Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Reposted by Journal of Clinical Investigation
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
November 11, 2025 at 5:05 PM
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
Reposted by Journal of Clinical Investigation
Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...
JCI -
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
www.jci.org
November 10, 2025 at 5:57 PM
Pleased to see the official release of our research letter in @jci.org ! In my first-ever corresponding author publication, we leveraged a publicly available scRNA-seq dataset and asked how prostate cancer cells systemically reprogram the cells of the bone marrow. www.jci.org/articles/vie...
Why do TLR7 and TLR9 have opposing effects (protective or proinflammatory) in systemic lupus erythematosus?
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
November 11, 2025 at 2:02 PM
Why do TLR7 and TLR9 have opposing effects (protective or proinflammatory) in systemic lupus erythematosus?
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
How can we enhance muscle insulin sensitivity in low-active individuals?
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
November 10, 2025 at 7:30 PM
How can we enhance muscle insulin sensitivity in low-active individuals?
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments.
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
November 10, 2025 at 2:05 PM
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments.
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Our work on #sleep and #ALS is out now. JCI - Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis www.jci.org/articles/vie...
JCI -
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
www.jci.org
November 7, 2025 at 1:17 PM
Our work on #sleep and #ALS is out now. JCI - Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis www.jci.org/articles/vie...
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
From earlier this week: Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
November 8, 2025 at 2:00 PM
From earlier this week: Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
November 7, 2025 at 7:30 PM
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
November 7, 2025 at 5:15 PM
TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
November 7, 2025 at 2:03 PM
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
JCI -
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
doi.org
November 7, 2025 at 11:14 AM
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
November 6, 2025 at 7:30 PM
Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
Long COVID can occur after SARS-CoV2 infection
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
November 6, 2025 at 5:15 PM
Long COVID can occur after SARS-CoV2 infection
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
November 6, 2025 at 2:04 PM
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
As part of the JCI’s ongoing Review Series: Clinical Innovation and Scientific Progress in GLP-1 Medicine, Mark E Cooper & Daniël H. van Raalte present: GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity: www.jci.org/articles/vie...
November 5, 2025 at 7:30 PM
As part of the JCI’s ongoing Review Series: Clinical Innovation and Scientific Progress in GLP-1 Medicine, Mark E Cooper & Daniël H. van Raalte present: GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity: www.jci.org/articles/vie...
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
November 5, 2025 at 5:15 PM
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
November 5, 2025 at 2:03 PM
Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Identification of a new, autosomal dominant form of familial partial lipodystrophy from Abhimanyu Garg and team. This disease is caused by a recurrent variant in ACAA2, which encodes an enzyme in mitochondrial fatty acid oxidation.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis and hypoglycemia
www.jci.org
November 4, 2025 at 5:01 PM
Identification of a new, autosomal dominant form of familial partial lipodystrophy from Abhimanyu Garg and team. This disease is caused by a recurrent variant in ACAA2, which encodes an enzyme in mitochondrial fatty acid oxidation.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Solute carrier (SLC) transporters are implicated in many human diseases. In @jclinicalinvest, we show that efavirenz potentiates metal transporter SLC39A8 via a cryptic allosteric pocket—revealing new potential for therapeutic targeting.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake
www.jci.org
November 4, 2025 at 8:52 PM
Solute carrier (SLC) transporters are implicated in many human diseases. In @jclinicalinvest, we show that efavirenz potentiates metal transporter SLC39A8 via a cryptic allosteric pocket—revealing new potential for therapeutic targeting.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
November 4, 2025 at 5:15 PM
Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Mark Shlomchik and and his team have solved a 20-year #lupus mystery! In a new @jci.org paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR
November 4, 2025 at 3:11 PM
Mark Shlomchik and and his team have solved a 20-year #lupus mystery! In a new @jci.org paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
November 4, 2025 at 2:04 PM
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
Reposted by Journal of Clinical Investigation
GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 3, 2025 at 5:20 PM
GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss
www.jci.org/articles/vie...
www.jci.org/articles/vie...