Pei Yee
@impeiyee.bsky.social
Cell biologist. Postdoc at Urbé/Clague lab. Previously at UCL-LMCB.
Fascinated by ubiquitin biology and membrane trafficking.
Fascinated by ubiquitin biology and membrane trafficking.
Pinned
Pei Yee
@impeiyee.bsky.social
· Mar 26
Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social
bscb.org/bscb-phd-awa...
bscb.org/bscb-phd-awa...
Deeply honoured to receive the 2025 Raff Medal!
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...
www.biorxiv.org
November 10, 2025 at 4:34 PM
Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Pei Yee
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
October 30, 2025 at 3:33 PM
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Our review "Proteostasis of immune checkpoint receptors" is out in Biochem J! @biochemsoc.bsky.social
We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
portlandpress.com/biochemj/art...
We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
portlandpress.com/biochemj/art...
Proteostasis of immune checkpoint receptors
Immunotherapy relies on the targeting of immune checkpoint receptors and their respective ligands by specific antibodies that bind to the cell surface proteins. The pace of this highly successful clin...
portlandpress.com
October 2, 2025 at 4:06 PM
Our review "Proteostasis of immune checkpoint receptors" is out in Biochem J! @biochemsoc.bsky.social
We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
portlandpress.com/biochemj/art...
We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
portlandpress.com/biochemj/art...
Reposted by Pei Yee
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Reposted by Pei Yee
📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin
#ubiquitin
July 11, 2025 at 7:08 AM
📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin
#ubiquitin
Check out our study on the rapid turnover of CTLA4, featured in JCB Immune Cell Biology 2025 Collection!
@impeiyee.bsky.social, Clague, Urbé et al. characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. rupress.org/jcb/article/...
📕 In Immune Cell Biology 2025: rupress.org/jcb/collecti...
#AAI2025
📕 In Immune Cell Biology 2025: rupress.org/jcb/collecti...
#AAI2025
May 7, 2025 at 5:00 PM
Check out our study on the rapid turnover of CTLA4, featured in JCB Immune Cell Biology 2025 Collection!
Reposted by Pei Yee
We are sponsoring the Scottish Cell Biology Meeting on 18th Sept. Save the date!
April 15, 2025 at 9:16 AM
We are sponsoring the Scottish Cell Biology Meeting on 18th Sept. Save the date!
Reposted by Pei Yee
Congratulations to Dr Pei Yee Tey (@impeiyee.bsky.social) from our Department of Biochemistry, Cell and Systems Biology, winner of the British Society of Cell Biology's 2025 Raff Medal for her research.
➡️ bit.ly/42evg4V
#PhD | #BSCB | #TeamLivUni
➡️ bit.ly/42evg4V
#PhD | #BSCB | #TeamLivUni
April 8, 2025 at 9:24 AM
Congratulations to Dr Pei Yee Tey (@impeiyee.bsky.social) from our Department of Biochemistry, Cell and Systems Biology, winner of the British Society of Cell Biology's 2025 Raff Medal for her research.
➡️ bit.ly/42evg4V
#PhD | #BSCB | #TeamLivUni
➡️ bit.ly/42evg4V
#PhD | #BSCB | #TeamLivUni
Reposted by Pei Yee
Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
www.nature.com
April 3, 2025 at 8:55 PM
Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pei Yee
Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….
https://nature.com/articles/s4155…
February 22, 2025 at 10:45 AM
Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….
Reposted by Pei Yee
March 27, 2025 at 1:53 PM
Reposted by Pei Yee
Excited to see @lmcb-ucl.bsky.social alumna Pei Yee winning the Raff PhD Medal 2025. Also a very special prize named after Professor Martin Raff, a major driving force in the development of the LMCB four-year PhD programme.
Read more about Pei Yee below 👇
Read more about Pei Yee below 👇
Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social
bscb.org/bscb-phd-awa...
bscb.org/bscb-phd-awa...
March 25, 2025 at 9:41 AM
Excited to see @lmcb-ucl.bsky.social alumna Pei Yee winning the Raff PhD Medal 2025. Also a very special prize named after Professor Martin Raff, a major driving force in the development of the LMCB four-year PhD programme.
Read more about Pei Yee below 👇
Read more about Pei Yee below 👇
Deeply honoured to receive the 2025 Raff Medal!
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social
bscb.org/bscb-phd-awa...
bscb.org/bscb-phd-awa...
March 26, 2025 at 6:40 AM
Deeply honoured to receive the 2025 Raff Medal!
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.
Reposted by Pei Yee
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import
The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms
and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are
strongly linked to mitochondrial ...
www.cell.com
February 10, 2025 at 8:19 AM
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Reposted by Pei Yee
"Research is messy. … Trying to protect students from that reality does them a disservice."
On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER
On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER
January 24, 2025 at 3:07 PM
"Research is messy. … Trying to protect students from that reality does them a disservice."
On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER
On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER
Reposted by Pei Yee
🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...
www.aginganddisease.org/EN/10.14336/...
Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function
<p>Axons are crucial for transmitting neurochemical signals. As organisms age, the ability of neurons to maintain their axons declines; hence, aged axons are more susceptible to damage or dysfunction....
www.aginganddisease.org
January 17, 2025 at 9:47 AM
🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...
www.aginganddisease.org/EN/10.14336/...
Reposted by Pei Yee
Happy to see this pre-print online where we supported volume EM needs of this collaborative effort led by the Booth lab to investigate the role of the chromosome periphery in meiosis vs mitosis. #liv-srf
www.biorxiv.org/content/10.1...
@livuni-livsrf.bsky.social @livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
@livuni-livsrf.bsky.social @livuni-ismib.bsky.social
The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes
Chromosomes and their constituent compartments are core elements of the cell division machinery. In mammalian oocytes, defects in the structure or composition of chromosomes are a leading cause of abe...
www.biorxiv.org
December 23, 2024 at 12:52 PM
Happy to see this pre-print online where we supported volume EM needs of this collaborative effort led by the Booth lab to investigate the role of the chromosome periphery in meiosis vs mitosis. #liv-srf
www.biorxiv.org/content/10.1...
@livuni-livsrf.bsky.social @livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...
@livuni-livsrf.bsky.social @livuni-ismib.bsky.social
Reposted by Pei Yee
Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...
www.biorxiv.org
December 3, 2024 at 11:54 PM
Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pei Yee
A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology
Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...
www.nature.com
January 10, 2025 at 3:07 PM
A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pei Yee
Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...
DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies
In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...
pubs.acs.org
January 9, 2025 at 5:50 PM
Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...
My friend Victoria is joining the knitt/crocheting challenge this December to raise funds for @cancerresearchuk.org
She created thoughtful science-inspired crochet gifts for our lab members (pics attached)
Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...
She created thoughtful science-inspired crochet gifts for our lab members (pics attached)
Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...
December 23, 2024 at 10:56 PM
My friend Victoria is joining the knitt/crocheting challenge this December to raise funds for @cancerresearchuk.org
She created thoughtful science-inspired crochet gifts for our lab members (pics attached)
Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...
She created thoughtful science-inspired crochet gifts for our lab members (pics attached)
Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...
Exciting PhD opportunity with @mcmillanlab.bsky.social in @livuni-ismib.bsky.social Liverpool! Kirsty is a great scientist and an extremely pleasant person to work with. Come join us if you're interested in membrane trafficking and neurodegeneration!
I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look:
www.findaphd.com/phds/project...
Please feel free to share.
www.findaphd.com/phds/project...
Please feel free to share.
The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool on FindAPhD.com
PhD Project - The Role of the Endosomal System in Alzheimer’s Disease. at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
December 19, 2024 at 10:04 AM
Exciting PhD opportunity with @mcmillanlab.bsky.social in @livuni-ismib.bsky.social Liverpool! Kirsty is a great scientist and an extremely pleasant person to work with. Come join us if you're interested in membrane trafficking and neurodegeneration!
Reposted by Pei Yee
🧪The Biologists @ 100 conference incorporates the BSCB and BSDB @bsdb.bsky.social Spring Meetings. View the cell and developmental biology programme and speakers at bit.ly/3B2uflr.
Abstracts are due less than 2 weeks away.
📆Abstract due: 13 December
#biologists100 #Devbio #cellbio
Abstracts are due less than 2 weeks away.
📆Abstract due: 13 December
#biologists100 #Devbio #cellbio
December 2, 2024 at 1:28 PM
🧪The Biologists @ 100 conference incorporates the BSCB and BSDB @bsdb.bsky.social Spring Meetings. View the cell and developmental biology programme and speakers at bit.ly/3B2uflr.
Abstracts are due less than 2 weeks away.
📆Abstract due: 13 December
#biologists100 #Devbio #cellbio
Abstracts are due less than 2 weeks away.
📆Abstract due: 13 December
#biologists100 #Devbio #cellbio