Sukrit Singh
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sukritsingh92.bsky.social
Sukrit Singh
@sukritsingh92.bsky.social
3K followers 1.1K following 43 posts
Biophysicist｜Damon Runyon QB & NCI Early Stage K99/R00 Fellow at MSKCC w/ @jchodera.bsky.social | @foldingathome.org | PhD with @drgregbowman.bsky.social | Variant Effects, Protein dynamics, Dogs, Games 🇮🇳🇸🇬🇺🇸

My website: https://sukritsingh.github.io
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sukritsingh92.bsky.social
Sukrit Singh @sukritsingh92.bsky.social · Nov 11
Intro time! I'm a Postdoc Research Fellow with @jchodera.bsky.social at Memorial Sloan Kettering Cancer Center! If you want to talk about protein dynamics, biophysics, precision medicine, drug resistance, and/or puppy photos, reach out! I'm on the job market looking for faculty positions!
A slide with the title "Different variants can have different selectivities" followed by 4 pictures of different dogs and an arrow pointing to their favorite toy. Each dog has a different favorite toy, and one dog, has no favorite toy at all! An image with an overview of Sukrit's research program. The top half is a workflow connecting patient samples to ranking therapeutic options by efficacy, connecting them using physics-based mechanistic models. The bottom half elaborates on the idea of physics based mechanistic modeling, with three different areas that correspond to different projects and their outcomes
Reposted by Sukrit Singh
klangin.bsky.social
How many STEM Ph.D.s were lost from the U.S. federal government last year?

My colleagues @mghersher.bsky.social and @policyhound.bsky.social dug into a recent data release to find the answer. A @science.org exclusive.

www.science.org/content/arti...
January 26, 2026 at 11:39 PM
Reposted by Sukrit Singh
neurodevkathy.bsky.social
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
January 2, 2026 at 3:19 AM
Reposted by Sukrit Singh
jchodera.bsky.social
This is more than half the NSF's total annual budget.
boycottcitizens.bsky.social Boycott Citizens @boycottcitizens.bsky.social · Dec 27
In just the past two months, DHS has awarded more than $4.8 billion in border contracts to two companies, entirely outside the normal competitive bidding process.
Screenshot of a spreadsheet listing major U.S. border barrier construction contracts. Columns include recipient_name, current_total_value, prime_award_base_transaction_description, potential_total_award_base, and a date column. Rows show awards to SLS Federal Services LLC and Fisher Sand & Gravel Co, with project descriptions such as “Del Rio Texas–3 Carrizo Springs waterborne & vertical barriers,” “vertical barrier construction,” “YUM-2 vertical border and waterborne barrier,” and “waterborne buoy system.” Contract values range from about $300 million to $1.57 billion, with potential totals extending up to $1.78 billion, and dates in November–December 2025.
December 27, 2025 at 10:18 PM
sukritsingh92.bsky.social
New preprint!
How many crystal structures do you need to trust your docking results? It turns out, if you know how your main scaffold binds in the pocket, not that many! Check out this work from recently-defended lab member @keysandcompounds.bsky.social

On BioRxiv:
www.biorxiv.org/content/10.1...
December 12, 2025 at 4:41 PM
Reposted by Sukrit Singh
jessbwhite.bsky.social
I'm honored to share that I've been selected as a 2026 PhRMA Foundation Predoctoral Fellow in Drug Discovery. This fellowship will support my research assessing how clinically relevant missense mutations impact kinase activity.

Read more about our work here.
December 12, 2025 at 3:06 PM
Reposted by Sukrit Singh
fionachembot.bsky.social
Are you a postdoc stuck in the US?! Is your research stalled or are you in any way affected by the whims of that unfettered madman? Interested in MD simulations of large biomolecules?!

Consider joining me at the University of Freiburg!

uni-freiburg.de/frias/call-f...
Call for Applications: Early Career Rescue Fellowship – Freiburg Institute for Advanced Studies
uni-freiburg.de
November 17, 2025 at 8:51 AM
Reposted by Sukrit Singh
biorxiv-biophys.bsky.social
How many crystal structures do you need to trust your docking results? https://www.biorxiv.org/content/10.1101/2025.09.19.677428v1
September 25, 2025 at 2:48 AM
Reposted by Sukrit Singh
aixbiobot.bsky.social
How many crystal structures do you need to trust your docking results? [new]
Accurate drug docking needs crystal struct. Template docking via mol. similarity helps w/ ltd. data.
How many crystal structures do you need to trust your docking results? Figure 2 Figure 3 Figure 4
September 25, 2025 at 2:54 AM
Reposted by Sukrit Singh
mskcancercenter.bsky.social
DYK: 76% of MSK postdoctoral researchers are international, coming from more than 60 countries for training and mentorship that translates into scientific discoveries across the globe? 🌎 Learn more about our incredible MSK postdocs:

#PostdocAppreciationWeek
International Postdocs From 60 Countries Are Training at MSK in 2025
What inspires the outstanding young scientists who come from around the world to train at MSK?
www.mskcc.org
September 15, 2025 at 1:51 PM
sukritsingh92.bsky.social
On Monday I took my Oath of Allegiance and become a Naturalized US Citizen! Huzzah!
Sukrit, dressed in a blue and gray suit, is standing in front of the stage at a Naturalization ceremony holding a US flag
July 9, 2025 at 12:47 AM
Reposted by Sukrit Singh
voelzlab.bsky.social
Excited to share work now out in #JCIM @acs.org !
doi.org/10.1021/acs....

Alchemical free energy calculations are indispensable in computational drug design. We present an improved approach for optimizing the schedule of alchemical intermediates by minimizing thermodynamic length.

1/7
Simple Method to Optimize the Spacing and Number of Alchemical Intermediates in Expanded Ensemble Free Energy Calculations
Alchemical free energy calculations are essential to modern structure-based drug design. Such calculations are usually performed at a series of discrete intermediates along a nonphysical thermodynamic...
doi.org
June 23, 2025 at 4:10 PM
Reposted by Sukrit Singh
dndi.org
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
March 25, 2025 at 7:33 PM
Reposted by Sukrit Singh
jchodera.bsky.social
This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
dndi.org Drugs for Neglected Diseases initiative (DNDi) @dndi.org · Mar 25
📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
March 25, 2025 at 7:47 PM
sukritsingh92.bsky.social
Happy Holi, from the @jchodera.bsky.social lab!!
Five people, covered in bright Holi powder, stand arm-in-arm in front of a waterfront railing with a cityscape in the background. They’re all smiling and wearing colorful, powder-stained clothes.
March 14, 2025 at 9:51 PM
sukritsingh92.bsky.social
This work is now published in J Phys Chem B! Check out our work showing that simulations predict the impact of distal mutations on kinase-inhibitor binding, and our experimental NanoBRET dataset of 94 kinase mutations that provide a benchmark for future methods. Link:
pubs.acs.org/doi/full/10....
Illustration showing a pipeline for predicting the impact of ABL1A kinase domain mutations on inhibitor binding. On the left, icons labeled 'Physics-based simulations' and 'Data-driven methods' feed into 'Prospective ΔΔG Predictions.' On the right, a 3D ribbon model of the ABL1A kinase domain (gray) highlights clinically observed mutations in orange and an inhibitor in blue.
March 10, 2025 at 6:19 PM
Reposted by Sukrit Singh
cbo.bsky.social
"No one is coming out of the sky to give you your grant money. Your citation portfolio won’t survive this market crash. Your credentials mean nothing. Everything is going to change."

New for @undark.org

undark.org/2025/03/06/o...
How Science Can Adapt to a New Normal
Opinion | In the wake of attacks on the research enterprise, scientists need to focus on protecting its fragile infrastructure.
undark.org
March 6, 2025 at 2:35 PM
Reposted by Sukrit Singh
prasad.bsky.social
NIH operates three cycles of grant review, approval for funding, and actual notice of award

right now all three cycles are blocked

if noncompeting awards are frozen, that's a fourth block

American science is running out of oxygen because of an acute airway obstruction
nanopharmnc.bsky.social Zoe McElligott @nanopharmnc.bsky.social · Mar 1
Can speak from personal experience that some non-competitive renewals are also not going out. We were expecting a non-competitive renewal on 2/1/25 that has not been received
jeremymberg.bsky.social Jeremy Berg @jeremymberg.bsky.social · Mar 1
Extending my grant update this morning. Here are data limited to new and competitive renewal applications.

The Pause is dead, Long live the Pause...
March 1, 2025 at 9:37 PM
sukritsingh92.bsky.social
It's important to communicate to the public the importance of basic science. Coco is happy to help explain drug binding mechanisms and enzyme kinetics basics:
#scicomm
Composite image illustrating enzyme inhibition concepts with a black dog in different poses: Top-left: The dog wears a pink flying disc on its head, labeled “Non-competitive (allosteric) inhibition (E–Inc).” Center: The dog in a tub, tongue out, labeled “E,” connected to “E–S” (enzyme–substrate). Top-right: The dog holding a yellow tennis ball, labeled “Competitive inhibition (E–Ic).” Bottom-center: The dog chewing a blue ball, labeled “Substrate binding.” Arrows and labels show the relationships between each form of the enzyme. Composite image demonstrating “good” versus “bad” enzyme–substrate binding with the same black dog: Left: The dog with a blue ball in its mouth, labeled “E–Sᵍ” (“bad” binding mode). Center-left: The dog in a tub with tongue out, labeled “E.” Center-right: The dog holding a blue ball in a more controlled way, labeled “E–S” (“good” binding mode). Far right: The dog beside shredded toy pieces, labeled “E + P” (product formation). Text labels and arrows illustrate the transition from enzyme–substrate complexes to products.
February 27, 2025 at 1:51 AM
Reposted by Sukrit Singh
annikabarber.bsky.social
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 24, 2025 at 4:17 PM
Reposted by Sukrit Singh
valeriejhorsley.bsky.social
Please share:
@delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group.

They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
2025 Federal Financial Assistance Freeze
On Monday, January 27th, 2025, President Trump issued an order to freeze virtually all of approved and legally required federal funding.
delauro.house.gov
February 24, 2025 at 12:09 PM
Reposted by Sukrit Singh
jmzmuda.bsky.social
An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.

#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 23, 2025 at 8:00 AM
Reposted by Sukrit Singh
jeremymberg.bsky.social
Graduate admissions being put on hold because of the chaos...
cbibberson.bsky.social Carolyn Ibberson @cbibberson.bsky.social · Feb 22
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 2:29 PM
Reposted by Sukrit Singh
jchodera.bsky.social
Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models!

I could not be more thrilled to be working with this dream team.

achira.ai
andrewedunn.bsky.social Andrew Dunn @andrewedunn.bsky.social · Feb 21
NEW: Achira has launched with a $33M seed round

I talked with CEO @jchodera.bsky.social about plans to combine AI- and physics-based methods for drug discovery and moving beyond 45 years of the same type of models behind molecular dynamics.

My latest @endpts.com:

endpts.com/achira-raise...
February 21, 2025 at 2:15 PM
Reposted by Sukrit Singh
sonyahanson.bsky.social
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
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February 17, 2025 at 1:55 AM