Doug Dyer
@douglaspdyer.bsky.social
Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
Pinned
What a week! So pleased to now also see the peer reviewed version in Science Signaling of @megtriesscience.bsky.social PhD work joint with the Saunders lab, see her great thread for explanation below www.science.org/doi/10.1126/...
Reposted by Doug Dyer
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by Doug Dyer
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
employment.ku.dk/faculty/?sho...
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 11, 2025 at 8:38 AM
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
Reposted by Doug Dyer
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
November 10, 2025 at 7:45 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
Reposted by Doug Dyer
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...
November 10, 2025 at 1:52 PM
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...
Reposted by Doug Dyer
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
November 5, 2025 at 2:01 PM
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
Well done @nabinapun.bsky.social getting your Radnet @cruk-mi.bsky.social @lydiabeckeriii.bsky.social @mcrcnews.bsky.social @mcrcellmatrix.bsky.social PhD work out
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
November 10, 2025 at 2:59 PM
Well done @nabinapun.bsky.social getting your Radnet @cruk-mi.bsky.social @lydiabeckeriii.bsky.social @mcrcnews.bsky.social @mcrcellmatrix.bsky.social PhD work out
Reposted by Doug Dyer
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by Doug Dyer
It’s a new immunology 101 to brighten your weekend cos your weekend can’t get started until you have marvelled over monoclonal antibodies. Its a reach I know but still hope you find time to read and enjoy 🧪
Immunology 101: Monoclonal antibodies
What monoclonals are and how we use them therapeutically.
open.substack.com
November 7, 2025 at 6:42 PM
It’s a new immunology 101 to brighten your weekend cos your weekend can’t get started until you have marvelled over monoclonal antibodies. Its a reach I know but still hope you find time to read and enjoy 🧪
Reposted by Doug Dyer
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
scim.ag
November 7, 2025 at 4:00 PM
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Thanks so much for inviting me, it was a great day and a particularly impressive group of students!!
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
November 6, 2025 at 7:59 AM
Thanks so much for inviting me, it was a great day and a particularly impressive group of students!!
Reposted by Doug Dyer
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
November 6, 2025 at 7:54 AM
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
Reposted by Doug Dyer
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 4, 2025 at 10:35 PM
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Reposted by Doug Dyer
Don’t miss this week’s issue of #ScienceSignaling!
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
November 4, 2025 at 10:00 PM
Don’t miss this week’s issue of #ScienceSignaling!
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
Reposted by Doug Dyer
Great to see this story in print! Congrats @megtriesscience.bsky.social @douglaspdyer.bsky.social and team! Looking forward to sharing Megan's first contributions as a postdoc in our lab at @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social soon... 👀
My PhD work is (finally) published in Science Signaling! And it made the cover!
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
November 4, 2025 at 8:03 PM
Great to see this story in print! Congrats @megtriesscience.bsky.social @douglaspdyer.bsky.social and team! Looking forward to sharing Megan's first contributions as a postdoc in our lab at @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social soon... 👀
What a week! So pleased to now also see the peer reviewed version in Science Signaling of @megtriesscience.bsky.social PhD work joint with the Saunders lab, see her great thread for explanation below www.science.org/doi/10.1126/...
November 4, 2025 at 8:06 PM
What a week! So pleased to now also see the peer reviewed version in Science Signaling of @megtriesscience.bsky.social PhD work joint with the Saunders lab, see her great thread for explanation below www.science.org/doi/10.1126/...
Amazing work from @megtriesscience.bsky.social so proud of you and how this story has turned out!! @lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
My PhD work is (finally) published in Science Signaling! And it made the cover!
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
November 4, 2025 at 7:57 PM
Amazing work from @megtriesscience.bsky.social so proud of you and how this story has turned out!! @lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social
Reposted by Doug Dyer
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Reposted by Doug Dyer
APOE plays a key role in cardiovascular and Alzheimer’s disease.
Reliable tools are needed to study its expression and function.
Among 14 antibodies tested, 4 showed excellent performance.
Pick up the right one.
Report: f1000research.com/articles/12-...
Data summary: onlygoodantibodies.co.uk/28/
Reliable tools are needed to study its expression and function.
Among 14 antibodies tested, 4 showed excellent performance.
Pick up the right one.
Report: f1000research.com/articles/12-...
Data summary: onlygoodantibodies.co.uk/28/
October 30, 2025 at 9:02 AM
APOE plays a key role in cardiovascular and Alzheimer’s disease.
Reliable tools are needed to study its expression and function.
Among 14 antibodies tested, 4 showed excellent performance.
Pick up the right one.
Report: f1000research.com/articles/12-...
Data summary: onlygoodantibodies.co.uk/28/
Reliable tools are needed to study its expression and function.
Among 14 antibodies tested, 4 showed excellent performance.
Pick up the right one.
Report: f1000research.com/articles/12-...
Data summary: onlygoodantibodies.co.uk/28/
Reposted by Doug Dyer
Excited to share my PhD work (in @douglaspdyer.bsky.social’s lab) now published in Mucosal Immunology! 🥳
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often
damages the healthy tissues, particularly the intestines, leading to radiation-induced
toxicities with limited treatme...
www.mucosalimmunology.org
October 29, 2025 at 5:51 PM
Excited to share my PhD work (in @douglaspdyer.bsky.social’s lab) now published in Mucosal Immunology! 🥳
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...
Reposted by Doug Dyer
Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…
www.sciencedirect.com
October 26, 2025 at 10:50 AM
Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...
So pleased to share the peer reviewed first study from our @cruk-ci.bsky.social @mcrcnews.bsky.social Radnet collab led by @nabinapun.bsky.social and Dr Cytlak with Prof Travis and Prof Illidge @lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social www.mucosalimmunology.org/article/S193...
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often
damages the healthy tissues, particularly the intestines, leading to radiation-induced
toxicities with limited treatme...
www.mucosalimmunology.org
October 29, 2025 at 5:23 PM
So pleased to share the peer reviewed first study from our @cruk-ci.bsky.social @mcrcnews.bsky.social Radnet collab led by @nabinapun.bsky.social and Dr Cytlak with Prof Travis and Prof Illidge @lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social www.mucosalimmunology.org/article/S193...
Reposted by Doug Dyer
📣 PhD opportunity led by @madhvimenon.bsky.social with @kathelse.bsky.social , @tracyh9494.bsky.social , and me open now:
"Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics"
apps due 15 November 2025 📣
www.findaphd.com/phds/project...
"Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics"
apps due 15 November 2025 📣
www.findaphd.com/phds/project...
(Bicentenary) Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics at The University of Manchester on FindAPhD.com
PhD Project - (Bicentenary) Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
October 27, 2025 at 3:24 PM
📣 PhD opportunity led by @madhvimenon.bsky.social with @kathelse.bsky.social , @tracyh9494.bsky.social , and me open now:
"Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics"
apps due 15 November 2025 📣
www.findaphd.com/phds/project...
"Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics"
apps due 15 November 2025 📣
www.findaphd.com/phds/project...
Reposted by Doug Dyer
Friday we celebrated our new MRC Centre of Research Excellence in Exposome Immunology: a joint venture with Oxford that we call MOXIE (Manchester-Oxford Immunology of the Exposome). This challenging adventure is off to a great start. @exposomeimmunology.bsky.social
October 20, 2025 at 1:09 PM
Friday we celebrated our new MRC Centre of Research Excellence in Exposome Immunology: a joint venture with Oxford that we call MOXIE (Manchester-Oxford Immunology of the Exposome). This challenging adventure is off to a great start. @exposomeimmunology.bsky.social
Reposted by Doug Dyer
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature
Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
www.nature.com
October 15, 2025 at 3:52 PM
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Reposted by Doug Dyer
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com