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prelights.bsky.social
preLights
@prelights.bsky.social
3.2K followers 920 following 200 posts
A preprint highlights service run by the biological community and supported by The Company of Biologists (@biologists.bsky.social).
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prelights.bsky.social
preLights @prelights.bsky.social · Sep 1
🚨 New call for preLighters!🚨

Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍

Interested? Apply today & help shape the future of science publishing! 📢

More info: prelights.biologists.com/news/join-th...
prelights.bsky.social
Two more recent preLights were written by Vibha Singh @vibhasingh.bsky.social 🙌

One that discusses Taxane-induced conformational changes in the microtubule lattice. #preprint from Joyce Meiring @joycemeiri.bsky.social and colleagues #UniUtrecht.

#preLight ⬇️
prelights.biologists.com/highlights/t...
Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling - preLights
More than just a stabilizer: Taxanes (cancer drugs) trigger the GEF-H1 – RhoA axis.
prelights.biologists.com
December 31, 2025 at 2:24 PM
prelights.bsky.social
Some excellent preLights to end 2025 🎆

The latest was written by Zhang-He Goh @goh-zhanghe.bsky.social, discussing an enzymatic method for tryptophan-specific bromination described in a recent #preprint from the lab of @amyweeks.bsky.social.

#preLight ⬇️
prelights.biologists.com/highlights/e...
Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling - preLights
Ready, set, brominate: RebH and engineered variant for bromination of peptidyl-Trp residues
prelights.biologists.com
December 31, 2025 at 2:14 PM
prelights.bsky.social
Check out the latest #preLight from the #preprint review initiative led by Marcus Oliveira #UFRJ #Brazil

⚡Characterising wavelength-selective regulation of keratinocyte metabolism from @aliciakowaltowski.bsky.social & team.

#preLight by Rickson Ribeiro ⬇️👀

prelights.biologists.com/highlights/m...
Mitochondrial Fatty Acid Oxidation is Stimulated by Red Light Irradiation - preLights
Different wavelengths of sunlight can modulate the viability of keratinocytes (Skin cells), and the metabolism. Red light, particularly, affects oxygen consumption during three days post-irradiation a...
prelights.biologists.com
December 19, 2025 at 11:38 AM
prelights.bsky.social
The failing heart hides a biochemical vulnerability ❤️‍🩹

Jeny Jose: By linking MGST1 loss to fibroblast activation, ROS accumulation, & ferroptosis susceptibility, this #preprint provides a new perspective on heart failure progression.

#preLight ⬇️
prelights.biologists.com/highlights/l...
Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure - preLights
The failing heart hides a biochemical vulnerability. MGST1, an antioxidant, down in fibroblasts means a ferroptosis-prone, oxidation-sensitive state. A new therapeutic angle surfaces.
prelights.biologists.com
December 17, 2025 at 8:44 AM
Reposted by preLights
focalplane.bsky.social
ICYMI, our #preprint list is now up on FocalPlane, highlighting the latest research using #microscopy to answer questions in #biology.
As always, send us any recommendations for preprints that we've missed: focalplane.biologists.com/2025/12/12/m...
Microscopy preprints - applications in biology - FocalPlane
Microscopy preprints - applications in biology - News
focalplane.biologists.com
December 15, 2025 at 11:44 AM
Reposted by preLights
inesfournon.bsky.social
Thrilled to share the preprint from my PhD! 🥳 Where I characterised epithelial cell extrusion in a sea anemone
🔗 www.biorxiv.org/content/10.6...
Big thanks to my supervisor @prhsteinmetz.bsky.social and coauthors @noahbruderer.bsky.social @lionlchristiaen.bsky.social at🇳🇴 @msarscentre.bsky.social ⬇️🧵
December 16, 2025 at 12:33 PM
prelights.bsky.social
WHOLISTIC: A whole-body functional atlas of cellular dynamics

@sinanmalik.bsky.social covers work from the @mishaahrens.bsky.social Lab.

“This #preprint represents the kind of transformative science that redefines what is possible in a field.”

#preLight ⬇️
prelights.biologists.com/highlights/i...
Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits - preLights
WHOLISTIC: A whole-body functional atlas of cellular dynamics
prelights.biologists.com
December 16, 2025 at 1:59 PM
prelights.bsky.social
Fibre for the win: Dietary influences on the gut microbiota 🦠

Jasmine Talevi covers recent work from Blake Dirks & colleagues describing the microbial functional response to two very different diets. #preprint #microbiome

#preLight ⬇️ 👀
prelights.biologists.com/highlights/m...
Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function - preLights
Fibre for the win: Dietary influences on the gut microbiota
prelights.biologists.com
December 16, 2025 at 11:53 AM
Reposted by preLights
the-node.bsky.social
For our November in #preprints, check out special picks from the list highlighted by preLighters @prelights.bsky.social with expertise across #DevBio and #StemCell biology. Find out why these preLighters are particularly excited about these preprints. ⬇️

thenode.biologists.com/prelighters-...
December 12, 2025 at 11:54 AM
prelights.bsky.social
Helping the next generation of scientists find their voice. 📣

Discover how @seahsamantha.bsky.social empowers students through her path from preLights to Executive Editor of the Journal of Emerging Investigators.

Interview: prelights.biologists.com/news/from-pr...
Collage of students in lab coats conducting experiments, analyzing data, and collaborating on research. Includes logos for JEI and eJRXIV, conveying a theme of scientific inquiry.
December 11, 2025 at 11:16 AM
Reposted by preLights
cmatthaeus.bsky.social
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social

Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
biorxivpreprint.bsky.social bioRxivpreprint @biorxivpreprint.bsky.social · 24d
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
prelights.bsky.social
Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism. #preprint from @marthafield.bsky.social & team

#preLight by Yan Aveiro dos Reis ⬇️👀
prelights.biologists.com/highlights/v...
Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice - preLights
Vitamin B12 preserves skeletal muscle mitochondrial DNA integrity and respiration, linking B12 deficiency to mtDNA uracil accumulation and impaired muscle energy metabolism.
prelights.biologists.com
December 10, 2025 at 12:14 PM
prelights.bsky.social
Meet TFlex— a new tool to uncover how natural & synthetic transcription factors shape human CD8+ T cell states. #Immunology

Inês Caiado highlights recent work from Riley Mullins & colleagues. #preprint

#preLight ⬇️ 👀
prelights.biologists.com/highlights/s...
Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states - preLights
Meet TFlex— a new tool to uncover how natural and synthetic transcription factors shape human CD8+ T cell states.
prelights.biologists.com
December 10, 2025 at 9:43 AM
prelights.bsky.social
A cardiomyocyte's journey to maturity ❤️

The #preprint authors, Mengmeng Huang & team #BurnsLab, generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.

A more visual #preLight by Theodora Stougiannou ⬇️ 👀
prelights.biologists.com/highlights/d...
Dosage-sensitive RBFOX2 autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome - preLights
A cardiomyocyte's journey to maturity: In the preprint highlighted here, the authors generate a model of RBFOX2 haploinsufficiency to identify the gene’s effects on cardiomyocyte maturation.
prelights.biologists.com
December 9, 2025 at 1:45 PM
prelights.bsky.social
Ancient Denisovan DNA from a 200,000-year-old genome + a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversity and local adaptation today.

#preLight by Siddharth Singh ⬇️ prelights.biologists.com/highlights/a...
A high-coverage genome from a 200,000-year-old Denisovan; A global map for introgressed structural variation and selection in humans - preLights
Ancient Denisovan DNA from a 200,000-year-old genome and a new global map of archaic structural variants show that inherited Denisovan segments, including whole centromeres, still shape human diversit...
prelights.biologists.com
December 8, 2025 at 1:20 PM
prelights.bsky.social
ILC2 orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines #immunology

André Luiz Amorim Costa discusses preprinted work from Rita Berkachy & colleagues now published in PLOS Pathogens. #postLight

#preLight⬇️
prelights.biologists.com/highlights/c...
Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells - preLights
ILC2—traditionally recognized for mediating anti-parasite responses—orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines
prelights.biologists.com
December 4, 2025 at 11:26 AM
prelights.bsky.social
On post-translational modifications & their contribution to help shape human cortical development 🧠

Jawdat Sandakly covers a recent #preprint from Julien Pigeon and colleagues @hassanbraindevlab.bsky.social. #DevBio #Neuroscience

Read the #preLight ⬇️👀
prelights.biologists.com/highlights/p...
Post-translational Tuning of Human Cortical Progenitor Neuronal Output - preLights
On post-translational modifications and their contribution to help shape human cortical development
prelights.biologists.com
December 3, 2025 at 11:18 AM
prelights.bsky.social
When gut microbes and CD4+ T cells go from chill to allergic drama queens 💥

Mitchell Sarmie teamed up with Serena Restori to highlight recent work from Alexa Weingarden & colleagues. #preprint #immunology

Check out the #preLight ⬇️
prelights.biologists.com/highlights/g...
Gut microbial composition modulates food-specific CD4+ T cells in food allergy - preLights
When gut microbes and CD4+ T cells go from chill to allergic drama queens
prelights.biologists.com
December 2, 2025 at 2:30 PM
Reposted by preLights
biologists.bsky.social
Our next extraordinary biologist is Grace Lim, a prolific preLighter @prelights.bsky.social and a contributor to @the-node.bsky.social and @dev-journal.bsky.social. #100biologists
the left and QR code to the right. Portrait of Grace Lim to the left, text to the right 100 extraordinary biologists Grace Lim Grace Lim is a prolific preLighter, contributor to the Node and a Development author. As a Senior Scientist at A*STAR in Singapore, Grace is leading innovative research at the frontier of stem cell biology through her discoveries on novel gastric cancer stem cell markers for targeted therapeutics. #100biologists #biologists100
November 30, 2025 at 3:32 PM
prelights.bsky.social
GV101 will, GV101 will ROCK you!

Collaborative #preprint from David Herrmann & team
@garvaninstitute.bsky.social describes the impact of a ROCK2-specific inhibitor on both stromal & epithelial cells in the context of triple-negative breast cancer.
#preLight by Sharvari Pitke ⬇️
ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion - preLights
GV101 will, GV101 will ROCK you!
prelights.biologists.com
November 28, 2025 at 2:43 PM
Reposted by preLights
the-node.bsky.social
After his wonderful webinar on ‘Creativity and Science Communication’ for the Node, Anatolii Kozlov @anatoliikozlov.bsky.social shares his thoughts on the process of sharing your science in a way that is unique to you.

Check it out ⤵️: thenode.biologists.com/creativity-a...

#scicomm #creativity
Creativity and Science Communication - the Node
Science communication isn’t just about podcasts or fairs—it’s about making research relatable. Jargon and narrow topics can create barriers, so the challenge is to blend scientific language with every...
thenode.biologists.com
November 27, 2025 at 1:22 PM
prelights.bsky.social
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis🩸

Hannah Pletcher covers work from Narges Pourmandi &colleagues @lyssiotislab.bsky.social
#preLight⬇️
prelights.biologists.com/highlights/a...
Aspartate transaminases are required for blood development - preLights
Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.
prelights.biologists.com
November 27, 2025 at 3:04 PM
prelights.bsky.social
When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning. 🌱 #PlantBiology

Goldy & team uncover a central role for F-actin as a cortical landmark.

#preLight by Jeny Jose @umeaplantsciencecentre.se ⬇️ 👀
prelights.biologists.com/highlights/a...
Actin Counters Geometry to Guide Plant Cell Division - preLights
When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning
prelights.biologists.com
November 27, 2025 at 10:42 AM
prelights.bsky.social
The challenge of diagnosing Schistosoma haematobium infections in school-aged children in SW Nigeria

@halataha.bsky.social highlights important work underscoring the urgent need for improved diagnostics & interventions in endemic regions #preprint
#preLight⬇️
prelights.biologists.com/highlights/s...
Schistosoma haematobium DNA and Eggs in the Urine Sample of School-Age Children (SAC) in South-West Nigeria - preLights
Schistosoma haematobium DNA & eggs detected in urine of school-aged children in SW Nigeria. Findings underscore the urgent need for improved diagnostics & interventions in endemic regions.
prelights.biologists.com
November 26, 2025 at 2:14 PM
prelights.bsky.social
Battling the TB blues...😷

A pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala & colleagues #IMI_ERA4TB to characterise the activity of TBAJ-587 and its metabolites. #preprint #pharmacology

Latest #preLight from @goh-zhanghe.bsky.social ⬇️👀
prelights.biologists.com/highlights/i...
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis - preLights
Battling the TB blues: a pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala and colleagues to characterise the activity of TBAJ-587 and its metabolites
prelights.biologists.com
November 25, 2025 at 4:44 PM