Psychiatric Genomics Consortium (PGC)
@pgcgenetics.bsky.social
With 1700+ international scientists & 900,000 participants, the PGC is the largest biological investigation in the history of psychiatry 🧬
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
October 29, 2025 at 3:04 PM
Congratulations to Dr. Wouter Peyrot, recipient of the 2025 Pamela Sklar Award at #WCPG2025! His innovative work continues to advance the field of psychiatric genomics. 🧬👏
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
June 21, 2025 at 4:47 PM
Attending the 2025 @behaviorgenetic.bsky.social Meeting in Atlanta? Be sure to check out some exciting work from members of the PGC-SUD working group:
That’s a wrap for the #MDD & #Anxiety takeover, thanks for joining us! Special thank you to Outreach Committee Liaisons @karmelchoi.bsky.social (MDD) & @abiterkuile.bsky.social (Anxiety) and all post contributors.
June 6, 2025 at 4:36 PM
That’s a wrap for the #MDD & #Anxiety takeover, thanks for joining us! Special thank you to Outreach Committee Liaisons @karmelchoi.bsky.social (MDD) & @abiterkuile.bsky.social (Anxiety) and all post contributors.
(2/2) Genetic correlations between anxiety and depression were reduced (from .90 to .53) when non-shared genetics of depression and anxiety were separately analyzed.
Prevalent comorbidities may contribute to the genetic overlaps observed across conditions.
www.medrxiv.org/content/10.1...
Prevalent comorbidities may contribute to the genetic overlaps observed across conditions.
www.medrxiv.org/content/10.1...
June 6, 2025 at 4:34 PM
(2/2) Genetic correlations between anxiety and depression were reduced (from .90 to .53) when non-shared genetics of depression and anxiety were separately analyzed.
Prevalent comorbidities may contribute to the genetic overlaps observed across conditions.
www.medrxiv.org/content/10.1...
Prevalent comorbidities may contribute to the genetic overlaps observed across conditions.
www.medrxiv.org/content/10.1...
AMBER is a collaborative effort to identify the determinants of antidepressant response, by integrating genomic/cellular data, EHRs, and patient perspectives.
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
June 5, 2025 at 7:10 PM
AMBER is a collaborative effort to identify the determinants of antidepressant response, by integrating genomic/cellular data, EHRs, and patient perspectives.
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
Check out this project and reach out to PI @cathrynlewis.bsky.social to learn more or collaborate!
www.kcl.ac.uk/research/amb...
(1/n) Can we use antidepressant patterns, captured by prescriptions, to assess whether (and why) treatment was effective?
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
June 5, 2025 at 3:39 PM
(1/n) Can we use antidepressant patterns, captured by prescriptions, to assess whether (and why) treatment was effective?
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
Lo et al. studied patients who switched from first-line antidepressants to another antidepressant.
Switching can imply the drug was not effective for depression symptoms.
(1/n) 🔍 Can we predict who will experience antidepressant side effects?
New study led by Danyang Li used machine learning in @gladstudy.bsky.social to predict side effects & discontinuation across SSRIs, SNRIs, and tricyclic antidepressants in over 4,000 participants.
New study led by Danyang Li used machine learning in @gladstudy.bsky.social to predict side effects & discontinuation across SSRIs, SNRIs, and tricyclic antidepressants in over 4,000 participants.
June 5, 2025 at 2:21 PM
(1/n) 🔍 Can we predict who will experience antidepressant side effects?
New study led by Danyang Li used machine learning in @gladstudy.bsky.social to predict side effects & discontinuation across SSRIs, SNRIs, and tricyclic antidepressants in over 4,000 participants.
New study led by Danyang Li used machine learning in @gladstudy.bsky.social to predict side effects & discontinuation across SSRIs, SNRIs, and tricyclic antidepressants in over 4,000 participants.
(2/2) The UK Biobank asked participants if antidepressants had helped them, and 75% responded ‘yes’.
Those who responded positively about antidepressants were more likely to be female, to have higher incomes, and shorter episodes of depression.
Those who responded positively about antidepressants were more likely to be female, to have higher incomes, and shorter episodes of depression.
June 5, 2025 at 2:15 PM
(2/2) The UK Biobank asked participants if antidepressants had helped them, and 75% responded ‘yes’.
Those who responded positively about antidepressants were more likely to be female, to have higher incomes, and shorter episodes of depression.
Those who responded positively about antidepressants were more likely to be female, to have higher incomes, and shorter episodes of depression.
(2/2) Pain et al. analysed the genetics of 5000 participants who took antidepressants as part of clinical trials and research studies.
Response to antidepressants had a genetic component, but the study was too small to identify which specific variants contributed to response or non-response.
Response to antidepressants had a genetic component, but the study was too small to identify which specific variants contributed to response or non-response.
June 5, 2025 at 1:55 PM
(2/2) Pain et al. analysed the genetics of 5000 participants who took antidepressants as part of clinical trials and research studies.
Response to antidepressants had a genetic component, but the study was too small to identify which specific variants contributed to response or non-response.
Response to antidepressants had a genetic component, but the study was too small to identify which specific variants contributed to response or non-response.
(4/4) Integrating #GWAS & #geneexpression data, Woodard et al identified drug mechanisms on targets enriched in anxiety genetic associations & reversed expression of those targets. This includes anxiolytics & novel drugs like sigma receptor and glutamate receptor agonists.
👉 doi.org/10.1016/j.ps...
👉 doi.org/10.1016/j.ps...
June 4, 2025 at 1:03 PM
(4/4) Integrating #GWAS & #geneexpression data, Woodard et al identified drug mechanisms on targets enriched in anxiety genetic associations & reversed expression of those targets. This includes anxiolytics & novel drugs like sigma receptor and glutamate receptor agonists.
👉 doi.org/10.1016/j.ps...
👉 doi.org/10.1016/j.ps...
(1/4) 🔬 How can we use #genetics to discover promising depression or anxiety drug targets?
Check out the drug repurposing approach in these two studies aiming to identify new anxiety & depression treatments to test and validate in further studies.
Check out the drug repurposing approach in these two studies aiming to identify new anxiety & depression treatments to test and validate in further studies.
June 4, 2025 at 1:03 PM
(1/4) 🔬 How can we use #genetics to discover promising depression or anxiety drug targets?
Check out the drug repurposing approach in these two studies aiming to identify new anxiety & depression treatments to test and validate in further studies.
Check out the drug repurposing approach in these two studies aiming to identify new anxiety & depression treatments to test and validate in further studies.
(1/2) Do anxiety and depression share inflammatory roots? In ~55k from the Dutch Lifelines cohort, higher C-reactive protein (CRP) was associated with ⬆️ depressive disorder, ⬇️ positive affect, and ⬆️ negative affect.
June 3, 2025 at 1:08 PM
(1/2) Do anxiety and depression share inflammatory roots? In ~55k from the Dutch Lifelines cohort, higher C-reactive protein (CRP) was associated with ⬆️ depressive disorder, ⬇️ positive affect, and ⬆️ negative affect.
(2/2) In a preprint led by @megsk.bsky.social @thaliaeley.bsky.social in @gladstudy.bsky.social, GWASs of #functionalimpairment, anxiety, and depressive symptoms revealed high genetic correlations, suggesting symptom measures may detect most of the genetics of functional impairment. 🔍 osf.io/4d6ju
June 3, 2025 at 12:53 PM
(2/2) In a preprint led by @megsk.bsky.social @thaliaeley.bsky.social in @gladstudy.bsky.social, GWASs of #functionalimpairment, anxiety, and depressive symptoms revealed high genetic correlations, suggesting symptom measures may detect most of the genetics of functional impairment. 🔍 osf.io/4d6ju
(1/1) 🧬Can genetics of functional impairment be captured by depression & anxiety symptom severity?
Despite its role in diagnosis and importance to patients, functional impairment is often overlooked in research & shows only moderate phenotypic correlations with depression & anxiety symptoms.
Despite its role in diagnosis and importance to patients, functional impairment is often overlooked in research & shows only moderate phenotypic correlations with depression & anxiety symptoms.
June 3, 2025 at 12:53 PM
(1/1) 🧬Can genetics of functional impairment be captured by depression & anxiety symptom severity?
Despite its role in diagnosis and importance to patients, functional impairment is often overlooked in research & shows only moderate phenotypic correlations with depression & anxiety symptoms.
Despite its role in diagnosis and importance to patients, functional impairment is often overlooked in research & shows only moderate phenotypic correlations with depression & anxiety symptoms.
(1/2) How do polygenic risk scores explain solo vs. comorbid diagnoses of depression and anxiety?
Using EHR data from almost 178k people, Coombes and colleagues studied how genetic factors contribute to comorbidity.
Using EHR data from almost 178k people, Coombes and colleagues studied how genetic factors contribute to comorbidity.
June 2, 2025 at 5:37 PM
(1/2) How do polygenic risk scores explain solo vs. comorbid diagnoses of depression and anxiety?
Using EHR data from almost 178k people, Coombes and colleagues studied how genetic factors contribute to comorbidity.
Using EHR data from almost 178k people, Coombes and colleagues studied how genetic factors contribute to comorbidity.
A gradient of genetic risk was found, with patients with comorbid diagnoses of depression and anxiety having greatest genetic risks.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
June 2, 2025 at 5:35 PM
A gradient of genetic risk was found, with patients with comorbid diagnoses of depression and anxiety having greatest genetic risks.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Individuals in the highest 10% of depressive symptom polygenic scores had over 5x higher odds of being prescribed medication for comorbid anxiety-depression vs lowest 10%, showing a dose-response relationship.
doi.org/10.1038/s413...
doi.org/10.1038/s413...
June 2, 2025 at 5:33 PM
Individuals in the highest 10% of depressive symptom polygenic scores had over 5x higher odds of being prescribed medication for comorbid anxiety-depression vs lowest 10%, showing a dose-response relationship.
doi.org/10.1038/s413...
doi.org/10.1038/s413...
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
bsky.app/profile/pgcg...
bsky.app/profile/pgcg...
June 2, 2025 at 5:33 PM
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
bsky.app/profile/pgcg...
bsky.app/profile/pgcg...
(5/5) A gradient of genetic risk was found, with patients with co-morbid diagnoses of depression and anxiety having greatest genetic risks.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
June 2, 2025 at 5:29 PM
(5/5) A gradient of genetic risk was found, with patients with co-morbid diagnoses of depression and anxiety having greatest genetic risks.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
(2/5) Study 1:
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
June 2, 2025 at 5:29 PM
(2/5) Study 1:
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
Tabrizi et al 2025 found both twin heritability (79% vs 41%/50%) & polygenic contributions were greater for comorbid anxiety-depression than for anxiety or depression only, suggesting stronger genetic influences when these conditions co-occur.
