Marta Filizola
@martafilizola.bsky.social
Computational biophysicist specialized in GPCRs, beta3 integrins, and other membrane proteins. Professor and Dean at Icahn School of Medicine at Mount Sinai.
Reposted by Marta Filizola
OUT NOW! The Graduate School of Biomedical Sciences Dean's Report and message from Dean @martafilizola.bsky.social. Learn about the Graduate School at Mount Sinai's growth, innovation and achievement, and how they have excelled in 2025 👉 reports.mountsinai.org/article/grad...
October 20, 2025 at 8:51 PM
OUT NOW! The Graduate School of Biomedical Sciences Dean's Report and message from Dean @martafilizola.bsky.social. Learn about the Graduate School at Mount Sinai's growth, innovation and achievement, and how they have excelled in 2025 👉 reports.mountsinai.org/article/grad...
It’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab
😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
October 17, 2025 at 4:50 AM
It’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab
😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
Our new work with Daniel Wacker’s Lab: not only do structurally different PAMs of the mu #opioid receptor bind at different sites but their modulatory mechanisms also differ as assessed by molecular #dynamics and information theory validated by functional experiments
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor
Positive allosteric modulators (PAMs) of the μ opioid receptor (MOR) offer a promising path toward safer opioid therapeutics, yet their mechanisms of action remain poorly understood. Here, we uncover ...
www.biorxiv.org
October 16, 2025 at 11:23 AM
Our new work with Daniel Wacker’s Lab: not only do structurally different PAMs of the mu #opioid receptor bind at different sites but their modulatory mechanisms also differ as assessed by molecular #dynamics and information theory validated by functional experiments
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
For your summer reading, check out the latest from our lab: www.biorxiv.org/content/10.1...
BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects Across Class A GPCRs
G protein-coupled receptors (GPCRs) are important targets for drug discovery owing to their ability to respond to a broad range of stimuli and their involvement in numerous pathologies. Although tradi...
www.biorxiv.org
August 6, 2025 at 11:25 AM
For your summer reading, check out the latest from our lab: www.biorxiv.org/content/10.1...
Join an ever-inquisitive community of scholars who make strategic and meaningful connections between science, medicine, education, and health care delivery. We look forward to welcoming new Master’s classes in Biomedical Sciences and Data Science and AI youtu.be/NPNm4KOfwco
Graduate School of Biomedical Sciences – Master’s Programs
YouTube video by Icahn School of Medicine
youtu.be
June 25, 2025 at 11:10 AM
Join an ever-inquisitive community of scholars who make strategic and meaningful connections between science, medicine, education, and health care delivery. We look forward to welcoming new Master’s classes in Biomedical Sciences and Data Science and AI youtu.be/NPNm4KOfwco
Reposted by Marta Filizola
It’s time to vote! If you give me your vote, I promise I will work hard and loud for you, the BPS community, and for science. Read my statement.
www.biophysics.org/elections/bp...
www.biophysics.org/elections/bp...
BPS Elections | Biophysical Society
www.biophysics.org
June 1, 2025 at 5:35 PM
It’s time to vote! If you give me your vote, I promise I will work hard and loud for you, the BPS community, and for science. Read my statement.
www.biophysics.org/elections/bp...
www.biophysics.org/elections/bp...
Reposted by Marta Filizola
Twenty case studies showing theoretical predictions in chemistry that were later confirmed experimentally. #CompChem 🧪
doi.org/10.1515/pac-...
doi.org/10.1515/pac-...
When theory came first: a review of theoretical chemical predictions ahead of experiments
For decades, computational theoretical chemistry has provided critical insights into molecular behavior, often anticipating experimental discoveries. This review surveys twenty notable examples from t...
doi.org
May 31, 2025 at 2:45 PM
Twenty case studies showing theoretical predictions in chemistry that were later confirmed experimentally. #CompChem 🧪
doi.org/10.1515/pac-...
doi.org/10.1515/pac-...
Reposted by Marta Filizola
The US will not only suffer a brain drain… but will also lose its background brain gain from the rest of the world.
econ.trib.al/3hYAuUZ
econ.trib.al/3hYAuUZ
May 28, 2025 at 8:51 AM
The US will not only suffer a brain drain… but will also lose its background brain gain from the rest of the world.
econ.trib.al/3hYAuUZ
econ.trib.al/3hYAuUZ
Reposted by Marta Filizola
25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.
“America First” Will Destroy U.S. Science
The U.S. government has sought to restrict immigration under the “America First” doctrine.
These policies severely harm American science by stripping it of talent and eliminating
a major driver of its...
www.cell.com
May 26, 2025 at 3:59 AM
25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.
Reposted by Marta Filizola
New insights from our group into how frogs resist toxic environments published today! 🎉🐸
Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford.
www.nature.com/articles/s41...
Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford.
www.nature.com/articles/s41...
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins
Nature Communications - Dinoflagellates and cyanobacteria produce saxitoxin (STX) congeners that block voltage-gated sodium channels. Here authors show how amphibians may sequester STX congeners...
www.nature.com
April 24, 2025 at 6:04 PM
New insights from our group into how frogs resist toxic environments published today! 🎉🐸
Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford.
www.nature.com/articles/s41...
Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford.
www.nature.com/articles/s41...
Reposted by Marta Filizola
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 11:30 AM
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
Filizola lab - Gmeiner lab finally revealed onlinelibrary.wiley.com/doi/abs/10.1...
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
The β2-adrenergic receptor (β2AR) is a critical target for the treatment of airway diseases such as asthma or chronic obstructive pulmonary disease (COPD). To better understand its mechanism of actio...
onlinelibrary.wiley.com
April 8, 2025 at 12:31 PM
Filizola lab - Gmeiner lab finally revealed onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Marta Filizola
"It’s kind of a textbook case of arbitrary and capricious.” A lawsuit alleges that NIH didn't follow proper procedure and was unconstitutionally vague when abruptly terminating >600 grants. My story @science.org www.science.org/content/arti...
Lawsuit aims to overturn many NIH grant terminations
Multiple groups and NIH-funded scientists challenge agency’s decision as arbitrary and capricious
www.science.org
April 2, 2025 at 10:10 PM
"It’s kind of a textbook case of arbitrary and capricious.” A lawsuit alleges that NIH didn't follow proper procedure and was unconstitutionally vague when abruptly terminating >600 grants. My story @science.org www.science.org/content/arti...
Reposted by Marta Filizola
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...
🔭 The Einstein AI model
I shared a controversial take the other day at an event and I decided to write it down in a longer format: I’m afraid AI won't give us a compressed 21st century.
thomwolf.io
March 22, 2025 at 4:06 PM
Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set
thomwolf.io/blog/scienti...
thomwolf.io/blog/scienti...
Are you aiming for leadership roles in pharmaceutical, biotech, high tech, or medical device companies? Consider applying to the revamped MSBS program @GradSchoolSinai @IcahnMountSinai, featuring 1 or 2-year tracks and non-thesis options tailored for industry professionals
March 21, 2025 at 5:38 PM
Are you aiming for leadership roles in pharmaceutical, biotech, high tech, or medical device companies? Consider applying to the revamped MSBS program @GradSchoolSinai @IcahnMountSinai, featuring 1 or 2-year tracks and non-thesis options tailored for industry professionals
At @GradSchoolSinai @IcahnMountSinai, we are excited to train the next generation of #datascience and #AI #professionals for #PrecisionMedicine @MountSinaiNYC
and beyond. Apply here: icahn.mssm.edu/education/ad...
and beyond. Apply here: icahn.mssm.edu/education/ad...
March 19, 2025 at 11:25 PM
At @GradSchoolSinai @IcahnMountSinai, we are excited to train the next generation of #datascience and #AI #professionals for #PrecisionMedicine @MountSinaiNYC
and beyond. Apply here: icahn.mssm.edu/education/ad...
and beyond. Apply here: icahn.mssm.edu/education/ad...
Reposted by Marta Filizola
You got 5 min to really understand the real costs of scientific research - check out this video
www.youtube.com/watch?v=GzNc...
www.youtube.com/watch?v=GzNc...
Understanding the Real Costs of Research
YouTube video by AAMCtoday
www.youtube.com
March 16, 2025 at 3:22 AM
You got 5 min to really understand the real costs of scientific research - check out this video
www.youtube.com/watch?v=GzNc...
www.youtube.com/watch?v=GzNc...
New picture for the Filizola lab on the relentless quest for breakthrough science to build a brighter future. Bring it on!
March 13, 2025 at 5:42 PM
New picture for the Filizola lab on the relentless quest for breakthrough science to build a brighter future. Bring it on!
FRESH OFF THE PRESS
@filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....
@filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....
Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs
G protein-coupled receptors (GPCRs) remain a focal point of research due to their critical roles in cell signaling and their prominence as drug targets. However, directly linking drug efficacy to the ...
pubs.acs.org
March 8, 2025 at 3:22 PM
FRESH OFF THE PRESS
@filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....
@filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....
Reposted by Marta Filizola
Large crowd in New York City at Stand Up for Science.
March 7, 2025 at 7:14 PM
Large crowd in New York City at Stand Up for Science.
Francis Collins Retires From N.I.H. www.nytimes.com/2025/03/01/u...
Francis Collins Retires From N.I.H., Saying Colleagues ‘Deserve the Utmost Respect’
Dr. Collins, a renowned geneticist, ran the National Institutes of Health for 12 years. His parting statement offered a pointed, if veiled, message to the Trump administration.
www.nytimes.com
March 1, 2025 at 8:57 PM
Francis Collins Retires From N.I.H. www.nytimes.com/2025/03/01/u...
Reposted by Marta Filizola
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...