Stephen Royle
@steveroyle.bsky.social
I'm into chord changes and cell biology.
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @steveroyle@biologists.social
Lab: https://roylelab.org
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @steveroyle@biologists.social
Lab: https://roylelab.org
Good morning, cells!
Surprisingly hard to get a good picture down the TC microscope.
Surprisingly hard to get a good picture down the TC microscope.
December 26, 2025 at 9:42 AM
Good morning, cells!
Surprisingly hard to get a good picture down the TC microscope.
Surprisingly hard to get a good picture down the TC microscope.
Reposted by Stephen Royle
We have been busy celebrating our 100-year anniversary this year. Scroll through our timeline to view the key milestones over the years www.biologists.com/100-years/ti...
#biologists100
#biologists100
100 years timeline
Back to 100 years anniversary page
www.biologists.com
December 24, 2025 at 1:42 PM
We have been busy celebrating our 100-year anniversary this year. Scroll through our timeline to view the key milestones over the years www.biologists.com/100-years/ti...
#biologists100
#biologists100
Reposted by Stephen Royle
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
December 24, 2025 at 12:12 AM
Should funders mandate where grantees can publish?
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Probably not.
But funders could mandate where grantees cannot publish.
🧵
1/11
Reposted by Stephen Royle
Enjoy these human epithelial cell nuclei - especially the bagel with a hole right through the middle!
MCF10A cells with labelled with DNA (blue; Hoechst), anti-lamin A/C (green), and F-actin (magenta; phalloidin).
3D z-stack taken with a Zeiss CellDiscoverer7 + LSM 900 Airyscan-2, 20X (NA 0.95).
MCF10A cells with labelled with DNA (blue; Hoechst), anti-lamin A/C (green), and F-actin (magenta; phalloidin).
3D z-stack taken with a Zeiss CellDiscoverer7 + LSM 900 Airyscan-2, 20X (NA 0.95).
December 23, 2025 at 3:32 PM
Enjoy these human epithelial cell nuclei - especially the bagel with a hole right through the middle!
MCF10A cells with labelled with DNA (blue; Hoechst), anti-lamin A/C (green), and F-actin (magenta; phalloidin).
3D z-stack taken with a Zeiss CellDiscoverer7 + LSM 900 Airyscan-2, 20X (NA 0.95).
MCF10A cells with labelled with DNA (blue; Hoechst), anti-lamin A/C (green), and F-actin (magenta; phalloidin).
3D z-stack taken with a Zeiss CellDiscoverer7 + LSM 900 Airyscan-2, 20X (NA 0.95).
Reposted by Stephen Royle
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
At the helm of JCS – Editors-in-Chief past, present… and future
The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...
doi.org
December 22, 2025 at 10:33 AM
What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....
Reposted by Stephen Royle
We were delighted to support the UK Membrane Trafficking Meeting organised by @jezcarlton.bsky.social and Chris Stefan. It sounds like the meeting was a huge success once again. Congratulations to Nikita Zubkoc (Munro lab) and Jack Stanley @edenlab.bsky.social, winners of the JCS short talk prizes.
December 16, 2025 at 4:21 PM
We were delighted to support the UK Membrane Trafficking Meeting organised by @jezcarlton.bsky.social and Chris Stefan. It sounds like the meeting was a huge success once again. Congratulations to Nikita Zubkoc (Munro lab) and Jack Stanley @edenlab.bsky.social, winners of the JCS short talk prizes.
Reposted by Stephen Royle
If you're wondering if your manuscript could be suitable for our special issue but are unsure, don't hesitate to reach out 👍
In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
journals.biologists.com/jcs/pages/im...
Submission deadline: 1 April 2026
#imaging #microscopy #cellbiology
Registration for our Imaging Cell Dynamics meeting is still open! Organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social and @giuliazanetti.bsky.social.
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
Find out more: www.biologists.com/meetings/jcs...
Early-bird deadline: 16 January
#imaging #microscopy
December 18, 2025 at 8:26 PM
If you're wondering if your manuscript could be suitable for our special issue but are unsure, don't hesitate to reach out 👍
Reposted by Stephen Royle
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
December 17, 2025 at 12:46 AM
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Reposted by Stephen Royle
Why do people publish in shoddy journals?
Last month, Science of the Total Environment was delisted from Clarivate’s Web of Science. Delisting is often a death knell. It signals a journal no longer meets expectations for publication ethics or quality.
🧵1/8
english.elpais.com/science-tech...
Last month, Science of the Total Environment was delisted from Clarivate’s Web of Science. Delisting is often a death knell. It signals a journal no longer meets expectations for publication ethics or quality.
🧵1/8
english.elpais.com/science-tech...
The fall of a prolific science journal exposes the billion-dollar profits of scientific publishing
One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. Its publisher, Elsevier, has a 38% profit margin that reached $1.5 bill...
english.elpais.com
December 16, 2025 at 11:36 PM
Why do people publish in shoddy journals?
Last month, Science of the Total Environment was delisted from Clarivate’s Web of Science. Delisting is often a death knell. It signals a journal no longer meets expectations for publication ethics or quality.
🧵1/8
english.elpais.com/science-tech...
Last month, Science of the Total Environment was delisted from Clarivate’s Web of Science. Delisting is often a death knell. It signals a journal no longer meets expectations for publication ethics or quality.
🧵1/8
english.elpais.com/science-tech...
Can anyone on a BBSRC panel answer this question:
Are hyperlinked references allowed in grant applications (i.e. no reference section)?
TFS guidance only says "references may be included in this section" for Vision and Approach. Previously hyperlinks were not allowed, but has this changed?
Are hyperlinked references allowed in grant applications (i.e. no reference section)?
TFS guidance only says "references may be included in this section" for Vision and Approach. Previously hyperlinks were not allowed, but has this changed?
December 16, 2025 at 9:14 AM
Can anyone on a BBSRC panel answer this question:
Are hyperlinked references allowed in grant applications (i.e. no reference section)?
TFS guidance only says "references may be included in this section" for Vision and Approach. Previously hyperlinks were not allowed, but has this changed?
Are hyperlinked references allowed in grant applications (i.e. no reference section)?
TFS guidance only says "references may be included in this section" for Vision and Approach. Previously hyperlinks were not allowed, but has this changed?
I had a great day yesterday at UK Membrane Traffic in London. Too many highlights to mention. There's so much exciting work in this field! This year there was a poster session which was a great addition to get more people involved in the meeting. Thanks to Chris Stefan & Jez Carlton for organising.
December 16, 2025 at 6:39 AM
I had a great day yesterday at UK Membrane Traffic in London. Too many highlights to mention. There's so much exciting work in this field! This year there was a poster session which was a great addition to get more people involved in the meeting. Thanks to Chris Stefan & Jez Carlton for organising.
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
www.biorxiv.org
December 16, 2025 at 6:35 AM
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Reposted by Stephen Royle
I was invited by @focalplane.bsky.social to write a short description about it:
focalplane.biologists.com/2025/12/12/a...
focalplane.biologists.com/2025/12/12/a...
December 15, 2025 at 8:40 AM
I was invited by @focalplane.bsky.social to write a short description about it:
focalplane.biologists.com/2025/12/12/a...
focalplane.biologists.com/2025/12/12/a...
Reposted by Stephen Royle
Haven’t posted for a while but @jezcarlton.bsky.social opening up the annual UK membrane trafficking meeting #UKMT seems like an appropriate reason to post!
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
December 15, 2025 at 9:43 AM
Haven’t posted for a while but @jezcarlton.bsky.social opening up the annual UK membrane trafficking meeting #UKMT seems like an appropriate reason to post!
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Reposted by Stephen Royle
A reminder to use the right P2A sequence to produce separate proteins - the images are from a GPCR-P2A-mCherry construct using a P2A variant without (upper row) and with (lower row) a preceding GSG linker.
December 12, 2025 at 5:55 PM
A reminder to use the right P2A sequence to produce separate proteins - the images are from a GPCR-P2A-mCherry construct using a P2A variant without (upper row) and with (lower row) a preceding GSG linker.
There are lots of cool papers in reply to this thread (check them out!).
If you know a foundational paper in your field, published/posted this year. Let me know! 🧪
If you know a foundational paper in your field, published/posted this year. Let me know! 🧪
HELP! Please suggest a cool paper/preprint in your field in the last year or so.
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
December 12, 2025 at 9:44 AM
There are lots of cool papers in reply to this thread (check them out!).
If you know a foundational paper in your field, published/posted this year. Let me know! 🧪
If you know a foundational paper in your field, published/posted this year. Let me know! 🧪
Hooray, @biologists.bsky.social have protected a tree in exchange for a peer review I did for J Cell Sci. One of the many reasons why I prefer to donate my time to them rather than a commercial publisher.
forest.biologists.com/landscape/?i...
forest.biologists.com/landscape/?i...
Landscape - The Forest of Biologists
forest.biologists.com
December 12, 2025 at 9:37 AM
Hooray, @biologists.bsky.social have protected a tree in exchange for a peer review I did for J Cell Sci. One of the many reasons why I prefer to donate my time to them rather than a commercial publisher.
forest.biologists.com/landscape/?i...
forest.biologists.com/landscape/?i...
Reposted by Stephen Royle
This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.
December 12, 2025 at 6:20 AM
This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.
HELP! Please suggest a cool paper/preprint in your field in the last year or so.
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
December 11, 2025 at 1:19 PM
HELP! Please suggest a cool paper/preprint in your field in the last year or so.
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.
1/2
Reposted by Stephen Royle
Happy to finally share micromorph with everyone!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
micromorph: a Python toolkit for measurement of microbial morphology
Detection of morphological phenotypes from light microscopy is a key part of microbiology. Despite advances in automated morphological analysis, accurate measurements still often require significant u...
www.biorxiv.org
December 11, 2025 at 8:53 AM
Happy to finally share micromorph with everyone!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you!
You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!
Reposted by Stephen Royle
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Reposted by Stephen Royle
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 10, 2025 at 2:14 PM
Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
Reposted by Stephen Royle
The @biologists.bsky.social is amazing 🧪
December 9, 2025 at 3:48 PM
The @biologists.bsky.social is amazing 🧪
Reposted by Stephen Royle
We are also highlighting Claire Moulton, previously our Publisher and @biologists.bsky.social's first ever CEO, who led the creation of The Forest of Biologists, as an extraordinary biologist this week. #100biologists
December 5, 2025 at 1:11 PM
We are also highlighting Claire Moulton, previously our Publisher and @biologists.bsky.social's first ever CEO, who led the creation of The Forest of Biologists, as an extraordinary biologist this week. #100biologists
Reposted by Stephen Royle
Visit The Company of Biologists' booth (1232) at #CellBio2025 and find out about our journals, grants and meetings and also collect notebooks, posters and other giveaways. Find us next to The Hangout in the Exhibit Hall
December 6, 2025 at 3:50 PM
Visit The Company of Biologists' booth (1232) at #CellBio2025 and find out about our journals, grants and meetings and also collect notebooks, posters and other giveaways. Find us next to The Hangout in the Exhibit Hall