Fong Kuan Wong
@brainotopia.bsky.social
Brain development enthusiast 🧠 @ University of Manchester
fongkuanwonglab.com
fongkuanwonglab.com
Pinned
Fong Kuan Wong
@brainotopia.bsky.social
· Feb 19
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
Reposted by Fong Kuan Wong
📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
October 21, 2025 at 12:54 PM
📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
October 10, 2025 at 1:55 PM
We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
tinyurl.com/2jxezabw
Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro
#multiomics
#singlecell
#physiology
It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.
tinyurl.com/4ede4jyb
tinyurl.com/4ede4jyb
September 8, 2025 at 6:58 AM
It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.
tinyurl.com/4ede4jyb
tinyurl.com/4ede4jyb
Reposted by Fong Kuan Wong
✨ Are you a pre-tenure faculty or advanced postdoc with an academic offer in hand? 🎓 Two weeks left to apply for the SDB New Faculty Boot Camp! 🚀 Deadline: Aug 22, 2025 Apply here 👉 tinyurl.com/SDBFaculty
August 13, 2025 at 1:09 PM
✨ Are you a pre-tenure faculty or advanced postdoc with an academic offer in hand? 🎓 Two weeks left to apply for the SDB New Faculty Boot Camp! 🚀 Deadline: Aug 22, 2025 Apply here 👉 tinyurl.com/SDBFaculty
Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.
@martijnselten.bsky.social @clembrnrd.bsky.social
@martijnselten.bsky.social @clembrnrd.bsky.social
July 16, 2025 at 8:29 AM
Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.
@martijnselten.bsky.social @clembrnrd.bsky.social
@martijnselten.bsky.social @clembrnrd.bsky.social
Reposted by Fong Kuan Wong
The paper is out in journal format at EJN! We thank the reviewers for their insightful comments, and how they shaped the final form of this story. Check it out here: onlinelibrary.wiley.com/doi/10.1111/...
As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪
As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪
July 14, 2025 at 9:55 AM
The paper is out in journal format at EJN! We thank the reviewers for their insightful comments, and how they shaped the final form of this story. Check it out here: onlinelibrary.wiley.com/doi/10.1111/...
As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪
As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪
Reposted by Fong Kuan Wong
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 12:04 PM
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Reposted by Fong Kuan Wong
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
July 3, 2025 at 10:20 AM
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
Reposted by Fong Kuan Wong
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1
doi.org
June 12, 2025 at 11:20 AM
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Reposted by Fong Kuan Wong
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com
May 21, 2025 at 4:57 PM
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com/v2/url?u=htt...
Reposted by Fong Kuan Wong
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
May 21, 2025 at 4:50 PM
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
Reposted by Fong Kuan Wong
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by Fong Kuan Wong
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
April 30, 2025 at 3:41 PM
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
Reposted by Fong Kuan Wong
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
April 28, 2025 at 7:42 AM
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
Reposted by Fong Kuan Wong
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
April 25, 2025 at 7:29 AM
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
Reposted by Fong Kuan Wong
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
April 17, 2025 at 3:45 PM
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
Reposted by Fong Kuan Wong
⏳🧠 Developmental timing is key during neocortex development. Our new review with @takashi-namba.bsky.social lab discusses the role of epigenetic and metabolic regulation of developmental timing in neocortex evolution.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Epigenetic and metabolic regulation of developmental timing in neocortex evolution
The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallma…
www.sciencedirect.com
March 28, 2025 at 11:12 AM
⏳🧠 Developmental timing is key during neocortex development. Our new review with @takashi-namba.bsky.social lab discusses the role of epigenetic and metabolic regulation of developmental timing in neocortex evolution.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Fong Kuan Wong
Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈
In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience
This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...
www.nature.com
March 25, 2025 at 6:59 PM
Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈
In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
Reposted by Fong Kuan Wong
I absolutely love this beginners guide to scientific conferences by @jens-cells.bsky.social. It's not only useful for beginners either- there is lots of great advice even for those of us who have been attending conferences since the last millenium.
thenode.biologists.com/the-beginner...
thenode.biologists.com/the-beginner...
the-beginners-guide-to-scientific-conferences
The Beginners Guide to Scientific Conferences
thenode.biologists.com
March 17, 2025 at 5:03 PM
I absolutely love this beginners guide to scientific conferences by @jens-cells.bsky.social. It's not only useful for beginners either- there is lots of great advice even for those of us who have been attending conferences since the last millenium.
thenode.biologists.com/the-beginner...
thenode.biologists.com/the-beginner...
We are showcasing our love for developmental biology for British Science Week this year with the different model organisms that we use in our division. 🪰🐸🐟🐣🐭🧠🔬🧬🧫
March 10, 2025 at 12:46 PM
We are showcasing our love for developmental biology for British Science Week this year with the different model organisms that we use in our division. 🪰🐸🐟🐣🐭🧠🔬🧬🧫
Reposted by Fong Kuan Wong
Fun paper celebrations across the developmental biology and @mcf-uom.bsky.social groupings this afternoon. Celebrating our latest paper and papers from the @brainotopia.bsky.social @lovegrovelab.bsky.social, Herbert, Manning, Bennett and Papalopulu labs. Congrats to all!
March 5, 2025 at 5:51 PM
Fun paper celebrations across the developmental biology and @mcf-uom.bsky.social groupings this afternoon. Celebrating our latest paper and papers from the @brainotopia.bsky.social @lovegrovelab.bsky.social, Herbert, Manning, Bennett and Papalopulu labs. Congrats to all!
Reposted by Fong Kuan Wong
Are you an undergraduate student considering a career in academic research?
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
March 4, 2025 at 9:48 AM
Are you an undergraduate student considering a career in academic research?
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Reposted by Fong Kuan Wong
Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.
We Are Recruiting Group Leaders - IBDM | Institut de Biologie du Développement de Marseille
The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in bio...
staging.ibdm.univ-amu.fr
March 4, 2025 at 10:15 AM
Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.
Reposted by Fong Kuan Wong
New work from @antoinedechevigny.bsky.social and colleagues in the team!
Fantastic resource for those interested in gene expression dynamics throughout cortical histogenesis and ligand-receptor interactions between cortical neurons.
#neuroscience #neuroskyence
Fantastic resource for those interested in gene expression dynamics throughout cortical histogenesis and ligand-receptor interactions between cortical neurons.
#neuroscience #neuroskyence
Delighted to showcase our atlas for the inference of ligand-receptor mediated interactions between neuronal subtypes during mouse cortex development. Herculean endeavor by former PhD student Rémi Mathieu (now @alleninstitute.bsky.social) and team, in collaboration with
@LudovicTelley
Thread
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@LudovicTelley
Thread
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February 28, 2025 at 7:54 AM
New work from @antoinedechevigny.bsky.social and colleagues in the team!
Fantastic resource for those interested in gene expression dynamics throughout cortical histogenesis and ligand-receptor interactions between cortical neurons.
#neuroscience #neuroskyence
Fantastic resource for those interested in gene expression dynamics throughout cortical histogenesis and ligand-receptor interactions between cortical neurons.
#neuroscience #neuroskyence