Sukrit Singh
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sukritsingh92.bsky.social
Sukrit Singh
@sukritsingh92.bsky.social
3K followers 1.1K following 42 posts
Biophysicist｜Damon Runyon QB & NCI Early Stage K99/R00 Fellow at MSKCC w/ @jchodera.bsky.social | @foldingathome.org | PhD with @drgregbowman.bsky.social | Variant Effects, Protein dynamics, Dogs, Games 🇮🇳🇸🇬🇺🇸

My website: https://sukritsingh.github.io
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sukritsingh92.bsky.social
On Monday I took my Oath of Allegiance and become a Naturalized US Citizen! Huzzah!
Sukrit, dressed in a blue and gray suit, is standing in front of the stage at a Naturalization ceremony holding a US flag
July 9, 2025 at 12:47 AM
sukritsingh92.bsky.social
Can't wait to simulate whatever this is 🤔
June 28, 2025 at 7:18 PM
sukritsingh92.bsky.social
Happy Holi, from the @jchodera.bsky.social lab!!
Five people, covered in bright Holi powder, stand arm-in-arm in front of a waterfront railing with a cityscape in the background. They’re all smiling and wearing colorful, powder-stained clothes.
March 14, 2025 at 9:51 PM
sukritsingh92.bsky.social
This work is now published in J Phys Chem B! Check out our work showing that simulations predict the impact of distal mutations on kinase-inhibitor binding, and our experimental NanoBRET dataset of 94 kinase mutations that provide a benchmark for future methods. Link:
pubs.acs.org/doi/full/10....
Illustration showing a pipeline for predicting the impact of ABL1A kinase domain mutations on inhibitor binding. On the left, icons labeled 'Physics-based simulations' and 'Data-driven methods' feed into 'Prospective ΔΔG Predictions.' On the right, a 3D ribbon model of the ABL1A kinase domain (gray) highlights clinically observed mutations in orange and an inhibitor in blue.
March 10, 2025 at 6:19 PM
sukritsingh92.bsky.social
It's important to communicate to the public the importance of basic science. Coco is happy to help explain drug binding mechanisms and enzyme kinetics basics:
#scicomm
Composite image illustrating enzyme inhibition concepts with a black dog in different poses: Top-left: The dog wears a pink flying disc on its head, labeled “Non-competitive (allosteric) inhibition (E–Inc).” Center: The dog in a tub, tongue out, labeled “E,” connected to “E–S” (enzyme–substrate). Top-right: The dog holding a yellow tennis ball, labeled “Competitive inhibition (E–Ic).” Bottom-center: The dog chewing a blue ball, labeled “Substrate binding.” Arrows and labels show the relationships between each form of the enzyme. Composite image demonstrating “good” versus “bad” enzyme–substrate binding with the same black dog: Left: The dog with a blue ball in its mouth, labeled “E–Sᵍ” (“bad” binding mode). Center-left: The dog in a tub with tongue out, labeled “E.” Center-right: The dog holding a blue ball in a more controlled way, labeled “E–S” (“good” binding mode). Far right: The dog beside shredded toy pieces, labeled “E + P” (product formation). Text labels and arrows illustrate the transition from enzyme–substrate complexes to products.
February 27, 2025 at 1:51 AM
sukritsingh92.bsky.social
Also from our lab: @markpolk.bsky.social will be presenting a poster (B60, Monday @ 2:45pm) on our high-throughput screening setup that measures kinase-inhibitor binding affinities! Come hear about our robots! bsky.app/profile/mark...
February 16, 2025 at 6:58 PM
sukritsingh92.bsky.social
I'll be presenting my work prospectively studying clinical mutations and their impact on kinase inhibitor binding at #bps2025! Come see my talk on Wednesday morning @ 8:45am.
February 16, 2025 at 6:53 PM
sukritsingh92.bsky.social
Excellent winter vacation vibes: A book on the Science of Indian cooking (from Krish Ashok) paired with an amazing coconut-washed Old Fashioned from Dishoom.
A view of an indoor lounge in the restaurant Dishoom in London. In the middle is a coffee table which has a cocktail and a book. The cocktail is an Old Fashioned that came in a bottle and a separate glass of ice to pour small amounts into. The book is Masala Lab from Krish Ashok on the Science of Indian cooking
December 9, 2024 at 8:42 PM
sukritsingh92.bsky.social
With the help of new technician @markpolk.bsky.social, we've got our wet lab robots rapidly (and consistently) measuring kinase-inhibitor binding! Stay tuned for more:
A graph plotting a series of fluorescence spectra, each curve measuring kinase-inhibitor at a different drug concentration (the drug concentration is indicated in the color legend on the right). A dose-response curve from the full spectra, corrected for native ligand fluorescence, reporting drug binding over a series of inhibitor concentrations
December 3, 2024 at 9:42 PM
sukritsingh92.bsky.social
To jump on the cocktail creation trend: My own personal project over the past couple of years has been making a cocktail of every color of the rainbow (as best I could).

Presenting: The Cocktail Rainbow, v. 1! Click to expand the full image
A horizontal banner like image of a bunch of cocktail beverages in a row. Going from left to right, the colors of the cocktails span the rainbow, with deep red colors on the left, greens and blues in the middle, and purple colors on the right (ROYGBIV style)
November 23, 2024 at 2:38 AM
sukritsingh92.bsky.social
Toying around with compatible video formats and size limits on bsky:
Here's a kinase trajectory from @foldingathome.bsky.social undergoing a DFG-flip (the trajectory is "smoothened" so atoms might look a bit funky). Stay tuned for the full work!
November 21, 2024 at 11:01 PM
sukritsingh92.bsky.social
Our dog Coco helps me explain my science (Myself and @sewfox.bsky.social are both researchers)!
November 18, 2024 at 4:53 AM
sukritsingh92.bsky.social
Post a picture you took to bring some zen to the timeline.
Picture of Coco, a black lab mix, looking at the camera in the park with a serious face. She is in a park and there is greenery behind her.
November 16, 2024 at 10:05 PM
sukritsingh92.bsky.social
Coco (and friends) help me explain my science!
November 12, 2024 at 2:03 AM
sukritsingh92.bsky.social
Intro time! I'm a Postdoc Research Fellow with @jchodera.bsky.social at Memorial Sloan Kettering Cancer Center! If you want to talk about protein dynamics, biophysics, precision medicine, drug resistance, and/or puppy photos, reach out! I'm on the job market looking for faculty positions!
A slide with the title "Different variants can have different selectivities" followed by 4 pictures of different dogs and an arrow pointing to their favorite toy. Each dog has a different favorite toy, and one dog, has no favorite toy at all! An image with an overview of Sukrit's research program. The top half is a workflow connecting patient samples to ranking therapeutic options by efficacy, connecting them using physics-based mechanistic models. The bottom half elaborates on the idea of physics based mechanistic modeling, with three different areas that correspond to different projects and their outcomes
November 11, 2024 at 10:27 PM
sukritsingh92.bsky.social
Now that it's official I can share the good news:
It me, having been awarded an NCI "K99/R00 for Early Stage Researchers!"
January 30, 2024 at 10:57 PM
sukritsingh92.bsky.social
Now that it's publicly announced on twitter I can post it here – I won an award for my Podium Presentation at the NCI Junior Investigator meeting this past month!
An image from the National Cancer Institute Junior Investigator meeting showing the date and location of the meeting, and the header "Podium Presentation Award" Underneath the header is the name and affiliation of the winner, "Dr. Sukrit Singh" and "MSKCC" followed by the title of the presentation, "Biophysical parsing of cancer drug resistance using exascale supercomputing" To the right of the image is a headshot of Sukrit, wearing a blue dress shirt
August 29, 2023 at 11:11 PM
sukritsingh92.bsky.social
For my first post here, probably most fitting to share Coco's 5 year rescuversary. She likes to lounge and eat, but doesn't mind modeling every so often for me to use her to explain protein conformations and dynamics!
A black dog lounging in the glass panting while wearing red sunglasses on top of her head A zoomed in photo of a black dog with her tongue out mid-lick of a a bone treat (that is an ice cream sandwich shaped like a bone) A black dog sitting profile relative to the camera. She is sitting on the grass and looking at the camera. Her mouth is open and tongue is out as she is happy and smiling A slide containing two pictures of coco, a black dog, resting in different positions on the floor and on the couch. One she is lounging with her head up and in the other she is curled up on the couch asleep. The slide title is "Static structures are informative about Coco" - conveying that the two pictures are different conformations.
July 28, 2023 at 8:47 PM