The authors present an “identifiability-guided assessment” framework—a new approach to pinpoint which parameters in a personalized digital twin model can be confidently trusted.

Do you love fashion shows? Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit.

Back to 100 years anniversary page

Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.

Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine and other charged amino acids to get truly pH-sensitive protein interact...

Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

The physics behind the immune response: focus on viscoelasticity

Symbioses have been fundamental to colonization of terrestrial ecosystems by plants and their evolution. Emergence of the ancient arbuscular mycorrhizal symbiosis was followed by the diversification of alternative intracellular symbioses, such as the ericoid mycorrhizae (ErM). We aimed at understanding how these diversifications occurred. We sequenced the genomes of ErM-forming liverworts, and reconstituted symbiosis under laboratory conditions. We demonstrated the existence of a nutrient-regulated symbiotic state that enables ErM and underlies intracellular colonization of plant tissues. Comparative transcriptomic analyses identified an ancestral gene module associated with intracellular symbiosis beyond ErM. Genetic manipulations in the liverwort Marchantia paleacea, phylogenetics and transactivation assays demonstrated its essential function for intracellular symbiosis. We conclude that plant have maintained, and convergently recruited, an ancestral gene module for intracellular symbioses.

A mathematical model translates aggregated single-cell RNA sequencing data into stages of disease

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv – use these

When the eyes disagree, the brain must decide.

Disrupt to discover: perturbing single-cell genomes maps the molecular roots of schizophrenia.

Newly discovered cytotoxic cell type in planarians carry out explosive, cross-species killing.

Biological conduction bridges skip a beat. The preprint authors generate AV node-like pacemaker cells from human pluripotent stem cell populations in order to create a biological conduction bridge.

Molecular roadmap of functionally defined optic-flow circuits.

The Medial Temporal Lobe (MTL) is key to human cognition, supporting memory, emotional processing, navigation, and semantic coding. Rare direct human MTL recordings revealed concept cells, which were ...

Delivery mode, water treatment and milk composition shape the microbiome and metabolome during the first six months of life.

Autocrine IGF-1: An emerging cell state controller of Fibro-adipogenic Progenitors (FAPs)

Small primate shows big promise? Grey mouse lemur exhibits various age-related changes in microglia

Red and near-infrared wavelengths are used to improve biological and behavioral parameters in rats with major depressive disorder.

Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.

Specifying primordial germ cells, a tale of transitions.