Centre for Developmental Neurobiology
@devneuro.bsky.social
Mechanisms of brain development. IoPPN, King's College London
Our Neureka! Seminar Series is back 🧠
We’re very pleased to welcome Professor Nicky Clayton from the University of Cambridge, who will be presenting the first seminar of the academic year, hosted by Alexi Mery.
Join us at 1pm today in the Large Meeting Room to hear about her exciting research!
We’re very pleased to welcome Professor Nicky Clayton from the University of Cambridge, who will be presenting the first seminar of the academic year, hosted by Alexi Mery.
Join us at 1pm today in the Large Meeting Room to hear about her exciting research!
October 2, 2025 at 9:26 AM
Our Neureka! Seminar Series is back 🧠
We’re very pleased to welcome Professor Nicky Clayton from the University of Cambridge, who will be presenting the first seminar of the academic year, hosted by Alexi Mery.
Join us at 1pm today in the Large Meeting Room to hear about her exciting research!
We’re very pleased to welcome Professor Nicky Clayton from the University of Cambridge, who will be presenting the first seminar of the academic year, hosted by Alexi Mery.
Join us at 1pm today in the Large Meeting Room to hear about her exciting research!
Huge congratulations to Dr. Leigh Wilson who recently won the award for Innovative and Inclusive Practice at the @vitae-news.bsky.social Impact, Culture and Engagement Awards! 🎉
@devneuroacademy.bsky.social
@devneuro.bsky.social
@kingsioppn.bsky.social
@devneuroacademy.bsky.social
@devneuro.bsky.social
@kingsioppn.bsky.social
September 29, 2025 at 11:02 AM
Huge congratulations to Dr. Leigh Wilson who recently won the award for Innovative and Inclusive Practice at the @vitae-news.bsky.social Impact, Culture and Engagement Awards! 🎉
@devneuroacademy.bsky.social
@devneuro.bsky.social
@kingsioppn.bsky.social
@devneuroacademy.bsky.social
@devneuro.bsky.social
@kingsioppn.bsky.social
We're very pleased to welcome Professor Thomas Reh from the University of Washington, who is visiting the CDN to present an external seminar hosted by Professor Benedikt Berninger.
Join us at 1pm today in the Large Meeting Room to hear all about his exciting research!
Join us at 1pm today in the Large Meeting Room to hear all about his exciting research!
September 3, 2025 at 10:32 AM
We're very pleased to welcome Professor Thomas Reh from the University of Washington, who is visiting the CDN to present an external seminar hosted by Professor Benedikt Berninger.
Join us at 1pm today in the Large Meeting Room to hear all about his exciting research!
Join us at 1pm today in the Large Meeting Room to hear all about his exciting research!
We’re delighted to welcome Prof. Dimphna Meijer from the Delft University of Technology, who will be presenting an external seminar today, hosted by Prof. Robert Hindges.
Join us at 1pm in the Large Meeting Room to hear her talk!
Join us at 1pm in the Large Meeting Room to hear her talk!
July 18, 2025 at 9:18 AM
We’re delighted to welcome Prof. Dimphna Meijer from the Delft University of Technology, who will be presenting an external seminar today, hosted by Prof. Robert Hindges.
Join us at 1pm in the Large Meeting Room to hear her talk!
Join us at 1pm in the Large Meeting Room to hear her talk!
Reposted by Centre for Developmental Neurobiology
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Centre for Developmental Neurobiology
Sneak peek of the exhibition happening today👀🤞
July 11, 2025 at 10:40 AM
Sneak peek of the exhibition happening today👀🤞
Reposted by Centre for Developmental Neurobiology
Happy Friday and Day 4 of DNA CREATE!!!
Today the students will be presenting their projects at the Science Gallery 🖼️🥼
Today the students will be presenting their projects at the Science Gallery 🖼️🥼
July 11, 2025 at 7:09 AM
Happy Friday and Day 4 of DNA CREATE!!!
Today the students will be presenting their projects at the Science Gallery 🖼️🥼
Today the students will be presenting their projects at the Science Gallery 🖼️🥼
Reposted by Centre for Developmental Neurobiology
Day 3 has been busy, busy, busy!!!
Students are focused working on their group projects! Excited for the exhibition tomorrow
Students are focused working on their group projects! Excited for the exhibition tomorrow
July 10, 2025 at 11:30 AM
Day 3 has been busy, busy, busy!!!
Students are focused working on their group projects! Excited for the exhibition tomorrow
Students are focused working on their group projects! Excited for the exhibition tomorrow
Reposted by Centre for Developmental Neurobiology
Day 1 of DNA CREATE is off to a great start!
We started the morning with some introductions, ice breakers and reflection as we created our own self portraits🙌
We started the morning with some introductions, ice breakers and reflection as we created our own self portraits🙌
July 8, 2025 at 12:54 PM
Day 1 of DNA CREATE is off to a great start!
We started the morning with some introductions, ice breakers and reflection as we created our own self portraits🙌
We started the morning with some introductions, ice breakers and reflection as we created our own self portraits🙌
Reposted by Centre for Developmental Neurobiology
Good morning and happy Wednesday from the DNA Create team!
Today’s morning session is all about brains (literally) 🧠
Our students are diving into neuroanatomy and getting a firsthand look at neuroscience research, thanks to our incredible researchers at @devneuro.bsky.social 🤞🤞🤞
Today’s morning session is all about brains (literally) 🧠
Our students are diving into neuroanatomy and getting a firsthand look at neuroscience research, thanks to our incredible researchers at @devneuro.bsky.social 🤞🤞🤞
July 9, 2025 at 7:47 AM
Good morning and happy Wednesday from the DNA Create team!
Today’s morning session is all about brains (literally) 🧠
Our students are diving into neuroanatomy and getting a firsthand look at neuroscience research, thanks to our incredible researchers at @devneuro.bsky.social 🤞🤞🤞
Today’s morning session is all about brains (literally) 🧠
Our students are diving into neuroanatomy and getting a firsthand look at neuroscience research, thanks to our incredible researchers at @devneuro.bsky.social 🤞🤞🤞
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
July 3, 2025 at 10:20 AM
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
We're #hiring! We're looking for an experienced and dynamic Research Strategy Manager to join our vibrant Centre. More details in link. Deadline 09 July
www.kcl.ac.uk/jobs/118025-...
www.kcl.ac.uk/jobs/118025-...
Research Strategy Manager
www.kcl.ac.uk
June 19, 2025 at 10:38 AM
We're #hiring! We're looking for an experienced and dynamic Research Strategy Manager to join our vibrant Centre. More details in link. Deadline 09 July
www.kcl.ac.uk/jobs/118025-...
www.kcl.ac.uk/jobs/118025-...
We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
Senior Executive Assistant
www.kcl.ac.uk
June 4, 2025 at 12:38 PM
We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
rdcu.be
May 15, 2025 at 8:26 AM
New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Reposted by Centre for Developmental Neurobiology
@houartlab.bsky.social first time at the comparative neuro conference. Fantastic #ECCN2025 meeting! The mix of ‘old’ and new technologies brings the field a new edge and the potential for new understanding of brain evolutionary mechanisms. Exciting!
Differences in neurogenesis across species appear since the earliest stages of development, as shows @cohouart.bsky.social
#ECCN2025 @borrell-lab.bsky.social @k4tj4.bsky.social
#ECCN2025 @borrell-lab.bsky.social @k4tj4.bsky.social
May 8, 2025 at 1:43 PM
@houartlab.bsky.social first time at the comparative neuro conference. Fantastic #ECCN2025 meeting! The mix of ‘old’ and new technologies brings the field a new edge and the potential for new understanding of brain evolutionary mechanisms. Exciting!
Reposted by Centre for Developmental Neurobiology
Dkk genes dynamically expressed in the zebrafish nervous system, some in very discreet brain populations (watch this space for brain images).
Malik Missaoui is using genetics to follow behaviour of endogenous proteins and crack their local functions.
@mrc-cndd.bsky.social @kingsioppn.bsky.social
Malik Missaoui is using genetics to follow behaviour of endogenous proteins and crack their local functions.
@mrc-cndd.bsky.social @kingsioppn.bsky.social
🎣 Fishing for Dkk in #zebrafish 🎣
In the lab, PhD student Malik Misssaoui looks for the expression patterns of the dkk genes in zebrafish. Dkk proteins are modulators of wnt singalling, and changes in their expression levels have been linked to neurodegenerative diseases like Alzheimers.
In the lab, PhD student Malik Misssaoui looks for the expression patterns of the dkk genes in zebrafish. Dkk proteins are modulators of wnt singalling, and changes in their expression levels have been linked to neurodegenerative diseases like Alzheimers.
May 8, 2025 at 1:08 PM
Dkk genes dynamically expressed in the zebrafish nervous system, some in very discreet brain populations (watch this space for brain images).
Malik Missaoui is using genetics to follow behaviour of endogenous proteins and crack their local functions.
@mrc-cndd.bsky.social @kingsioppn.bsky.social
Malik Missaoui is using genetics to follow behaviour of endogenous proteins and crack their local functions.
@mrc-cndd.bsky.social @kingsioppn.bsky.social
Reposted by Centre for Developmental Neurobiology
10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu
www.nature.com
April 30, 2025 at 3:12 PM
10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu
Reposted by Centre for Developmental Neurobiology
9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust
April 30, 2025 at 3:12 PM
9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust
Reposted by Centre for Developmental Neurobiology
8/10 Importantly, this mechanism also regulates the connectivity of PV interneurons during learning, for example, in a fear-conditioning paradigm
April 30, 2025 at 3:12 PM
8/10 Importantly, this mechanism also regulates the connectivity of PV interneurons during learning, for example, in a fear-conditioning paradigm
Reposted by Centre for Developmental Neurobiology
7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons
April 30, 2025 at 3:12 PM
7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons
Reposted by Centre for Developmental Neurobiology
6/10 Incidentally, the Greenberg lab described a few years ago that hippocampal pyramidal cells use Scg2 to modulate the inhibition they receive from PV and CCK interneurons. You can find their paper here www.nature.com/articles/s41...
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network - Nature
Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the role...
www.nature.com
April 30, 2025 at 3:12 PM
6/10 Incidentally, the Greenberg lab described a few years ago that hippocampal pyramidal cells use Scg2 to modulate the inhibition they receive from PV and CCK interneurons. You can find their paper here www.nature.com/articles/s41...
Reposted by Centre for Developmental Neurobiology
5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity
April 30, 2025 at 3:12 PM
5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity
Reposted by Centre for Developmental Neurobiology
4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity
April 30, 2025 at 3:12 PM
4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity
Reposted by Centre for Developmental Neurobiology
3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability
April 30, 2025 at 3:12 PM
3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability
Reposted by Centre for Developmental Neurobiology
2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons
April 30, 2025 at 3:12 PM
2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons