Lucas Dent
@cellsandculture.bsky.social
https://cell.codes
Australian Researcher,
Charras Lab. London Centre for Nanotechnology,
Alumni of Bakal Lab, ICR.
PhD, Harvey Lab, Peter Mac
Plant powered 🌱
Fascinated about how cells work
#SystemsBio #CellShape #MechBio #Rstats #Imaging #MorphoGenesis
Australian Researcher,
Charras Lab. London Centre for Nanotechnology,
Alumni of Bakal Lab, ICR.
PhD, Harvey Lab, Peter Mac
Plant powered 🌱
Fascinated about how cells work
#SystemsBio #CellShape #MechBio #Rstats #Imaging #MorphoGenesis
Reposted by Lucas Dent
Reposted by Lucas Dent
Felix Zhou's u-Segment3D is out:
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
November 12, 2025 at 2:41 AM
Felix Zhou's u-Segment3D is out:
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
www.nature.com/articles/s41...
It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation.
It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
Reposted by Lucas Dent
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
September 30, 2025 at 2:43 PM
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Reposted by Lucas Dent
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
September 25, 2025 at 3:01 PM
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Please vote for Frankie’s image 👇 (if you like it!). Frankie is screening compounds to regenerate heart muscle. Your vote will help raise funds for this remarkable work.
Please vote for my #ARTxSCIENCE2025 submission! Voting takes 10 secs
renew.science/artxscience/...
My image shows stem-cell derived heart cells treated with a drug that makes cardiomyocytes (pink) proliferate—without activating fibroblasts #HeartRegeneration #Microscopy #StemCells
renew.science/artxscience/...
My image shows stem-cell derived heart cells treated with a drug that makes cardiomyocytes (pink) proliferate—without activating fibroblasts #HeartRegeneration #Microscopy #StemCells
September 1, 2025 at 3:04 PM
Please vote for Frankie’s image 👇 (if you like it!). Frankie is screening compounds to regenerate heart muscle. Your vote will help raise funds for this remarkable work.
Reposted by Lucas Dent
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Lucas Dent
#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 4:15 PM
#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
Reposted by Lucas Dent
Started my first day as a Walter Benjamin Fellow! 🥳
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
May 1, 2025 at 3:27 AM
Started my first day as a Walter Benjamin Fellow! 🥳
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology!
Big thanks to the @dfg.de for funding my research.
Reposted by Lucas Dent
Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff!
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
May 25, 2025 at 2:42 AM
Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff!
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
👉 'New directions in epithelial mechanoadaptation'
www.sciencedirect.com/science/arti...
Reposted by Lucas Dent
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
May 10, 2025 at 11:15 AM
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Reposted by Lucas Dent
📢Registration is open for our IPLS Annual Symposium, 11th June 2025!
We will showcase exciting #interdisciplinary #research performed by IPLS researchers and collaborators.
Limited spaces, register early to avoid disappointment 👇
ucl.ac.uk/physics-livi...
We will showcase exciting #interdisciplinary #research performed by IPLS researchers and collaborators.
Limited spaces, register early to avoid disappointment 👇
ucl.ac.uk/physics-livi...
April 8, 2025 at 1:15 PM
📢Registration is open for our IPLS Annual Symposium, 11th June 2025!
We will showcase exciting #interdisciplinary #research performed by IPLS researchers and collaborators.
Limited spaces, register early to avoid disappointment 👇
ucl.ac.uk/physics-livi...
We will showcase exciting #interdisciplinary #research performed by IPLS researchers and collaborators.
Limited spaces, register early to avoid disappointment 👇
ucl.ac.uk/physics-livi...
Reposted by Lucas Dent
Has been added to our history collection on droso4public: droso4public.wordpress.com/history/
May 2, 2025 at 7:59 PM
Has been added to our history collection on droso4public: droso4public.wordpress.com/history/
Reposted by Lucas Dent
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
April 19, 2025 at 2:11 PM
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
We’ve had an incredible experience being hosted at the AIC at Janelia for iPALM imaging. Tremendous support and expertise.
If your project could benefit from advanced imaging, check out their instruments (FIB-SEM, iPALM, LLSM and others) and get in touch.👇
If your project could benefit from advanced imaging, check out their instruments (FIB-SEM, iPALM, LLSM and others) and get in touch.👇
The latest AIC Call for Proposals is now open! Deadline is June 16, 2025. Come use @hhmijanelia.bsky.social imaging technology and expertise for FREE. Visit www.aicjanelia.org/apply for details. Before applying, contact us to schedule a technical consultation!
Apply | aicjanelia
Apply to use the advanced microscopes housed at the AIC.
www.aicjanelia.org
April 15, 2025 at 8:40 PM
We’ve had an incredible experience being hosted at the AIC at Janelia for iPALM imaging. Tremendous support and expertise.
If your project could benefit from advanced imaging, check out their instruments (FIB-SEM, iPALM, LLSM and others) and get in touch.👇
If your project could benefit from advanced imaging, check out their instruments (FIB-SEM, iPALM, LLSM and others) and get in touch.👇
Reposted by Lucas Dent
If you train people in ImageJ, Fiji, whatever, even if it isn't your day job, please let us know, and please share this post! Thanks a ton, we really appreciate it. (2/2) forms.gle/C8dUpg8qZkbD... #bioimaging #microscopy #bioimageanalysis
Open Source Bioimage Analysis Training Survey
We are attempting for a publication to estimate the number of biologists who have attended a tutorial or training course in open source bioimage analysis (especially user friendly tools, but anything ...
forms.gle
April 8, 2025 at 2:32 PM
If you train people in ImageJ, Fiji, whatever, even if it isn't your day job, please let us know, and please share this post! Thanks a ton, we really appreciate it. (2/2) forms.gle/C8dUpg8qZkbD... #bioimaging #microscopy #bioimageanalysis
Reposted by Lucas Dent
Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology"
journals.biologists.com/jcs/article/...
Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful
Many thanks to @jcellsci.bsky.social for publishing it
journals.biologists.com/jcs/article/...
Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful
Many thanks to @jcellsci.bsky.social for publishing it
Practical considerations for data exploration in quantitative cell biology
Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to dat...
journals.biologists.com
April 7, 2025 at 9:15 AM
Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology"
journals.biologists.com/jcs/article/...
Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful
Many thanks to @jcellsci.bsky.social for publishing it
journals.biologists.com/jcs/article/...
Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful
Many thanks to @jcellsci.bsky.social for publishing it
Reposted by Lucas Dent
For all you interested in small GTPase biology and membrane pattern formation - this is an essential read from the labs of Peter Bieling and Bill Bement
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
April 4, 2025 at 1:56 PM
For all you interested in small GTPase biology and membrane pattern formation - this is an essential read from the labs of Peter Bieling and Bill Bement
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Lucas Dent
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Reposted by Lucas Dent
AusBIAS is now on bluesky! We have a website, a logo, and a dream to connect all the bioimage analysts in Australia.
March 24, 2025 at 8:50 AM
AusBIAS is now on bluesky! We have a website, a logo, and a dream to connect all the bioimage analysts in Australia.
Reposted by Lucas Dent
"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/...
Bonus: My son Luca's first pub
Bonus: My son Luca's first pub
Synaptic architecture of a memory engram in the mouse hippocampus
Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...
www.science.org
March 21, 2025 at 10:50 PM
"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/...
Bonus: My son Luca's first pub
Bonus: My son Luca's first pub
Reposted by Lucas Dent
PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 23, 2025 at 2:06 PM
PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lucas Dent
Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3
January 31, 2025 at 9:42 PM
Reposted by Lucas Dent
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Lucas Dent
Announcing this upcoming conference:
GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan
Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!
📅 14–17 October 2025
📍 Paris, France
GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan
Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!
📅 14–17 October 2025
📍 Paris, France
January 28, 2025 at 8:14 AM
Announcing this upcoming conference:
GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan
Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!
📅 14–17 October 2025
📍 Paris, France
GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan
Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!
📅 14–17 October 2025
📍 Paris, France
Reposted by Lucas Dent
First official post! A new paper out about #cytokinesis in #epithelia
www.embopress.org/doi/full/10....
Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.
www.embopress.org/doi/full/10....
Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.
November 15, 2024 at 6:41 PM
First official post! A new paper out about #cytokinesis in #epithelia
www.embopress.org/doi/full/10....
Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.
www.embopress.org/doi/full/10....
Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.