Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...
journals.physiology.org
October 25, 2025 at 5:56 PM
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
New insights into cancer cachexia reveal two molecular subtypes of muscle tissue, highlighting complex biological pathways and potential targets for future therapies. doi.org/g94268
Research team reveals complex biology behind severe muscle wasting in cancer
A University of Alberta research team is shedding much-needed light on cancer cachexia, a severe muscle-wasting syndrome linked to up to a third of cancer deaths.
medicalxpress.com
October 22, 2025 at 5:20 PM
New insights into cancer cachexia reveal two molecular subtypes of muscle tissue, highlighting complex biological pathways and potential targets for future therapies. doi.org/g94268
We were working with GSK on a cachexia drug almost 20 years ago.
Suddenly all work stopped as big pharma fired almost all of their scientists and retooled business to focus on existing drugs for off label applications.
I am glad to see something finally come to market for cachexia.
Suddenly all work stopped as big pharma fired almost all of their scientists and retooled business to focus on existing drugs for off label applications.
I am glad to see something finally come to market for cachexia.
Fingers crossed. Cachexia is a horrible & frequent clinical feature of cancer.
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
Cancer cachexia contender enters first pivotal trial
Can Pfizer’s GDF15-blocking, appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process?
www.nature.com
October 19, 2025 at 2:08 PM
We were working with GSK on a cachexia drug almost 20 years ago.
Suddenly all work stopped as big pharma fired almost all of their scientists and retooled business to focus on existing drugs for off label applications.
I am glad to see something finally come to market for cachexia.
Suddenly all work stopped as big pharma fired almost all of their scientists and retooled business to focus on existing drugs for off label applications.
I am glad to see something finally come to market for cachexia.
Fingers crossed. Cachexia is a horrible & frequent clinical feature of cancer.
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
Cancer cachexia contender enters first pivotal trial
Can Pfizer’s GDF15-blocking, appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process?
www.nature.com
October 18, 2025 at 8:11 PM
Fingers crossed. Cachexia is a horrible & frequent clinical feature of cancer.
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
“It’s a cachexia moment,” says Vickie Baracos, a cachexia expert at the University of Alberta. “A positive phase III result would be amazing. We’ve been waiting for this for a long time”
Cancer cachexia contender enters first pivotal trial www.nature.com/articles/d41...
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
October 10, 2025 at 2:22 PM
Cancer cachexia contender enters first pivotal trial www.nature.com/articles/d41...
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Celebrating the first Cancer Cachexia Awareness day organized by @cancercachexia.bsky.social. @giuliabiffi.bsky.social presented phenomenally our work on CAFs in pancreatic cancer cachexia.
Grateful to @ec.europa.eu #MSCAactions for making attending this meeting possible! Visit poster #129 to talk
Grateful to @ec.europa.eu #MSCAactions for making attending this meeting possible! Visit poster #129 to talk
September 26, 2025 at 10:29 AM
Celebrating the first Cancer Cachexia Awareness day organized by @cancercachexia.bsky.social. @giuliabiffi.bsky.social presented phenomenally our work on CAFs in pancreatic cancer cachexia.
Grateful to @ec.europa.eu #MSCAactions for making attending this meeting possible! Visit poster #129 to talk
Grateful to @ec.europa.eu #MSCAactions for making attending this meeting possible! Visit poster #129 to talk
Proud to be part of this important conversation on cancer-related cachexia on today - the first ever Cancer Cachexia Awareness Day. Be sure to tune in today at 13.30 ET/1830 UK.
Not too late to register: reg.eventmobi.com/ilcsc2025
@lungevity.bsky.social @cancercachexia.bsky.social 👇
Not too late to register: reg.eventmobi.com/ilcsc2025
@lungevity.bsky.social @cancercachexia.bsky.social 👇
September 26, 2025 at 9:18 AM
Proud to be part of this important conversation on cancer-related cachexia on today - the first ever Cancer Cachexia Awareness Day. Be sure to tune in today at 13.30 ET/1830 UK.
Not too late to register: reg.eventmobi.com/ilcsc2025
@lungevity.bsky.social @cancercachexia.bsky.social 👇
Not too late to register: reg.eventmobi.com/ilcsc2025
@lungevity.bsky.social @cancercachexia.bsky.social 👇
Dasgupta lab is hiring!
We study cancer associated muscle wasting/cachexia and tumor-muscle crosstalk.
We are hiring postdocs, research tech and graduate students! More details can be found on me website!
@myoblue.bsky.social
pages.charlotte.edu/adasgup2/peo...
We study cancer associated muscle wasting/cachexia and tumor-muscle crosstalk.
We are hiring postdocs, research tech and graduate students! More details can be found on me website!
@myoblue.bsky.social
pages.charlotte.edu/adasgup2/peo...
People – Aneesha Dasgupta
pages.charlotte.edu
September 15, 2025 at 6:52 PM
Dasgupta lab is hiring!
We study cancer associated muscle wasting/cachexia and tumor-muscle crosstalk.
We are hiring postdocs, research tech and graduate students! More details can be found on me website!
@myoblue.bsky.social
pages.charlotte.edu/adasgup2/peo...
We study cancer associated muscle wasting/cachexia and tumor-muscle crosstalk.
We are hiring postdocs, research tech and graduate students! More details can be found on me website!
@myoblue.bsky.social
pages.charlotte.edu/adasgup2/peo...
New concepts for #cancer cachexia here IL-6–JAK–STAT-signalling-mediated induction of Pck1 and Pdk3 expression in the liver @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice - Nature Metabolism
In Drosophila and mouse models of cancer cachexia, Liu et al. show that tumour-derived cytokines induce hepatic gluconeogenesis, which in turn leads to dysregulation of metabolism and drives cancer ca...
www.nature.com
April 16, 2025 at 10:03 AM
New concepts for #cancer cachexia here IL-6–JAK–STAT-signalling-mediated induction of Pck1 and Pdk3 expression in the liver @naturemetabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Previously noted, absolutely not enough attention paid to the role of anxiety in etiology especially if so predisposed. And the symptomology of cachexia explained does not suggest difficulty in diagnosis.
December 23, 2024 at 8:13 PM
Previously noted, absolutely not enough attention paid to the role of anxiety in etiology especially if so predisposed. And the symptomology of cachexia explained does not suggest difficulty in diagnosis.
New JCO study from Teresa Zimmers, PhD: Tocilizumab + gem/nab-paclitaxel didn't change median OS, but improved 18-mo survival and reduced cachexia in adv pancreatic cancer. IL-6 blockade may support precision anticachexia strategies.
To read:
bit.ly/tz51525
#PancreasResearch #Cachexia #JCO #BCCPC
To read:
bit.ly/tz51525
#PancreasResearch #Cachexia #JCO #BCCPC
Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia
PURPOSEThis randomized phase-II trial (ClinicalTrials.gov identifier: NCT02767557) compared efficacy of gemcitabine/nab-paclitaxel (Gem/Nab) with or without the anti–interleukin-6
(IL-6) receptor anti...
bit.ly
May 15, 2025 at 3:54 PM
New JCO study from Teresa Zimmers, PhD: Tocilizumab + gem/nab-paclitaxel didn't change median OS, but improved 18-mo survival and reduced cachexia in adv pancreatic cancer. IL-6 blockade may support precision anticachexia strategies.
To read:
bit.ly/tz51525
#PancreasResearch #Cachexia #JCO #BCCPC
To read:
bit.ly/tz51525
#PancreasResearch #Cachexia #JCO #BCCPC
Frequently the parents walled off their child from any contact while they wasted away -cachexia- & were cared for by their partner. The few who had a house, or other valuable assets when they passed made the parents pop up to claim the inheritance.
#ReligiousJerks
#ReligiousJerks
June 19, 2025 at 3:25 AM
Frequently the parents walled off their child from any contact while they wasted away -cachexia- & were cared for by their partner. The few who had a house, or other valuable assets when they passed made the parents pop up to claim the inheritance.
#ReligiousJerks
#ReligiousJerks
Low PTH in CKD
✅ Often linked to adynamic bone disease (ABD)
✅ Or to malnutrition-inflammation cachexia syndrome (MICS)
✅ Low PTH → impaired bone turnover, ↑ mortality risk
⚠️ MICS: driven by inflammation, protein-energy wasting & chronic illness
#ECNeph
pmc.ncbi.nlm.nih.gov...
✅ Often linked to adynamic bone disease (ABD)
✅ Or to malnutrition-inflammation cachexia syndrome (MICS)
✅ Low PTH → impaired bone turnover, ↑ mortality risk
⚠️ MICS: driven by inflammation, protein-energy wasting & chronic illness
#ECNeph
pmc.ncbi.nlm.nih.gov...
Malnutrition-Inflammation Complex Syndrome: A Cause of Low Parathyroid Hormone in Patients With Chronic Kidney Disease - PMC
Secondary hyperparathyroidism is commonly seen in patients with chronic kidney disease (CKD) due to hypocalcemia, hyperphosphatemia and low vitamin D levels and is associated with high-turnover bone disease. In contrast, some patients with advanced ...
pmc.ncbi.nlm.nih.gov
May 30, 2025 at 4:13 PM
Low PTH in CKD
✅ Often linked to adynamic bone disease (ABD)
✅ Or to malnutrition-inflammation cachexia syndrome (MICS)
✅ Low PTH → impaired bone turnover, ↑ mortality risk
⚠️ MICS: driven by inflammation, protein-energy wasting & chronic illness
#ECNeph
pmc.ncbi.nlm.nih.gov...
✅ Often linked to adynamic bone disease (ABD)
✅ Or to malnutrition-inflammation cachexia syndrome (MICS)
✅ Low PTH → impaired bone turnover, ↑ mortality risk
⚠️ MICS: driven by inflammation, protein-energy wasting & chronic illness
#ECNeph
pmc.ncbi.nlm.nih.gov...
The gut microbiome regulates inflammation, metabolism, and appetite — all disrupted in cancer cachexia.
Our work aims to improve patient outcomes and create personalized medicine solutions.
Join us in celebrating #WorldMicrobiomeDay and supporting microbiome science!
4/n
Our work aims to improve patient outcomes and create personalized medicine solutions.
Join us in celebrating #WorldMicrobiomeDay and supporting microbiome science!
4/n
June 23, 2025 at 8:28 AM
The gut microbiome regulates inflammation, metabolism, and appetite — all disrupted in cancer cachexia.
Our work aims to improve patient outcomes and create personalized medicine solutions.
Join us in celebrating #WorldMicrobiomeDay and supporting microbiome science!
4/n
Our work aims to improve patient outcomes and create personalized medicine solutions.
Join us in celebrating #WorldMicrobiomeDay and supporting microbiome science!
4/n
September 26 is the first-ever Cancer Cachexia Awareness Day – a debilitating weakness and wasting of the body that affects 80% of people with advanced cancer.
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
September 26, 2025 at 5:15 PM
September 26 is the first-ever Cancer Cachexia Awareness Day – a debilitating weakness and wasting of the body that affects 80% of people with advanced cancer.
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
Let's Start this 2025 (and this new Social) with a Post :)
Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social
Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al.
#Research #CancerCachexia #Metabolism #Muscle
Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social
Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al.
#Research #CancerCachexia #Metabolism #Muscle
authors.elsevier.com
January 7, 2025 at 11:15 AM
Let's Start this 2025 (and this new Social) with a Post :)
Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social
Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al.
#Research #CancerCachexia #Metabolism #Muscle
Our review on inter-organ crosstalk driving Cancer Cachexia is now available @cp-trendsendomet.bsky.social
Systemic metabolic crosstalk as a driver of cancer cachexia by Wyart et al.
#Research #CancerCachexia #Metabolism #Muscle
🧪 Two recent papers from Robert Paval (fantastic PhD student) on biomarkers/inflammation in cancer/cancer cachexia: 10.1002/jcsm.12912 and (this week) 10.3389/fonc.2024.1198555
March 2, 2024 at 1:31 PM
🧪 Two recent papers from Robert Paval (fantastic PhD student) on biomarkers/inflammation in cancer/cancer cachexia: 10.1002/jcsm.12912 and (this week) 10.3389/fonc.2024.1198555
Meaning of #caquectico CAQUECTICO: RELATIVE TO CACHEXIA: MALNUTRITION. WEAKENING. EXHAUSTION... caquectico
January 25, 2025 at 10:32 AM
Meaning of #caquectico CAQUECTICO: RELATIVE TO CACHEXIA: MALNUTRITION. WEAKENING. EXHAUSTION... caquectico
Count me in. We use mouse models of aging, cancer cachexia and sepsis.
November 20, 2024 at 7:49 PM
Count me in. We use mouse models of aging, cancer cachexia and sepsis.
This is a fun list to preface a chapter of Mr. Casaubon
cachexia = wasting disease
rheums = rheumatoid arthritis
bradypepsia = slow digestion
oppilations = severe constipation 🛖
cachexia = wasting disease
rheums = rheumatoid arthritis
bradypepsia = slow digestion
oppilations = severe constipation 🛖
March 3, 2024 at 2:29 PM
This is a fun list to preface a chapter of Mr. Casaubon
cachexia = wasting disease
rheums = rheumatoid arthritis
bradypepsia = slow digestion
oppilations = severe constipation 🛖
cachexia = wasting disease
rheums = rheumatoid arthritis
bradypepsia = slow digestion
oppilations = severe constipation 🛖
Partly. He's about half the weight that my orange boy Moses was at his heaviest, before the CKD cachexia set in, but he's nonetheless growing up to be quite the beast.
February 9, 2024 at 9:18 PM
Partly. He's about half the weight that my orange boy Moses was at his heaviest, before the CKD cachexia set in, but he's nonetheless growing up to be quite the beast.
www.cell.com/cell-metabol...
"- Low expression of DNMT3A is a key epigenetic factor in muscle atrophy
- Methionine or SAM supplementation alleviates cachexia-induced muscle wasting"
"- Low expression of DNMT3A is a key epigenetic factor in muscle atrophy
- Methionine or SAM supplementation alleviates cachexia-induced muscle wasting"
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1
Cancer cachexia affects patients’ quality of life. Lin et al. identify a novel mechanism
by which dysregulated methionine metabolism and reduced DNMT3A levels lead to increased
REDD1, which promotes m...
www.cell.com
February 7, 2025 at 9:37 PM
www.cell.com/cell-metabol...
"- Low expression of DNMT3A is a key epigenetic factor in muscle atrophy
- Methionine or SAM supplementation alleviates cachexia-induced muscle wasting"
"- Low expression of DNMT3A is a key epigenetic factor in muscle atrophy
- Methionine or SAM supplementation alleviates cachexia-induced muscle wasting"
Pharmacologic treatments for cancer cachexia are limited. A phase 1b study of the monoclonal antibody ponsegromab showed improved outcomes in patients with an elevated GDF-15 cytokine level. Phase 2 findings are summarized in a Quick Take video. youtu.be/ZcjtQjf-cNk
#MedSky
#MedSky
Ponsegromab for Cancer Cachexia | NEJM
YouTube video by NEJM Group
youtu.be
December 22, 2024 at 2:55 PM
Pharmacologic treatments for cancer cachexia are limited. A phase 1b study of the monoclonal antibody ponsegromab showed improved outcomes in patients with an elevated GDF-15 cytokine level. Phase 2 findings are summarized in a Quick Take video. youtu.be/ZcjtQjf-cNk
#MedSky
#MedSky
Liver Found as Key Driver of Cancer Cachexia Wasting
https://www.newsbeep.com/au/11504/
The Silenced Clock Gene In cachexia, liver metabolism is fundamentally reprogrammed. One gene, which normally regulates the liver’s…
https://www.newsbeep.com/au/11504/
The Silenced Clock Gene In cachexia, liver metabolism is fundamentally reprogrammed. One gene, which normally regulates the liver’s…
Liver Found as Key Driver of Cancer Cachexia Wasting - Australia News Beep
The Silenced Clock Gene
www.newsbeep.com
July 21, 2025 at 7:20 PM
Liver Found as Key Driver of Cancer Cachexia Wasting
https://www.newsbeep.com/au/11504/
The Silenced Clock Gene In cachexia, liver metabolism is fundamentally reprogrammed. One gene, which normally regulates the liver’s…
https://www.newsbeep.com/au/11504/
The Silenced Clock Gene In cachexia, liver metabolism is fundamentally reprogrammed. One gene, which normally regulates the liver’s…
National CBD Day - What is Jannabis Wellness? Janice Newell Bissex, RDN, a Holistic Cannabis Practitioner & Culinary Nutritionist, notes initial positive results of #CBD & #cannabis for IBD/IBS, cachexia, Parkinson’s, nausea, pain, depression & anxiety. dietitians-online.blogspot.com/2019/08/nati...
National CBD Day <br> What is Jannabis Wellness?
Registered Dietitian Nutritionist Nutrition News Food Events Nutrient Analysis
dietitians-online.blogspot.com
August 8, 2025 at 12:34 PM
National CBD Day - What is Jannabis Wellness? Janice Newell Bissex, RDN, a Holistic Cannabis Practitioner & Culinary Nutritionist, notes initial positive results of #CBD & #cannabis for IBD/IBS, cachexia, Parkinson’s, nausea, pain, depression & anxiety. dietitians-online.blogspot.com/2019/08/nati...