Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Adding new information to our understanding of critical illness phenotypes
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction: doi.org/10.1172/JCI1...
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction: doi.org/10.1172/JCI1...
February 11, 2026 at 1:41 PM
Adding new information to our understanding of critical illness phenotypes
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction: doi.org/10.1172/JCI1...
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction: doi.org/10.1172/JCI1...
A new contributor to cardiac allograft vasculopathy (CAV)…
Emmanuel Zorn & team discover plasma cells in human cardiac allografts with vasculopathy target bilirubin, revealing local heme catabolism: doi.org/10.1172/JCI1...
Emmanuel Zorn & team discover plasma cells in human cardiac allografts with vasculopathy target bilirubin, revealing local heme catabolism: doi.org/10.1172/JCI1...
February 10, 2026 at 5:15 PM
A new contributor to cardiac allograft vasculopathy (CAV)…
Emmanuel Zorn & team discover plasma cells in human cardiac allografts with vasculopathy target bilirubin, revealing local heme catabolism: doi.org/10.1172/JCI1...
Emmanuel Zorn & team discover plasma cells in human cardiac allografts with vasculopathy target bilirubin, revealing local heme catabolism: doi.org/10.1172/JCI1...
In a cohort of 1000+ patients with breast cancer,
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor for RAB11A, and its inhibition lowers lung metastasis & cell spreading in triple negative breast cancer models: doi.org/10.1172/JCI1...
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor for RAB11A, and its inhibition lowers lung metastasis & cell spreading in triple negative breast cancer models: doi.org/10.1172/JCI1...
February 10, 2026 at 12:15 PM
In a cohort of 1000+ patients with breast cancer,
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor for RAB11A, and its inhibition lowers lung metastasis & cell spreading in triple negative breast cancer models: doi.org/10.1172/JCI1...
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor for RAB11A, and its inhibition lowers lung metastasis & cell spreading in triple negative breast cancer models: doi.org/10.1172/JCI1...
A new approach to photodynamics in vision that’s worth seeing
Krzysztof Palczewski & team develop a method for visualizing retinoid distribution and movement in the retina of heathy and diseased mouse models: doi.org/10.1172/JCI1...
Krzysztof Palczewski & team develop a method for visualizing retinoid distribution and movement in the retina of heathy and diseased mouse models: doi.org/10.1172/JCI1...
February 9, 2026 at 9:02 PM
A new approach to photodynamics in vision that’s worth seeing
Krzysztof Palczewski & team develop a method for visualizing retinoid distribution and movement in the retina of heathy and diseased mouse models: doi.org/10.1172/JCI1...
Krzysztof Palczewski & team develop a method for visualizing retinoid distribution and movement in the retina of heathy and diseased mouse models: doi.org/10.1172/JCI1...
Proanthocyanidins are flavonoid antioxidants found in many fruits and vegetables.
Here, Sanhong Liu & team report proanthocyanidins promote PD-L1 degradation via SYVN1 to enhance antitumor immunity in preclinical models of lung and colon cancer: doi.org/10.1172/JCI1...
Here, Sanhong Liu & team report proanthocyanidins promote PD-L1 degradation via SYVN1 to enhance antitumor immunity in preclinical models of lung and colon cancer: doi.org/10.1172/JCI1...
February 9, 2026 at 12:15 PM
Proanthocyanidins are flavonoid antioxidants found in many fruits and vegetables.
Here, Sanhong Liu & team report proanthocyanidins promote PD-L1 degradation via SYVN1 to enhance antitumor immunity in preclinical models of lung and colon cancer: doi.org/10.1172/JCI1...
Here, Sanhong Liu & team report proanthocyanidins promote PD-L1 degradation via SYVN1 to enhance antitumor immunity in preclinical models of lung and colon cancer: doi.org/10.1172/JCI1...
Previously shared: Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
February 8, 2026 at 2:01 PM
Previously shared: Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
ICYMI: It’s about TIME (tumor immune microenvironment) for breast cancer
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
February 7, 2026 at 2:01 PM
ICYMI: It’s about TIME (tumor immune microenvironment) for breast cancer
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Neurodegeneration biomarkers in Alzheimer’s disease: Axonal density index expands the “N” in the ATN framework: doi.org/10.1172/JCI2...
Ryn Flaherty & Arjun V. Masurkar comment on Zhaoyuan Gong et al., highlighting a measure of neurodegeneration: doi.org/10.1172/JCI1...
Ryn Flaherty & Arjun V. Masurkar comment on Zhaoyuan Gong et al., highlighting a measure of neurodegeneration: doi.org/10.1172/JCI1...
February 6, 2026 at 9:01 PM
Neurodegeneration biomarkers in Alzheimer’s disease: Axonal density index expands the “N” in the ATN framework: doi.org/10.1172/JCI2...
Ryn Flaherty & Arjun V. Masurkar comment on Zhaoyuan Gong et al., highlighting a measure of neurodegeneration: doi.org/10.1172/JCI1...
Ryn Flaherty & Arjun V. Masurkar comment on Zhaoyuan Gong et al., highlighting a measure of neurodegeneration: doi.org/10.1172/JCI1...
Breaking Down to Rebuild: Lymphatic Ablation Enhances Osteoclast-Driven Regeneration: doi.org/10.1172/JCI1...
Matthijs Luxen et al. comment on Neda Vishlaghi et al.: doi.org/10.1172/JCI2...
Matthijs Luxen et al. comment on Neda Vishlaghi et al.: doi.org/10.1172/JCI2...
February 6, 2026 at 5:15 PM
Breaking Down to Rebuild: Lymphatic Ablation Enhances Osteoclast-Driven Regeneration: doi.org/10.1172/JCI1...
Matthijs Luxen et al. comment on Neda Vishlaghi et al.: doi.org/10.1172/JCI2...
Matthijs Luxen et al. comment on Neda Vishlaghi et al.: doi.org/10.1172/JCI2...
Reposted by Journal of Clinical Investigation
New research out in @jci.org finds that concomitant COX-1 & COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use ft. Kayla Barekat & Emanuela Ricciotti (@itmat.bsky.social) @FitzGerald__Lab www.jci.org/articles/vie...
February 5, 2026 at 6:17 PM
New research out in @jci.org finds that concomitant COX-1 & COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use ft. Kayla Barekat & Emanuela Ricciotti (@itmat.bsky.social) @FitzGerald__Lab www.jci.org/articles/vie...
Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer: doi.org/10.1172/JCI2...
Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...
Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...
February 6, 2026 at 12:15 PM
Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer: doi.org/10.1172/JCI2...
Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...
Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...
The fingertip has notable regenerative capacity, yet the underlying mechanisms—especially the role of lymphatics—have been debated
Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...
Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...
February 5, 2026 at 5:15 PM
The fingertip has notable regenerative capacity, yet the underlying mechanisms—especially the role of lymphatics—have been debated
Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...
Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
February 3, 2026 at 9:27 PM
Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...
Could curbing inflammation prevent the progression of TP53-mutant clonal
hematopoiesis to myeloid blood cancers?
Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...
hematopoiesis to myeloid blood cancers?
Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...
February 5, 2026 at 12:15 PM
Could curbing inflammation prevent the progression of TP53-mutant clonal
hematopoiesis to myeloid blood cancers?
Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...
hematopoiesis to myeloid blood cancers?
Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...
Current methods for tracking cognitive decline in Alzheimer’s disease are invasive and expensive
Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...
Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...
February 4, 2026 at 5:15 PM
Current methods for tracking cognitive decline in Alzheimer’s disease are invasive and expensive
Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...
Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...
It’s about TIME (tumor immune microenvironment) for breast cancer
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
February 4, 2026 at 12:15 PM
It’s about TIME (tumor immune microenvironment) for breast cancer
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
February 3, 2026 at 5:15 PM
Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
Reposted by Journal of Clinical Investigation
Congratulations to our Okoye, Estes, Axthelm, and Picker Lab teams with their contributors on their new publication which investigates the magnitude and activation of SIV-specific CD8+ T cells.
Read more about SIV T Cell responses by visiting the below link.
pubmed.ncbi.nlm.nih.gov/41609736/
Read more about SIV T Cell responses by visiting the below link.
pubmed.ncbi.nlm.nih.gov/41609736/
February 2, 2026 at 7:22 PM
Congratulations to our Okoye, Estes, Axthelm, and Picker Lab teams with their contributors on their new publication which investigates the magnitude and activation of SIV-specific CD8+ T cells.
Read more about SIV T Cell responses by visiting the below link.
pubmed.ncbi.nlm.nih.gov/41609736/
Read more about SIV T Cell responses by visiting the below link.
pubmed.ncbi.nlm.nih.gov/41609736/
Over 100 years ago, platelets were observed to interact with neutrophils in blood clots
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
February 3, 2026 at 12:15 PM
Over 100 years ago, platelets were observed to interact with neutrophils in blood clots
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Rhythms of risk: the intersection of clocks, cancer, and chronotherapy
In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...
In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...
February 2, 2026 at 9:03 PM
Rhythms of risk: the intersection of clocks, cancer, and chronotherapy
In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...
In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...
A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
February 2, 2026 at 5:15 PM
A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models
Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...
Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...
February 2, 2026 at 1:30 PM
CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models
Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...
Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...
From earlier this week: Elevated tRNA halves in olfactory epithelial cells of schizophrenia patients
In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...
In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...
February 1, 2026 at 2:00 PM
From earlier this week: Elevated tRNA halves in olfactory epithelial cells of schizophrenia patients
In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...
In this Research Letter, Yohei Kirino & team find increased immunostimulatory tRNA halves in patient-derived cells that retain neural traits: doi.org/10.1172/JCI1...
ICYMI: This study marks the first description of a tumor suppressor role for FBXO11 in AML
@alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...
@alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...
January 31, 2026 at 2:00 PM
ICYMI: This study marks the first description of a tumor suppressor role for FBXO11 in AML
@alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...
@alykarsan.bsky.social & team show depleted FBXO11 expression in AML promotes stem cell quiescence by attenuating mitochondrial metabolism through mislocalization of LONP1: doi.org/10.1172/JCI1...
Reposted by Journal of Clinical Investigation
#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience
JCI -
Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use
www.jci.org
January 29, 2026 at 6:54 PM
#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience