Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Chronic kidney disease currently affects 850 million people
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
November 11, 2025 at 7:30 PM
Chronic kidney disease currently affects 850 million people
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
Behind the Scenes: Dr. Mark Shlomchik and Dr. Sebastien Gingras of @pitt-immunology.bsky.social discuss data that led to the discovery that divergent signaling domains in TLR7 and TLR9 control their opposing effects on lupus.
November 11, 2025 at 2:02 PM
Behind the Scenes: Dr. Mark Shlomchik and Dr. Sebastien Gingras of @pitt-immunology.bsky.social discuss data that led to the discovery that divergent signaling domains in TLR7 and TLR9 control their opposing effects on lupus.
Why do TLR7 and TLR9 have opposing effects (protective or proinflammatory) in systemic lupus erythematosus?
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
November 11, 2025 at 2:02 PM
Why do TLR7 and TLR9 have opposing effects (protective or proinflammatory) in systemic lupus erythematosus?
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
Here, Mark J. Shlomchik & team swapped specific intracellular receptor regions in lupus-prone mice, discovering divergent TIR signaling domains.
www.jci.org/articles/vie...
How can we enhance muscle insulin sensitivity in low-active individuals?
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
November 10, 2025 at 7:30 PM
How can we enhance muscle insulin sensitivity in low-active individuals?
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Rasmus Kjøbsted & team find intermittent ischemia-reperfusion with knee-extensions improves insulin sensitivity via increased blood flow and reduced muscle decanoyl-L-carnitine.
www.jci.org/articles/vie...
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone.
www.jci.org/articles/vie...
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments.
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
November 10, 2025 at 2:05 PM
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments.
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Martin K. Lotz & team now discover histamine H1 receptor inverse agonists improve structure and pain in an #osteoarthritis mouse model: www.jci.org/articles/vie...
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
From earlier this week: Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
November 8, 2025 at 2:00 PM
From earlier this week: Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice: www.jci.org/articles/vie...
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
November 7, 2025 at 7:30 PM
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
November 7, 2025 at 5:15 PM
TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Shojiro Haji & Yoshihiro Ogawa comment on Beibei Liu et al.: www.jci.org/articles/vie...
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
November 7, 2025 at 2:03 PM
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
November 6, 2025 at 7:30 PM
Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
In this Review Caglar Cosarderelioglu & Peter M. Abadir discuss RAAS as a driver of age-related disease & a modifiable player in aging: www.jci.org/articles/vie...
Long COVID can occur after SARS-CoV2 infection
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
November 6, 2025 at 5:15 PM
Long COVID can occur after SARS-CoV2 infection
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
Gisela Gabernet @ggabernet.bsky.social et al. describe a multi-omics recovery factor that predicts long COVID in the IMPACC cohort & reveals LC biomarkers & potential treatment targets
www.jci.org/articles/vie...
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
November 6, 2025 at 2:04 PM
A new mechanism helps explain idiopathic pulmonary fibrosis
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue.
www.jci.org/articles/vie...
As part of the JCI’s ongoing Review Series: Clinical Innovation and Scientific Progress in GLP-1 Medicine, Mark E Cooper & Daniël H. van Raalte present: GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity: www.jci.org/articles/vie...
November 5, 2025 at 7:30 PM
As part of the JCI’s ongoing Review Series: Clinical Innovation and Scientific Progress in GLP-1 Medicine, Mark E Cooper & Daniël H. van Raalte present: GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity: www.jci.org/articles/vie...
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
November 5, 2025 at 5:15 PM
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
November 5, 2025 at 2:03 PM
Some macrophages have their toe in multiple inflammatory diseases…
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Yingqun Huang & team reveal pathogenic TET3-overexpressing macrophages (Toe-Macs) across multiple inflammatory diseases that can be selectively eliminated in mice.
www.jci.org/articles/vie...
Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
November 4, 2025 at 5:15 PM
Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...
Behind the Scenes: Drs. Marc Rothenberg and Yrina Rochman converse about allergen-mRNA experiments.
November 4, 2025 at 3:23 PM
Behind the Scenes: Drs. Marc Rothenberg and Yrina Rochman converse about allergen-mRNA experiments.
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
November 4, 2025 at 2:04 PM
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
This editorial on Gold Standard Science by @emmcnally.bsky.social, @sarahcjack.bsky.social, Corinne Williams, & Oliver Eickelberg urges the NIH to work hand-in-hand with journals in their future plans to enhance rigor and reproducibility. 🧵1/12 #skytorial
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 3, 2025 at 8:30 PM
This editorial on Gold Standard Science by @emmcnally.bsky.social, @sarahcjack.bsky.social, Corinne Williams, & Oliver Eickelberg urges the NIH to work hand-in-hand with journals in their future plans to enhance rigor and reproducibility. 🧵1/12 #skytorial
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Anti-inflammatory actions of glucagon-like peptide 1 medicines beyond metabolic benefits
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
November 3, 2025 at 7:30 PM
Anti-inflammatory actions of glucagon-like peptide 1 medicines beyond metabolic benefits
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 3, 2025 at 5:15 PM
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
ICYMI: Protection against the fungus among us after mold spore inhalation…
@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.
www.jci.org/articles/vie...
@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.
www.jci.org/articles/vie...
November 2, 2025 at 2:01 PM
ICYMI: Protection against the fungus among us after mold spore inhalation…
@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.
www.jci.org/articles/vie...
@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.
www.jci.org/articles/vie...
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
November 1, 2025 at 1:01 PM
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...