RSC Chemical Biology
@rscchembio.rsc.org
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.
🌐 Website: rsc.li/rscchembio Published by @rsc.org
🌐 Website: rsc.li/rscchembio Published by @rsc.org
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
November 5, 2025 at 8:04 AM
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk
Read the full paper here👉 doi.org/10.1039/D5CB...
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
October 29, 2025 at 12:32 PM
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"
Read the full paper here👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
Looking forward to today's #EMBOEpitrans by @events.embl.org! Get in touch or meet me in tomorrow's "Meet the Editors" session if you'd like to find out about @rscchembio.rsc.org and @molecularomics.rsc.org
October 28, 2025 at 7:07 AM
Looking forward to today's #EMBOEpitrans by @events.embl.org! Get in touch or meet me in tomorrow's "Meet the Editors" session if you'd like to find out about @rscchembio.rsc.org and @molecularomics.rsc.org
Reposted by RSC Chemical Biology
Looking forward to attending the @embo.org | @embl.org "The Epitranscriptome" meeting next week, on behalf of @rscchembio.rsc.org! I'll be taking part in the "Meet the Editor" session during Tuesday's lunch break. Feel free to message me to set up a meeting, or find me any time during the event.
October 21, 2025 at 3:45 PM
Looking forward to attending the @embo.org | @embl.org "The Epitranscriptome" meeting next week, on behalf of @rscchembio.rsc.org! I'll be taking part in the "Meet the Editor" session during Tuesday's lunch break. Feel free to message me to set up a meeting, or find me any time during the event.
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
October 21, 2025 at 2:30 PM
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays
Read the full paper👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
One more week until registration closes for this year's Chemical Science symposium on the chemistry of imaging, biosensing and diagnostics on 18-19 November in London!
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
October 13, 2025 at 11:34 AM
One more week until registration closes for this year's Chemical Science symposium on the chemistry of imaging, biosensing and diagnostics on 18-19 November in London!
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
October 15, 2025 at 1:48 PM
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism
Read more 👉 doi.org/10.1039/D5CB...
Reposted by RSC Chemical Biology
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
October 8, 2025 at 2:14 PM
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
October 7, 2025 at 1:21 PM
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
"19F NMR-tags for peptidyl prolyl conformation analysis"
Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.
Read the paper 👉 doi.org/10.1039/D5CB...
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
October 2, 2025 at 3:06 PM
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!
Let’s connect and talk science and publishing!
🔗 chembioparis2025.com
#ChemicalBiology #ICBS #ECBS
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
October 1, 2025 at 2:36 PM
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
September 23, 2025 at 12:49 PM
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium!
Congratulations to all the winners!
Congratulations to all the winners!
News - Tri-Institutional PhD Program in Chemical Biology
Latest news and events in the TPCB chemical biology graduate program.
chembio.triiprograms.org
September 19, 2025 at 2:20 PM
RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium!
Congratulations to all the winners!
Congratulations to all the winners!
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
September 18, 2025 at 11:00 AM
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
📖 Read the paper here: doi.org/10.1039/D4CB...
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
September 17, 2025 at 11:16 AM
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
September 16, 2025 at 10:47 AM
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
September 9, 2025 at 12:41 PM
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch
September 3, 2025 at 3:05 PM
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...
#RSCChemicalBiology #NIRPIT #CancerResearch
#RSCChemicalBiology #NIRPIT #CancerResearch
🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology.
🔗 Read now: https://rsc.li/cbbmt25
🔗 Read now: https://rsc.li/cbbmt25
August 26, 2025 at 12:00 PM
🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology.
🔗 Read now: https://rsc.li/cbbmt25
🔗 Read now: https://rsc.li/cbbmt25
🧠 New bioconjugation trick for tracking serotonylation — no tryptophan needed!
📝 New work from Qingfei Zheng et al.
📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation"
🔗 Read the full paper:
📝 New work from Qingfei Zheng et al.
📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation"
🔗 Read the full paper:
Semi-enzymatic synthesis and application of 13C-isotopically labelled inositol-(1,4,5)-trisphosphate
Inositol-(1,4,5)-trisphosphate (Ins(1,4,5)P3) is a crucial secondary messenger that controls calcium (Ca2+) levels inside cells, yet many questions regarding Ins(1,4,5)P3 metabolism are challenging to address with current methods. Here, a semi-enzymatic milligram scale synthesis of isotopically labeled [13C6]Ins(1,
doi.org
August 19, 2025 at 1:35 PM
🧠 New bioconjugation trick for tracking serotonylation — no tryptophan needed!
📝 New work from Qingfei Zheng et al.
📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation"
🔗 Read the full paper:
📝 New work from Qingfei Zheng et al.
📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation"
🔗 Read the full paper:
🚨 Breakthrough in targeting cancer-related protein aggregation:
"Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al.
🔗 Read the full article:
"Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al.
🔗 Read the full article:
Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation
Triazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties via a reversible ene-type reaction. Previous studies showed that the TAD probes could selectively modify tyrosine and tryptophan side-chains within proteins and peptides under dist
doi.org
August 13, 2025 at 3:13 PM
🚨 Breakthrough in targeting cancer-related protein aggregation:
"Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al.
🔗 Read the full article:
"Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al.
🔗 Read the full article:
Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
August 11, 2025 at 2:57 PM
Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
Proudly sponsored by RSC ChemBio + @rscmedchem.rsc.org!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At @mskcancercenter.bsky.social
Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
From Rheinheimera japonica 🦠 — a marine LPS with unusual structure 🌊 and weak TLR4 activation, but able to antagonize E. coli LPS. Published in RSC Chemical Biology.
🔗 Read the full article: doi.org/10.1039/D5CB...
#MarineBiology #Immunology #RSCChemicalBiology
🔗 Read the full article: doi.org/10.1039/D5CB...
#MarineBiology #Immunology #RSCChemicalBiology
Signals from the sea: the structural peculiarity of lipid A and weak immunostimulatory lipopolysaccharide from Rheinheimera japonica
Lipopolysaccharides (LPSs) isolated from marine bacteria represent a valuable resource for biomedical innovation. Here, we report the first structural elucidation of the lipid A moiety and a preliminary immunological assessment of the full LPS from the marine Gram-negative Rheinheimera japonica KMM 9513T. Using MAL
doi.org
August 4, 2025 at 5:59 PM
From Rheinheimera japonica 🦠 — a marine LPS with unusual structure 🌊 and weak TLR4 activation, but able to antagonize E. coli LPS. Published in RSC Chemical Biology.
🔗 Read the full article: doi.org/10.1039/D5CB...
#MarineBiology #Immunology #RSCChemicalBiology
🔗 Read the full article: doi.org/10.1039/D5CB...
#MarineBiology #Immunology #RSCChemicalBiology
📣 Present your research at EMBL’s The Epitranscriptome (28–30 Oct)!
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.
🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.
🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky
August 4, 2025 at 10:02 AM
📣 Present your research at EMBL’s The Epitranscriptome (28–30 Oct)!
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.
🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.
🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky
New in RSC Chemical Biology: Synthetic mucins 🧬 — made with native-like glycans to probe how glycosylation affects protein structure and degradation. A new tool for glycobiology and biomedical research.
🔗 Read full article: doi.org/10.1039/D5CB...
#Glycobiology #RSCChemicalBiology
🔗 Read full article: doi.org/10.1039/D5CB...
#Glycobiology #RSCChemicalBiology
Chemoenzymatic synthesis of sialylated and fucosylated mucin analogs reveals glycan-dependent effects on protein conformation and degradation
Mucin proteins are essential for life but are challenging to study due to their complex glycosylation patterns. Synthetic mimics have become vital tools for understanding and modulating the roles of mucins in human health and disease. These materials also have diverse biomedical applications as lubricants and anti-
doi.org
July 28, 2025 at 10:52 AM
New in RSC Chemical Biology: Synthetic mucins 🧬 — made with native-like glycans to probe how glycosylation affects protein structure and degradation. A new tool for glycobiology and biomedical research.
🔗 Read full article: doi.org/10.1039/D5CB...
#Glycobiology #RSCChemicalBiology
🔗 Read full article: doi.org/10.1039/D5CB...
#Glycobiology #RSCChemicalBiology