Ross Wilson
@rosswilsonlab.org
CRISPR whisperer in perpetual training. We're working to enable safe & accessible delivery of genome editing therapeutics. rosswilsonlab.org
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells, as seen by editor @srishtisahu.bsky.social #CRISPR
April 22, 2025 at 8:21 AM
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells, as seen by editor @srishtisahu.bsky.social #CRISPR
I'm proud to share our protocol on CRISPR enzyme delivery in primary human cells using PERC, a non-viral & hardware-independent technology. We previously described PERC in T cells, and here we extend its use to hematopoietic stem/progenitor cells (HSPCs).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells - Nature Protocols
Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) uses an amphiphilic peptide reagent to mediate intracellular delivery of CRISPR enzymes for high-efficiency editing of stimulat...
www.nature.com
March 19, 2025 at 8:14 AM
I'm proud to share our protocol on CRISPR enzyme delivery in primary human cells using PERC, a non-viral & hardware-independent technology. We previously described PERC in T cells, and here we extend its use to hematopoietic stem/progenitor cells (HSPCs).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I'm proud to share our review on CRISPR therapies for the blood. It has been about a year since Casgevy was approved for treatment of sickle cell disease, and edited CAR-T cells are showing more and more promise. Key figures shared below; paper is open access here: www.liebertpub.com/doi/full/10....
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects | The CRISPR Journal
Hematopoietic stem cells (HSCs) provide the body with a continuous supply of healthy, functional blood cells. In patients with hematopoietic malignancies, immunodeficiencies, lysosomal storage disorde...
www.liebertpub.com
January 27, 2025 at 7:41 AM
I'm proud to share our review on CRISPR therapies for the blood. It has been about a year since Casgevy was approved for treatment of sickle cell disease, and edited CAR-T cells are showing more and more promise. Key figures shared below; paper is open access here: www.liebertpub.com/doi/full/10....
The Wilson lab has two new PhD candidates: congrats to Brigette Manohar and Christy George on passing their qualifying exams in the Cal MCB program! They're both working to improve CRISPR delivery, potentially enabling new therapies for the central nervous system.
May 7, 2024 at 1:46 AM
The Wilson lab has two new PhD candidates: congrats to Brigette Manohar and Christy George on passing their qualifying exams in the Cal MCB program! They're both working to improve CRISPR delivery, potentially enabling new therapies for the central nervous system.
Reposted by Ross Wilson
Congrats to Karikó and Weissman on the Nobel for mRNA modifications! Their work was not appreciated by the university or reviewers at the time, but has saved millions of lives. A great example of the value of discovery science and reminder to not limit academic research to immediate applications.
October 2, 2023 at 2:55 PM
Congrats to Karikó and Weissman on the Nobel for mRNA modifications! Their work was not appreciated by the university or reviewers at the time, but has saved millions of lives. A great example of the value of discovery science and reminder to not limit academic research to immediate applications.