Sukrit Singh
@sukritsingh92.bsky.social
Biophysicist｜Damon Runyon QB & NCI Early Stage K99/R00 Fellow at MSKCC w/ @jchodera.bsky.social | @foldingathome.org | PhD with @drgregbowman.bsky.social | Variant Effects, Protein dynamics, Dogs, Games 🇮🇳🇸🇬🇺🇸
My website: https://sukritsingh.github.io
My website: https://sukritsingh.github.io
Pinned
Sukrit Singh
@sukritsingh92.bsky.social
· Nov 11
Intro time! I'm a Postdoc Research Fellow with @jchodera.bsky.social at Memorial Sloan Kettering Cancer Center! If you want to talk about protein dynamics, biophysics, precision medicine, drug resistance, and/or puppy photos, reach out! I'm on the job market looking for faculty positions!
Reposted by Sukrit Singh
How many crystal structures do you need to trust your docking results? https://www.biorxiv.org/content/10.1101/2025.09.19.677428v1
September 25, 2025 at 2:48 AM
How many crystal structures do you need to trust your docking results? https://www.biorxiv.org/content/10.1101/2025.09.19.677428v1
Reposted by Sukrit Singh
How many crystal structures do you need to trust your docking results? [new]
Accurate drug docking needs crystal struct. Template docking via mol. similarity helps w/ ltd. data.
Accurate drug docking needs crystal struct. Template docking via mol. similarity helps w/ ltd. data.
September 25, 2025 at 2:54 AM
How many crystal structures do you need to trust your docking results? [new]
Accurate drug docking needs crystal struct. Template docking via mol. similarity helps w/ ltd. data.
Accurate drug docking needs crystal struct. Template docking via mol. similarity helps w/ ltd. data.
Reposted by Sukrit Singh
DYK: 76% of MSK postdoctoral researchers are international, coming from more than 60 countries for training and mentorship that translates into scientific discoveries across the globe? 🌎 Learn more about our incredible MSK postdocs:
#PostdocAppreciationWeek
#PostdocAppreciationWeek
International Postdocs From 60 Countries Are Training at MSK in 2025
What inspires the outstanding young scientists who come from around the world to train at MSK?
www.mskcc.org
September 15, 2025 at 1:51 PM
DYK: 76% of MSK postdoctoral researchers are international, coming from more than 60 countries for training and mentorship that translates into scientific discoveries across the globe? 🌎 Learn more about our incredible MSK postdocs:
#PostdocAppreciationWeek
#PostdocAppreciationWeek
On Monday I took my Oath of Allegiance and become a Naturalized US Citizen! Huzzah!
July 9, 2025 at 12:47 AM
On Monday I took my Oath of Allegiance and become a Naturalized US Citizen! Huzzah!
Reposted by Sukrit Singh
Excited to share work now out in #JCIM @acs.org !
doi.org/10.1021/acs....
Alchemical free energy calculations are indispensable in computational drug design. We present an improved approach for optimizing the schedule of alchemical intermediates by minimizing thermodynamic length.
1/7
doi.org/10.1021/acs....
Alchemical free energy calculations are indispensable in computational drug design. We present an improved approach for optimizing the schedule of alchemical intermediates by minimizing thermodynamic length.
1/7
Simple Method to Optimize the Spacing and Number of Alchemical Intermediates in Expanded Ensemble Free Energy Calculations
Alchemical free energy calculations are essential to modern structure-based drug design. Such calculations are usually performed at a series of discrete intermediates along a nonphysical thermodynamic...
doi.org
June 23, 2025 at 4:10 PM
Excited to share work now out in #JCIM @acs.org !
doi.org/10.1021/acs....
Alchemical free energy calculations are indispensable in computational drug design. We present an improved approach for optimizing the schedule of alchemical intermediates by minimizing thermodynamic length.
1/7
doi.org/10.1021/acs....
Alchemical free energy calculations are indispensable in computational drug design. We present an improved approach for optimizing the schedule of alchemical intermediates by minimizing thermodynamic length.
1/7
Reposted by Sukrit Singh
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
March 25, 2025 at 7:33 PM
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
Reposted by Sukrit Singh
This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
March 25, 2025 at 7:47 PM
This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
Happy Holi, from the @jchodera.bsky.social lab!!
March 14, 2025 at 9:51 PM
Happy Holi, from the @jchodera.bsky.social lab!!
This work is now published in J Phys Chem B! Check out our work showing that simulations predict the impact of distal mutations on kinase-inhibitor binding, and our experimental NanoBRET dataset of 94 kinase mutations that provide a benchmark for future methods. Link:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
March 10, 2025 at 6:19 PM
This work is now published in J Phys Chem B! Check out our work showing that simulations predict the impact of distal mutations on kinase-inhibitor binding, and our experimental NanoBRET dataset of 94 kinase mutations that provide a benchmark for future methods. Link:
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Sukrit Singh
"No one is coming out of the sky to give you your grant money. Your citation portfolio won’t survive this market crash. Your credentials mean nothing. Everything is going to change."
New for @undark.org
undark.org/2025/03/06/o...
New for @undark.org
undark.org/2025/03/06/o...
How Science Can Adapt to a New Normal
Opinion | In the wake of attacks on the research enterprise, scientists need to focus on protecting its fragile infrastructure.
undark.org
March 6, 2025 at 2:35 PM
"No one is coming out of the sky to give you your grant money. Your citation portfolio won’t survive this market crash. Your credentials mean nothing. Everything is going to change."
New for @undark.org
undark.org/2025/03/06/o...
New for @undark.org
undark.org/2025/03/06/o...
Reposted by Sukrit Singh
NIH operates three cycles of grant review, approval for funding, and actual notice of award
right now all three cycles are blocked
if noncompeting awards are frozen, that's a fourth block
American science is running out of oxygen because of an acute airway obstruction
right now all three cycles are blocked
if noncompeting awards are frozen, that's a fourth block
American science is running out of oxygen because of an acute airway obstruction
Can speak from personal experience that some non-competitive renewals are also not going out. We were expecting a non-competitive renewal on 2/1/25 that has not been received
Extending my grant update this morning. Here are data limited to new and competitive renewal applications.
The Pause is dead, Long live the Pause...
The Pause is dead, Long live the Pause...
March 1, 2025 at 9:37 PM
NIH operates three cycles of grant review, approval for funding, and actual notice of award
right now all three cycles are blocked
if noncompeting awards are frozen, that's a fourth block
American science is running out of oxygen because of an acute airway obstruction
right now all three cycles are blocked
if noncompeting awards are frozen, that's a fourth block
American science is running out of oxygen because of an acute airway obstruction
It's important to communicate to the public the importance of basic science. Coco is happy to help explain drug binding mechanisms and enzyme kinetics basics:
#scicomm
#scicomm
February 27, 2025 at 1:51 AM
It's important to communicate to the public the importance of basic science. Coco is happy to help explain drug binding mechanisms and enzyme kinetics basics:
#scicomm
#scicomm
Reposted by Sukrit Singh
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 24, 2025 at 4:17 PM
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
Reposted by Sukrit Singh
Please share:
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.
They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.
They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
2025 Federal Financial Assistance Freeze
On Monday, January 27th, 2025, President Trump issued an order to freeze virtually all of approved and legally required federal funding.
delauro.house.gov
February 24, 2025 at 12:09 PM
Please share:
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.
They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.
They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
Reposted by Sukrit Singh
An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 23, 2025 at 8:00 AM
Reposted by Sukrit Singh
Graduate admissions being put on hold because of the chaos...
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 2:29 PM
Graduate admissions being put on hold because of the chaos...
Reposted by Sukrit Singh
Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!
I could not be more thrilled to be working with this dream team.
achira.ai
I could not be more thrilled to be working with this dream team.
achira.ai
NEW: Achira has launched with a $33M seed round
I talked with CEO @jchodera.bsky.social about plans to combine AI- and physics-based methods for drug discovery and moving beyond 45 years of the same type of models behind molecular dynamics.
My latest @endpts.com:
endpts.com/achira-raise...
I talked with CEO @jchodera.bsky.social about plans to combine AI- and physics-based methods for drug discovery and moving beyond 45 years of the same type of models behind molecular dynamics.
My latest @endpts.com:
endpts.com/achira-raise...
February 21, 2025 at 2:15 PM
Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!
I could not be more thrilled to be working with this dream team.
achira.ai
I could not be more thrilled to be working with this dream team.
achira.ai
Reposted by Sukrit Singh
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
February 17, 2025 at 1:55 AM
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Reposted by Sukrit Singh
Everything is chaos, but I wanted to share some awesome recent science from the lab that hints at where the future of biomolecular simulation is headed:
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
February 19, 2025 at 7:30 PM
Everything is chaos, but I wanted to share some awesome recent science from the lab that hints at where the future of biomolecular simulation is headed:
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
Reposted by Sukrit Singh
Nice time catching up with folks from @foldingathome.org at #bps2025
February 16, 2025 at 11:55 PM
Nice time catching up with folks from @foldingathome.org at #bps2025
Reposted by Sukrit Singh
Excited to be in LA for #BPS2025 @biophysicalsoc.bsky.social! I’ll be presenting a poster on our high-throughput fluorescence-based assay for kinase inhibitor binding in the West Exhibit Hall on Monday at 2:45 PM (board B60).
February 16, 2025 at 6:47 PM
Excited to be in LA for #BPS2025 @biophysicalsoc.bsky.social! I’ll be presenting a poster on our high-throughput fluorescence-based assay for kinase inhibitor binding in the West Exhibit Hall on Monday at 2:45 PM (board B60).
I'll be presenting my work prospectively studying clinical mutations and their impact on kinase inhibitor binding at #bps2025! Come see my talk on Wednesday morning @ 8:45am.
February 16, 2025 at 6:53 PM
I'll be presenting my work prospectively studying clinical mutations and their impact on kinase inhibitor binding at #bps2025! Come see my talk on Wednesday morning @ 8:45am.
Reposted by Sukrit Singh
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Sukrit Singh
**screams in early career scientist**
January 28, 2025 at 3:00 AM
**screams in early career scientist**