Jacki Heraud-Farlow
@jackiheraudfarlow.bsky.social
RNA biologist working at Hudson Institute in Melbourne. Interested in intersection of RNA modifications (A-to-I editing), dsRNA structure and RBPs with innate immunity and autoinflammatory disease. She/her.
Good point, I mean we know that’s true right?! Maybe the reduced coverage we see of these elements we always see in sequencing data is actually due to splicing, not structure like we have always assumed ….
February 19, 2025 at 10:19 PM
Good point, I mean we know that’s true right?! Maybe the reduced coverage we see of these elements we always see in sequencing data is actually due to splicing, not structure like we have always assumed ….
No problems. I always enjoy a conference recap from those I’ve missed too! Most of the talks will be available to stream for a limited time too if you’ve got regrets (and can afford it!)
February 5, 2025 at 8:47 AM
No problems. I always enjoy a conference recap from those I’ve missed too! Most of the talks will be available to stream for a limited time too if you’ve got regrets (and can afford it!)
Capped off the trip with a visit to the lovely group at the Kampmann lab @kampmann.bsky.social in San Francisco full of awesome discussions about all their cool screens and presenting some of our data too.
February 4, 2025 at 5:04 AM
Capped off the trip with a visit to the lovely group at the Kampmann lab @kampmann.bsky.social in San Francisco full of awesome discussions about all their cool screens and presenting some of our data too.
...
- All the talks on LINE1 and HUSH complex - I learned a lot! Kathleen Burns, Paul Lehner, Helen Rowe,
- Kristin Patrick from @thepwlab.bsky.social with very cool imaging of nuclear condensates in macrophage immune response.
- and so many others but I've run out of steam!
- All the talks on LINE1 and HUSH complex - I learned a lot! Kathleen Burns, Paul Lehner, Helen Rowe,
- Kristin Patrick from @thepwlab.bsky.social with very cool imaging of nuclear condensates in macrophage immune response.
- and so many others but I've run out of steam!
February 4, 2025 at 5:04 AM
...
- All the talks on LINE1 and HUSH complex - I learned a lot! Kathleen Burns, Paul Lehner, Helen Rowe,
- Kristin Patrick from @thepwlab.bsky.social with very cool imaging of nuclear condensates in macrophage immune response.
- and so many others but I've run out of steam!
- All the talks on LINE1 and HUSH complex - I learned a lot! Kathleen Burns, Paul Lehner, Helen Rowe,
- Kristin Patrick from @thepwlab.bsky.social with very cool imaging of nuclear condensates in macrophage immune response.
- and so many others but I've run out of steam!
A few other talk highlights that are not yet published:
- Tiffany Hsu from Sun Hur's lab presenting on MDA5 in Dermatomyositis.
- @kseskv.bsky.social with awesome datasets on B cell development
- Qin Li on RNA editing in T1D
...
- Tiffany Hsu from Sun Hur's lab presenting on MDA5 in Dermatomyositis.
- @kseskv.bsky.social with awesome datasets on B cell development
- Qin Li on RNA editing in T1D
...
February 4, 2025 at 5:04 AM
A few other talk highlights that are not yet published:
- Tiffany Hsu from Sun Hur's lab presenting on MDA5 in Dermatomyositis.
- @kseskv.bsky.social with awesome datasets on B cell development
- Qin Li on RNA editing in T1D
...
- Tiffany Hsu from Sun Hur's lab presenting on MDA5 in Dermatomyositis.
- @kseskv.bsky.social with awesome datasets on B cell development
- Qin Li on RNA editing in T1D
...
Eric Poeschla presented this fascinating story on a mouse with chronic dsRNA production that develops SIngleton-Merton syndrome like phenotype following haploinsufficiency of Adar1. This one really had me thinking!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy
Sensing of viral double-stranded RNA by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornav...
www.biorxiv.org
February 4, 2025 at 5:04 AM
Eric Poeschla presented this fascinating story on a mouse with chronic dsRNA production that develops SIngleton-Merton syndrome like phenotype following haploinsufficiency of Adar1. This one really had me thinking!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Yorgo Modis presented a really interesting story on the trade off of different MDA5 variants.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
MDA5 variants trade antiviral activity for protection from autoimmune disease
Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studie...
www.medrxiv.org
February 4, 2025 at 5:04 AM
Yorgo Modis presented a really interesting story on the trade off of different MDA5 variants.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
@dulinlab.bsky.social did an impressive job explaining biophysics to biologists to uncover a new model of MDA5 activation which is super cool.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An alternative mechanism for activation of innate immune signaling by MDA5
Long double-stranded (ds) RNA in the cytosol acts as a potent inflammatory molecule recognized by the receptor MDA5, triggering the innate immune response. Mutations in MDA5 affecting dsRNA recognitio...
www.biorxiv.org
February 4, 2025 at 5:04 AM
@dulinlab.bsky.social did an impressive job explaining biophysics to biologists to uncover a new model of MDA5 activation which is super cool.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Fellow @hudsonresearch.bsky.social researcher @gantierlab.bsky.social presented his incredible story on new modes of TLR7/8 antagonism by tiny RNA fragments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism
Recognition of RNA fragments by Toll-like receptors (TLR) 7 and 8 is a key contributor to the initiation of a protective innate immune response against pathogens. A long-standing enigma is how degrada...
www.biorxiv.org
February 4, 2025 at 5:04 AM
Fellow @hudsonresearch.bsky.social researcher @gantierlab.bsky.social presented his incredible story on new modes of TLR7/8 antagonism by tiny RNA fragments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...