Kinga Kamieniarz-Gdula
@stoplab.bsky.social
Molecular biologists fascinated by gene ends.
PI at IBMiB and CAT, Adam Mickiewicz University in Poznan, Poland.
Oxford University and @mpi_ie Freiburg alumna.
STOPlab.org
PI at IBMiB and CAT, Adam Mickiewicz University in Poznan, Poland.
Oxford University and @mpi_ie Freiburg alumna.
STOPlab.org
Reposted by Kinga Kamieniarz-Gdula
Scientists have found a little RNA molecule – small enough to potentially form spontaneously, yet sophisticated enough to copy itself – that cd explain how life on Earth arose. Thanks @edogia.bsky.social of the @philholliger.bsky.social lab! blog.sciencemuseum.org.uk/in-the-begin...
In the beginning - Science Museum Blog
A tiny self-copying molecule offers the clearest answer yet to the mystery of the origins of biology, reports Science Director Roger Highfield.
blog.sciencemuseum.org.uk
February 13, 2026 at 3:54 PM
Scientists have found a little RNA molecule – small enough to potentially form spontaneously, yet sophisticated enough to copy itself – that cd explain how life on Earth arose. Thanks @edogia.bsky.social of the @philholliger.bsky.social lab! blog.sciencemuseum.org.uk/in-the-begin...
Reposted by Kinga Kamieniarz-Gdula
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
New online: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
Nature Structural & Molecular Biology, Published online: 12 February 2026; doi:10.1038/s41594-026-01746-2Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag), and showed that its GAP activity is essential for both rapid inactivation and reactivation of TORC1.
dlvr.it
February 13, 2026 at 12:56 PM
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
Reposted by Kinga Kamieniarz-Gdula
my head is still spinning from EMBO Selfish Genetic Elements this week! incredible gamut of mostly "non-model" species gives us appreciation and insights into diversity of unusual chromosome dynamics, selfish genes and weird sex. tx @lucasoldini.bsky.social @laurarossevo.bsky.social tanja schwander!
February 13, 2026 at 4:59 PM
my head is still spinning from EMBO Selfish Genetic Elements this week! incredible gamut of mostly "non-model" species gives us appreciation and insights into diversity of unusual chromosome dynamics, selfish genes and weird sex. tx @lucasoldini.bsky.social @laurarossevo.bsky.social tanja schwander!
Reposted by Kinga Kamieniarz-Gdula
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 11:42 AM
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Reposted by Kinga Kamieniarz-Gdula
Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
February 13, 2026 at 10:02 AM
Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
Reposted by Kinga Kamieniarz-Gdula
A vanishing star births a black hole—without the fireworks | Science | AAAS @science.org 🔭🧪 www.science.org/content/arti...
A vanishing star births a black hole—without the fireworks
Failed supernova candidate points to a stealthy pathway of stellar collapse
www.science.org
February 13, 2026 at 12:38 AM
A vanishing star births a black hole—without the fireworks | Science | AAAS @science.org 🔭🧪 www.science.org/content/arti...
Reposted by Kinga Kamieniarz-Gdula
Thrilled to announce that I’ve just opened my research lab at @helmholtz-hiri.bsky.social !
A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
February 6, 2026 at 12:35 PM
Thrilled to announce that I’ve just opened my research lab at @helmholtz-hiri.bsky.social !
A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
Reposted by Kinga Kamieniarz-Gdula
Excited to share our latest study in Nature Communications ✨
We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.
Paper: www.nature.com/articles/s41...
#Genomics #DNADamage #CellBiology
We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.
Paper: www.nature.com/articles/s41...
#Genomics #DNADamage #CellBiology
February 13, 2026 at 6:22 PM
Excited to share our latest study in Nature Communications ✨
We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.
Paper: www.nature.com/articles/s41...
#Genomics #DNADamage #CellBiology
We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track.
Paper: www.nature.com/articles/s41...
#Genomics #DNADamage #CellBiology
Attention RNA biology and antisense therapy folks: this is HUUUUUUGE!!! Termination windows as therapeutic opportunity!
Interested in antisense oligonucleotides?
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.
link to BioRxiv:
www.biorxiv.org/content/10.6...
February 11, 2026 at 2:31 PM
Attention RNA biology and antisense therapy folks: this is HUUUUUUGE!!! Termination windows as therapeutic opportunity!
Reposted by Kinga Kamieniarz-Gdula
I’m super excited to be opening a lab at WEHI. We’ll be focussing on how double-stranded RNA is regulated in cells, how failures in these pathways drive disease and new therapies to manipulate inflammatory responses to RNA.
#newPI #RNAsky
#newPI #RNAsky
Say hello to our incoming lab heads! 👋 Excited to announce Dr Danika Hill, Dr Jacki Heraud-Farlow and Dr Sylvie Callegari will soon be establishing new labs at WEHI.
More info:
www.wehi.edu.au/news/excepti...
bsky.app/profile/sylv...
bsky.app/profile/jack...
bsky.app/profile/prec...
More info:
www.wehi.edu.au/news/excepti...
bsky.app/profile/sylv...
bsky.app/profile/jack...
bsky.app/profile/prec...
February 6, 2026 at 5:51 AM
Reposted by Kinga Kamieniarz-Gdula
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
February 6, 2026 at 7:57 AM
Our new preprint on SMCHD1! We’ve shown SMCHD1’s ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
Reposted by Kinga Kamieniarz-Gdula
I've joined the Editorial Board of @plosbiology.org
PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.
#CellBiology
PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.
#CellBiology
February 6, 2026 at 10:00 AM
I've joined the Editorial Board of @plosbiology.org
PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.
#CellBiology
PLOS Biology is the flagship #PLOS journal in the Life Sciences. I'm looking forward to handling terrific cell biology papers for them.
#CellBiology
Reposted by Kinga Kamieniarz-Gdula
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Gladys Mae West obituary: mathematician who pioneered GPS technology
She made key contributions to US cold-war science despite facing huge barriers as a Black woman.
www.nature.com
February 6, 2026 at 9:09 AM
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Reposted by Kinga Kamieniarz-Gdula
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding.
My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
UK science policy in transition – Soft Machines, by Richard Jones
softmachines.org
February 6, 2026 at 8:48 AM
The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding.
My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252
Reposted by Kinga Kamieniarz-Gdula
Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
January 20, 2026 at 3:30 PM
Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Deadline: 4 May 2026
https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
Reposted by Kinga Kamieniarz-Gdula
Sign up now for the EMBO Workshop "#RNA metabolism: Perspective from physiology to brain disorder" in Darjeeling, India, 25–28 October 2026.
Deadline: 15 May 2026
https://meetings.embo.org/event/26-rna-metabolism
#EMBOrnaMetabolism #RNAsky #LifeSciences #research #conference #EMBOevents 🧪
Deadline: 15 May 2026
https://meetings.embo.org/event/26-rna-metabolism
#EMBOrnaMetabolism #RNAsky #LifeSciences #research #conference #EMBOevents 🧪
January 27, 2026 at 1:13 PM
Sign up now for the EMBO Workshop "#RNA metabolism: Perspective from physiology to brain disorder" in Darjeeling, India, 25–28 October 2026.
Deadline: 15 May 2026
https://meetings.embo.org/event/26-rna-metabolism
#EMBOrnaMetabolism #RNAsky #LifeSciences #research #conference #EMBOevents 🧪
Deadline: 15 May 2026
https://meetings.embo.org/event/26-rna-metabolism
#EMBOrnaMetabolism #RNAsky #LifeSciences #research #conference #EMBOevents 🧪
Reposted by Kinga Kamieniarz-Gdula
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
www.biorxiv.org
January 31, 2026 at 1:13 AM
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
Reposted by Kinga Kamieniarz-Gdula
Join us;
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
Job profile
hrwebapp.qub.ac.uk
February 2, 2026 at 2:46 PM
Join us;
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system.
#Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs
hrwebapp.qub.ac.uk/tlive_webrec...
Reposted by Kinga Kamieniarz-Gdula
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 10:37 AM
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Reposted by Kinga Kamieniarz-Gdula
Washington Post reporter laid off while freezing in a war zone by one of the world’s richest people.
A publisher who lays off a reporter whose pen is freezing because she's covering a frigid war zone while dodging missiles is not an editor you want to work for, in a more perfect world
February 4, 2026 at 5:23 PM
Washington Post reporter laid off while freezing in a war zone by one of the world’s richest people.
Reposted by Kinga Kamieniarz-Gdula
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
www.researchprofessionalnews.com
January 31, 2026 at 11:12 PM
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Reposted by Kinga Kamieniarz-Gdula
Have a look at this fantastic meeting and save the date!
The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.
genetics.org.uk/events/rna-i...
The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.
genetics.org.uk/events/rna-i...
RNA in physiology and disease | Genetics Society
Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...
genetics.org.uk
January 31, 2026 at 9:43 AM
Have a look at this fantastic meeting and save the date!
The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.
genetics.org.uk/events/rna-i...
The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.
genetics.org.uk/events/rna-i...
Reposted by Kinga Kamieniarz-Gdula
... and we're off. Great kick-off meeting for the start of the ERC synergy GeneMotors project. So much energy and enthusiasm. @ceesdekker.bsky.social @erc.europa.eu
February 1, 2026 at 2:11 PM
... and we're off. Great kick-off meeting for the start of the ERC synergy GeneMotors project. So much energy and enthusiasm. @ceesdekker.bsky.social @erc.europa.eu
Which one is in you experience a more reliable and robust kit for sterility test (i.e in CAR-T samples): Sartorius or Thermofisher?
January 30, 2026 at 5:04 PM
Which one is in you experience a more reliable and robust kit for sterility test (i.e in CAR-T samples): Sartorius or Thermofisher?
Reposted by Kinga Kamieniarz-Gdula
Our journals Development, Journal of Cell Science, Disease Models & Mechanisms and Biology Open are pleased to be media partners for a number of @embo.org and @embl.org conferences, workshops and courses during 2026. See the full calendar of events at www.embl.org/about/info/c....
January 28, 2026 at 2:02 PM
Our journals Development, Journal of Cell Science, Disease Models & Mechanisms and Biology Open are pleased to be media partners for a number of @embo.org and @embl.org conferences, workshops and courses during 2026. See the full calendar of events at www.embl.org/about/info/c....