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pallettlab.bsky.social
Pallett Lab UCL
@pallettlab.bsky.social
3.4K followers 940 following 120 posts
Research group within the Institute of Immunity & Transplantation, UCL. Interested in liver #immunology, immunometabolism, adaptations of tissue resident T cells, stromal cells & fibrosis | UKRI FLF 👩‍🔬🧪

#liversky #immunosky
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pallettlab.bsky.social
Pallett Lab UCL @pallettlab.bsky.social · Sep 22
SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Reposted by Pallett Lab UCL
cp-cell.bsky.social
Now online! Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
Human pancreatic cancer cells sense specific components of the ECM to fine-tune their autophagy flux levels, conferring the ability to coordinate proliferation, survival, and responsiveness to chemotherapy. Targeting ECM sensing may turn this ability into a therapeutic opportunity.
dlvr.it
February 16, 2026 at 3:59 PM
Reposted by Pallett Lab UCL
joris-vd-haar.bsky.social
Postdoc alert in spatial biology!

Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology.

Learn more / apply here: www.nki.nl/careers-stud...
Computational Postdoc | Netherlands Cancer Institute
Computational Postdoc Voest Lab (fully funded) — Spatial Decoding of Unconventional Antitumor Immunity in Colorectal Cancer
www.nki.nl
February 15, 2026 at 6:59 PM
Reposted by Pallett Lab UCL
astroroyalscot.bsky.social
Thanks to @iansample.bsky.social at the Guardian for covering the devastating funding cuts that are being proposed for UK (astro)physics, and the dire impact these would have on young researchers. Will UKRI/STFC reconsider? Will the UKGov step in?🤞👩‍🔬🧪⚛️🔭

www.theguardian.com/science/2026...
February 7, 2026 at 8:08 AM
Reposted by Pallett Lab UCL
lucienheurtier.bsky.social
On the difficult situation of young UK researchers 🧪🔭

Thanks @fionamcintyre.bsky.social and @isaacbarbosa1.bsky.social for the interview & excellent article.

#stfc #ukri #saveSTFC @ukri.org

UKRI funding changes ‘pushing junior researchers abroad’ www.researchprofessionalnews.com/rr-news-uk-r...
UKRI funding changes ‘pushing junior researchers abroad’ - Research Professional News
Disruptions to core funding streams raise fears for a “generation” of early career researchers
www.researchprofessionalnews.com
February 11, 2026 at 9:09 AM
Reposted by Pallett Lab UCL
science.org
No matter where they live, kids cooperate according to their community’s social norms by middle childhood.

Learn more in #ScienceAdvances: https://scim.ag/4r0Rxga
The emergence of cooperative behaviors, norms, and strategies across five diverse societies
Children’s cooperative behaviors and norms develop along distinct cultural pathways shaped by local norms.
scim.ag
February 6, 2026 at 7:45 PM
Reposted by Pallett Lab UCL
davidfinlaytcd.bsky.social
****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...
Single Cell Glucose Uptake Assays: A Cautionary Tale
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...
pmc.ncbi.nlm.nih.gov
January 30, 2026 at 1:57 AM
Reposted by Pallett Lab UCL
cp-immunity.bsky.social
Online now: B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells
B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentiation of CD25+ age-associated B cells toward a regulatory, IL-10-producing phenotype that is protective in neuroinflammation.
dlvr.it
January 31, 2026 at 1:53 PM
Reposted by Pallett Lab UCL
jennyrohn.bsky.social
Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky

journals.plos.org/plosbiology/...
Biomedical and life science articles by female researchers spend longer under review
Women are underrepresented in academia, especially in STEMM fields, at top institutions, and in senior positions. This study analyzes millions of biomedical and life science articles, revealing that f...
journals.plos.org
January 21, 2026 at 2:38 PM
Reposted by Pallett Lab UCL
vikilovesfacs.bsky.social
Vaccination against whooping cough, RSV and flu during pregnancy saves babies lives, but expectant parents are sometimes unsure.

How do I know it's safe? Will it protect my baby?

To answer these questions, we've created www.vaccinesinpregnancy.org

#ObGynSky #MedSky #ImmunoSky

1/
Vaccines in Pregnancy, UK | Learn More About Vaccination Today
Comprehensive guide to vaccines during pregnancy in the UK, including timing and locations for vaccination. Essential information for expectant parents and healthcare providers.
www.vaccinesinpregnancy.org
January 16, 2026 at 10:02 AM
pallettlab.bsky.social
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"

Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science

📆16-17th April

www.immunology.org/events/fuell...
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
www.immunology.org
January 6, 2026 at 3:02 PM
Reposted by Pallett Lab UCL
labwaggoner.bsky.social
Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection @katekazane.bsky.social @ucsdmedschool.bsky.social
www.pnas.org/doi/10.1073/...
January 3, 2026 at 9:07 PM
Reposted by Pallett Lab UCL
cyrilpedia.bsky.social
'The presence of CD8+ T cells coexpressing residency and exhaustion molecules in chronic diseases often correlate with clinical outcomes; however, the relationship between these cells and conventional tissue-resident memory (TRM) cells or exhausted CD8+ T (TEX) cells is unclear.'
#Immunology
Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease - Nature Immunology
Here the authors show that persistent antigen stimulation drives the generation of CD8+ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness w...
www.nature.com
December 30, 2025 at 11:49 PM
Reposted by Pallett Lab UCL
reisesousalab.bsky.social
Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff!

www.cell.com/cell/fulltex...
The effect of shingles vaccination at different stages of the dementia disease course
A natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...
www.cell.com
December 12, 2025 at 11:12 AM
pallettlab.bsky.social
Get to turn up to work to see these faces every day #ExtendedMainiFamily
December 10, 2025 at 10:33 PM
Reposted by Pallett Lab UCL
cp-immunity.bsky.social
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore, they validate a bystander activation gene set induced by IL-15 and decreased upon TCR stimulation.
dlvr.it
December 10, 2025 at 8:56 PM
Reposted by Pallett Lab UCL
labwaggoner.bsky.social
@cp-immunity.bsky.social preview @pgtimmune.bsky.social : Importance of CD8+ Trm cell-derived interferon-γ in epithelial reprogramming for barrier defense in humans
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
December 9, 2025 at 5:58 PM
Reposted by Pallett Lab UCL
labwaggoner.bsky.social
Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes @cp-iscience.bsky.social
www.cell.com/iscience/ful...
December 9, 2025 at 4:10 PM
pallettlab.bsky.social
Great to see our recent hepatic TRM review as the inspiration behind the @natrevgastrohep.nature.com December issue cover!

#ScienceWin ❤️
natrevgastrohep.nature.com Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · Nov 25
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!

www.nature.com/nrgastro/vol...
COVER: ‘Jekyll and Hyde’ roles of memory T cells in the liver, inspired by the Review on p814.
December 7, 2025 at 9:19 PM
Reposted by Pallett Lab UCL
emmaschambers.bsky.social
Interested in developing an asthma organ-on-a-chip model? Then your luck is in! As I have a funded PhD as part of the COaCT PhD programme www.cpm.qmul.ac.uk/cdt/projects...
PhD Projects 2026: QMUL Centre for Predictive in vitro Models
The Centre for Predictive in vitro Models (CPM) represents multidisciplinary research focusing on the development and use of predictive in vitro models at Queen Mary University of London. This incorpo...
www.cpm.qmul.ac.uk
December 6, 2025 at 8:54 PM
Reposted by Pallett Lab UCL
bcellsrosser.bsky.social
Yes I’m reposting myself! Vote!!!
December 3, 2025 at 6:19 PM
Reposted by Pallett Lab UCL
carersinstemm.bsky.social
Less than 3 weeks until our final report launch event
9th Dec. (London) 10am

We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)

Register here: www.carersinstemm.co.uk
November 19, 2025 at 8:52 AM
Reposted by Pallett Lab UCL
whelanfj.bsky.social
Very insightful launch of @carersinstemm.bsky.social today at @manchester.ac.uk! Understanding the barriers associated with caring responsibilities is something I'm really passionate about and its amazing to see Carers in STEMM quantifying and advocating for carers in academia.
carersinstemm.bsky.social Carers In STEMM @carersinstemm.bsky.social · Nov 7
To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us

Manchester: 13th November
London: 9th December
(Both hybrid)

Spread the word!
November 13, 2025 at 11:36 AM
Reposted by Pallett Lab UCL
carersinstemm.bsky.social
To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us

Manchester: 13th November
London: 9th December
(Both hybrid)

Spread the word!
November 7, 2025 at 3:38 PM
Reposted by Pallett Lab UCL
labwaggoner.bsky.social
IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...
November 2, 2025 at 10:48 PM
Reposted by Pallett Lab UCL
labwaggoner.bsky.social
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
October 31, 2025 at 8:47 PM