Chaitanya Dingare
@chaitanyadingare.bsky.social
Postdoctoral researcher at Cambridge University studying Developmental Metabolism | PhD at Freiburg University | 🇬🇧🇩🇪🇮🇳
Pinned
Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids
Dingare et al. identified a critical role for mannose-dependent glycosylation during
early mesoderm specification both in mouse embryonic stem-cell-derived gastruloids
and in gastrulating mouse embryo...
www.cell.com
Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids: Developmental Cell www.cell.com/developmenta...
Reposted by Chaitanya Dingare
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of
mitochondrial ribosomes in response to metabolic state. This structural “gear-switching”
mechanism fine-tunes mitoch...
www.cell.com
November 6, 2025 at 6:37 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Reposted by Chaitanya Dingare
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
www.science.org
November 5, 2025 at 7:03 PM
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chaitanya Dingare
Hi bsky!
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
August 7, 2025 at 3:01 PM
Hi bsky!
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity!
w/ A. Delahaye & @bensteventon.bsky.social
shorturl.at/v01DO
Reposted by Chaitanya Dingare
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
November 2, 2025 at 9:02 AM
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
Reposted by Chaitanya Dingare
Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm.
bsky.app/profile/epim...
bsky.app/profile/epim...
October 25, 2025 at 7:03 AM
Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm.
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Chaitanya Dingare
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - Nature Biotechnology
A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.
go.nature.com
October 23, 2025 at 2:34 PM
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
Reposted by Chaitanya Dingare
Congratulations Ahmed and colleagues in the @niakanlab.bsky.social on this beautiful work tracking mitotic errors by live imaging the human embryos!
Thrilled to see this published!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
October 23, 2025 at 9:15 PM
Congratulations Ahmed and colleagues in the @niakanlab.bsky.social on this beautiful work tracking mitotic errors by live imaging the human embryos!
Reposted by Chaitanya Dingare
Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b
MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com
tinyurl.com
October 24, 2025 at 8:53 AM
Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b
Reposted by Chaitanya Dingare
A developmental atlas of zebrafish gills links early vascular patterning to adult architecture
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 21, 2025 at 12:36 PM
A developmental atlas of zebrafish gills links early vascular patterning to adult architecture
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Congratulations @vlecaudey.bsky.social @mathpreu.bsky.social
A developmental atlas of zebrafish gills links early vascular patterning to adult architecture
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 22, 2025 at 2:38 AM
Congratulations @vlecaudey.bsky.social @mathpreu.bsky.social
Reposted by Chaitanya Dingare
1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...
#DevBio #Zebrafish
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...
#DevBio #Zebrafish
September 17, 2025 at 1:59 PM
1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...
#DevBio #Zebrafish
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...
#DevBio #Zebrafish
Reposted by Chaitanya Dingare
New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!
Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
September 16, 2025 at 4:20 PM
New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!
Reposted by Chaitanya Dingare
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into
cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells
self-organize within 6 days i...
www.cell.com
September 16, 2025 at 4:12 PM
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.
Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms
Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...
www.biorxiv.org
September 16, 2025 at 3:30 PM
www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.
Reposted by Chaitanya Dingare
Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
September 16, 2025 at 7:31 AM
Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
September 16, 2025 at 3:21 PM
Reposted by Chaitanya Dingare
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
June 27, 2025 at 3:07 PM
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
Reposted by Chaitanya Dingare
Nerve-to-cancer transfer of mitochondria during cancer metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...
www.nature.com
June 25, 2025 at 3:11 PM
Nerve-to-cancer transfer of mitochondria during cancer metastasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chaitanya Dingare
GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling https://www.biorxiv.org/content/10.1101/2025.06.20.660704v1
June 25, 2025 at 3:31 PM
GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling https://www.biorxiv.org/content/10.1101/2025.06.20.660704v1
Reposted by Chaitanya Dingare
An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1
June 22, 2025 at 10:30 AM
An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1
Reposted by Chaitanya Dingare
June 13, 2025 at 9:31 PM
Reposted by Chaitanya Dingare
The weekly Metabolites-driven PTMs focusing on cancer Biomed News is out ☺️ biomed.news/bims-prolim/...
June 9, 2025 at 7:16 AM
The weekly Metabolites-driven PTMs focusing on cancer Biomed News is out ☺️ biomed.news/bims-prolim/...
Reposted by Chaitanya Dingare
If you’ve ever wondered how those intricate gill structures emerge—and how gills develop throughout a zebrafish’s lifespan—check out my new preprint!
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟
#zebrafish #microscopy
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟
#zebrafish #microscopy
June 5, 2025 at 7:51 AM
If you’ve ever wondered how those intricate gill structures emerge—and how gills develop throughout a zebrafish’s lifespan—check out my new preprint!
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟
#zebrafish #microscopy
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟
#zebrafish #microscopy
Reposted by Chaitanya Dingare
New preprint from the lab! Beautiful work by @mathpreu.bsky.social, who delved into the early development of gills and their intricate vasculature. Thanks to the Clusterproject ENABLE and @goetheuni.bsky.social for the funding! www.biorxiv.org/content/10.1...
www.biorxiv.org
June 5, 2025 at 6:08 AM
New preprint from the lab! Beautiful work by @mathpreu.bsky.social, who delved into the early development of gills and their intricate vasculature. Thanks to the Clusterproject ENABLE and @goetheuni.bsky.social for the funding! www.biorxiv.org/content/10.1...
Reposted by Chaitanya Dingare
COMMENT | KS Li, X Su & T Huan (Rutgers U, UBC):
Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.
https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.
https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
May 31, 2025 at 6:01 PM
COMMENT | KS Li, X Su & T Huan (Rutgers U, UBC):
Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.
https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.
https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab