Zachary H. Gursky
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zachary-gursky.bsky.social
Zachary H. Gursky
@zachary-gursky.bsky.social
190 followers 790 following 24 posts
he/him. Studies how the brain 🧠 understands its own body 🦠 throughout life. Musician 🎼 for fun. Appreciates tea 🫖🍵. Newfound biker🚴🏻 Opinions are my own
Posts Replies Media Videos
Reposted by Zachary H. Gursky
oozguc.bsky.social
When #halloween meets #FluorescenceFriday 🎃
October 31, 2025 at 4:21 PM
zachary-gursky.bsky.social
Absolutely fantastic work on an underappreciated pocket of the brain and body! (Our understanding of) Meningeal macrophages get cooler every day!
October 5, 2025 at 2:02 AM
zachary-gursky.bsky.social
Such an interesting experiment exploring interplay between cognition and basic bodily functions, like breathing.
September 27, 2025 at 5:47 PM
zachary-gursky.bsky.social
🧵1/3 Excited for my recent 🧪research out at @jclinical-invest.bsky.social! At @yaleschoolofmed.bsky.social Anesthesiology, we manipulated coupling between brain (cerebrospinal fluid🧠💧[CSF]) and cervical lymph vessels. We saw age-based drainage changes, ⬆️📈neuroinflammation and ⬇️📉brain homeostasis.
jci.org Journal of Clinical Investigation @jci.org · Sep 3
How does impaired lymphatic drainage affect cerebral homeostasis?

Helene Benveniste & team use dynamic CE-MRI and computational fluid dynamics in a rat model of mechanical stress to deep cervical lymph nodes, revealing the brain’s adaptive response.

buff.ly/k9sGQoQ
September 4, 2025 at 7:26 PM
zachary-gursky.bsky.social
It is great to welcome @shariwiseman.bsky.social (back) to Yale along with the Yale Neuro Postdoc Committee [YNPC], @kavliatyale.bsky.social, and @yaleneuro.bsky.social ! Pictures are of her first talk to a packed room of trainees, about scientific publishing and related careers
Shari Wiseman standing in front of a room and speaking to trainee scientists, mostly postdoctoral researchers and graduate students. A different angle of Shari Wiseman standing in front of a room and speaking to trainee scientists, mostly postdoctoral researchers and graduate students.
August 19, 2025 at 4:46 PM
zachary-gursky.bsky.social
This is a great opportunity for any postdoc with a scientific story that they want to share and a drive to meet more researchers in the field! I highly recommend applying even if you are uncertain
schandralab.bsky.social Sreeganga Chandra Lab at Yale @schandralab.bsky.social · Aug 8
Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th
August 14, 2025 at 7:05 PM
zachary-gursky.bsky.social
Very excited to contribute to this recent review where we discuss ways in which the immune system interacts with the brain, focusing on inhibitory neurons of the cortex!
authors.elsevier.com/c/1lWWR3Q9h2...
authors.elsevier.com
August 7, 2025 at 4:38 PM
zachary-gursky.bsky.social
Excited to be representing the @emiliafavuzzi.bsky.social lab at @krfoundation.org 's 2025 Innovations symposium! If you're here, feel free to say hi and come talk about brain-immune system interactions! #idb #brain #neuroscience #immunology #research #scicomm
Picture of symposium room with podium. Two projector screens on the sides of the podium say "Kenneth Rainin Foundation 2025 Innovations Symposium" with a picture of Turtle Bay Oahu, Hawaii. Picture of Zachary Gursky, smiling, holding a name tag that says "Kenneth Rainin Foundation 2025 Innovations Symposium, Zachary Gursky, Yale University, Grantee"
July 18, 2025 at 6:18 PM
zachary-gursky.bsky.social
Very interesting preprint on ligand-independent activation of GABA-B receptors (GPCRs more broadly?) by mechanical force transduction in the brain! Could this mechanism be at play in GABAergic circuits elsewhere in the body, as well?
biorxivpreprint.bsky.social bioRxivpreprint @biorxivpreprint.bsky.social · Jun 13
GABA-independent activation of GABAB receptor by mechanical forces https://www.biorxiv.org/content/10.1101/2025.06.09.658551v1
June 13, 2025 at 6:05 PM
Reposted by Zachary H. Gursky
lehtinenlab.bsky.social
Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development
Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...
rdcu.be
May 28, 2025 at 12:56 PM
zachary-gursky.bsky.social
Just attended a college graduation where the majority of speeches referenced the necessity and inevitability of AI (when AI was not in curricula). Very interesting choice to prioritize this over the academic efforts and achievements of the new graduates.
May 28, 2025 at 4:58 PM
Reposted by Zachary H. Gursky
mariangelesmoro.bsky.social
www.thelancet.com/journals/lan...
CSF transport at the brain–meningeal border: effects on neurological health and disease
The existence of specialised structures that allow a continuous exchange of CSF between different anatomical compartments at the brain–meningeal border is challenging conventional notions around molec...
www.thelancet.com
May 22, 2025 at 3:39 AM
Reposted by Zachary H. Gursky
marinlab.bsky.social
4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity
April 30, 2025 at 3:12 PM
Reposted by Zachary H. Gursky
rtnconference.bsky.social
🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/
April 16, 2025 at 12:35 AM
Reposted by Zachary H. Gursky
ologies.bsky.social
Just a reminder that if you’re an ologist or passionate expert in something (or have someone to suggest) shoot your friggin shot on this app & tweet me.

I may not get to interview everyone but I love knowing whom’s whom. 🎤💚🎧

(oh but check to see if we’ve already covered it: www.ologies.com)
alie ward
www.ologies.com
April 14, 2025 at 7:31 PM
zachary-gursky.bsky.social
I'm excited to host Dr. Pandey tomorrow for what will certainly be an outstanding talk! Thanks to @kavliatyale.bsky.social and @yaleneuro.bsky.social for providing the opportunity to bring in our scientific peers and connect postdocs and facilty across institutions
yaleneuro.bsky.social Yale Neuroscience @yaleneuro.bsky.social · Apr 2
TOMORROW (4/3) Kiran Pandey, PhD 🥼 from @weillcornell.bsky.social will be presenting a #SYNAPSES seminar 🗣️ on "Pericyte-Neuron Interactions in Long Term Memory" 🧠

Thank you to @zachary-gursky.bsky.social for hosting 🙌 We hope to see you there! 👀

Co-sponsored by @kavliatyale.bsky.social
Flyer for SYNAPSES seminar by Kiran Pandey, PhD on April 3rd
April 2, 2025 at 3:11 PM
Reposted by Zachary H. Gursky
jonykipnis.bsky.social
Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||

www.sciencedirect.com/science/arti...
Meningeal lymphatics-microglia axis regulates synaptic physiology
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previo…
www.sciencedirect.com
March 21, 2025 at 3:53 PM
zachary-gursky.bsky.social
Today, I donated blood for the first time in my life with @americanredcross.bsky.social. I have always been wildly uncomfortable around needles and particularly IVs, but the world needs more people helping each other right now. Be kind to those around you, and help where you can.
February 26, 2025 at 9:21 PM
Reposted by Zachary H. Gursky
brainotopia.bsky.social
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!

As per tradition here is a graphical summary of our paper in comic form.

www.science.org/doi/10.1126/...
February 19, 2025 at 8:47 PM
Reposted by Zachary H. Gursky
martafilizola.bsky.social
Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.
February 8, 2025 at 11:32 PM
zachary-gursky.bsky.social
Excited to hear from @nytimes.com science writer @carlzimmer.com on crafting scientific narratives and scientific storytelling and his ideas on the state of science. #scicomm #science #journalism
Picture of Carl Zimmer standing at a podium in tue front of a room, pointing to a powerpoint slide which contains examples of headlines and header images from articles that he wrote for the New York Times.
February 7, 2025 at 8:07 PM
zachary-gursky.bsky.social
Despite everything else going on in the world, it was incredible to hear Maria Lehtinen's talk on #CSF and #choroidplexus during brain development and sickness today. Many familiar pictures (and videos) from the posts of @scienceyael.bsky.social . Such amazing #neuroscience #neuroimmune research
Photograph of a woman, Maria K. Lehtinen, PhD, standing at a podium while speaking. Behind her, a large blue slide shows the title of her talk, "Uncovering choroid plexus-CSF contributions to brain development and lifelong brain health." The slide also has a picture of art that resembles the brain cells central to the topic of her talk.
February 4, 2025 at 7:00 PM