Jacki Heraud-Farlow
@jackiheraudfarlow.bsky.social
RNA biologist working at Hudson Institute in Melbourne. Interested in intersection of RNA modifications (A-to-I editing), dsRNA structure and RBPs with innate immunity and autoinflammatory disease. She/her.
Pinned
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
www.science.org
Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky
If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X
www.science.org/doi/10.1126/...
#RNASky #ImmunoSky
Reposted by Jacki Heraud-Farlow
ARC says Discovery Projects outcomes will be tomorrow (Tuesday). Linkage Projects (2025, round 1) on Wed. Over past ~year, it's often been at about 11am (Canberra).
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
October 26, 2025 at 11:17 PM
ARC says Discovery Projects outcomes will be tomorrow (Tuesday). Linkage Projects (2025, round 1) on Wed. Over past ~year, it's often been at about 11am (Canberra).
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
Reposted by Jacki Heraud-Farlow
Happy to share our review on the Interplay between RNA-protein interactions and RNA structures. The open access article can be accessed here: doi.org/10.1002/2211...
FEBS Press
Methodological advances in mapping transcriptome-wide RNA-protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA...
doi.org
September 12, 2025 at 8:30 AM
Happy to share our review on the Interplay between RNA-protein interactions and RNA structures. The open access article can be accessed here: doi.org/10.1002/2211...
Reposted by Jacki Heraud-Farlow
Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky
September 3, 2025 at 3:27 AM
Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky
Reposted by Jacki Heraud-Farlow
Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠
We had a set of amazing talks in the #RNA in immunity session at #ARNASydney2025. Presentations by Stacey Horner, @drnatsampaio.bsky.social, Elizabeth Chan and Kitty McCaffrey. From viral infections to bacterial toxins, a really great session.
#RNASky
#RNASky
September 2, 2025 at 5:54 AM
Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠
Reposted by Jacki Heraud-Farlow
Application for 2025/2026 RNA Salons is now open. Please apply by 31st August to receive support your local or regional RNA activities. @rnasociety.bsky.social #Lexogen www.rnasociety.org/salons
www.rnasociety.org
August 17, 2025 at 8:32 AM
Application for 2025/2026 RNA Salons is now open. Please apply by 31st August to receive support your local or regional RNA activities. @rnasociety.bsky.social #Lexogen www.rnasociety.org/salons
Reposted by Jacki Heraud-Farlow
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
July 22, 2025 at 9:59 PM
Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
Reposted by Jacki Heraud-Farlow
Registration for A-RNA 2025 is now open!!!
Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events
Register: www.a-rnameeting.org.au/registration
Early bird rate ends July 30th, 2025
#RNASky
Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events
Register: www.a-rnameeting.org.au/registration
Early bird rate ends July 30th, 2025
#RNASky
June 17, 2025 at 4:03 AM
Registration for A-RNA 2025 is now open!!!
Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events
Register: www.a-rnameeting.org.au/registration
Early bird rate ends July 30th, 2025
#RNASky
Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events
Register: www.a-rnameeting.org.au/registration
Early bird rate ends July 30th, 2025
#RNASky
Reposted by Jacki Heraud-Farlow
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting
New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease
Nature Reviews Genetics, Published online: 14 April 2025; doi:10.1038/s41576-025-00830-5ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-mediated RNA editing, which are now providing insights for the development of potential therapies that target these mechanisms.
www.nature.com
April 15, 2025 at 1:45 AM
I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting
Reposted by Jacki Heraud-Farlow
Reposted by Jacki Heraud-Farlow
Today is Rare Disease Day
Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au
Five rare diseases and support groups:
Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au
Five rare diseases and support groups:
Peak body for Australians with rare diseases including genetic disorders
An estimated two million Australians live with a rare disease. Approximately 80% of rare diseases are genetic disorders.
rarevoices.org.au
February 27, 2025 at 9:26 PM
Today is Rare Disease Day
Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au
Five rare diseases and support groups:
Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au
Five rare diseases and support groups:
Reposted by Jacki Heraud-Farlow
Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 6:06 PM
Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇
Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5?
#RNASky #ImmunoSky
#RNASky #ImmunoSky
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=
t.co
February 19, 2025 at 9:10 PM
Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5?
#RNASky #ImmunoSky
#RNASky #ImmunoSky
Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.
For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at www.rnavic.com
RNA Victoria minisymposium | RNA Victoria Network
www.rnavic.com
February 18, 2025 at 3:47 AM
Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.
Reposted by Jacki Heraud-Farlow
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
February 7, 2025 at 1:45 PM
Reposted by Jacki Heraud-Farlow
#IL_NAT25
Yuval Dor on RNA editing in diabetes.
Thought inflamation caused by virus, but no virus found.
Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation?
Data indicates yes, by ADAR KO mouse model.
Phenotype similar to progression of diabetes in humans
Yuval Dor on RNA editing in diabetes.
Thought inflamation caused by virus, but no virus found.
Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation?
Data indicates yes, by ADAR KO mouse model.
Phenotype similar to progression of diabetes in humans
February 5, 2025 at 9:58 AM
#IL_NAT25
Yuval Dor on RNA editing in diabetes.
Thought inflamation caused by virus, but no virus found.
Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation?
Data indicates yes, by ADAR KO mouse model.
Phenotype similar to progression of diabetes in humans
Yuval Dor on RNA editing in diabetes.
Thought inflamation caused by virus, but no virus found.
Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation?
Data indicates yes, by ADAR KO mouse model.
Phenotype similar to progression of diabetes in humans
The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions.
#RNASky #Immunosky
#RNASky #Immunosky
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 7, 2025 at 12:02 AM
The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions.
#RNASky #Immunosky
#RNASky #Immunosky
Waiting for flight back to Oz and reflecting on the awesome @keystonesymposia.bsky.social last week on #RNA mediated regulation of #immunity. Here are a few highlights with links to the published or preprinted papers which you should definitely check out if you haven't yet ...
#RNAsky #Immunosky
#RNAsky #Immunosky
February 4, 2025 at 5:04 AM
Waiting for flight back to Oz and reflecting on the awesome @keystonesymposia.bsky.social last week on #RNA mediated regulation of #immunity. Here are a few highlights with links to the published or preprinted papers which you should definitely check out if you haven't yet ...
#RNAsky #Immunosky
#RNAsky #Immunosky
Reposted by Jacki Heraud-Farlow
Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity"
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
www.sciencedirect.com
January 20, 2025 at 9:57 PM
Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity"
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly.
www.sciencedirect.com/science/arti...
Reposted by Jacki Heraud-Farlow
Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention
#RNAbiology #RNAlocalization
www.nature.com/articles/s41...
#RNAbiology #RNAlocalization
www.nature.com/articles/s41...
Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention - Nature Communications
Here the authors study how interactions with nuclear speckles help localize mRNA in cells. They find that modifications of the proteins in these structures affects their cohesion and can modulate mRNA...
www.nature.com
January 6, 2025 at 12:08 PM
Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention
#RNAbiology #RNAlocalization
www.nature.com/articles/s41...
#RNAbiology #RNAlocalization
www.nature.com/articles/s41...
Reposted by Jacki Heraud-Farlow
Proud to share our paper on the impact of transcription inhibition on mRNA export in cancer.
A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social
A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
www.cell.com
January 2, 2025 at 10:55 PM
Proud to share our paper on the impact of transcription inhibition on mRNA export in cancer.
A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social
A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social
Reposted by Jacki Heraud-Farlow
At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)
Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end.
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
December 27, 2024 at 4:55 PM
At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)
Reposted by Jacki Heraud-Farlow
Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284
🤔 useful to further reduce translational load during #ISR?
#RNAbiology
🤔 useful to further reduce translational load during #ISR?
#RNAbiology
December 21, 2024 at 1:36 AM
Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284
🤔 useful to further reduce translational load during #ISR?
#RNAbiology
🤔 useful to further reduce translational load during #ISR?
#RNAbiology
Reposted by Jacki Heraud-Farlow
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
Sasaki et al. demonstrate that chromosome missegregation induced by SAC inhibition results in cytoplasmic dsRNA accumulation, primarily generated from non-exonic regions in the MNs. Activation of MAVS-mediated dsRNA sensing cooperates with dsDNA sensing to promote anti-tumor immunity.
www.cell.com
December 19, 2024 at 5:13 PM
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Jacki Heraud-Farlow
Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social!
www.nature.com/articles/s41...
#RNA #RNABiology #RNAsky #Translation #mRNA
www.nature.com/articles/s41...
#RNA #RNABiology #RNAsky #Translation #mRNA
Efficient circular RNA synthesis for potent rolling circle translation - Nature Biomedical Engineering
Trans-splicing-based methods that are independent of bacterial sequences and that allow the incorporation of RNA modifications enable the reliable synthesis of circular RNAs and enhance the efficiency...
www.nature.com
December 18, 2024 at 1:01 AM
Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social!
www.nature.com/articles/s41...
#RNA #RNABiology #RNAsky #Translation #mRNA
www.nature.com/articles/s41...
#RNA #RNABiology #RNAsky #Translation #mRNA
Reposted by Jacki Heraud-Farlow
Very important study to consider in light of the many miRNA cancer network and association studies out there!
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 17, 2024 at 2:24 PM
Very important study to consider in light of the many miRNA cancer network and association studies out there!