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rscchembio.rsc.org
RSC Chemical Biology
@rscchembio.rsc.org
410 followers 49 following 63 posts
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.

🌐 Website: rsc.li/rscchembio Published by @rsc.org
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rscchembio.rsc.org
Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social

New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment.

👉 Read the full paper here: doi.org/10.1039/D5CB...
November 14, 2025 at 10:45 AM
rscchembio.rsc.org
Fresh from Yogo Sakakibara et al.!

"Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein."

👉Read the full article here: doi.org/10.1039/D5CB...
November 12, 2025 at 12:10 PM
rscchembio.rsc.org
New in RSC Chemical Biology:
Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk

Read the full paper here👉 doi.org/10.1039/D5CB...
November 5, 2025 at 8:04 AM
rscchembio.rsc.org
New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory:

"Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein"

Read the full paper here👉 doi.org/10.1039/D5CB...
October 29, 2025 at 12:32 PM
Reposted by RSC Chemical Biology
alexwhiteside.bsky.social
Looking forward to today's #EMBOEpitrans by @events.embl.org! Get in touch or meet me in tomorrow's "Meet the Editors" session if you'd like to find out about @rscchembio.rsc.org and @molecularomics.rsc.org
October 28, 2025 at 7:07 AM
Reposted by RSC Chemical Biology
alexwhiteside.bsky.social
Looking forward to attending the @embo.org | @embl.org "The Epitranscriptome" meeting next week, on behalf of @rscchembio.rsc.org! I'll be taking part in the "Meet the Editor" session during Tuesday's lunch break. Feel free to message me to set up a meeting, or find me any time during the event.
October 21, 2025 at 3:45 PM
rscchembio.rsc.org
New from @llparker100.bsky.social et al. from @uminnpress.bsky.social

Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays

Read the full paper👉 doi.org/10.1039/D5CB...
October 21, 2025 at 2:30 PM
Reposted by RSC Chemical Biology
chemicalscience.rsc.org
One more week until registration closes for this year's Chemical Science symposium on the chemistry of imaging, biosensing and diagnostics on 18-19 November in London!

Join us in person or online to hear from our expert speakers and the 2025 Lectureship winner next month: www.rsc.org/events/d...
Promotional image for the 2025 Chemical Science Symposium, with a background image of a target and a cell, aligning with this year's theme on the chemistry of imaging, biosensing and diagnostics. Register by 20 October 2025.
October 13, 2025 at 11:34 AM
rscchembio.rsc.org
Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences:

Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism

Read more 👉 doi.org/10.1039/D5CB...
October 15, 2025 at 1:48 PM
Reposted by RSC Chemical Biology
digital-discovery.rsc.org
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
October 8, 2025 at 2:14 PM
rscchembio.rsc.org
New from Christopher Coxon et al., from @edinburgh-uni.bsky.social

"19F NMR-tags for peptidyl prolyl conformation analysis"

Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions.

Read the paper 👉 doi.org/10.1039/D5CB...
October 7, 2025 at 1:21 PM
rscchembio.rsc.org
Excited to support #ChemBioParis2025 this October 6 in Paris!
Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi!

Let’s connect and talk science and publishing!

🔗 chembioparis2025.com

#ChemicalBiology #ICBS #ECBS
October 2, 2025 at 3:06 PM
rscchembio.rsc.org
🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions!
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #StructuralBiology #Biosensors
October 1, 2025 at 2:36 PM
rscchembio.rsc.org
🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities.
Read it here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #AntibioticResistance #BetaLactamase
September 23, 2025 at 12:49 PM
rscchembio.rsc.org
RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium!

Congratulations to all the winners!
News - Tri-Institutional PhD Program in Chemical Biology
Latest news and events in the TPCB chemical biology graduate program.
chembio.triiprograms.org
September 19, 2025 at 2:20 PM
rscchembio.rsc.org
Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling!
📖 Read the paper here: doi.org/10.1039/D4CB...
September 18, 2025 at 11:00 AM
rscchembio.rsc.org
🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
September 17, 2025 at 11:16 AM
rscchembio.rsc.org
RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)!

🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person!
(Virtual registration open until 13 Oct.)
👉 www.embl.org/about/i...
#Epitranscriptome
September 16, 2025 at 10:47 AM
rscchembio.rsc.org
🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry
September 9, 2025 at 12:41 PM
rscchembio.rsc.org
🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB...

#RSCChemicalBiology #NIRPIT #CancerResearch
September 3, 2025 at 3:05 PM
rscchembio.rsc.org
🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology.

🔗 Read now: https://rsc.li/cbbmt25
August 26, 2025 at 12:00 PM
rscchembio.rsc.org
🧠 New bioconjugation trick for tracking serotonylation — no tryptophan needed!

📝 New work from Qingfei Zheng et al.
📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation"

🔗 Read the full paper:
Semi-enzymatic synthesis and application of 13C-isotopically labelled inositol-(1,4,5)-trisphosphate
Inositol-(1,4,5)-trisphosphate (Ins(1,4,5)P3) is a crucial secondary messenger that controls calcium (Ca2+) levels inside cells, yet many questions regarding Ins(1,4,5)P3 metabolism are challenging to address with current methods. Here, a semi-enzymatic milligram scale synthesis of isotopically labeled [13C6]Ins(1,
doi.org
August 19, 2025 at 1:35 PM
rscchembio.rsc.org
🚨 Breakthrough in targeting cancer-related protein aggregation:
"Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al.
🔗 Read the full article:
Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation
Triazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties via a reversible ene-type reaction. Previous studies showed that the TAD probes could selectively modify tyrosine and tryptophan side-chains within proteins and peptides under dist
doi.org
August 13, 2025 at 3:13 PM
rscchembio.rsc.org
Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬
Proudly sponsored by RSC ChemBio + ‪@rscmedchem.rsc.org‬!
🗓️ Reg closes Aug 20
🧪 Posters welcome from all attendees
📍 At ‪@mskcancercenter.bsky.social‬

Be there!
#ChemBio #MedChem #ScienceSymposium #RSCJournals
August 11, 2025 at 2:57 PM
rscchembio.rsc.org
From Rheinheimera japonica 🦠 — a marine LPS with unusual structure 🌊 and weak TLR4 activation, but able to antagonize E. coli LPS. Published in RSC Chemical Biology.
🔗 Read the full article: doi.org/10.1039/D5CB...
#MarineBiology #Immunology #RSCChemicalBiology
Signals from the sea: the structural peculiarity of lipid A and weak immunostimulatory lipopolysaccharide from Rheinheimera japonica
Lipopolysaccharides (LPSs) isolated from marine bacteria represent a valuable resource for biomedical innovation. Here, we report the first structural elucidation of the lipid A moiety and a preliminary immunological assessment of the full LPS from the marine Gram-negative Rheinheimera japonica KMM 9513T. Using MAL
doi.org
August 4, 2025 at 5:59 PM