María A. Moro
LightNews LightNews
mariangelesmoro.bsky.social
María A. Moro
@mariangelesmoro.bsky.social
180 followers 110 following 200 posts
Researcher at CNIC, Madrid, Spain. Former Professor of Pharmacology at UCM. Professional interests: stroke, vascular dementia, neurovascular pathophysiology, cardiovascular risk factors and brain health, mentoring
Posts Replies Media Videos
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function - Nature Medicine
Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.
www.nature.com
November 16, 2025 at 5:23 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Shaping neutrophil morphology and function: the importance of a segmented nucleus - Nature Reviews Immunology
In this Review, the authors consider a long-standing immunological conundrum — why do neutrophils have a segmented nucleus? They discuss the mechanisms that may underlie segmentation of the neutrophil...
www.nature.com
November 14, 2025 at 9:33 PM
mariangelesmoro.bsky.social
www.science.org/doi/10.1126/...
A whole-brain single-cell atlas of circadian neural activity in mice
The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. However, how spontaneous neural activity is coordinated across regions over the ...
www.science.org
November 14, 2025 at 4:33 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Lymphoid gene expression supports neuroprotective microglia function - Nature
PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...
www.nature.com
November 6, 2025 at 5:33 PM
mariangelesmoro.bsky.social
www.nature.com/articles/d41...
Alzheimer’s decline slows with just a few thousand steps a day
A modest increase in physical activity can delay cognitive decline by three years — or more.
www.nature.com
November 6, 2025 at 5:29 PM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging - Nature Neuroscience
Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...
www.nature.com
November 5, 2025 at 6:46 AM
mariangelesmoro.bsky.social
www.cell.com/neuron/fullt...
The brain neurovascular epigenome and its association with dementia
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and bro...
www.cell.com
October 30, 2025 at 9:26 PM
mariangelesmoro.bsky.social
www.thelancet.com/journals/lan...
Making time for brain health: recognising temporal inequity in dementia risk reduction
Time is an under-recognised social determinant of brain health, and is potentially as important as education or income for dementia risk. Temporal inequity refers to the unequal distribution of discre...
www.thelancet.com
October 30, 2025 at 9:21 PM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Fibroblasts take center stage in brain repair - Nature Immunology
A recent Nature paper presents findings that highlight brain fibroblasts as dynamic regulators of tissue repair and immunomodulation after injury, with implications for understanding scar formation, f...
www.nature.com
October 30, 2025 at 6:54 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature
Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local im...
www.nature.com
October 30, 2025 at 6:53 AM
mariangelesmoro.bsky.social
www.pnas.org/doi/10.1073/...
Engineered 3D immuno-glial-neurovascular human miBrain model | PNAS
Patient-specific, human-based cellular models integrating a biomimetic blood–brain barrier, immune, and myelinated neuron components are critically...
www.pnas.org
October 21, 2025 at 6:44 PM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an ...
www.nature.com
October 16, 2025 at 4:16 PM
Reposted by María A. Moro
vcoelhosantoslab.bsky.social
@mariangelesmoro.bsky.social @blacoste.bsky.social

@ucoimbra.bsky.social @eurobioimaging.bsky.social
October 12, 2025 at 9:54 AM
Reposted by María A. Moro
maburto.bsky.social
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
October 14, 2025 at 11:43 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature
Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...
www.nature.com
October 16, 2025 at 4:10 PM
mariangelesmoro.bsky.social
www.cell.com/neuron/fullt...
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders
Liu et al. reveal that neutrophil extracellular traps (NETs) serve as markers of post-stroke emotional disorders. The infiltration of NETs into the brain parenchyma leads to the morphological and func...
www.cell.com
October 11, 2025 at 4:55 AM
mariangelesmoro.bsky.social
www.cell.com/neuron/fullt...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Gleichman et al. identify and profile zones of reactive astrocytes after two clinically distinct forms of ischemic stroke, revealing similarities and differences. Astrocytes in cortical, but not white...
www.cell.com
October 11, 2025 at 4:30 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
www.nature.com
October 7, 2025 at 3:51 PM
mariangelesmoro.bsky.social
www.science.org/doi/10.1126/...
Intercellular communication in the brain through a dendritic nanotubular network
Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...
www.science.org
October 2, 2025 at 9:01 PM
mariangelesmoro.bsky.social
www.cell.com/cell/fulltex...
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
Meningeal mast cells, via the receptor Mrgprb2/X2, orchestrate brain inflammation after stroke by recruiting and promoting the transfer of skull bone marrow neutrophils into the brain, highlighting th...
www.cell.com
October 2, 2025 at 6:20 PM
mariangelesmoro.bsky.social
www.cell.com/cell/fulltex...
Mast cells regulate the brain-dura interface and CSF dynamics
Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...
www.cell.com
October 2, 2025 at 6:19 PM
mariangelesmoro.bsky.social
www.ahajournals.org/doi/full/10....
Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis | Circulation Research
BACKGROUND: Neutrophil extracellular traps (NETs) contribute to atherosclerosis progression and are linked to adverse clinical outcomes such as myocardial infarction and stroke. Although the triggers ...
www.ahajournals.org
October 2, 2025 at 8:43 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions - Nature Reviews Cardiology
In this Roadmap, Aggarwal and colleagues summarize current research and knowledge gaps on the relationship between sleep, circadian rhythms and cardiovascular resilience; highlight potential therapeut...
www.nature.com
September 19, 2025 at 10:07 PM
mariangelesmoro.bsky.social
www.cell.com/cell/fulltex...
Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications
Analysis of the conserved intercellular interactome in human vascular dementia and in a mouse model reveals the Serpine2-Lrp1 and CD39-A3AR signaling axes as potential therapeutic targets.
www.cell.com
September 19, 2025 at 10:37 AM
mariangelesmoro.bsky.social
www.nature.com/articles/s41...
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
www.nature.com
September 18, 2025 at 11:03 AM