A simple website based on [*folio](https://github.com/bogoli/-folio) design.

Arabidopsis thaliana was always an unlikely candidate for the limelight. But 25 years ago, the diminutive thale cress launched the botanical world into the molecular era.

Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...

PhD Project - BBSRC Yorkshire Bioscience DLA Programme: Convergence or divergence? Evolution of phagocytosis molecular mechanisms in animal macrophages at University of Sheffield, listed on FindAPhD.c...

Journals are considering doing identity checks to expose fake authors — but there are downsides.

A comprehensive single-nucleus RNA-seq atlas of >367,000 nuclei from male and female Aedes aegypti mosquitoes reveals sexual dimorphism in sensory systems and brain cell types and widespread co-expres...

FlyBase: a database for drosophila genetics and molecular biology

RNA:DNA hybrids accumulate at DNA double-strand breaks (DSBs) and were shown to regulate homologous recombination repair. The mechanism responsible for the formation of these non-canonical RNA:DNA structures remains unclear although they were proposed to arise consequently to RNA polymerase II or III loading followed by DSB-induced de novo transcription at the break site. Here, we found no evidence of RNA polymerase recruitment at DSBs. Rather, strand-specific R-loop mapping revealed that RNA:DNA hybrids are mainly generated at DSBs occurring in transcribing loci, from the hybridization of pre-existing RNA to the 3′ overhang left by DNA end resection. We further identified the H3K4me3 reader spindlin 1 and the transcriptional regulator PAF1 as factors promoting RNA:DNA hybrid accumulation at DSBs, through their role in mediating transcriptional repression in cis to DSBs. Altogether, we provide evidence that RNA:DNA hybrids accumulate at DSBs occurring in transcribing loci as a result o

Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing modifications to support...