#RNAstability
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rscchembio.rsc.org
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
September 17, 2025 at 11:16 AM
plosbiology.org
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
February 7, 2025 at 6:20 PM
jsantoyo.bsky.social
RNA stability enhancers for durable base-modified mRNA therapeutics. #RNAstability #mRNAtherapeutics @natbiotech.nature.com
www.nature.com/articles/s41...
November 8, 2025 at 4:01 PM
plosbiology.org
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
February 7, 2025 at 1:16 PM
genesndiseases.bsky.social
This review explores both m⁶A-related and independent pathways through which #METTL16 regulates #RNAstability, emphasizes its critical role in #Cancer progression, and highlights METTL16 as a promising #therapeutic target in #Oncology. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
September 17, 2025 at 1:18 PM
molinalab.bsky.social
Any RNA biologists in the room? Does this makes sense? Is your favourite RBP in the list? #RNAbiology #RNAexport #RNAstability
molinalab.bsky.social Nacho Molina @molinalab.bsky.social · Nov 26
2) Waves of RNA export rates and top predicted RBPs: It seems that Nxf1, Hnrnpk, Taf15, Rbm10, Strap, and Ep300 may have a role in RNA export or/and cell cycle regulation.
December 3, 2024 at 8:28 AM
plosbiology.org
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
February 10, 2025 at 10:41 AM
jsantoyo.bsky.social
RNA methylation in retrotransposon control. #RNAmethylation #6mA #LTR #L1#ERV #RetrotransposonControl #RNAdecay #RNAstability #GenomeRegulation #CellularDifferentiation @cp-trendsgenetics.bsky.social‬
www.cell.com/trends/genet...
www.cell.com
June 7, 2025 at 10:49 AM
jsantoyo.bsky.social
Genetic variants affecting RNA stability influence complex traits and disease risk. #RNAstability #DiseaseRisks #GeneticVariants #Genomics @natgenet.nature.com
www.nature.com/articles/s41...
September 12, 2025 at 11:15 AM