Nicholas Clifton
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nicl2.bsky.social
Nicholas Clifton
@nicl2.bsky.social
Researcher in neuroscience and psychiatric genomics, University of Exeter
Reposted by Nicholas Clifton
"Ever feel the need to switch off? Your vagus nerve might hold the key"

The review says the article is balanced and quotes experts, but evidence for “vagus nerve training” is weak. Benefits could be placebo, and it shouldn’t replace medical advice.
authentisci.com/article/5101...
AuthentiSci review for Ever feel the need to switch off? Your vagus nerve might hold the key
AuthentiSci review for Ever feel the need to switch off? Your vagus nerve might hold the key
authentisci.com
November 12, 2025 at 7:54 PM
Reposted by Nicholas Clifton
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data

www.biorxiv.org/content/10.1...

Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing
Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...
www.biorxiv.org
November 8, 2025 at 9:31 AM
Reposted by Nicholas Clifton
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June 28, 2025 at 10:41 AM
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1
doi.org
June 12, 2025 at 11:20 AM
Reposted by Nicholas Clifton
"Understanding the molecular diversity of synapses" new review by my boss @erin-schuman.bsky.social and former postdoc @marcvoo.bsky.social out now in Nature Reviews Neuroscience:

www.nature.com/articles/s41...
Understanding the molecular diversity of synapses - Nature Reviews Neuroscience
The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...
www.nature.com
December 5, 2024 at 5:58 PM