Genes & Diseases Journal
@genesndiseases.bsky.social
International Open Access journal publishing on molecular and translational medicine. IF 2024,9.4; Scopus Citescore 2024, 8.4.
Pinned
Genes & Diseases invites reviewers with expertise in:
Human genetics & genomics
Cancer biology
Neurological, cardiovascular, and metabolic disorders
Translational medicine and more
Contact us: overseas@genesndiseases.com
#Genetics #PeerReview #GenesAndDiseases
Human genetics & genomics
Cancer biology
Neurological, cardiovascular, and metabolic disorders
Translational medicine and more
Contact us: overseas@genesndiseases.com
#Genetics #PeerReview #GenesAndDiseases
Obesity-associated fibroblasts reshape the #TME across #cancers, identify the TS.FIBRO.OBESITY.SIG signature linked to #ECM remodeling, #ImmuneSuppression and #TherapyResistance, and highlight key genes that may guide prognosis and treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 4:34 PM
Obesity-associated fibroblasts reshape the #TME across #cancers, identify the TS.FIBRO.OBESITY.SIG signature linked to #ECM remodeling, #ImmuneSuppression and #TherapyResistance, and highlight key genes that may guide prognosis and treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Genes & Diseases Journal
Groundbreaking study paves the way for #noninvasive #BladderCancerScreening tools that enhance patient comfort and improve outcomes.
#BladderCancer #UrineTest #CellFreeDNA
#BladderCancer #UrineTest #CellFreeDNA
A simple urine test could revolutionize bladder cancer diagnosis and treatment – BioNews Central
Groundbreaking study paves the way for noninvasive bladder cancer screening tools that enhance patient comfort and improve outcomes. ...
sbee.link
December 5, 2025 at 7:56 PM
Groundbreaking study paves the way for #noninvasive #BladderCancerScreening tools that enhance patient comfort and improve outcomes.
#BladderCancer #UrineTest #CellFreeDNA
#BladderCancer #UrineTest #CellFreeDNA
Reposted by Genes & Diseases Journal
Improving representation in clinical trials is vital to understanding cancer. Researchers at a recent conference shared new approaches to more people with cancer. Read more in Cancer Today. buff.ly/Sc1pLFT
December 6, 2025 at 1:15 PM
Improving representation in clinical trials is vital to understanding cancer. Researchers at a recent conference shared new approaches to more people with cancer. Read more in Cancer Today. buff.ly/Sc1pLFT
Reposted by Genes & Diseases Journal
#ESMOAsia25: Studies in cancer of unknown primary (#CUP) highlight the need to perform routine comprehensive #GenomicProfiling and then provide access to the appropriate #TargetedTherapy. Find out more in the #ESMODailyReporter ➡️https://ow.ly/sK6H50XF5t7
December 7, 2025 at 11:05 AM
#ESMOAsia25: Studies in cancer of unknown primary (#CUP) highlight the need to perform routine comprehensive #GenomicProfiling and then provide access to the appropriate #TargetedTherapy. Find out more in the #ESMODailyReporter ➡️https://ow.ly/sK6H50XF5t7
IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 12:49 PM
IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review explores the action mechanism of PARPi, the mechanisms underlying #PARPi resistance in cancers, and summarizes the strategies to overcome PARPi resistance, to extend PARPi applications and improve patient outcomes. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 2:56 AM
This review explores the action mechanism of PARPi, the mechanisms underlying #PARPi resistance in cancers, and summarizes the strategies to overcome PARPi resistance, to extend PARPi applications and improve patient outcomes. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review examines #GPR126's expression, #ligandreceptor interactions, signaling, and roles in development/diseases, highlighting small molecule, #peptide, and #monobody modulators as promising #aGPCRs-targeted therapies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 5:25 PM
This review examines #GPR126's expression, #ligandreceptor interactions, signaling, and roles in development/diseases, highlighting small molecule, #peptide, and #monobody modulators as promising #aGPCRs-targeted therapies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the tissue distribution, transfection rates and #Immunogenicity of recombinant adeno-associated virus serotype 8 (#AAV8) in gene therapy, with insights into the applications and challenges of using AAV8 as a vector.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 12:25 PM
Reviewing the tissue distribution, transfection rates and #Immunogenicity of recombinant adeno-associated virus serotype 8 (#AAV8) in gene therapy, with insights into the applications and challenges of using AAV8 as a vector.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Genes & Diseases Journal
Submit an abstract by December 8 for the AACR Special Conference on RAS Oncogenesis and Therapeutics (March 5-8, 2026; Los Angeles), chaired by Andrew J. Aguirre, Channing J. Der, David S. Hong, and Kevan M. Shokat. Learn more:
buff.ly/KSYsLWC
#AACRras26
buff.ly/KSYsLWC
#AACRras26
December 5, 2025 at 6:13 PM
Submit an abstract by December 8 for the AACR Special Conference on RAS Oncogenesis and Therapeutics (March 5-8, 2026; Los Angeles), chaired by Andrew J. Aguirre, Channing J. Der, David S. Hong, and Kevan M. Shokat. Learn more:
buff.ly/KSYsLWC
#AACRras26
buff.ly/KSYsLWC
#AACRras26
Reposted by Genes & Diseases Journal
A new review highlights five ways #microplastics can trigger #inflammation and #BrainDamage.
#Neuroinflammation #NeurodegenerativeDiseases #Alzheimers #Parkinsons
#Neuroinflammation #NeurodegenerativeDiseases #Alzheimers #Parkinsons
Five ways microplastics may harm your brain – BioNews Central
A new review highlights five ways microplastics can trigger inflammation and damage in the brain. ...
sbee.link
December 5, 2025 at 6:43 PM
A new review highlights five ways #microplastics can trigger #inflammation and #BrainDamage.
#Neuroinflammation #NeurodegenerativeDiseases #Alzheimers #Parkinsons
#Neuroinflammation #NeurodegenerativeDiseases #Alzheimers #Parkinsons
Reposted by Genes & Diseases Journal
Last Chance! Nominate your mentor for the @conquercancer.bsky.social Women Who Conquer Cancer Mentorship Award. Deadline is December 12th. Don't miss this final call! wwcc.secure-platform.com/a
December 5, 2025 at 7:11 PM
Last Chance! Nominate your mentor for the @conquercancer.bsky.social Women Who Conquer Cancer Mentorship Award. Deadline is December 12th. Don't miss this final call! wwcc.secure-platform.com/a
This review highlights #CRISPRCas9 as a precise #GeneEditing tool with therapeutic applications across #cancers, and acquired diseases, discussing #ClinicalTrials, off‑target challenges, and advances in #viral and #NonViralDelivery systems.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 1:25 AM
This review highlights #CRISPRCas9 as a precise #GeneEditing tool with therapeutic applications across #cancers, and acquired diseases, discussing #ClinicalTrials, off‑target challenges, and advances in #viral and #NonViralDelivery systems.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 4:34 PM
A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Researchers elucidate how #Hypoxiainduciblefactor1α drives #tumor progression in solid and hematological malignancies by regulating proliferation, #angiogenesis, metabolism, immunity, and therapy resistance in #hypoxic #microenvironments.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 12:59 PM
Researchers elucidate how #Hypoxiainduciblefactor1α drives #tumor progression in solid and hematological malignancies by regulating proliferation, #angiogenesis, metabolism, immunity, and therapy resistance in #hypoxic #microenvironments.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Genes & Diseases Journal
Dr. Sumanta Pal of @cityofhope.bsky.social & @lymphomadoc.bsky.social of @mdanderson.bsky.social discuss two of the major challenges facing oncologists in 2026 on the latest episode of the #ASCODailyNews Podcast: brnw.ch/21wY5Tt
December 4, 2025 at 11:37 PM
Dr. Sumanta Pal of @cityofhope.bsky.social & @lymphomadoc.bsky.social of @mdanderson.bsky.social discuss two of the major challenges facing oncologists in 2026 on the latest episode of the #ASCODailyNews Podcast: brnw.ch/21wY5Tt
Reposted by Genes & Diseases Journal
📣 Welcome to ESMO Asia 2025!
Together we bring dedication, expertise and shared purpose to one of the most important oncology meetings in the Asia-Pacific region.
Let’s move forward as one. #ESMOAsia25 #esmomeetings
🔗 buff.ly/z5gybDc
Together we bring dedication, expertise and shared purpose to one of the most important oncology meetings in the Asia-Pacific region.
Let’s move forward as one. #ESMOAsia25 #esmomeetings
🔗 buff.ly/z5gybDc
December 5, 2025 at 1:02 AM
📣 Welcome to ESMO Asia 2025!
Together we bring dedication, expertise and shared purpose to one of the most important oncology meetings in the Asia-Pacific region.
Let’s move forward as one. #ESMOAsia25 #esmomeetings
🔗 buff.ly/z5gybDc
Together we bring dedication, expertise and shared purpose to one of the most important oncology meetings in the Asia-Pacific region.
Let’s move forward as one. #ESMOAsia25 #esmomeetings
🔗 buff.ly/z5gybDc
Reposted by Genes & Diseases Journal
In the #ESMODailyReporter, Eileen Yi Ling Poon discusses addressing the medical and psychosocial needs of adolescents and young adults (#AYA) w/ cancer, providing individualised treatment, targeted emotional support and age-appropriate information: https://ow.ly/O94S50XCBee
#ESMOAsia25
#ESMOAsia25
December 5, 2025 at 8:10 AM
In the #ESMODailyReporter, Eileen Yi Ling Poon discusses addressing the medical and psychosocial needs of adolescents and young adults (#AYA) w/ cancer, providing individualised treatment, targeted emotional support and age-appropriate information: https://ow.ly/O94S50XCBee
#ESMOAsia25
#ESMOAsia25
This review explains how tumor cell heterogeneity, including resistant and tolerant subpopulations and quiescent states, drives #TherapyAdaptation and cancer survival, highlighting mechanisms that may help prevent recurrence. #cancer #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 6:14 AM
This review explains how tumor cell heterogeneity, including resistant and tolerant subpopulations and quiescent states, drives #TherapyAdaptation and cancer survival, highlighting mechanisms that may help prevent recurrence. #cancer #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the structure, regulation, and function of RRM2 and its inhibitors, its critical role in promoting tumor malignancy, #TumorImmunity, #TherapyResistance & the #TumorMicroenvironment, with insights into RRM2-targeted therapies. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 2:55 AM
Reviewing the structure, regulation, and function of RRM2 and its inhibitors, its critical role in promoting tumor malignancy, #TumorImmunity, #TherapyResistance & the #TumorMicroenvironment, with insights into RRM2-targeted therapies. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights the CD47‑SIRPα axis as a key #ImmuneCheckpoint in #lymphoma, detailing current therapeutic strategies, including #FcFusionProteins and #peptides, and underscores their potential in treating Hodgkin and #NonHodgkinlymphomas.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 4, 2025 at 5:25 PM
This review highlights the CD47‑SIRPα axis as a key #ImmuneCheckpoint in #lymphoma, detailing current therapeutic strategies, including #FcFusionProteins and #peptides, and underscores their potential in treating Hodgkin and #NonHodgkinlymphomas.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Genes & Diseases Journal
📌The #ThinkNENs program is designed to empower PCPs with the knowledge to recognize NENs and refer NEN patients earlier.
• Free, online & CME-accredited
• Available in 7 languages
• Endorsed by top NEN societies
✅Start today: incalliance.org/think-nens/
#LetsTalkAboutNETs
• Free, online & CME-accredited
• Available in 7 languages
• Endorsed by top NEN societies
✅Start today: incalliance.org/think-nens/
#LetsTalkAboutNETs
December 4, 2025 at 7:25 AM
📌The #ThinkNENs program is designed to empower PCPs with the knowledge to recognize NENs and refer NEN patients earlier.
• Free, online & CME-accredited
• Available in 7 languages
• Endorsed by top NEN societies
✅Start today: incalliance.org/think-nens/
#LetsTalkAboutNETs
• Free, online & CME-accredited
• Available in 7 languages
• Endorsed by top NEN societies
✅Start today: incalliance.org/think-nens/
#LetsTalkAboutNETs
Reposted by Genes & Diseases Journal
🚨 Submit your abstract for #ELCC26!
Share your research and help shape the future of #LungCancer care.
⏰ Deadline: 13 January 2026, Copenhagen & Online | 25–28 March 2026
🔗 https://ow.ly/E4N350XAv5k
Share your research and help shape the future of #LungCancer care.
⏰ Deadline: 13 January 2026, Copenhagen & Online | 25–28 March 2026
🔗 https://ow.ly/E4N350XAv5k
December 4, 2025 at 8:15 AM
🚨 Submit your abstract for #ELCC26!
Share your research and help shape the future of #LungCancer care.
⏰ Deadline: 13 January 2026, Copenhagen & Online | 25–28 March 2026
🔗 https://ow.ly/E4N350XAv5k
Share your research and help shape the future of #LungCancer care.
⏰ Deadline: 13 January 2026, Copenhagen & Online | 25–28 March 2026
🔗 https://ow.ly/E4N350XAv5k
Reposted by Genes & Diseases Journal
The Trainee Track is available in the #EAPCI26 programme
Built for growth, it delivers expert-led theory, practical guidance, tools & hands-on training w/ an EAPCI-certified completion to support your next step.
Explore the programme & register by 8 Dec to save https://bit.ly/3K3hHin
#EAPCI
Built for growth, it delivers expert-led theory, practical guidance, tools & hands-on training w/ an EAPCI-certified completion to support your next step.
Explore the programme & register by 8 Dec to save https://bit.ly/3K3hHin
#EAPCI
December 4, 2025 at 9:00 AM
The Trainee Track is available in the #EAPCI26 programme
Built for growth, it delivers expert-led theory, practical guidance, tools & hands-on training w/ an EAPCI-certified completion to support your next step.
Explore the programme & register by 8 Dec to save https://bit.ly/3K3hHin
#EAPCI
Built for growth, it delivers expert-led theory, practical guidance, tools & hands-on training w/ an EAPCI-certified completion to support your next step.
Explore the programme & register by 8 Dec to save https://bit.ly/3K3hHin
#EAPCI
This review outlines how EV-ncRNAs drive #PreMetastaticNiche formation by shaping #immunosuppression, #VascularRemodeling, #inflammation, metabolism, and #fibroblast activation across #cancers, highlighting their promise as #biomarkers.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 4, 2025 at 1:25 AM
This review outlines how EV-ncRNAs drive #PreMetastaticNiche formation by shaping #immunosuppression, #VascularRemodeling, #inflammation, metabolism, and #fibroblast activation across #cancers, highlighting their promise as #biomarkers.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reposted by Genes & Diseases Journal
Trontinemab, designed to reach the brain better than gantenerumab, led to amyloid negativity in 92 percent of patients at the highest dose in a Phase Ib/IIa trial.
Roche Optimistic Over New Formulation of Shelved Alzheimer's Drug After Seeing Anti-Amyloid Activity
www.precisionmedicineonline.com
December 3, 2025 at 4:08 PM
Trontinemab, designed to reach the brain better than gantenerumab, led to amyloid negativity in 92 percent of patients at the highest dose in a Phase Ib/IIa trial.