Psychiatric Genomics Consortium (PGC)
@pgcgenetics.bsky.social
With 1700+ international scientists & 900,000 participants, the PGC is the largest biological investigation in the history of psychiatry 🧬
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
October 29, 2025 at 3:04 PM
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
Reposted by Psychiatric Genomics Consortium (PGC)
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights
Suicidality is heritable and a leading cause of global morbidity and mortality, yet its biological etiology remains largely elusive. We conducted multi-ancestry genome-wide association study meta-anal...
www.medrxiv.org
October 27, 2025 at 4:20 PM
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Reposted by Psychiatric Genomics Consortium (PGC)
Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
September 24, 2025 at 7:34 PM
Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
People with schizophrenia are underrepresented in volunteer-based biobanks. A new UK Biobank study shows that those who do participate tend to have milder symptoms, lower polygenic risk scores, lower rates of copy-number variants, and higher levels of education and employment.
Genetic and Phenotypic Features of Schizophrenia in the UK Biobank
This cross-sectional study compares genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium and compares ...
jamanetwork.com
September 24, 2025 at 12:30 PM
People with schizophrenia are underrepresented in volunteer-based biobanks. A new UK Biobank study shows that those who do participate tend to have milder symptoms, lower polygenic risk scores, lower rates of copy-number variants, and higher levels of education and employment.
A new preprint reports the largest genetic study of schizophrenia in people of African ancestry, identifying 3 genetic signals unique to this group using data from the Million Veteran Program (MVP) and the All of Us Research Program: pubmed.ncbi.nlm.nih.gov/39252912/
Biological Insights from Schizophrenia-associated Loci in Ancestral Populations - PubMed
Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electroni...
pubmed.ncbi.nlm.nih.gov
September 24, 2025 at 12:28 PM
A new preprint reports the largest genetic study of schizophrenia in people of African ancestry, identifying 3 genetic signals unique to this group using data from the Million Veteran Program (MVP) and the All of Us Research Program: pubmed.ncbi.nlm.nih.gov/39252912/
Schizophrenia is often misunderstood and highly complex. Learn about its prevalence and health impact in the WHO Fact Sheet 💡:
www.who.int/news-room/fa...
www.who.int/news-room/fa...
Schizophrenia
Fact sheet on schizophrenia: key facts, symptoms, causes, support, WHO response
www.who.int
September 17, 2025 at 6:03 PM
Schizophrenia is often misunderstood and highly complex. Learn about its prevalence and health impact in the WHO Fact Sheet 💡:
www.who.int/news-room/fa...
www.who.int/news-room/fa...
1/ 🧵 For 10+ years, the Schizophrenia Working Group of the PGC has been dedicated to understanding the genetic risk factors for schizophrenia.
September 17, 2025 at 6:02 PM
1/ 🧵 For 10+ years, the Schizophrenia Working Group of the PGC has been dedicated to understanding the genetic risk factors for schizophrenia.
Hi from the PGC Schizophrenia working group! During the next 2 weeks, we will be posting about schizophrenia genetics and related topics. Stay tuned!
September 16, 2025 at 4:20 PM
Hi from the PGC Schizophrenia working group! During the next 2 weeks, we will be posting about schizophrenia genetics and related topics. Stay tuned!
Reposted by Psychiatric Genomics Consortium (PGC)
Today is #WorldSuicidePreventionDay.
Worried someone might be struggling with suicidal thoughts?
Your presence can be powerful. A simple check-in could be the lifeline they need. 💙
Learn more about #SuicidePrevention 👉 bit.ly/4phPYKi
Worried someone might be struggling with suicidal thoughts?
Your presence can be powerful. A simple check-in could be the lifeline they need. 💙
Learn more about #SuicidePrevention 👉 bit.ly/4phPYKi
September 10, 2025 at 9:34 AM
Today is #WorldSuicidePreventionDay.
Worried someone might be struggling with suicidal thoughts?
Your presence can be powerful. A simple check-in could be the lifeline they need. 💙
Learn more about #SuicidePrevention 👉 bit.ly/4phPYKi
Worried someone might be struggling with suicidal thoughts?
Your presence can be powerful. A simple check-in could be the lifeline they need. 💙
Learn more about #SuicidePrevention 👉 bit.ly/4phPYKi
Reposted by Psychiatric Genomics Consortium (PGC)
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
June 17, 2025 at 12:46 PM
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Reposted by Psychiatric Genomics Consortium (PGC)
On 10 September, the world comes together for #WorldSuicidePreventionDay under the theme, Changing the Narrative on Suicide. This year, we’re making resources more accessible than ever - translated into more languages, to reach more communities worldwide. bit.ly/469incZ
September 8, 2025 at 7:12 AM
On 10 September, the world comes together for #WorldSuicidePreventionDay under the theme, Changing the Narrative on Suicide. This year, we’re making resources more accessible than ever - translated into more languages, to reach more communities worldwide. bit.ly/469incZ
Brenda Cabrera-Mendoza, postdoctoral associate at Yale Psychiatry, has been awarded a MQ US Fellow grant from MQ Mental Health Research. Her project will integrate genetic and clinical data to improve suicide risk stratification.
September 8, 2025 at 3:42 PM
Brenda Cabrera-Mendoza, postdoctoral associate at Yale Psychiatry, has been awarded a MQ US Fellow grant from MQ Mental Health Research. Her project will integrate genetic and clinical data to improve suicide risk stratification.
Over the next couple of tweets, we will highlight some of the funded research projects in the PGC SUI Workgroup, which are working toward understanding the genetics of suicide. #PGCSUI #suicidegenetics
September 8, 2025 at 3:41 PM
Over the next couple of tweets, we will highlight some of the funded research projects in the PGC SUI Workgroup, which are working toward understanding the genetics of suicide. #PGCSUI #suicidegenetics
This fall members of the PGC Suicide Workgroup will be presenting at the upcoming IASR/AFSP International Summit on Suicide Research and the World Congress of Psychiatric Genetics. We look forward to sharing our latest findings with the scientific community.
#WCPG2025 #IASR2025
#WCPG2025 #IASR2025
September 4, 2025 at 3:20 PM
📢 For the next two weeks, the Suicide Working Group is taking over this space.
September is Suicide Prevention Awareness Month — a time to break stigma, share resources, and highlight research and action that can save lives.
#SuicidePrevention #SuicideAwarenessMonth
September is Suicide Prevention Awareness Month — a time to break stigma, share resources, and highlight research and action that can save lives.
#SuicidePrevention #SuicideAwarenessMonth
September 4, 2025 at 3:17 PM
📢 For the next two weeks, the Suicide Working Group is taking over this space.
September is Suicide Prevention Awareness Month — a time to break stigma, share resources, and highlight research and action that can save lives.
#SuicidePrevention #SuicideAwarenessMonth
September is Suicide Prevention Awareness Month — a time to break stigma, share resources, and highlight research and action that can save lives.
#SuicidePrevention #SuicideAwarenessMonth
Reposted by Psychiatric Genomics Consortium (PGC)
Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...
August 20, 2025 at 5:47 PM
Excited to share that our manuscript describing a multi-ancestry GWAS of nicotine dependence has now been published: doi.org/10.1017/S003...
Reposted by Psychiatric Genomics Consortium (PGC)
"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
July 21, 2025 at 2:20 PM
"A contextual genomic perspective on physical activity and its relationship to health, well being and illness" led by Marco Galimberti at @yaleschoolofmed.bsky.social and US Dept. of Veterans Affairs is now online at Nature Genetics (@natureportfolio.nature.com)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:47 PM
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:41 PM
Attending the @rsaofficial.bsky.social meeting in New Orleans? Be sure to check out some exciting work from members of the PGC-SUD working group:
New preprint alert 📢: First genome-wide significant loci identified for panic attacks and panic disorder
Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n
June 19, 2025 at 3:30 PM
New preprint alert 📢: First genome-wide significant loci identified for panic attacks and panic disorder
(1/9) 📣 OUT NOW! 📣
So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open @jaacapjournals.bsky.social.
doi.org/10.1016/j.ja...
A (long) thread of our main findings ⤵️
So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open @jaacapjournals.bsky.social.
doi.org/10.1016/j.ja...
A (long) thread of our main findings ⤵️
Redirecting
doi.org
June 12, 2025 at 12:44 PM
That’s a wrap for the #MDD & #Anxiety takeover, thanks for joining us! Special thank you to Outreach Committee Liaisons @karmelchoi.bsky.social (MDD) & @abiterkuile.bsky.social (Anxiety) and all post contributors.
June 6, 2025 at 4:36 PM
That’s a wrap for the #MDD & #Anxiety takeover, thanks for joining us! Special thank you to Outreach Committee Liaisons @karmelchoi.bsky.social (MDD) & @abiterkuile.bsky.social (Anxiety) and all post contributors.
(1/2) GWAS studies of anxiety and depression often include cases who have both, making it hard to tease apart genetic influences.
Tesfaye et al. recently showed how unaccounted comorbidity contributes to high genetic overlap in genome-wide studies.
www.medrxiv.org/content/10.1...
Tesfaye et al. recently showed how unaccounted comorbidity contributes to high genetic overlap in genome-wide studies.
www.medrxiv.org/content/10.1...
June 6, 2025 at 4:34 PM
(1/2) GWAS studies of anxiety and depression often include cases who have both, making it hard to tease apart genetic influences.
Tesfaye et al. recently showed how unaccounted comorbidity contributes to high genetic overlap in genome-wide studies.
www.medrxiv.org/content/10.1...
Tesfaye et al. recently showed how unaccounted comorbidity contributes to high genetic overlap in genome-wide studies.
www.medrxiv.org/content/10.1...
AMBER is a collaborative effort to identify the determinants of antidepressant response, by integrating genomic/cellular data, EHRs, and patient perspectives.
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
June 5, 2025 at 7:10 PM
AMBER is a collaborative effort to identify the determinants of antidepressant response, by integrating genomic/cellular data, EHRs, and patient perspectives.
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
(1/n) Can we use antidepressant patterns, captured by prescriptions, to assess whether (and why) treatment was effective?
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
June 5, 2025 at 3:39 PM
(1/n) Can we use antidepressant patterns, captured by prescriptions, to assess whether (and why) treatment was effective?
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.