husband claims it’s hard to read. So: left- or both- margins justified for grants????? Please help!
Reposted by WRGordonlab-UMN
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells, as seen by editor @srishtisahu.bsky.social #CRISPR
April 22, 2025 at 8:21 AM
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells, as seen by editor @srishtisahu.bsky.social #CRISPR
Reposted by WRGordonlab-UMN
Elastic properties of leukemic cells linked to maturation stage and integrin activation
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Elastic properties of leukemic cells linked to maturation stage and integrin activation
Acute myeloid leukemia (AML) remains challenging to cure. In addition to mutations that alter cell functioning, biophysical properties are modulated by external cues. In particular, membrane proteins ...
pmc.ncbi.nlm.nih.gov
April 16, 2025 at 10:33 AM
Elastic properties of leukemic cells linked to maturation stage and integrin activation
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by WRGordonlab-UMN
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading
Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellula…
www.sciencedirect.com
April 8, 2025 at 10:29 PM
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by WRGordonlab-UMN
Just listened to the second episode of Marloes ten Kate's "How to present science" podcast.
Very interesting insights, how to deliver the key message in the beginning to increase engagement as well as into the ABT model. (Although the Tesla references did not age well) (1/2)
open.spotify.com/epi...
Very interesting insights, how to deliver the key message in the beginning to increase engagement as well as into the ABT model. (Although the Tesla references did not age well) (1/2)
open.spotify.com/epi...
2. Great presentations start with the key message
How to present science · Episode
open.spotify.com
March 31, 2025 at 6:00 AM
Just listened to the second episode of Marloes ten Kate's "How to present science" podcast.
Very interesting insights, how to deliver the key message in the beginning to increase engagement as well as into the ABT model. (Although the Tesla references did not age well) (1/2)
open.spotify.com/epi...
Very interesting insights, how to deliver the key message in the beginning to increase engagement as well as into the ABT model. (Although the Tesla references did not age well) (1/2)
open.spotify.com/epi...
Reposted by WRGordonlab-UMN
Nice review about the opportunities of implementing AI/ML in mechanobiology by Roger Oria, Kashish Jain and Valerie Weaver (didn't find them on bluesky yet):
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Exploring the intersection of mechanobiology and artificial intelligence - npj Biological Physics and Mechanics
npj Biological Physics and Mechanics - Exploring the intersection of mechanobiology and artificial intelligence
www.nature.com
March 29, 2025 at 5:27 PM
Nice review about the opportunities of implementing AI/ML in mechanobiology by Roger Oria, Kashish Jain and Valerie Weaver (didn't find them on bluesky yet):
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by WRGordonlab-UMN
U of Michigan @umich.edu set aside funds from central to support researchers with unexpected disruption in federal funding for up to 6 months.
Are any other institutions doing this? Seems like a good move.
#Medsky #NIH #federalfunding #researchfunding 🧪
record.umich.edu/articles/uni...
Are any other institutions doing this? Seems like a good move.
#Medsky #NIH #federalfunding #researchfunding 🧪
record.umich.edu/articles/uni...
University launches new research support program | The University Record
record.umich.edu
March 14, 2025 at 6:31 PM
U of Michigan @umich.edu set aside funds from central to support researchers with unexpected disruption in federal funding for up to 6 months.
Are any other institutions doing this? Seems like a good move.
#Medsky #NIH #federalfunding #researchfunding 🧪
record.umich.edu/articles/uni...
Are any other institutions doing this? Seems like a good move.
#Medsky #NIH #federalfunding #researchfunding 🧪
record.umich.edu/articles/uni...
Reposted by WRGordonlab-UMN
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
www.nature.com
March 17, 2025 at 12:53 PM
🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
www.nature.com
January 29, 2025 at 5:00 PM
Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation - Oncogene
Oncogene - ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com
March 15, 2025 at 8:30 AM
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
@bladoux.bsky.social lab on mechanical cell competition
@naturematerials.bsky.social
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared!
www.nature.com/articles/s41...
@naturematerials.bsky.social
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared!
www.nature.com/articles/s41...
Force transmission is a master regulator of mechanical cell competition - Nature Materials
Differences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication...
www.nature.com
March 14, 2025 at 1:26 PM
@bladoux.bsky.social lab on mechanical cell competition
@naturematerials.bsky.social
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared!
www.nature.com/articles/s41...
@naturematerials.bsky.social
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared!
www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
Really cool work from friend and colleague Katie Galloway @mitcheme.bsky.social!
Researchers at MIT turned a skin cell into a neuron without having to go through that pesky intermediate stem cell step. Truly incredible.
news.mit.edu/2025/mit-eng...
news.mit.edu/2025/mit-eng...
MIT engineers turn skin cells directly into neurons for cell therapy
MIT researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuri...
news.mit.edu
March 13, 2025 at 9:49 PM
Really cool work from friend and colleague Katie Galloway @mitcheme.bsky.social!
Reposted by WRGordonlab-UMN
The hits just keep coming for this cohort. First f*cked by COVID and now these delays and obstructions. We need to pursue creative funding strategies and keep the pipeline flowing.
UMASS IS RESCINDING ALL GRAD POSITIONS FOR THIS YEAR
March 12, 2025 at 8:56 PM
The hits just keep coming for this cohort. First f*cked by COVID and now these delays and obstructions. We need to pursue creative funding strategies and keep the pipeline flowing.
Reposted by WRGordonlab-UMN
Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs https://www.biorxiv.org/content/10.1101/2025.03.09.642226v1
March 11, 2025 at 12:04 PM
Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs https://www.biorxiv.org/content/10.1101/2025.03.09.642226v1
Reposted by WRGordonlab-UMN
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 10, 2025 at 1:33 PM
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
Interested in nuclear mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @jcellsci.bsky.social:
journals.biologists.com/jcs/article-...
journals.biologists.com/jcs/article-...
Feeling the force from within – new tools and insights into nuclear mechanotransduction
Summary: This Review discusses new insights and technological advances in understanding how the nucleus contributes to the ability of the cell to translate mechanical stimuli into transcriptional resp...
journals.biologists.com
March 11, 2025 at 3:13 AM
Interested in nuclear mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @jcellsci.bsky.social:
journals.biologists.com/jcs/article-...
journals.biologists.com/jcs/article-...
Reposted by WRGordonlab-UMN
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
Fast Antibiotic resistance-Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR)
Protein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency causing low knock-in rates. We ...
arxiv.org
February 19, 2025 at 8:43 AM
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
Reposted by WRGordonlab-UMN
Villari G, et al. Luminescent sensing of conformational integrin activation in living cells. Cell Rep. 2025 Feb 17;44(2):115319. [Epub ahead of print] PMID: 39964812
February 19, 2025 at 8:59 AM
Villari G, et al. Luminescent sensing of conformational integrin activation in living cells. Cell Rep. 2025 Feb 17;44(2):115319. [Epub ahead of print] PMID: 39964812
Reposted by WRGordonlab-UMN
Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio
https://buff.ly/41e7Wnb
https://buff.ly/41e7Wnb
February 16, 2025 at 2:59 PM
Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio
https://buff.ly/41e7Wnb
https://buff.ly/41e7Wnb
Reposted by WRGordonlab-UMN
#CellMigration for #FluorescenceFriday 🧪🔬
If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes...
OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide.
More in the paper: www.nature.com/articles/s41...
If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes...
OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide.
More in the paper: www.nature.com/articles/s41...
January 24, 2025 at 11:37 AM
#CellMigration for #FluorescenceFriday 🧪🔬
If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes...
OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide.
More in the paper: www.nature.com/articles/s41...
If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes...
OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide.
More in the paper: www.nature.com/articles/s41...
Reposted by WRGordonlab-UMN
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
January 23, 2025 at 9:08 AM
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
Reposted by WRGordonlab-UMN
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by WRGordonlab-UMN
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
November 17, 2024 at 10:58 PM
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange