Lucien Hinderling
@lhinderling.bsky.social
tries to make microscopes smarter · bioimage analysis, optogenetics, ml, 3d printing, open science · phd student in cellular signalling dynamics @PertzLab
Pinned
Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...
Reposted by Lucien Hinderling
Reposted by Lucien Hinderling
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Injury-induced electrochemical coupling triggers organ growth
Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.
www.science.org
February 5, 2026 at 9:56 AM
Reposted by Lucien Hinderling
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
An mTurquoise2-Based Glucose Biosensor
Glucose is an important substrate for organisms to acquire energy needed for cellular growth. Despite the importance of this metabolite, single-cell information at a fast time-scale about the dynamics...
pubs.acs.org
February 3, 2026 at 9:10 PM
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
Reposted by Lucien Hinderling
Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social
Roffay, C., García-Arcos, J. M., Chapuis, P., López-Andarias, J., Schneider, F., ...., Roux, A., & Mercier, V. (2024). Tutorial: fluorescence lifetime microscopy of membrane mechanosensitive Flipper probes. Nature protocols, 19(12), 3457–3469. #EpithelialMechanicsReview
buff.ly/mTlcVwn
buff.ly/mTlcVwn
February 5, 2026 at 8:10 AM
Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social
Reposted by Lucien Hinderling
Mammalian cells labeled with lysotracker are perfect for teaching live cell imaging.
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
January 30, 2026 at 8:12 PM
Mammalian cells labeled with lysotracker are perfect for teaching live cell imaging.
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Reposted by Lucien Hinderling
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
January 31, 2026 at 8:55 AM
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Reposted by Lucien Hinderling
Curious if anyone has applied #MCP in materials physics or other scientific fields. Concrete use cases, prototypes, or lessons learned are very welcome. Looking to connect with fellow scientists and exchange experiences in this area.
#OpenScience #MaterialsPhysics #Physics #Langchain
#OpenScience #MaterialsPhysics #Physics #Langchain
January 31, 2026 at 7:49 PM
Curious if anyone has applied #MCP in materials physics or other scientific fields. Concrete use cases, prototypes, or lessons learned are very welcome. Looking to connect with fellow scientists and exchange experiences in this area.
#OpenScience #MaterialsPhysics #Physics #Langchain
#OpenScience #MaterialsPhysics #Physics #Langchain
Reposted by Lucien Hinderling
AMAZING JOB OPPORTUNITY ALERT!!!
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
January 31, 2026 at 2:35 PM
AMAZING JOB OPPORTUNITY ALERT!!!
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
Reposted by Lucien Hinderling
JCS snapshot - Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
January 29, 2026 at 2:24 PM
JCS snapshot - Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
Reposted by Lucien Hinderling
A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The missing data for intelligent scientific instruments - Nature Methods
Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting...
www.nature.com
January 26, 2026 at 6:01 PM
A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lucien Hinderling
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Photonics West 2026 impressions
The Photonics West conference includes a gigantic tradeshow spanning 2 halls of the Moscone Center and some of the space in between. I visited on two consecutive afternoon, trying to at least walk by ...
nicost.github.io
January 26, 2026 at 6:55 PM
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Reposted by Lucien Hinderling
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Lucien Hinderling
Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...
GitHub - TheDeanLab/navigate: navigate - open source light-sheet microscope controls
navigate - open source light-sheet microscope controls - TheDeanLab/navigate
github.com
January 20, 2026 at 12:01 PM
Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...
Reposted by Lucien Hinderling
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 10:24 AM
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Real-time control of cell migration with closed-loop feedback, interoperability of smart microscopes, image analysis with Convpaint & our chatGPT microscope! Excited for this meeting!
January 20, 2026 at 10:14 AM
Real-time control of cell migration with closed-loop feedback, interoperability of smart microscopes, image analysis with Convpaint & our chatGPT microscope! Excited for this meeting!
some nice circular micropatterns by @bgraedel.bsky.social and msc student moritz in @olivierpertz.bsky.social lab! stamp printed with our microfab method.
January 20, 2026 at 8:12 AM
some nice circular micropatterns by @bgraedel.bsky.social and msc student moritz in @olivierpertz.bsky.social lab! stamp printed with our microfab method.
Reposted by Lucien Hinderling
📯👨🚀 Calling all #bioimage analysis aficionados. #EZInput is out! We wanted to bring #ImageJ’s capacity to record settings to the #Python ecosystem 🐍. It is a declarative library for generating UIs that just work. Done with @guijacquemet.bsky.social lab
arxiv.org/abs/2601.08859 #ScientificComputing
arxiv.org/abs/2601.08859 #ScientificComputing
January 15, 2026 at 11:36 AM
📯👨🚀 Calling all #bioimage analysis aficionados. #EZInput is out! We wanted to bring #ImageJ’s capacity to record settings to the #Python ecosystem 🐍. It is a declarative library for generating UIs that just work. Done with @guijacquemet.bsky.social lab
arxiv.org/abs/2601.08859 #ScientificComputing
arxiv.org/abs/2601.08859 #ScientificComputing
Reposted by Lucien Hinderling
@thorlabs.bsky.social teaching scopes are all set up and ready for my #microscopy lab course!
January 15, 2026 at 4:21 PM
@thorlabs.bsky.social teaching scopes are all set up and ready for my #microscopy lab course!
Reposted by Lucien Hinderling
Kind of flew under the radar, BUT we released napari-omero 0.6 recently 🥳 @openmicroscopy.org
You can now down-/upload ROIs from and to OMERO inside @napari.org 🤩Bringing the power of napari for annotation to the management of OMERO :)
Thanks @psobolewskiphd.bsky.social and other maintainers!
You can now down-/upload ROIs from and to OMERO inside @napari.org 🤩Bringing the power of napari for annotation to the management of OMERO :)
Thanks @psobolewskiphd.bsky.social and other maintainers!
January 7, 2026 at 1:27 PM
Kind of flew under the radar, BUT we released napari-omero 0.6 recently 🥳 @openmicroscopy.org
You can now down-/upload ROIs from and to OMERO inside @napari.org 🤩Bringing the power of napari for annotation to the management of OMERO :)
Thanks @psobolewskiphd.bsky.social and other maintainers!
You can now down-/upload ROIs from and to OMERO inside @napari.org 🤩Bringing the power of napari for annotation to the management of OMERO :)
Thanks @psobolewskiphd.bsky.social and other maintainers!
Won best thesis award with this video! 4 years of research and play in 3 minutes :')
youtu.be/so0fPlK1-LM
youtu.be/so0fPlK1-LM
Smart microscopy, computer vision, and controlling cells with light -- my PhD thesis in 3 minutes
YouTube video by Pertz Lab
youtu.be
January 7, 2026 at 11:27 AM
Won best thesis award with this video! 4 years of research and play in 3 minutes :')
youtu.be/so0fPlK1-LM
youtu.be/so0fPlK1-LM
Reposted by Lucien Hinderling
If you have time tomorrow, join my online talk about LLS/single molecule/microtubules and 3D data at @bioimagingna.bsky.social user group (18:00 CET for Europe).
I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.
I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.
#HappyMicroscpyMonday #microscopycommunity - Join us tomorrow, Tue Jan 6 for a talk by Eugene Katrukha on "Single molecule imaging using LLS7", hosted by the BINA Lattice Lightsheet User Group
Learn more & register here: buff.ly/US5Xd2q
Learn more & register here: buff.ly/US5Xd2q
January 5, 2026 at 7:36 PM
If you have time tomorrow, join my online talk about LLS/single molecule/microtubules and 3D data at @bioimagingna.bsky.social user group (18:00 CET for Europe).
I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.
I hope I manage to fit 25 movies into 20 cohesive slides and connection will be ok.
Tune in on 23. jan to hear about our work on smart microscopy:
🎉 New year, new registration link for the #EuroBioImaging #VirtualPub! Don't miss out on all of the great talks we have planned. Please visit our website for an overview & to register. 🔽
www.eurobioimaging.eu/our-events/v...
www.eurobioimaging.eu/our-events/v...
January 2, 2026 at 11:44 AM
Tune in on 23. jan to hear about our work on smart microscopy:
Reposted by Lucien Hinderling
Finally, we’ve solved a long-standing mystery: what tintinnid shells are actually made of:
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
December 27, 2025 at 10:30 AM
Finally, we’ve solved a long-standing mystery: what tintinnid shells are actually made of:
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
A new class of biomaterial formed by remarkable structural proteins unique to tintinnids.
A major milestone after 3 years of work! Read about it in our preprint: doi.org/10.64898/202...
#ProtistsOnSky
Reposted by Lucien Hinderling
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
December 25, 2025 at 1:41 PM
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Reposted by Lucien Hinderling
Pfffffff. Chains of transformations are hard. It took me two releases to get the live deskew slider right and looking ok (hopefully) #bigvolumebrowser
December 22, 2025 at 10:40 PM
Pfffffff. Chains of transformations are hard. It took me two releases to get the live deskew slider right and looking ok (hopefully) #bigvolumebrowser