Stephen Royle
@steveroyle.bsky.social
I'm into chord changes and cell biology.
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @steveroyle@biologists.social
Lab: https://roylelab.org
Professor - University of Warwick. Director - The Company of Biologists. Views are my own and not those of any organisation I am associated with.
Mastodon: @steveroyle@biologists.social
Lab: https://roylelab.org
Reposted by Stephen Royle
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Applications for ERC Synergy Grants 2026: Facts and figures
The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:
erc.europa.eu
November 11, 2025 at 1:22 PM
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
erc.europa.eu/news-events/...
Reposted by Stephen Royle
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...
www.biorxiv.org
November 10, 2025 at 4:34 PM
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Stephen Royle
📢 Enhance your bioimage analysis skills - 2-day hands-on napari workshop.
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
CBIAS napari workshop 2025
www.crick.ac.uk
November 7, 2025 at 10:49 AM
📢 Enhance your bioimage analysis skills - 2-day hands-on napari workshop.
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Learn to:
- Set up conda envis install napari
- Navigate napari GUI install plugins
- Jupyter notebooks for basic IA
- Apply new skills to real datasets w expert guidance
📅 Apply by NOW!
www.crick.ac.uk/whats-on/cbi...
Reposted by Stephen Royle
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Stephen Royle
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
November 6, 2025 at 3:59 PM
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Adventures in Code VII: getting started with napari – quantixed
quantixed.org
November 4, 2025 at 10:00 AM
I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way.
quantixed.org/2025/11/04/a...
quantixed.org/2025/11/04/a...
Reposted by Stephen Royle
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
November 4, 2025 at 1:41 AM
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
Reposted by Stephen Royle
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Stephen Royle
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Reposted by Stephen Royle
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
blog.arxiv.org
November 2, 2025 at 5:33 PM
I’ve spent many years explaining/defending biorxiv’s “no reviews” policy.
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
The logic was always that opening Word and opining is a far lower barrier than doing actual research, so noise’d be >> signal and we didn’t want to make subjective quality judgements.
LLMs mean it makes even more sense 1/2
Reposted by Stephen Royle
Our new paper on type VII - showing a role in delaying macrophage death-
The staphylococcal type VII secretion system delays macrophage cell death through modulating multiple cell death pathways https://www.biorxiv.org/content/10.1101/2025.10.30.685513v1
November 1, 2025 at 2:10 PM
Our new paper on type VII - showing a role in delaying macrophage death-
Reposted by Stephen Royle
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 1:18 PM
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
Reposted by Stephen Royle
How a trick from flow cytometry can help colocalization visualization for microscopy forum.image.sc/t/cytofluoro...
October 31, 2025 at 10:32 AM
How a trick from flow cytometry can help colocalization visualization for microscopy forum.image.sc/t/cytofluoro...
There's a year-old problem with looping movies in Powerpoint on Mac. Movie plays once, jitters and then shows blocky artefacts. Same pptx works fine on Windows. Problem seems to be Mac-side (QT?) but 15.7.1 and 26.0.1 both show this behaviour.
A solution, in case it helps anyone:
1/2
A solution, in case it helps anyone:
1/2
October 31, 2025 at 10:42 AM
There's a year-old problem with looping movies in Powerpoint on Mac. Movie plays once, jitters and then shows blocky artefacts. Same pptx works fine on Windows. Problem seems to be Mac-side (QT?) but 15.7.1 and 26.0.1 both show this behaviour.
A solution, in case it helps anyone:
1/2
A solution, in case it helps anyone:
1/2
Reposted by Stephen Royle
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
October 30, 2025 at 2:18 PM
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
Reposted by Stephen Royle
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
October 27, 2025 at 5:02 PM
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Reposted by Stephen Royle
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
October 21, 2025 at 6:15 PM
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
Reposted by Stephen Royle
Read more about this research in our interview with first author Will Scott, a postdoc fellow in Mohan Balasubramanian's lab at University of Warwick, UK, interested in engineering proteins and synthesising organic molecules to tackle actin cytoskeleton-associated challenges. doi.org/10.1242/bio....
October 22, 2025 at 6:59 AM
Read more about this research in our interview with first author Will Scott, a postdoc fellow in Mohan Balasubramanian's lab at University of Warwick, UK, interested in engineering proteins and synthesising organic molecules to tackle actin cytoskeleton-associated challenges. doi.org/10.1242/bio....
Reposted by Stephen Royle
As part of our monthly meeting, we do a run-down of all* the new #bioimageanalysis tools that have been published in the last couple of weeks on BioRxiv**, so I thought I'd start sharing here as well.
*I will miss some, apologies if I miss your paper
*I will miss some, apologies if I miss your paper
October 17, 2025 at 7:17 AM
As part of our monthly meeting, we do a run-down of all* the new #bioimageanalysis tools that have been published in the last couple of weeks on BioRxiv**, so I thought I'd start sharing here as well.
*I will miss some, apologies if I miss your paper
*I will miss some, apologies if I miss your paper
Reposted by Stephen Royle
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 3:31 PM
Compared to other publishers, The Company of Biologists is small fry with fewer than 70 staff supporting 5 journals from a single office. But, for over 100 years now, it’s punched above its weight in innovation, prestige and community support.
Reposted by Stephen Royle
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
That's a new one. We ordered five genes by custom synthesis and we received one gene + four empty tubes! And that was after waiting for almost week with the order being delayed at Customs.
#LifeOfPI #EndlessScreaming
#LifeOfPI #EndlessScreaming
October 17, 2025 at 6:49 AM
That's a new one. We ordered five genes by custom synthesis and we received one gene + four empty tubes! And that was after waiting for almost week with the order being delayed at Customs.
#LifeOfPI #EndlessScreaming
#LifeOfPI #EndlessScreaming
Reposted by Stephen Royle
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:02 PM
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Stephen Royle
Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553
October 15, 2025 at 1:46 PM
Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553
Reposted by Stephen Royle
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...