David Turner
@gastruloids.bsky.social
Stem cell and developmental biologist at the University of Liverpool
Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b
MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com
tinyurl.com
October 24, 2025 at 8:53 AM
Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b
Reposted by David Turner
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
Briscoe Lab | Cellular Dynamics and Pattern Formation in Vertebrate Development
www.crick.ac.uk
October 6, 2025 at 11:37 AM
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
Reposted by David Turner
New insights directly link WT1 and smooth muscle cell lineages
Read this Research Highlight showcasing work from Suad Alsukari, Huei Teng Ng, @gastruloids.bsky.social, Bettina Wilm @bwilm.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this Research Highlight showcasing work from Suad Alsukari, Huei Teng Ng, @gastruloids.bsky.social, Bettina Wilm @bwilm.bsky.social and colleagues:
journals.biologists.com/dev/article/...
July 11, 2025 at 2:08 PM
New insights directly link WT1 and smooth muscle cell lineages
Read this Research Highlight showcasing work from Suad Alsukari, Huei Teng Ng, @gastruloids.bsky.social, Bettina Wilm @bwilm.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this Research Highlight showcasing work from Suad Alsukari, Huei Teng Ng, @gastruloids.bsky.social, Bettina Wilm @bwilm.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Reposted by David Turner
Very happy to announce that this article is now published @dev-journal.bsky.social @biologists.bsky.social
journals.biologists.com/dev/article/...
With Suad Alsukari and Huei Teng Ng and @gastruloids.bsky.social
journals.biologists.com/dev/article/...
With Suad Alsukari and Huei Teng Ng and @gastruloids.bsky.social
Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently of mesothelial fate
Highlighted Article: Genetic lineage tracing and expression analyses reveal insights into the developmental lineage of smooth muscle cells in the intestine and mesentery, specified by WT1 expression d...
journals.biologists.com
July 9, 2025 at 10:11 AM
Very happy to announce that this article is now published @dev-journal.bsky.social @biologists.bsky.social
journals.biologists.com/dev/article/...
With Suad Alsukari and Huei Teng Ng and @gastruloids.bsky.social
journals.biologists.com/dev/article/...
With Suad Alsukari and Huei Teng Ng and @gastruloids.bsky.social
Reposted by David Turner
An englishman, down and out in Paris…..trying to read the news and laughing....at a french joke?
@gastruloids.bsky.social
@gastruloids.bsky.social
July 4, 2025 at 5:53 PM
An englishman, down and out in Paris…..trying to read the news and laughing....at a french joke?
@gastruloids.bsky.social
@gastruloids.bsky.social
Reposted by David Turner
Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells - BMC Biology
Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...
bmcbiol.biomedcentral.com
May 13, 2025 at 3:46 PM
Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....
Reposted by David Turner
I cannot help but think of these rod-rings as oh so pretty. amazing work by some of our @cci-liv.bsky.social users.
Look at this amount of work that has gone into the analysis of these beautiful (yes, we are biased) images of rods and rings. Now you can automatically classify these structures which is rather tedious to do manually. 🔬📷🖼️💻📄 bmcbiol.biomedcentral.com/articles/10....
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells - BMC Biology
Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...
bmcbiol.biomedcentral.com
May 13, 2025 at 3:49 PM
I cannot help but think of these rod-rings as oh so pretty. amazing work by some of our @cci-liv.bsky.social users.
Great preprint out from the MicroAge team in
@livuni-ilcams.bsky.social! www.biorxiv.org/content/10.1...
@livuni-ilcams.bsky.social! www.biorxiv.org/content/10.1...
www.biorxiv.org
June 23, 2025 at 10:04 PM
Great preprint out from the MicroAge team in
@livuni-ilcams.bsky.social! www.biorxiv.org/content/10.1...
@livuni-ilcams.bsky.social! www.biorxiv.org/content/10.1...
Reposted by David Turner
Excellent work supporting #modularity of the mammalian #embryo, a role for #hypoxia & how development exploits these features. It shows what we can learn from assemblies of #gastruloids @ spatio-temporal coordination of the modules in AP organization. Putting modules together, extremely informative
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 5:51 PM
Excellent work supporting #modularity of the mammalian #embryo, a role for #hypoxia & how development exploits these features. It shows what we can learn from assemblies of #gastruloids @ spatio-temporal coordination of the modules in AP organization. Putting modules together, extremely informative
Reposted by David Turner
The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social group. Building models to learn and learning.
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social group. Building models to learn and learning.
June 23, 2025 at 3:06 PM
The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social group. Building models to learn and learning.
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social group. Building models to learn and learning.
Reposted by David Turner
This was a fabulous collaboration! Thanks @gastruloids.bsky.social and to Suad and Huei who worked incredibly hard to make it happen!
Great to see our article published in @dev-journal.bsky.social! Wonderfull collaboration with @bwilm.bsky.social to understand how Wt1 guides cell fate in the early gastrulating embryo! journals.biologists.com/dev/article/...
Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate
The Wilms’ Tumour protein (WT1) was previously linked to the mesothelial and vascular smooth muscle cell (vSMC) lineage in the mouse intestine, with evidence suggesting that intestinal vSMCs arise fro...
journals.biologists.com
June 17, 2025 at 11:08 AM
This was a fabulous collaboration! Thanks @gastruloids.bsky.social and to Suad and Huei who worked incredibly hard to make it happen!
Reposted by David Turner
Also, an interesting reflection from Bob Edwards on the contrast between Research Institutes and Universities. Having spent my academic life in the latter, I can relate. From "A matter of life" a first hand account of the path to IVF that I suggest as a read for those interested in human #DevBio
June 17, 2025 at 7:54 AM
Also, an interesting reflection from Bob Edwards on the contrast between Research Institutes and Universities. Having spent my academic life in the latter, I can relate. From "A matter of life" a first hand account of the path to IVF that I suggest as a read for those interested in human #DevBio
Great to see our article published in @dev-journal.bsky.social! Wonderfull collaboration with @bwilm.bsky.social to understand how Wt1 guides cell fate in the early gastrulating embryo! journals.biologists.com/dev/article/...
Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate
The Wilms’ Tumour protein (WT1) was previously linked to the mesothelial and vascular smooth muscle cell (vSMC) lineage in the mouse intestine, with evidence suggesting that intestinal vSMCs arise fro...
journals.biologists.com
June 17, 2025 at 10:43 AM
Great to see our article published in @dev-journal.bsky.social! Wonderfull collaboration with @bwilm.bsky.social to understand how Wt1 guides cell fate in the early gastrulating embryo! journals.biologists.com/dev/article/...
Reposted by David Turner
We previously showed that DNA Typewriter can record high-resolution lineage trees in cultured cells (HEK293T). www.nature.com/articles/s41... But could we use it to study how clonal memory shapes cell fate decisions during development? (2/13)
A time-resolved, multi-symbol molecular recorder via sequential genome editing - Nature
A DNA memory device, DNA Typewriter, uses sequential prime editing to record the order of multiple cellular events.
www.nature.com
May 27, 2025 at 2:57 PM
We previously showed that DNA Typewriter can record high-resolution lineage trees in cultured cells (HEK293T). www.nature.com/articles/s41... But could we use it to study how clonal memory shapes cell fate decisions during development? (2/13)
Reposted by David Turner
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Lineage recording in monoclonal gastruloids reveals heritable modes of early development
Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...
www.biorxiv.org
May 27, 2025 at 2:57 PM
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Reposted by David Turner
We've just updated our manuscript to a more 'publishable' version!
www.biorxiv.org/content/10.1...
New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates
www.biorxiv.org/content/10.1...
New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates
May 16, 2025 at 7:06 AM
We've just updated our manuscript to a more 'publishable' version!
www.biorxiv.org/content/10.1...
New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates
www.biorxiv.org/content/10.1...
New details about the role of Wnt in suppressing neural differentiation and fostering a posterior epiblast state, and the temporal effect of Nodal signalling in driving mesendodermal fates
Our new paper just arrived! Fun collaborative effort led by Sam Ball and Meagan Hennessy to develop an AI tool to segment and classify #IMPDH2 rod-rings in mouse ESCs doi.org/10.1186/s129...
Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells - BMC Biology
Background Inosine monophosphate dehydrogenase 2 (IMPDH2) is an enzyme that catalyses the rate-limiting step of guanine nucleotides. In mouse embryonic stem cells (ESCs), IMPDH2 forms large multi-prot...
doi.org
May 12, 2025 at 7:29 AM
Our new paper just arrived! Fun collaborative effort led by Sam Ball and Meagan Hennessy to develop an AI tool to segment and classify #IMPDH2 rod-rings in mouse ESCs doi.org/10.1186/s129...
Reposted by David Turner
March 27, 2025 at 8:51 AM
Reposted by David Turner
Right after the spanish edition of #TheMasterBuilder comes the Portuguese one, thanks to www.temasedebates.pt
Have a look for a cell’s eye view of Biology in contrast with the widespread gene’s eye.
#CellsRUs #NotInTheGenes
Have a look for a cell’s eye view of Biology in contrast with the widespread gene’s eye.
#CellsRUs #NotInTheGenes
March 28, 2025 at 8:18 AM
Right after the spanish edition of #TheMasterBuilder comes the Portuguese one, thanks to www.temasedebates.pt
Have a look for a cell’s eye view of Biology in contrast with the widespread gene’s eye.
#CellsRUs #NotInTheGenes
Have a look for a cell’s eye view of Biology in contrast with the widespread gene’s eye.
#CellsRUs #NotInTheGenes
Reposted by David Turner
Wonderful evening in #Barcelona w/ friends sharing memories, science and hope in these troubled times.
March 21, 2025 at 6:11 AM
Wonderful evening in #Barcelona w/ friends sharing memories, science and hope in these troubled times.
Reposted by David Turner
In the wake of Barcelona #Gastruloid meeting, we can say w/ some confidence that this is a system w/ potential in several areas of biomedical research: models, rather than replicas, are useful &also teach. For details
linkinghub.elsevier.com/retrieve/pii...
onlinelibrary.wiley.com/doi/10.1002/...
linkinghub.elsevier.com/retrieve/pii...
onlinelibrary.wiley.com/doi/10.1002/...
March 22, 2025 at 8:48 AM
In the wake of Barcelona #Gastruloid meeting, we can say w/ some confidence that this is a system w/ potential in several areas of biomedical research: models, rather than replicas, are useful &also teach. For details
linkinghub.elsevier.com/retrieve/pii...
onlinelibrary.wiley.com/doi/10.1002/...
linkinghub.elsevier.com/retrieve/pii...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by David Turner
Delighted to announce our preprint on modelling of the peritoneum in endometriosis research, by Dimas Rahmana, with Dharani Hapangama's group, Liverpool Women's Hospital, with essential contribution from Chris Hill
www.biorxiv.org/content/10.1...
@livunihls.bsky.social @liverpooluni.bsky.social
www.biorxiv.org/content/10.1...
@livunihls.bsky.social @liverpooluni.bsky.social
Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis
Peritoneal endometriosis causes pelvic pain and infertility, but the underlying mechanisms related to these symptoms are not fully understood. Endometriosis diagnosis is typically delayed; thus, patie...
www.biorxiv.org
March 22, 2025 at 10:51 AM
Delighted to announce our preprint on modelling of the peritoneum in endometriosis research, by Dimas Rahmana, with Dharani Hapangama's group, Liverpool Women's Hospital, with essential contribution from Chris Hill
www.biorxiv.org/content/10.1...
@livunihls.bsky.social @liverpooluni.bsky.social
www.biorxiv.org/content/10.1...
@livunihls.bsky.social @liverpooluni.bsky.social
Reposted by David Turner
First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference
March 20, 2025 at 2:45 PM
First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference
Reposted by David Turner
Fun collaboration! All the nitty-gritty about N2B27 and gastruloids. Kudos to all the authors, particularly Tina Balayo (¡que va de primero!)
New Gastruloid preprint just landed... nice collaboration between our lab, @dias-andre.bsky.social, and @amartinezarias.bsky.social www.biorxiv.org/content/10.1...
N2B27 media formulations influence gastruloid development
Gastruloids are 3D aggregates of pluripotent stem cells grown in suspension culture that mimic many aspects of gastrulation and early axial elongation. The N2B27 basal medium in which mouse gastruloid...
www.biorxiv.org
March 17, 2025 at 12:09 PM
Fun collaboration! All the nitty-gritty about N2B27 and gastruloids. Kudos to all the authors, particularly Tina Balayo (¡que va de primero!)
New Gastruloid preprint just landed... nice collaboration between our lab, @dias-andre.bsky.social, and @amartinezarias.bsky.social www.biorxiv.org/content/10.1...
N2B27 media formulations influence gastruloid development
Gastruloids are 3D aggregates of pluripotent stem cells grown in suspension culture that mimic many aspects of gastrulation and early axial elongation. The N2B27 basal medium in which mouse gastruloid...
www.biorxiv.org
March 17, 2025 at 9:20 AM
New Gastruloid preprint just landed... nice collaboration between our lab, @dias-andre.bsky.social, and @amartinezarias.bsky.social www.biorxiv.org/content/10.1...