Luc Reym⌬nd
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lreymond.bsky.social
Luc Reym⌬nd
@lreymond.bsky.social
2.6K followers 3.5K following 220 posts
Organic chemistry passionate 🧪, mountain addict 🧗 & freediver 🤿. EPFL scientist and @spirochrome.com co-founder. 🇨🇭
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Reposted by Luc Reym⌬nd
spirochrome.com
Thank you @prelights.bsky.social for highlighting HAK-actin!

HAK-actin is a great tool for ExM actin staining.

spirochrome.com/product/hak-...
November 20, 2025 at 9:54 AM
Reposted by Luc Reym⌬nd
prelights.bsky.social
Reliable actin labelling in expansion #microscopy 🔬

Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social

Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 11:58 AM
Reposted by Luc Reym⌬nd
dudinlab.bsky.social
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !

Discover HAK-Actin if you haven't already ;)
November 19, 2025 at 12:36 PM
lreymond.bsky.social
Cool, the HAK-actin preprint was showcased by @prelights.bsky.social
A good reason to read it if you haven't yet 😜
November 19, 2025 at 12:28 PM
lreymond.bsky.social
Hike'n fondue in Valais with friends! 😋

The fall colors are splendid.
Fall Alpine landscape with fiery orange larch trees. 3 packs of Swiss cheese fondue mix A red fondue pot with the Swiss white cross, forks and alcohol burner
November 15, 2025 at 2:34 PM
Reposted by Luc Reym⌬nd
clairedeo.bsky.social
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇

www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
Reposted by Luc Reym⌬nd
rhodamine110.bsky.social
Cool paper using a new JF derivative to map synaptic proteins. And AI didn't like the generality of our general synthetic methods section (that we've used for years), so we expanded them from 2 succinct paragraphs to 1.5 gloriously unreadable pages. Better than Ambien. www.nature.com/articles/s41...
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain - Nature Communications
Synapses are diverse within a single neuron. Here, the authors present a method for single-cell synaptome imaging of endogenous protein subpopulations in the mouse brain, enabling spatial mapping of s...
www.nature.com
November 11, 2025 at 6:19 PM
lreymond.bsky.social
Went looking for quartz over the weekend. I was lucky to find a nice untouched pocket with well-formed crystals (after 3h of search!). The first picture shows the cluster in situ within the crack and the other one shows the same crystals as a detached piece.
A closeup view into a crack in granit with transparent quartz crystals visible. A cluster of shiny and transparent quartz crystals.
November 10, 2025 at 8:23 PM
lreymond.bsky.social
Firing water rockets with the kids never gets old, especially for me! 🚀
November 8, 2025 at 3:41 PM
lreymond.bsky.social
🥝 The kiwi harvest is the last one of the year in the garden.
Happily surprised by the quantity given the very moderate bloom in spring.
Two boxes containing a lot of kiwis
November 8, 2025 at 3:30 PM
Reposted by Luc Reym⌬nd
michellefrei17.bsky.social
🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩‍🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️
D-CHAB @ethz.ch
www.nature.com/articles/s41...
Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology
Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...
www.nature.com
November 5, 2025 at 9:29 PM
Reposted by Luc Reym⌬nd
spirochrome.com
More information about Flipper-TR on our website spirochrome.com/product/flip...
Flipper-TR® - Live cell membrane tension probe - spirochrome
Flipper-TR® is a live cell membrane tension probe
spirochrome.com
November 4, 2025 at 9:19 AM
Reposted by Luc Reym⌬nd
spirochrome.com
👉🦠Interested in bacterial membrane tension?

Our membrane tension probe Flipper-TR is a top tool for the job!

A new article in @pnas.org demonstrates how Flipper-TR efficiently stains bacterial membranes and responds to various stimuli altering membrane tension.

🔗 doi.org/10.1073/pnas...
🧪
Exploring bacteria–surface interactions with a fluorescent membrane tension probe | PNAS
Understanding how bacteria interact with surfaces is critical for advancing applications in biofilm and biofouling prevention, biomaterial developm...
doi.org
November 4, 2025 at 9:19 AM
lreymond.bsky.social
👻 Spooky cookies 🎃
October 30, 2025 at 6:55 PM
Reposted by Luc Reym⌬nd
spirochrome.com
Find out how SPY650-FastAct_X can help your research here:

spirochrome.com/product/spy6...
A group of live HeLa cells stained with SPY650-FastAct_X and imaged by STED microscopy. The image was kindly provided by Prof. Till Stephan.
October 29, 2025 at 9:30 AM
Reposted by Luc Reym⌬nd
spirochrome.com
Live cell ACTIN imaging has never been easier with SPY650-FastAct_X!

1. Add the probe to the cells
2. Image 1h later

SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell.

image credits: @stephanlab.bsky.social
October 29, 2025 at 9:30 AM
Reposted by Luc Reym⌬nd
loxstoplox.bsky.social
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 23, 2025 at 7:57 PM
lreymond.bsky.social
There are only a few things in life cooler than crawling inside a lava tunnel.
Incredible geological formations, narrow sections followed by rooms with over 3m high ceilings and pilars.
The view inside a lava tunnel. There is a narrow section only about 40cm high The ceiling of a lava tube section with vitrified protusions evenly spaced A rock inside the tunnel with many shades of oxidized iron hues A tunnel ceiling image with large vitrified stalactites of basalt hanging
October 18, 2025 at 2:08 PM
Reposted by Luc Reym⌬nd
heilemannlab.bsky.social
It was a tremendous pleasure to have @zhixingchen2.bsky.social visiting us today in Frankfurt and listen to his great science on developing photostable and gentle fluorophores for microscopy.
Thank you, Zhixing, for this inspiring seminar! 🙏
@goetheuni.bsky.social @scale-cluster-ffm.bsky.social
October 7, 2025 at 3:29 PM
Reposted by Luc Reym⌬nd
spirochrome.com
An incredibly comprehensive and meticulous study of Flipper-TR lifetime analysis to make your membrane tension measurements using Flipper-TR more robust and reliable.

Thanks to @juanmagararc.bsky.social and @rouxlab.bsky.social for this very valuable resource!
October 7, 2025 at 8:21 AM
Reposted by Luc Reym⌬nd
juanmagararc.bsky.social
🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM
Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...
www.biorxiv.org
October 5, 2025 at 4:04 PM
lreymond.bsky.social
Cold blurry colors for a cold morning hike at dawn. We hoped to hear the deer rut calls (Brame du cerf in French) but the mountain remained silent today.
October 5, 2025 at 11:36 AM
lreymond.bsky.social
Quince/apple gelly workshop. Currently extracting the polymers responsible for the gelation before filtration, sugar addition, evaporation of 40% the solvent and aliquoting.
Kitchen chemistry!
October 4, 2025 at 11:50 AM
lreymond.bsky.social
Sichuan pepper from the garden, that's the 2nd year I get some berries.
Smells incredibly good.
October 4, 2025 at 10:03 AM
Reposted by Luc Reym⌬nd
spirochrome.com
📢📄 A new preprint by @katecavanaugh.bsky.social links reduced fertility stemming from impaired implantation from older mothers to embryo hypercontractility
SPY650-FastAct was the key probe to track actin dynamics in live embryos implantation movies over 24 h long 🤯
doi.org/10.1101/2025...
#imaging
October 2, 2025 at 8:40 AM