José Silva & Lab
@josesilvalab.bsky.social
Reprogramming cells for fun and to create embryo models in the tropical Greater Bay Area
https://www.jose-silva-lab.com/ 🇵🇹🇨🇳🇬🇧
Guangzhou/Cantāo 🌴☀️, China中国
https://www.jose-silva-lab.com/ 🇵🇹🇨🇳🇬🇧
Guangzhou/Cantāo 🌴☀️, China中国
Reposted by José Silva & Lab
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days into post-implantation structures mimicking Carnegie stages 5–7 embryos, including gastrulation, with high morphological and molecular fidelity.
dlvr.it
September 16, 2025 at 7:09 PM
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into
cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells
self-organize within 6 days i...
www.cell.com
September 16, 2025 at 4:12 PM
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...
(1/3) A while back, my then-PhD student @htstuart.bsky.social stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀
September 15, 2025 at 1:51 AM
(1/3) A while back, my then-PhD student @htstuart.bsky.social stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀
Reposted by José Silva & Lab
💓 Researchers in the @josesilvalab.bsky.social used #SmallMolecules to convert mouse ESCs into embryo founder cells, which generated a complete embryo model!
Article: bit.ly/4orpbLb
Episode with discussion: bit.ly/4oTURt2
Article: bit.ly/4orpbLb
Episode with discussion: bit.ly/4oTURt2
August 26, 2025 at 4:29 PM
💓 Researchers in the @josesilvalab.bsky.social used #SmallMolecules to convert mouse ESCs into embryo founder cells, which generated a complete embryo model!
Article: bit.ly/4orpbLb
Episode with discussion: bit.ly/4oTURt2
Article: bit.ly/4orpbLb
Episode with discussion: bit.ly/4oTURt2
Reposted by José Silva & Lab
🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
bit.ly
August 14, 2025 at 8:42 PM
🥂Congrats to Gao, Li & co for their new @natcellbio.nature.com study: they derive #trophectoderm stem cells from 32-cell mouse #embryos. These cells represent an early trophectoderm state, develop into #placenta cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
Capturing early TE stem cells. From Zhang Jian’s lab, “Mouse trophectoderm stem cells generated
with morula signalling inducers capture an early trophectoderm state”, with a small contribution from us.
www.nature.com/articles/s41...
with morula signalling inducers capture an early trophectoderm state”, with a small contribution from us.
www.nature.com/articles/s41...
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
www.nature.com
August 14, 2025 at 10:47 PM
Capturing early TE stem cells. From Zhang Jian’s lab, “Mouse trophectoderm stem cells generated
with morula signalling inducers capture an early trophectoderm state”, with a small contribution from us.
www.nature.com/articles/s41...
with morula signalling inducers capture an early trophectoderm state”, with a small contribution from us.
www.nature.com/articles/s41...
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
August 7, 2025 at 3:58 PM
Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)
Reposted by José Silva & Lab
Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
July 8, 2025 at 10:54 AM
Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET
Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis
Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
Reposted by José Silva & Lab
Thank you VGZT community for your active participation 🌎
See below the session flyers for the rest of the season:
🌞 Eastern sessions: Happening on Wednesdays.
Our keynote for this season: Maithreyi Narasimha and @josesilvalab.bsky.social
[1/2]
See below the session flyers for the rest of the season:
🌞 Eastern sessions: Happening on Wednesdays.
Our keynote for this season: Maithreyi Narasimha and @josesilvalab.bsky.social
[1/2]
April 21, 2025 at 10:45 PM
Thank you VGZT community for your active participation 🌎
See below the session flyers for the rest of the season:
🌞 Eastern sessions: Happening on Wednesdays.
Our keynote for this season: Maithreyi Narasimha and @josesilvalab.bsky.social
[1/2]
See below the session flyers for the rest of the season:
🌞 Eastern sessions: Happening on Wednesdays.
Our keynote for this season: Maithreyi Narasimha and @josesilvalab.bsky.social
[1/2]
Very grateful to the @lundstem.bsky.social and Filipe Pereira for hosting me. I truly enjoyed meeting and discussing with many colleagues at the Center. I also received very interesting feedback that will hopefully lead to collaborations and help further improve our embryo models.
💡✨Can reprogramming stem cells into "embryo founder-like cells" advance their use in the clinic? Yesterday, José Silva from Guangzhou National Laboratory joined our Stem Cell Stars Seminar to explore this. #StemCells
Thanks @josesilvalab.bsky.social for great discussions, insights & connections! 👏
Thanks @josesilvalab.bsky.social for great discussions, insights & connections! 👏
February 21, 2025 at 5:32 PM
Very grateful to the @lundstem.bsky.social and Filipe Pereira for hosting me. I truly enjoyed meeting and discussing with many colleagues at the Center. I also received very interesting feedback that will hopefully lead to collaborations and help further improve our embryo models.
