Psychiatric Genomics Consortium (PGC)
@pgcgenetics.bsky.social
With 1700+ international scientists & 900,000 participants, the PGC is the largest biological investigation in the history of psychiatry 🧬
We are deeply saddened by the passing of Professor Dan Stein, an internationally respected leader in psychiatry and neuroscience, and chair of the Department of Psychiatry and Mental Health at @UCT_news.
December 16, 2025 at 1:57 PM
We are deeply saddened by the passing of Professor Dan Stein, an internationally respected leader in psychiatry and neuroscience, and chair of the Department of Psychiatry and Mental Health at @UCT_news.
❗Join us to discuss: ‘Scientifically accurate and ethically responsible science communication in psychiatric genetics’ on 14th Jan !
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
December 15, 2025 at 11:33 AM
❗Join us to discuss: ‘Scientifically accurate and ethically responsible science communication in psychiatric genetics’ on 14th Jan !
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social
Register: us02web.zoom.us/webinar/regi...
🌟It has been great to learn the full breadth of @pgc_fg #genes #cells #omics #mentalhealth and the bright 🧠👨🎓 behind the work ! The second year has been a wonderful experience and get's us excited for the next 🍾🥂🎉
December 15, 2025 at 11:26 AM
🌟It has been great to learn the full breadth of @pgc_fg #genes #cells #omics #mentalhealth and the bright 🧠👨🎓 behind the work ! The second year has been a wonderful experience and get's us excited for the next 🍾🥂🎉
Looking forward to meeting in-person again at #WCPG2026 in Glasgow, Scotland! 🏴 #functionalgenomics #mentalhealth
December 14, 2025 at 7:57 AM
Looking forward to meeting in-person again at #WCPG2026 in Glasgow, Scotland! 🏴 #functionalgenomics #mentalhealth
👩🔬👨🔬in October, we @fg-pgc.bsky.social had our in-person meeting at #WCPG2025 in Cancun, Mexico ! We loved strategizing about how we can make #functionalgenomics #tools and #datasets in #mentalhealth useful for all, to understand the biology of genetic risk ! 🧬🧠
December 14, 2025 at 7:52 AM
👩🔬👨🔬in October, we @fg-pgc.bsky.social had our in-person meeting at #WCPG2025 in Cancun, Mexico ! We loved strategizing about how we can make #functionalgenomics #tools and #datasets in #mentalhealth useful for all, to understand the biology of genetic risk ! 🧬🧠
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
December 14, 2025 at 7:11 AM
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
🌟... #functionalgenomics @fg-pgc.bsky.social travels from Germany to Toronto, Canada, @utoronto.ca where Dr PAVEL POWLOWSKI recently obtained his PhD👨🎓and studies #genes #endocannabinoids and human cells in a dish #iPSCs in #bipolardisorder. 🧬🧠
December 13, 2025 at 7:41 AM
🌟... #functionalgenomics @fg-pgc.bsky.social travels from Germany to Toronto, Canada, @utoronto.ca where Dr PAVEL POWLOWSKI recently obtained his PhD👨🎓and studies #genes #endocannabinoids and human cells in a dish #iPSCs in #bipolardisorder. 🧬🧠
🧠... our next young #functionalgenomics brain is Dr FATIMA MOHAMEDELMUGADAM from @unibonn.bsky.social in Germany🌟 She is interested in how genetic variants in different populations of the world contribute to #autism and #ADHD in kids👨👩👧👧
December 12, 2025 at 6:55 AM
🧠... our next young #functionalgenomics brain is Dr FATIMA MOHAMEDELMUGADAM from @unibonn.bsky.social in Germany🌟 She is interested in how genetic variants in different populations of the world contribute to #autism and #ADHD in kids👨👩👧👧
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
December 11, 2025 at 10:21 AM
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
December 10, 2025 at 9:38 AM
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
🧵3/3
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December 9, 2025 at 11:45 AM
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
🧵3/3
🧵3/3
@pgc_fg and @PGCgenetics our work is global 🌎🌍🌏 so no surprise that our #brains #earlycareerresearchers #phd_students #postdocs hail from all corners of the world ! So get ready ✨🤓
🧵2/3
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December 9, 2025 at 11:44 AM
@pgc_fg and @PGCgenetics our work is global 🌎🌍🌏 so no surprise that our #brains #earlycareerresearchers #phd_students #postdocs hail from all corners of the world ! So get ready ✨🤓
🧵2/3
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✨Now that we have heard what our project groups have been up to, let's meet some of the brains doing the work !🧠👩🎓⭐️
We'll give the #earlycareerresearchers #ecr #phd #postdoc the stage. They actually do the work that the #prinicpalinvestigator #PI get to talk about ! 😉
🧵1/3
We'll give the #earlycareerresearchers #ecr #phd #postdoc the stage. They actually do the work that the #prinicpalinvestigator #PI get to talk about ! 😉
🧵1/3
December 9, 2025 at 11:43 AM
✨Now that we have heard what our project groups have been up to, let's meet some of the brains doing the work !🧠👩🎓⭐️
We'll give the #earlycareerresearchers #ecr #phd #postdoc the stage. They actually do the work that the #prinicpalinvestigator #PI get to talk about ! 😉
🧵1/3
We'll give the #earlycareerresearchers #ecr #phd #postdoc the stage. They actually do the work that the #prinicpalinvestigator #PI get to talk about ! 😉
🧵1/3
Our last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group!
Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠
🧵1/2
Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠
🧵1/2
December 8, 2025 at 3:24 PM
Our last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group!
Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠
🧵1/2
Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠
🧵1/2
Our fourth group is the ✨Multi-level Quantitative Trait Loci✨group!
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
December 7, 2025 at 3:41 PM
Our fourth group is the ✨Multi-level Quantitative Trait Loci✨group!
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
🧬AKA themQTL group🧬
🔎QTL analysis is a way to understand how genetic sequences🧬affect gene expression...
🧐Think RNA transcripts and proteins!
All these methods to understand genetics🤩
Next up is the awesome✨Methylation-wide association studies✨group!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
December 6, 2025 at 5:11 PM
Next up is the awesome✨Methylation-wide association studies✨group!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
AKA the MWAS group😉
#Epigenetics are changes that happen to DNA expression🧬without actually changing the sequence!
Instead, these changes happen to molecules that are attached to the DNA - how cool 🤯!
The second of our 5 project groups we are thrilled to introduce is the✨Isoforms✨group!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
December 5, 2025 at 3:33 PM
The second of our 5 project groups we are thrilled to introduce is the✨Isoforms✨group!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
Isoforms are different versions of RNA transcripts or proteins🧬
They are a result of splicing✂️during gene expression and are an important part of how one gene can act in different ways!
The @fg-pgc.bsky.social is all about understanding how our genetic findings🔬translate into psychiatric conditions 🧠
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
December 4, 2025 at 4:43 PM
The @fg-pgc.bsky.social is all about understanding how our genetic findings🔬translate into psychiatric conditions 🧠
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
We have 5 project groups, and we are excited to introduce the✨Functional Validation✨group first!
We asked them for a status update and a highlight of the year...
So, who are the the Functional Genomics Working Group?
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
December 3, 2025 at 5:37 PM
So, who are the the Functional Genomics Working Group?
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
🎯Our goal is to understand how genes🧬, cells🦠and molecules💠contribute to psychiatric disorders🧠
We work with other PGC groups and different 'omics data (methylation, cytometry, single cell etc.) to do this🧪
🧵1/3
Before we get started, let’s introduce our two Social Media Reps - @natashaberthold.bsky.social and @evacschulte.bsky.social!
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
December 2, 2025 at 2:35 PM
Before we get started, let’s introduce our two Social Media Reps - @natashaberthold.bsky.social and @evacschulte.bsky.social!
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
We're here for the #functionalgenomics🧬, and #Science #Communication📡is a🔑key part!
💫Check out their profiles💫
✨Welcome to the Functional Genomics Takeover of the PGC main account!✨
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
December 2, 2025 at 2:22 PM
✨Welcome to the Functional Genomics Takeover of the PGC main account!✨
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
For the next 2 weeks @natashaberthold.bsky.social and @evacschulte.bsky.social will be taking you through the achievements and highlights of year 2 in the @fg-pgc.bsky.social.
So sit forward, get excited, and celebrate with us!
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
October 29, 2025 at 3:04 PM
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
Reposted by Psychiatric Genomics Consortium (PGC)
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights
Suicidality is heritable and a leading cause of global morbidity and mortality, yet its biological etiology remains largely elusive. We conducted multi-ancestry genome-wide association study meta-anal...
www.medrxiv.org
October 27, 2025 at 4:20 PM
🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct.
www.medrxiv.org/content/10.1...
Reposted by Psychiatric Genomics Consortium (PGC)
Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
September 24, 2025 at 7:34 PM
Some recent work led by @peterjonghona.bsky.social and myself at @yaleschoolofmed.bsky.social looks at environmental, psychiatric, and genetic predictors of alcohol use disorder.
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
Online today at The American Journal of Psychiatry (@apapsychiatric.bsky.social):
psychiatryonline.org/doi/10.1176/...
People with schizophrenia are underrepresented in volunteer-based biobanks. A new UK Biobank study shows that those who do participate tend to have milder symptoms, lower polygenic risk scores, lower rates of copy-number variants, and higher levels of education and employment.
Genetic and Phenotypic Features of Schizophrenia in the UK Biobank
This cross-sectional study compares genetic liability to psychiatric disorders in individuals with schizophrenia in the UK Biobank with individuals in the Psychiatric Genomics Consortium and compares ...
jamanetwork.com
September 24, 2025 at 12:30 PM
People with schizophrenia are underrepresented in volunteer-based biobanks. A new UK Biobank study shows that those who do participate tend to have milder symptoms, lower polygenic risk scores, lower rates of copy-number variants, and higher levels of education and employment.