Jalees Rehman
@jalees.bsky.social
Head, Dept of Biochemistry & Molecular Genetics, Univ of Illinois, College of Medicine: cell biology, vascular biology, genomics, computational biology, immunology, regeneration, neuroscience; https://chicago.medicine.uic.edu/bmg/profiles/rehman-jalees/
Reposted by Jalees Rehman
Vaccines don’t just prevent deadly and dangerous diseases like measles, polio and COVID-19.
A new study found that people who got the shingles vaccine had a 20% lower risk of developing dementia. buff.ly/5p4z5NS By Anand Kumar and @jalees.bsky.social @uicdom.bsky.social #VaccinesWork 🩺
A new study found that people who got the shingles vaccine had a 20% lower risk of developing dementia. buff.ly/5p4z5NS By Anand Kumar and @jalees.bsky.social @uicdom.bsky.social #VaccinesWork 🩺
Vaccines hold tantalizing promise in the fight against dementia
A prominent Nature study and related research raise the possibility that vaccines may have a broader role in experimental therapeutics outside the realm of infectious diseases.
buff.ly
August 10, 2025 at 3:48 AM
Vaccines don’t just prevent deadly and dangerous diseases like measles, polio and COVID-19.
A new study found that people who got the shingles vaccine had a 20% lower risk of developing dementia. buff.ly/5p4z5NS By Anand Kumar and @jalees.bsky.social @uicdom.bsky.social #VaccinesWork 🩺
A new study found that people who got the shingles vaccine had a 20% lower risk of developing dementia. buff.ly/5p4z5NS By Anand Kumar and @jalees.bsky.social @uicdom.bsky.social #VaccinesWork 🩺
Grateful for thoughtful News and Views by
@cancercachexia.bsky.social pioneers @teresazimmers.bsky.social and Denis Guttridge
nature.com/articles/s43... on our paper nature.com/articles/s43...
@natcancer.nature.com - highlights need for cross-disciplinary approaches to tackle #cancer #cachexia
@cancercachexia.bsky.social pioneers @teresazimmers.bsky.social and Denis Guttridge
nature.com/articles/s43... on our paper nature.com/articles/s43...
@natcancer.nature.com - highlights need for cross-disciplinary approaches to tackle #cancer #cachexia
Vascular collapse leads to muscle wasting in cancer cachexia - Nature Cancer
Muscle atrophy in cachexia drives weight loss and represents a major complication for patients with cancer. The tumor-derived cytokine activin A is now shown to decrease endothelial cell viability in ...
nature.com
July 1, 2025 at 8:12 PM
Grateful for thoughtful News and Views by
@cancercachexia.bsky.social pioneers @teresazimmers.bsky.social and Denis Guttridge
nature.com/articles/s43... on our paper nature.com/articles/s43...
@natcancer.nature.com - highlights need for cross-disciplinary approaches to tackle #cancer #cachexia
@cancercachexia.bsky.social pioneers @teresazimmers.bsky.social and Denis Guttridge
nature.com/articles/s43... on our paper nature.com/articles/s43...
@natcancer.nature.com - highlights need for cross-disciplinary approaches to tackle #cancer #cachexia
Reposted by Jalees Rehman
📢Article now online at Nature Cancer!
'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'
✏️By Young-Mee Kim, Jalees Rehman and colleagues
🔗 www.nature.com/articles/s43...
'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'
✏️By Young-Mee Kim, Jalees Rehman and colleagues
🔗 www.nature.com/articles/s43...
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer
Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...
www.nature.com
June 4, 2025 at 10:06 AM
📢Article now online at Nature Cancer!
'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'
✏️By Young-Mee Kim, Jalees Rehman and colleagues
🔗 www.nature.com/articles/s43...
'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'
✏️By Young-Mee Kim, Jalees Rehman and colleagues
🔗 www.nature.com/articles/s43...
Thrilled to share this publication from our lab on muscle wasting in #Cancer and #vascularbiology, spearheaded by Young-Mee Kim in @natcancer.nature.com
nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health
@uicancercenter.bsky.social @uofilsystem.bsky.social
nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health
@uicancercenter.bsky.social @uofilsystem.bsky.social
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer
Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...
nature.com
May 29, 2025 at 6:43 PM
Thrilled to share this publication from our lab on muscle wasting in #Cancer and #vascularbiology, spearheaded by Young-Mee Kim in @natcancer.nature.com
nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health
@uicancercenter.bsky.social @uofilsystem.bsky.social
nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health
@uicancercenter.bsky.social @uofilsystem.bsky.social
Reposted by Jalees Rehman
Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...
Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications
Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...
www.nature.com
February 24, 2025 at 7:31 PM
Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41... by@const-ae.bsky.social @wkhuber.bsky.social in @naturegenet.bsky.social
LEMUR Github: github.com/const-ae/lemur
pyLEMUR: github.com/const-ae/pyL...
www.nature.com/articles/s41... by@const-ae.bsky.social @wkhuber.bsky.social in @naturegenet.bsky.social
LEMUR Github: github.com/const-ae/lemur
pyLEMUR: github.com/const-ae/pyL...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
www.nature.com
January 3, 2025 at 7:49 PM
Analysis of multi-condition single-cell data with latent embedding multivariate regression
www.nature.com/articles/s41... by@const-ae.bsky.social @wkhuber.bsky.social in @naturegenet.bsky.social
LEMUR Github: github.com/const-ae/lemur
pyLEMUR: github.com/const-ae/pyL...
www.nature.com/articles/s41... by@const-ae.bsky.social @wkhuber.bsky.social in @naturegenet.bsky.social
LEMUR Github: github.com/const-ae/lemur
pyLEMUR: github.com/const-ae/pyL...
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome
Single-cell CRISPR screens link genetic perturbations to transcriptional states, but high-throughput methods connecting these induced changes to their…
www.sciencedirect.com
January 3, 2025 at 4:49 PM
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Best practices for differential accessibility analysis in single-cell epigenomics
www.nature.com/articles/s41... @naturecomms.bsky.social
www.nature.com/articles/s41... @naturecomms.bsky.social
Best practices for differential accessibility analysis in single-cell epigenomics - Nature Communications
The authors conduct a comprehensive assessment of statistical methods for identifying differentially accessible (DA) regions in scATAC-seq data, using a compendium of scATAC-seq experiments paired wit...
www.nature.com
January 3, 2025 at 4:48 PM
Best practices for differential accessibility analysis in single-cell epigenomics
www.nature.com/articles/s41... @naturecomms.bsky.social
www.nature.com/articles/s41... @naturecomms.bsky.social
TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
December 20, 2024 at 4:24 PM
TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation
www.science.org/doi/10.1126/...
Perspective: A neuronal gene that loops the loop
www.science.org/doi/10.1126/...
in @science.org
www.science.org/doi/10.1126/...
Perspective: A neuronal gene that loops the loop
www.science.org/doi/10.1126/...
in @science.org
December 20, 2024 at 4:22 PM
A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation
www.science.org/doi/10.1126/...
Perspective: A neuronal gene that loops the loop
www.science.org/doi/10.1126/...
in @science.org
www.science.org/doi/10.1126/...
Perspective: A neuronal gene that loops the loop
www.science.org/doi/10.1126/...
in @science.org
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...
www.science.org
December 20, 2024 at 4:20 PM
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
Synthetic organizer cells guide development via spatial and biochemical instructions
www.cell.com/cell/fulltex... in @cp-cell.bsky.social
"synthetic organizer cells" integrate spatial, temporal, and biochemical information, direct fate trajectories within the morphogenetic landscape
www.cell.com/cell/fulltex... in @cp-cell.bsky.social
"synthetic organizer cells" integrate spatial, temporal, and biochemical information, direct fate trajectories within the morphogenetic landscape
Synthetic organizer cells guide development via spatial and biochemical instructions
Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.
www.cell.com
December 20, 2024 at 4:18 PM
Synthetic organizer cells guide development via spatial and biochemical instructions
www.cell.com/cell/fulltex... in @cp-cell.bsky.social
"synthetic organizer cells" integrate spatial, temporal, and biochemical information, direct fate trajectories within the morphogenetic landscape
www.cell.com/cell/fulltex... in @cp-cell.bsky.social
"synthetic organizer cells" integrate spatial, temporal, and biochemical information, direct fate trajectories within the morphogenetic landscape
Conventional chemotherapy: millions of cures, unresolved therapeutic index
www.nature.com/articles/s41... in @natrevcancer.bsky.social
www.nature.com/articles/s41... in @natrevcancer.bsky.social
Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer
Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...
www.nature.com
December 20, 2024 at 4:16 PM
Conventional chemotherapy: millions of cures, unresolved therapeutic index
www.nature.com/articles/s41... in @natrevcancer.bsky.social
www.nature.com/articles/s41... in @natrevcancer.bsky.social
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitoc...
www.science.org
December 20, 2024 at 4:15 AM
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
www.science.org/doi/10.1126/...
@science.org
"coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help"
www.science.org/doi/10.1126/...
@science.org
"coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help"
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
www.science.org
December 20, 2024 at 4:14 AM
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
www.science.org/doi/10.1126/...
@science.org
"coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help"
www.science.org/doi/10.1126/...
@science.org
"coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help"
Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs
Lewis and Xie et al. systematically quantified translation functions of >30,000 human 5′ UTRs, revealing regulatory sequence elements and RNA modifications that impact the initiation process. This approach can aid the design of therapeutic mRNA and facilitate the dissection of the molecular mechanisms of translation initiation.
www.cell.com
December 20, 2024 at 4:11 AM
Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
GenomeDelta: detecting recent transposable element invasions without repeat library
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
GenomeDelta: detecting recent transposable element invasions without repeat library - Genome Biology
We present GenomeDelta, a novel tool for identifying sample-specific sequences, such as recent transposable element (TE) invasions, without requiring a repeat library. GenomeDelta compares high-qualit...
genomebiology.biomedcentral.com
December 20, 2024 at 4:08 AM
GenomeDelta: detecting recent transposable element invasions without repeat library
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
www.cell.com/cell/fulltex...
@cp-cell.bsky.social
www.cell.com/cell/fulltex...
@cp-cell.bsky.social
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.
www.cell.com
December 19, 2024 at 10:09 PM
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
www.cell.com/cell/fulltex...
@cp-cell.bsky.social
www.cell.com/cell/fulltex...
@cp-cell.bsky.social
Unser Parlament wird aufgelöst, nach den Wahlen gibt es bestimmt Politchaos, weil man sich bei den Umfragewerten kaum eine funktionierende Koalition vorstellen kann. Aber wenigstens hat der Zoll die richtigen Prioritäten:
Zoll stoppt geschmuggelte Dubai-Schokolade
www.zoll.de/SharedDocs/P...
Zoll stoppt geschmuggelte Dubai-Schokolade
www.zoll.de/SharedDocs/P...
Zoll stoppt geschmuggelte Dubai-Schokolade
Steuerstrafverfahren eingeleitet und Einfuhrabgaben von knapp 920 Euro nacherhoben
www.zoll.de
December 19, 2024 at 8:55 PM
Unser Parlament wird aufgelöst, nach den Wahlen gibt es bestimmt Politchaos, weil man sich bei den Umfragewerten kaum eine funktionierende Koalition vorstellen kann. Aber wenigstens hat der Zoll die richtigen Prioritäten:
Zoll stoppt geschmuggelte Dubai-Schokolade
www.zoll.de/SharedDocs/P...
Zoll stoppt geschmuggelte Dubai-Schokolade
www.zoll.de/SharedDocs/P...
I hope that @jeremymberg.bsky.social will be assembling these insightful and informative anecdotes into a book or Netflix series:
The Life and Opinions of Jeremy Berg, Gentlescientist
The Life and Opinions of Jeremy Berg, Gentlescientist
Bluetorial: Adventures with tenure-Part 2
My experiences on the Johns Hopkins School of Medicine Professorial Promotions Committee with some thoughts about scholarship vs fund raising success, team science, hyperproductivity, and the age distribution of the professoriate.
My experiences on the Johns Hopkins School of Medicine Professorial Promotions Committee with some thoughts about scholarship vs fund raising success, team science, hyperproductivity, and the age distribution of the professoriate.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
December 19, 2024 at 8:47 PM
I hope that @jeremymberg.bsky.social will be assembling these insightful and informative anecdotes into a book or Netflix series:
The Life and Opinions of Jeremy Berg, Gentlescientist
The Life and Opinions of Jeremy Berg, Gentlescientist
Cellular RNA interacts with MAVS to promote antiviral signaling
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 19, 2024 at 8:43 PM
Cellular RNA interacts with MAVS to promote antiviral signaling
www.science.org/doi/10.1126/... in @science.org
www.science.org/doi/10.1126/... in @science.org
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
Sasaki et al. demonstrate that chromosome missegregation induced by SAC inhibition results in cytoplasmic dsRNA accumulation, primarily generated from non-exonic regions in the MNs. Activation of MAVS-mediated dsRNA sensing cooperates with dsDNA sensing to promote anti-tumor immunity.
www.cell.com
December 19, 2024 at 5:13 PM
RNA sensing induced by chromosome missegregation augments anti-tumor immunity
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury
www.jci.org/articles/vie... in @jclinical-invest.bsky.social
with commentary
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs
www.jci.org/articles/vie...
www.jci.org/articles/vie... in @jclinical-invest.bsky.social
with commentary
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs
www.jci.org/articles/vie...
December 18, 2024 at 11:05 PM
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury
www.jci.org/articles/vie... in @jclinical-invest.bsky.social
with commentary
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs
www.jci.org/articles/vie...
www.jci.org/articles/vie... in @jclinical-invest.bsky.social
with commentary
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs
www.jci.org/articles/vie...
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing me...
www.biorxiv.org
December 18, 2024 at 9:12 PM
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon
LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome...
www.biorxiv.org
December 18, 2024 at 9:07 PM
Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...