GlycoShape
@glycoshape.org
Glycan 3D database and toolbox for the reconstruction of glycoproteins from the RCSB PDB and EMBL-EBI AlphaFold repositories or own. Find us at https://glycoshape.org. Curated by head chef @elisafadda.bsky.social and sous chef @ojas-singh.bsky.social
Tuesday #glycotime 🥄🍬
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
December 2, 2025 at 5:36 PM
Tuesday #glycotime 🥄🍬
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Today we are attending the @biochemsoc.bsky.social International Glycoimmunology Online Symposium, enjoying brilliant talks and discussions around the key role of glycans in regulating our immune system in health and disease Phenomenal #glycotime 👏👏🤩
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December 1, 2025 at 5:32 PM
Today we are attending the @biochemsoc.bsky.social International Glycoimmunology Online Symposium, enjoying brilliant talks and discussions around the key role of glycans in regulating our immune system in health and disease Phenomenal #glycotime 👏👏🤩
It's Fucose Friday 🔺, the best #glycotime of the week!
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 28, 2025 at 7:07 PM
It's Fucose Friday 🔺, the best #glycotime of the week!
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on
November 27, 2025 at 6:14 PM
To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on
Today we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746]
Super fun 3D edu #glycotime!
Super fun 3D edu #glycotime!
![title slide of the workshop held today for the Advance Pharmacology module at the University of Southampton (E. Fadda lecturer and coordinator) right-hand side in the bubble, human EPO (grey) with glycosylation reconstructed according to [10.1021/acs.analchem.0c01794] bound to the EPO receptor (cyan) in PDB 1CN4. Slide background is blue](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:xorrvcukxonsyeoudfzmnmhz/bafkreiactex7lfbmup6a3e7ezk4rao6zq4zvnbpprgkvuk4buvghhbqy6a@jpeg)
November 26, 2025 at 3:28 PM
Today we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746]
Super fun 3D edu #glycotime!
Super fun 3D edu #glycotime!
To welcome our new friends, first spoonful of sugar 🥄🍬
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
November 25, 2025 at 9:02 AM
To welcome our new friends, first spoonful of sugar 🥄🍬
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
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November 24, 2025 at 4:50 PM
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime