Lucien Hinderling
@lhinderling.bsky.social
tries to make microscopes smarter · bioimage analysis, optogenetics, ml, 3d printing, open science · phd student in cellular signalling dynamics @PertzLab
Pinned
Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...
Reposted by Lucien Hinderling
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
February 8, 2026 at 7:59 AM
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
Reposted by Lucien Hinderling
I witnessed the Flipper-TR development from day 1. I remember how I told myself "it can't work" when I first saw the concept. Until it actually worked beautifully! It took a decade, but now Flipper-TR is a widely used tool and an inspiring tale.
Congrats to the many who contributed to this journey!🧪
Congrats to the many who contributed to this journey!🧪
Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!
February 9, 2026 at 12:27 PM
I witnessed the Flipper-TR development from day 1. I remember how I told myself "it can't work" when I first saw the concept. Until it actually worked beautifully! It took a decade, but now Flipper-TR is a widely used tool and an inspiring tale.
Congrats to the many who contributed to this journey!🧪
Congrats to the many who contributed to this journey!🧪
Reposted by Lucien Hinderling
1/ 🚀🧪🤖 Big update for #Omega — the LLM-powered autonomous agent for bioimage analysis in @napari.org ! Custom LLM endpoints, layer actions, plugin extensibility, agentic widget maker, modernized UI, & 30+ fixes. Here's what's new in version *2026.2.8.2*:
February 9, 2026 at 6:40 AM
1/ 🚀🧪🤖 Big update for #Omega — the LLM-powered autonomous agent for bioimage analysis in @napari.org ! Custom LLM endpoints, layer actions, plugin extensibility, agentic widget maker, modernized UI, & 30+ fixes. Here's what's new in version *2026.2.8.2*:
Reposted by Lucien Hinderling
Reposted by Lucien Hinderling
New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687
Injury-induced electrochemical coupling triggers organ growth
Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.
www.science.org
February 5, 2026 at 9:56 AM
Reposted by Lucien Hinderling
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
An mTurquoise2-Based Glucose Biosensor
Glucose is an important substrate for organisms to acquire energy needed for cellular growth. Despite the importance of this metabolite, single-cell information at a fast time-scale about the dynamics...
pubs.acs.org
February 3, 2026 at 9:10 PM
Great to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
Reposted by Lucien Hinderling
Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social
Roffay, C., García-Arcos, J. M., Chapuis, P., López-Andarias, J., Schneider, F., ...., Roux, A., & Mercier, V. (2024). Tutorial: fluorescence lifetime microscopy of membrane mechanosensitive Flipper probes. Nature protocols, 19(12), 3457–3469. #EpithelialMechanicsReview
buff.ly/mTlcVwn
buff.ly/mTlcVwn
February 5, 2026 at 8:10 AM
Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social
Reposted by Lucien Hinderling
Mammalian cells labeled with lysotracker are perfect for teaching live cell imaging.
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
January 30, 2026 at 8:12 PM
Mammalian cells labeled with lysotracker are perfect for teaching live cell imaging.
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Minimal preparation, always works, and, as a bonus, results in nice data for #FluorescenceFriday
Reposted by Lucien Hinderling
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
January 31, 2026 at 8:55 AM
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Reposted by Lucien Hinderling
Curious if anyone has applied #MCP in materials physics or other scientific fields. Concrete use cases, prototypes, or lessons learned are very welcome. Looking to connect with fellow scientists and exchange experiences in this area.
#OpenScience #MaterialsPhysics #Physics #Langchain
#OpenScience #MaterialsPhysics #Physics #Langchain
January 31, 2026 at 7:49 PM
Curious if anyone has applied #MCP in materials physics or other scientific fields. Concrete use cases, prototypes, or lessons learned are very welcome. Looking to connect with fellow scientists and exchange experiences in this area.
#OpenScience #MaterialsPhysics #Physics #Langchain
#OpenScience #MaterialsPhysics #Physics #Langchain
working on microscope control for cell biology! happy to chat
January 31, 2026 at 7:53 PM
working on microscope control for cell biology! happy to chat
Reposted by Lucien Hinderling
AMAZING JOB OPPORTUNITY ALERT!!!
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
January 31, 2026 at 2:35 PM
AMAZING JOB OPPORTUNITY ALERT!!!
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
@calm-stp.bsky.social is hiring a Data & Systems Steward! 🧬
🔹Manage #bioimage data & #OMERO admin
🔹Automate via #Python/#Bash
🔹Support #FAIR principles
🔹Work closely with @crick-ia-team.bsky.social
⏰ Deadline: 08 Feb 2026
Apply: www.crick.ac.uk/careers-stud...
Reposted by Lucien Hinderling
JCS snapshot - Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
January 29, 2026 at 2:24 PM
JCS snapshot - Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
@macdobry.bsky.social presents the key findings from their recent JCS paper with @bgraedel.bsky.social and colleagues @olivierpertz.bsky.social.
journals.biologists.com/jcs/article/...
Reposted by Lucien Hinderling
A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The missing data for intelligent scientific instruments - Nature Methods
Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting...
www.nature.com
January 26, 2026 at 6:01 PM
A Comment discusses how commands, data, and metadata currently discarded by scientific instruments could be used to train AI systems to learn to conduct experiments. @henrypinkard.bsky.social @nilsnorlin.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lucien Hinderling
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Photonics West 2026 impressions
The Photonics West conference includes a gigantic tradeshow spanning 2 halls of the Moscone Center and some of the space in between. I visited on two consecutive afternoon, trying to at least walk by ...
nicost.github.io
January 26, 2026 at 6:55 PM
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Thanks for sharing! The vialux dmd system for <20k seems a very good price compared to the other dmd systems on the market (excluding diy builds)! Are there open/uManager compatible drivers?
January 26, 2026 at 8:35 PM
Thanks for sharing! The vialux dmd system for <20k seems a very good price compared to the other dmd systems on the market (excluding diy builds)! Are there open/uManager compatible drivers?
should be on youtube in a few days :))
January 23, 2026 at 6:48 PM
should be on youtube in a few days :))
Thank you! Happy for any feedback. Thank you for joining! (even with camera on, appreciated haha!)
January 23, 2026 at 6:19 PM
Thank you! Happy for any feedback. Thank you for joining! (even with camera on, appreciated haha!)
Reposted by Lucien Hinderling
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Lucien Hinderling
Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...
GitHub - TheDeanLab/navigate: navigate - open source light-sheet microscope controls
navigate - open source light-sheet microscope controls - TheDeanLab/navigate
github.com
January 20, 2026 at 12:01 PM
Navigate can now run entirely with ASI's Tiger Controller, eliminating the NI data acquisition board altogether, simplifying the optoelectronics, and providing deterministic frame-to-frame operation. Documentation coming soon... github.com/TheDeanLab/n...
Reposted by Lucien Hinderling
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
January 20, 2026 at 10:24 AM
@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Real-time control of cell migration with closed-loop feedback, interoperability of smart microscopes, image analysis with Convpaint & our chatGPT microscope! Excited for this meeting!
January 20, 2026 at 10:14 AM
Real-time control of cell migration with closed-loop feedback, interoperability of smart microscopes, image analysis with Convpaint & our chatGPT microscope! Excited for this meeting!
Rat fibroblast cells with actin & nuclear stain :)
January 20, 2026 at 9:20 AM
Rat fibroblast cells with actin & nuclear stain :)
some nice circular micropatterns by @bgraedel.bsky.social and msc student moritz in @olivierpertz.bsky.social lab! stamp printed with our microfab method.
January 20, 2026 at 8:12 AM
some nice circular micropatterns by @bgraedel.bsky.social and msc student moritz in @olivierpertz.bsky.social lab! stamp printed with our microfab method.