This Review summarizes our current knowledge about the genetic underpinnings of metabolic-dysfunction-associated steatotic liver disease and highlights its causal association with type 2 diabetes and insulin resistance.

Nature Metabolism, Published online: 27 January 2026; doi:10.1038/s42255-026-01468-1Author Correction: m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice

Nature Metabolism, Published online: 27 January 2026; doi:10.1038/s42255-025-01444-1Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four ancestries, the authors advance our understanding of the genetic architecture of type 2 diabetes

Mauvais-Jarvis and Bhasin provide an in-depth review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from testosterone replacement therapy in humans and mechanistic research in rodent models.

Nature Metabolism, Published online: 03 February 2026; doi:10.1038/s42255-026-01461-8Reduced mitochondrial activity during development triggers a specific superoxide signal that downregulates the biosynthesis of unsaturated fatty acids. This metabolic shift limits lipid peroxidation, preserving nuclear envelope integrity and delaying ageing in Caenorhabditis elegans and in mammalian cells.

Nature Metabolism, Published online: 03 February 2026; doi:10.1038/s42255-026-01452-9Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

This Review summarizes existing data, as well as crucial knowledge gaps, emerging from clinical trials involving NAD+ precursor supplementation in humans.

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta), three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs.

In this Perspective, the authors discuss reasons for the increased cardiometabolic disease risk observed in Asian populations, including nutrition, genetic factors and environmental adversity.

Nature Metabolism, Published online: 30 January 2026; doi:10.1038/s42255-025-01437-0Glucose deprivation triggers the secretion of the cytokine LIF, which promotes angiogenesis and immune suppression in lung cancer models.

Nature Metabolism, Published online: 29 January 2026; doi:10.1038/s42255-025-01441-4In this Perspective, the authors discuss reasons for the increased cardiometabolic disease risk observed in Asian populations, including nutrition, genetic factors and environmental adversity.

Chaperone-mediated autophagy declines with age in skeletal muscle of humans and mice, leading to muscle dysfunction characterized by impaired calcium homoeostasis and mitochondrial function.

Intercellular mitochondria transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticism. In this Viewpoint, different experts in mitochondrial biology share their personal view on the topic.

Age-related decline of chaperone-mediated autophagy blunts the regenerative capacity of muscle stem cells, partly due to impaired glycolytic shift required for normal stem cell expansion.

Nature Metabolism, Published online: 28 January 2026; doi:10.1038/s42255-025-01447-yUsing tissue- and ancestry-aware causal inference analyses, we identified 923 genes and 46 proteins whose expression levels causally influence type 2 diabetes risk. Tissue-related heterogeneity was high, whereas ancestry-related heterogeneity was low, although some effects were observed only in non-European populations. These results underscore the need to investigate disease-relevant tissues and diverse populations.

Nature Metabolism, Published online: 21 January 2026; doi:10.1038/s42255-025-01439-yA pathogenic subset of NK cells is identified that promotes type 1 diabetes and is generated via T cell-derived IL-21.

Nature Metabolism, Published online: 28 January 2026; doi:10.1038/s42255-025-01449-wMetabolism regulates cell fates through the epigenome. Wang, Shi et al. demonstrate that the cell fates of pluripotency, differentiation and ageing emerge from how a nuclear protein channels metabolic fluxes into distinct epigenetic marks by regulating expression of metabolic genes.

Nature Metabolism, Published online: 28 January 2026; doi:10.1038/s42255-025-01443-2Lamin A/C in the nuclear lamina is identified as a regulator of cysteine catabolic flux, necessary for cell fate decisions and function.

Nature Metabolism, Published online: 20 January 2026; doi:10.1038/s42255-025-01429-0Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves targeting the iBAT parenchyma control local blood flow and heat production, while those innervating the iBAT vasculature regulate systemic glucose metabolism.

Nature Metabolism, Published online: 20 January 2026; doi:10.1038/s42255-025-01435-2In this issue of Nature Metabolism, Neri et al. show that two distinct stellate ganglion subcircuits innervating interscapular brown adipose tissue (iBAT) separately control thermogenesis and glucose tolerance, providing a mechanistic explanation for temperature-independent benefits of iBAT on glycaemia.