Doug Dyer
@douglaspdyer.bsky.social
Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
Pinned
Doug Dyer
@douglaspdyer.bsky.social
· Nov 20
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
www.immunology.org
January 6, 2026 at 3:02 PM
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Reposted by Doug Dyer
Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade
December 18, 2025 at 9:48 AM
Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade
Reposted by Doug Dyer
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
www.nature.com
December 16, 2025 at 3:01 PM
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
Reposted by Doug Dyer
🏆 Huge congratulations to our Director Professor Tracy Hussell @tracyh9494.bsky.social who has been awarded the Nature 2025 Lifetime Achievement Award for Mentoring in Science for her exceptional support of emerging scientists.
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
Professor Tracy Hussell Receives Nature Lifetime Achievement Award for Mentoring in Science
Professor Tracy Hussell receives the 2025 Nature Lifetime Achievement Award for Mentoring in Science, recognising her outstanding support of early-career researchers.
sites.manchester.ac.uk
December 10, 2025 at 1:38 PM
🏆 Huge congratulations to our Director Professor Tracy Hussell @tracyh9494.bsky.social who has been awarded the Nature 2025 Lifetime Achievement Award for Mentoring in Science for her exceptional support of emerging scientists.
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
Reposted by Doug Dyer
Beautiful talk by Matt Hepworth, so many exciting things happening at barrier surfaces. @hepworth-lab.bsky.social #BSI2025 @britsocimm.bsky.social @lydiabeckeriii.bsky.social
December 4, 2025 at 3:18 PM
Beautiful talk by Matt Hepworth, so many exciting things happening at barrier surfaces. @hepworth-lab.bsky.social #BSI2025 @britsocimm.bsky.social @lydiabeckeriii.bsky.social
Reposted by Doug Dyer
Really looking forward to speaking about my PhD work at this webinar with @merrylabnotts.bsky.social @themeshwork.bsky.social ! 🦠🎄
🔬 Glycobiology geeks — this one’s for you!
“Beyond Proteins: Exploring the Hidden World of Glycans” With @merrylabnotts.bsky.social + @megtriesscience.bsky.social 📅 December 9 ⏲️ 2pm (GMT), 3pm (CET), 9am (EST)
Don't miss out!! @amsocmatbio.bsky.social
“Beyond Proteins: Exploring the Hidden World of Glycans” With @merrylabnotts.bsky.social + @megtriesscience.bsky.social 📅 December 9 ⏲️ 2pm (GMT), 3pm (CET), 9am (EST)
Don't miss out!! @amsocmatbio.bsky.social
November 27, 2025 at 2:38 PM
Really looking forward to speaking about my PhD work at this webinar with @merrylabnotts.bsky.social @themeshwork.bsky.social ! 🦠🎄
Reposted by Doug Dyer
Thanks for sharing @mucosalimmunol.bsky.social. This work was led by @lizihegarty.bsky.social during her PhD @edinuni-irr.bsky.social funded by @wellcometrust.bsky.social. Now being continued after our relocation to @uofgsii.bsky.social.
Might be of interest to @emds2025.bsky.social attendees!
Might be of interest to @emds2025.bsky.social attendees!
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair in this work from @lizihegarty.bsky.social, @bainlab.bsky.social, and colleagues: www.mucosalimmunology.org/article/S193...
November 27, 2025 at 8:52 AM
Thanks for sharing @mucosalimmunol.bsky.social. This work was led by @lizihegarty.bsky.social during her PhD @edinuni-irr.bsky.social funded by @wellcometrust.bsky.social. Now being continued after our relocation to @uofgsii.bsky.social.
Might be of interest to @emds2025.bsky.social attendees!
Might be of interest to @emds2025.bsky.social attendees!
Reposted by Doug Dyer
🧬 A new study by Dr Alex Eckersley and @tracyh9494.bsky.social uncovers why severe viral infections can cause long-term breathlessness & fatigue.
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Study unravels puzzle of how viruses can cause long-term lung damage
Researchers at The University of Manchester reveal how severe viral infections like flu and long COVID cause long-term lung damage by disrupting basement membranes, offering new targets for future the...
tinyurl.com
November 26, 2025 at 6:41 PM
🧬 A new study by Dr Alex Eckersley and @tracyh9494.bsky.social uncovers why severe viral infections can cause long-term breathlessness & fatigue.
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Reposted by Doug Dyer
🔬 New research led by @douglaspdyer.bsky.social shows that CCR2-mediated monocyte recruitment is essential for limiting radiotherapy-induced intestinal toxicity - pointing to new strategies for reducing off-target tissue damage. @cruk-mi.bsky.social #ImmunoSky #Cancer #RadNet
tinyurl.com/34uu4nr9
tinyurl.com/34uu4nr9
Key Immune Cells Found to Protect the Gut During Radiotherapy
New research reveals how CCR2-driven monocyte recruitment protects the gut from radiotherapy damage, offering potential pathways to reduce treatment side effects.
tinyurl.com
November 26, 2025 at 7:43 PM
🔬 New research led by @douglaspdyer.bsky.social shows that CCR2-mediated monocyte recruitment is essential for limiting radiotherapy-induced intestinal toxicity - pointing to new strategies for reducing off-target tissue damage. @cruk-mi.bsky.social #ImmunoSky #Cancer #RadNet
tinyurl.com/34uu4nr9
tinyurl.com/34uu4nr9
Reposted by Doug Dyer
Reposted by Doug Dyer
Last stretch for these positions, as the deadline for this is on Sunday!
employment.ku.dk/faculty/?sho...
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 25, 2025 at 4:02 AM
Last stretch for these positions, as the deadline for this is on Sunday!
Reposted by Doug Dyer
Hello #glycotime! GlycoShape makes its debut on bsky today 🦋🎉 Follow us for news, updates and fun-facts (I take full responsibility for those, Ojas @ojas-singh.bsky.social 😆) below ⬇️
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 24, 2025 at 4:53 PM
Hello #glycotime! GlycoShape makes its debut on bsky today 🦋🎉 Follow us for news, updates and fun-facts (I take full responsibility for those, Ojas @ojas-singh.bsky.social 😆) below ⬇️
Reposted by Doug Dyer
Love a story where the environment wins the argument every single time
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
November 22, 2025 at 7:03 PM
Love a story where the environment wins the argument every single time
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
Reposted by Doug Dyer
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
November 20, 2025 at 8:13 PM
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
November 20, 2025 at 8:13 PM
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair
Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…
www.sciencedirect.com
November 19, 2025 at 5:09 PM
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Doug Dyer
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
July 1, 2025 at 4:46 AM
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Reposted by Doug Dyer
Less than 3 weeks until our final report launch event
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
November 19, 2025 at 8:52 AM
Less than 3 weeks until our final report launch event
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
Reposted by Doug Dyer
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
November 17, 2025 at 8:35 AM
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
Reposted by Doug Dyer
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by Doug Dyer
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
employment.ku.dk/faculty/?sho...
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 11, 2025 at 8:38 AM
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
Reposted by Doug Dyer
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
November 10, 2025 at 7:45 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
Reposted by Doug Dyer
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...
November 10, 2025 at 1:52 PM
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...