Pallett Lab UCL
@pallettlab.bsky.social
Research group within the Institute of Immunity & Transplantation, UCL. Interested in liver #immunology, immunometabolism, adaptations of tissue resident T cells, stromal cells & fibrosis | UKRI FLF 👩🔬🧪
#liversky #immunosky
#liversky #immunosky
Pinned
Pallett Lab UCL
@pallettlab.bsky.social
· Sep 22
New online! Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.
www.nature.com
SOOOOO excited to see this online IN REAL-LIFE!!
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Reposted by Pallett Lab UCL
Very insightful launch of @carersinstemm.bsky.social today at @manchester.ac.uk! Understanding the barriers associated with caring responsibilities is something I'm really passionate about and its amazing to see Carers in STEMM quantifying and advocating for carers in academia.
To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
November 13, 2025 at 11:36 AM
Very insightful launch of @carersinstemm.bsky.social today at @manchester.ac.uk! Understanding the barriers associated with caring responsibilities is something I'm really passionate about and its amazing to see Carers in STEMM quantifying and advocating for carers in academia.
Reposted by Pallett Lab UCL
To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
November 7, 2025 at 3:38 PM
To hear more about the Carers in STEMM survey - the hidden barrier to parents and carers - there is still time to join us
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
Manchester: 13th November
London: 9th December
(Both hybrid)
Spread the word!
Reposted by Pallett Lab UCL
IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
November 2, 2025 at 10:48 PM
IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Pallett Lab UCL
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 31, 2025 at 8:47 PM
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Pallett Lab UCL
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
October 30, 2025 at 11:47 AM
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
Reposted by Pallett Lab UCL
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Interested in melanoma research from lab to life?
Register to join a leading melanoma conference focusing on translational research & treatment advances in Manchester
When: 12-13 March 2026
sites.manchester.ac.uk/from-lab-to-...
Share widely 🧪
Register to join a leading melanoma conference focusing on translational research & treatment advances in Manchester
When: 12-13 March 2026
sites.manchester.ac.uk/from-lab-to-...
Share widely 🧪
Home
Lab to Life: Innovations in Melanoma is a UK conference in Manchester on cutting-edge melanoma research, translational science and advances in treatments.
sites.manchester.ac.uk
October 27, 2025 at 2:40 PM
Interested in melanoma research from lab to life?
Register to join a leading melanoma conference focusing on translational research & treatment advances in Manchester
When: 12-13 March 2026
sites.manchester.ac.uk/from-lab-to-...
Share widely 🧪
Register to join a leading melanoma conference focusing on translational research & treatment advances in Manchester
When: 12-13 March 2026
sites.manchester.ac.uk/from-lab-to-...
Share widely 🧪
Reposted by Pallett Lab UCL
Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
www.science.org/content/arti... @science.org
@biorxivpreprint.bsky.social @karalmckinley.bsky.social
www.biorxiv.org/content/10.1...
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
www.science.org/content/arti... @science.org
@biorxivpreprint.bsky.social @karalmckinley.bsky.social
www.biorxiv.org/content/10.1...
October 23, 2025 at 6:43 PM
Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
www.science.org/content/arti... @science.org
@biorxivpreprint.bsky.social @karalmckinley.bsky.social
www.biorxiv.org/content/10.1...
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
www.science.org/content/arti... @science.org
@biorxivpreprint.bsky.social @karalmckinley.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Pallett Lab UCL
Reposted by Pallett Lab UCL
UKRI #FLF community please help us and spread the word about our @carersinstemm.bsky.social upcoming report launch events.
➡️ First stop The University of Edinburgh on 22nd October
Register here: forms.office.com/pages/respon...
#UKRIFLF #FutureLeadersFellows
➡️ First stop The University of Edinburgh on 22nd October
Register here: forms.office.com/pages/respon...
#UKRIFLF #FutureLeadersFellows
October 6, 2025 at 3:00 PM
UKRI #FLF community please help us and spread the word about our @carersinstemm.bsky.social upcoming report launch events.
➡️ First stop The University of Edinburgh on 22nd October
Register here: forms.office.com/pages/respon...
#UKRIFLF #FutureLeadersFellows
➡️ First stop The University of Edinburgh on 22nd October
Register here: forms.office.com/pages/respon...
#UKRIFLF #FutureLeadersFellows
Reposted by Pallett Lab UCL
Oh hello there!!! The printed copies of our report have arrived - and I am the chosen Laura to lug them across the country!
So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!
forms.office.com/Pages/Respon...
So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!
forms.office.com/Pages/Respon...
October 7, 2025 at 10:56 AM
Oh hello there!!! The printed copies of our report have arrived - and I am the chosen Laura to lug them across the country!
So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!
forms.office.com/Pages/Respon...
So, come and join us in Edinburgh on the 22nd of October for our first @carersinstemm.bsky.social report launch and get your own copy!
forms.office.com/Pages/Respon...
Reposted by Pallett Lab UCL
Conventional wisdom says motherhood should wait for tenure as before you land a permanent post, #academia is just not that family friendly🙁
@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩🔬🧪🔭⚛️
ℹ️: carersinstemm.co.uk
@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩🔬🧪🔭⚛️
ℹ️: carersinstemm.co.uk
October 4, 2025 at 7:24 AM
Conventional wisdom says motherhood should wait for tenure as before you land a permanent post, #academia is just not that family friendly🙁
@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩🔬🧪🔭⚛️
ℹ️: carersinstemm.co.uk
@carersinstemm.bsky.social are calling for change and to celebrate their new report, a Saturday🧵on parenting & academia! 1/9 👩🔬🧪🔭⚛️
ℹ️: carersinstemm.co.uk
Reposted by Pallett Lab UCL
We are pleased to announce the publication of our STEMM sector-wide survey
The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk
Please share especially w/ institutions, funders & allies
@laurawolz.bsky.social @carterlj.bsky.social
The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk
Please share especially w/ institutions, funders & allies
@laurawolz.bsky.social @carterlj.bsky.social
September 26, 2025 at 2:08 PM
We are pleased to announce the publication of our STEMM sector-wide survey
The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk
Please share especially w/ institutions, funders & allies
@laurawolz.bsky.social @carterlj.bsky.social
The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk
Please share especially w/ institutions, funders & allies
@laurawolz.bsky.social @carterlj.bsky.social
Reposted by Pallett Lab UCL
Do we have any contacts at a Northern Ireland university? 🙏🧪
September 26, 2025 at 1:56 PM
Do we have any contacts at a Northern Ireland university? 🙏🧪
Reposted by Pallett Lab UCL
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry
High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...
currentprotocols.onlinelibrary.wiley.com
September 25, 2025 at 5:06 PM
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Pallett Lab UCL
🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
New online! Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.
www.nature.com
September 22, 2025 at 4:11 PM
🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!
Reposted by Pallett Lab UCL
Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
September 22, 2025 at 4:52 PM
Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...
SOOOOO excited to see this online IN REAL-LIFE!!
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
New online! Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.
www.nature.com
September 22, 2025 at 12:35 PM
SOOOOO excited to see this online IN REAL-LIFE!!
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪
Reposted by Pallett Lab UCL
🚨We're going on tour!🚨
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!
We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.
Spread the word!📣
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!
We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.
Spread the word!📣
September 21, 2025 at 10:28 AM
🚨We're going on tour!🚨
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!
We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.
Spread the word!📣
Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home!
We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers.
Spread the word!📣
Reposted by Pallett Lab UCL
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Pallett Lab UCL
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Lecturer in Neuroimmunology, Medicine, Medical Sciences & Nutrition (MED243A) | The University of Aberdeen
Browse and apply for current job openings at the University of Aberdeen across various schools, departments and roles, including admin and academic.
www.abdn.ac.uk
September 19, 2025 at 7:55 AM
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Reposted by Pallett Lab UCL
MASH: the nexus of metabolism, inflammation and fibrosis
This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn
This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn
September 18, 2025 at 3:33 PM
MASH: the nexus of metabolism, inflammation and fibrosis
This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn
This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn
Reposted by Pallett Lab UCL
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
www.nature.com
September 17, 2025 at 4:18 PM
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pallett Lab UCL
Now online! Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
A pro-fibrotic, mechanosensitive CTHRC1+ fibroblast population derived from creeping fat drives intestinal fibrosis in Crohn’s disease.
dlvr.it
September 17, 2025 at 3:00 PM
Now online! Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
Reposted by Pallett Lab UCL
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma @miriammerad.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 14, 2025 at 5:17 PM
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma @miriammerad.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...