Martijn Selten
@martijnselten.bsky.social
Neuroscientist | Research Associate @ King's College London | Exploring inhibitory interneuron plasticity & neural circuit dynamics in health & disease
📍London, UK | 🔬Marinlab
📍London, UK | 🔬Marinlab
Pinned
Martijn Selten
@martijnselten.bsky.social
· Apr 30
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
Reposted by Martijn Selten
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f
Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience
➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?
Check out what we found!
🧵1/n
Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience
➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?
Check out what we found!
🧵1/n
September 10, 2025 at 3:08 PM
Reposted by Martijn Selten
Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.
@martijnselten.bsky.social @clembrnrd.bsky.social
@martijnselten.bsky.social @clembrnrd.bsky.social
July 16, 2025 at 8:29 AM
Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.
@martijnselten.bsky.social @clembrnrd.bsky.social
@martijnselten.bsky.social @clembrnrd.bsky.social
Reposted by Martijn Selten
New research has established the molecular mechanism that drives interneurons in the cerebral cortex to mature.
The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.
Click to learn more👇
bit.ly/3THw7Gb
The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.
Click to learn more👇
bit.ly/3THw7Gb
"Molecular switch” in the brain may explain why toddlers are uncoordinated
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established the molecular mechanism that drives interneurons in the cerebral cortex to mat...
bit.ly
July 17, 2025 at 8:20 AM
New research has established the molecular mechanism that drives interneurons in the cerebral cortex to mature.
The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.
Click to learn more👇
bit.ly/3THw7Gb
The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.
Click to learn more👇
bit.ly/3THw7Gb
Reposted by Martijn Selten
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 15, 2025 at 3:18 PM
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
Reposted by Martijn Selten
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Distinct dendritic integration strategies control dynamics of inhibition in the neocortex
Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…
www.sciencedirect.com
July 3, 2025 at 10:12 AM
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Martijn Selten
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
July 3, 2025 at 10:20 AM
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
Reposted by Martijn Selten
Fos labels a distinct excitatory neuron ensemble for memory retrieval https://www.biorxiv.org/content/10.1101/2025.06.14.659414v1
June 15, 2025 at 7:15 AM
Fos labels a distinct excitatory neuron ensemble for memory retrieval https://www.biorxiv.org/content/10.1101/2025.06.14.659414v1
Reposted by Martijn Selten
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
www.sciencedirect.com
June 11, 2025 at 11:34 AM
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Reposted by Martijn Selten
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS
Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to
stabilize key features of network activity, but whether these di...
www.pnas.org
May 31, 2025 at 3:19 PM
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Martijn Selten
1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
May 27, 2025 at 7:49 AM
1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social
Reposted by Martijn Selten
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
rdcu.be
May 15, 2025 at 8:26 AM
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex!
New collab with @igenescu.bsky.social.
New collab with @igenescu.bsky.social.
May 14, 2025 at 2:29 PM
Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex!
New collab with @igenescu.bsky.social.
New collab with @igenescu.bsky.social.
Reposted by Martijn Selten
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.
https://go.nature.com/4lWkesG
https://go.nature.com/4lWkesG
Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.
go.nature.com
May 5, 2025 at 9:27 AM
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.
https://go.nature.com/4lWkesG
https://go.nature.com/4lWkesG
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
April 30, 2025 at 3:41 PM
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
Reposted by Martijn Selten
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
April 25, 2025 at 7:29 AM
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
Reposted by Martijn Selten
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
April 17, 2025 at 3:45 PM
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
Paper accepted!!!
Stay tuned for updates very soon!
(Now time for a little celebration)
Stay tuned for updates very soon!
(Now time for a little celebration)
March 26, 2025 at 9:56 AM
Paper accepted!!!
Stay tuned for updates very soon!
(Now time for a little celebration)
Stay tuned for updates very soon!
(Now time for a little celebration)
Reposted by Martijn Selten
Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...
Dynamic regulation of cortical interneuron wiring
Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…
www.sciencedirect.com
February 26, 2025 at 4:22 PM
Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...
Reposted by Martijn Selten
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
February 19, 2025 at 8:47 PM
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...