Niakan Lab
@niakanlab.bsky.social
Our group investigates the function of genes regulating early human development and molecular mechanisms directing cell fate in human embryos. Posts from any member of the lab.
Check out our website: https://niakanlab.com
Check out our website: https://niakanlab.com
Thrilled to see this published!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - Nature Biotechnology
A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.
go.nature.com
October 23, 2025 at 8:13 PM
Thrilled to see this published!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated.
Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Reposted by Niakan Lab
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Niakan Lab
Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
October 2, 2025 at 8:15 AM
Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
Reposted by Niakan Lab
Hot off the press!
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 - Nature Communications
Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.
www.nature.com
September 30, 2025 at 4:16 PM
Hot off the press!
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
www.nature.com/articles/s41...
Reposted by Niakan Lab
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful!
niakanlab.com/resources/
niakanlab.com/resources/
September 30, 2025 at 5:57 PM
One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful!
niakanlab.com/resources/
niakanlab.com/resources/
🚀 Exciting news: our new lab website is live! 🌐
Check it out here: niakanlab.com
We’ll be sharing updates on our research, publications, outreach, resources etc.
Curious to hear what you think! ✨
#LabLife #Research #StemCells #DevelopmentalBiology
Check it out here: niakanlab.com
We’ll be sharing updates on our research, publications, outreach, resources etc.
Curious to hear what you think! ✨
#LabLife #Research #StemCells #DevelopmentalBiology
Niakan lab
niakanlab.com
September 23, 2025 at 10:46 AM
🚀 Exciting news: our new lab website is live! 🌐
Check it out here: niakanlab.com
We’ll be sharing updates on our research, publications, outreach, resources etc.
Curious to hear what you think! ✨
#LabLife #Research #StemCells #DevelopmentalBiology
Check it out here: niakanlab.com
We’ll be sharing updates on our research, publications, outreach, resources etc.
Curious to hear what you think! ✨
#LabLife #Research #StemCells #DevelopmentalBiology
Today we had our lab retreat at the Eddington Postdoc Centre for the first time in a while!🧪
We had so much fun combining workshops and team-building activities, and we definitely made the most of our time together.
Do you do retreats in your lab? What are they usually like?
We will read you below!👇
We had so much fun combining workshops and team-building activities, and we definitely made the most of our time together.
Do you do retreats in your lab? What are they usually like?
We will read you below!👇
September 15, 2025 at 6:51 PM
Today we had our lab retreat at the Eddington Postdoc Centre for the first time in a while!🧪
We had so much fun combining workshops and team-building activities, and we definitely made the most of our time together.
Do you do retreats in your lab? What are they usually like?
We will read you below!👇
We had so much fun combining workshops and team-building activities, and we definitely made the most of our time together.
Do you do retreats in your lab? What are they usually like?
We will read you below!👇
Last Friday, we said goodbye to our amazing summer student, Yiping! Thank you for your hard work and bringing great energy to our team this summer. Wishing you the best in your next chapter!☀️
August 27, 2025 at 10:06 AM
Last Friday, we said goodbye to our amazing summer student, Yiping! Thank you for your hard work and bringing great energy to our team this summer. Wishing you the best in your next chapter!☀️
Reposted by Niakan Lab
Our protocol with all the details you'll need to detect and quantify phospo-SMAD proteins in your (human) embryo, is finally out today @cp-starprotocols.bsky.social.
Thanks again to my wonderful co-author @toddfallesen.bsky.social and the @niakanlab.bsky.social.
www.sciencedirect.com/science/arti...
Thanks again to my wonderful co-author @toddfallesen.bsky.social and the @niakanlab.bsky.social.
www.sciencedirect.com/science/arti...
Protocol for immunofluorescence detection and quantification of phosphorylated SMAD proteins in human blastocysts
The transforming growth factor β (TGF-β) signaling superfamily includes NODAL and bone morphogenetic protein (BMP) signaling, which lead to the phosph…
www.sciencedirect.com
May 28, 2025 at 9:42 AM
Our protocol with all the details you'll need to detect and quantify phospo-SMAD proteins in your (human) embryo, is finally out today @cp-starprotocols.bsky.social.
Thanks again to my wonderful co-author @toddfallesen.bsky.social and the @niakanlab.bsky.social.
www.sciencedirect.com/science/arti...
Thanks again to my wonderful co-author @toddfallesen.bsky.social and the @niakanlab.bsky.social.
www.sciencedirect.com/science/arti...
Reposted by Niakan Lab
This project has been very special to me. I want to thank James @lab-turner.bsky.social who gave me the chance to build my own research line outside of the lab's main focus on sex chromosomes, and to our collaborators Chris Barrington, Clare Critcher, Waz Varsally, Greg Alanis @niakanlab.bsky.social
July 24, 2025 at 5:07 PM
This project has been very special to me. I want to thank James @lab-turner.bsky.social who gave me the chance to build my own research line outside of the lab's main focus on sex chromosomes, and to our collaborators Chris Barrington, Clare Critcher, Waz Varsally, Greg Alanis @niakanlab.bsky.social
Reposted by Niakan Lab
Very happy to see this nice collaboration with @niakanlab.bsky.social bear fruit. Beautiful work by @clairesimon.bsky.social culturing human embryos in the presence of FGF/ERK stimulation/inhibition. www.nature.com/articles/s41...
Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst - Nature Communications
The authors show human embryo lineage specification in the blastocyst is driven by differential FGF/ERK signaling, which segregates yolk sac-fated hypoblast and embryonic epiblast. They establish naïv...
www.nature.com
August 11, 2025 at 1:38 PM
Very happy to see this nice collaboration with @niakanlab.bsky.social bear fruit. Beautiful work by @clairesimon.bsky.social culturing human embryos in the presence of FGF/ERK stimulation/inhibition. www.nature.com/articles/s41...
Very sorry to hear of the passing of Roger Pedersen. He was an outstanding developmental and stem cell biologist & helped to establish the Cambridge Stem Cell Institute. Our thoughts are with his family.
obgyn.stanford.edu/in-the-news/...
obgyn.stanford.edu/in-the-news/...
Roger-Pedersen-Obituary-2025
obgyn.stanford.edu
February 13, 2025 at 7:34 PM
Very sorry to hear of the passing of Roger Pedersen. He was an outstanding developmental and stem cell biologist & helped to establish the Cambridge Stem Cell Institute. Our thoughts are with his family.
obgyn.stanford.edu/in-the-news/...
obgyn.stanford.edu/in-the-news/...
Reposted by Niakan Lab
Very sorry to hear of the passing of Professor Roger Pedersen, whose visionary leadership helped establish the @scicambridge.bsky.social. I will never forget how Roger personally taught my group how to dissect early post-implantation mouse embryos; watching him at the microscope was truly inspiring
February 13, 2025 at 6:02 AM
Very sorry to hear of the passing of Professor Roger Pedersen, whose visionary leadership helped establish the @scicambridge.bsky.social. I will never forget how Roger personally taught my group how to dissect early post-implantation mouse embryos; watching him at the microscope was truly inspiring
Reposted by Niakan Lab
#announcement please share 📢
We're delighted to launch registration for the Annual Meeting 2025 'The Placenta at Term' bit.ly/annualmeetin...
And, applications open for Placental Biology Course, returning in-person, in Cambridge bit.ly/placentalbio...
25 places, application deadline 21 March!
We're delighted to launch registration for the Annual Meeting 2025 'The Placenta at Term' bit.ly/annualmeetin...
And, applications open for Placental Biology Course, returning in-person, in Cambridge bit.ly/placentalbio...
25 places, application deadline 21 March!
January 22, 2025 at 10:38 AM
#announcement please share 📢
We're delighted to launch registration for the Annual Meeting 2025 'The Placenta at Term' bit.ly/annualmeetin...
And, applications open for Placental Biology Course, returning in-person, in Cambridge bit.ly/placentalbio...
25 places, application deadline 21 March!
We're delighted to launch registration for the Annual Meeting 2025 'The Placenta at Term' bit.ly/annualmeetin...
And, applications open for Placental Biology Course, returning in-person, in Cambridge bit.ly/placentalbio...
25 places, application deadline 21 March!
Reposted by Niakan Lab
'Why do people have children?'
That's the question we're posing at our next Forum. Join us on 12 March at West Hub, Cambridge from 3pm.
Interdisciplinary dialogues, flash talks and a networking reception.
Registration open on Eventbrite www.eventbrite.co.uk/e/1151888342...
That's the question we're posing at our next Forum. Join us on 12 March at West Hub, Cambridge from 3pm.
Interdisciplinary dialogues, flash talks and a networking reception.
Registration open on Eventbrite www.eventbrite.co.uk/e/1151888342...
Cambridge Reproduction Forum: Why do people have children?
Join us for an afternoon of interdisciplinary conversation, flash talks and a networking reception.
www.eventbrite.co.uk
January 29, 2025 at 10:18 AM
'Why do people have children?'
That's the question we're posing at our next Forum. Join us on 12 March at West Hub, Cambridge from 3pm.
Interdisciplinary dialogues, flash talks and a networking reception.
Registration open on Eventbrite www.eventbrite.co.uk/e/1151888342...
That's the question we're posing at our next Forum. Join us on 12 March at West Hub, Cambridge from 3pm.
Interdisciplinary dialogues, flash talks and a networking reception.
Registration open on Eventbrite www.eventbrite.co.uk/e/1151888342...
Reposted by Niakan Lab
We have extended the abstract submission deadline to January 26th—don’t miss this opportunity!
We’re also delighted to announce that Dr. Kathy Niakan will be delivering the 2024 Mary Lyon Medal Lecture during the conference. @gensocuk.bsky.social
@niakanlab.bsky.social
We’re also delighted to announce that Dr. Kathy Niakan will be delivering the 2024 Mary Lyon Medal Lecture during the conference. @gensocuk.bsky.social
@niakanlab.bsky.social
January 14, 2025 at 3:16 PM
We have extended the abstract submission deadline to January 26th—don’t miss this opportunity!
We’re also delighted to announce that Dr. Kathy Niakan will be delivering the 2024 Mary Lyon Medal Lecture during the conference. @gensocuk.bsky.social
@niakanlab.bsky.social
We’re also delighted to announce that Dr. Kathy Niakan will be delivering the 2024 Mary Lyon Medal Lecture during the conference. @gensocuk.bsky.social
@niakanlab.bsky.social