Jonathan Kipnis
@jonykipnis.bsky.social
#TCellsMakeYouSmart
This is my personal account where I will likely talk mostly about science… produced by us and others.
This is my personal account where I will likely talk mostly about science… produced by us and others.
Reposted by Jonathan Kipnis
Look Up! ✨
The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!
#WashU #northernlights #AuroraBorealis
The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!
#WashU #northernlights #AuroraBorealis
November 13, 2025 at 11:46 PM
Look Up! ✨
The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!
#WashU #northernlights #AuroraBorealis
The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao!
#WashU #northernlights #AuroraBorealis
Reposted by Jonathan Kipnis
We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
October 15, 2025 at 3:34 PM
We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
#RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
Reposted by Jonathan Kipnis
The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.
The Booker shortlist honors authors 'in total command' of their craft
The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.
n.pr
September 23, 2025 at 8:50 PM
The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.
Reposted by Jonathan Kipnis
Some thoughts on meningeal mast cells inspired by Xinzhong Dong and @jonykipnis.bsky.social recent (and AWESOME) papers. Lead: @fakesamir.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
www.cell.com
September 18, 2025 at 8:28 PM
Some thoughts on meningeal mast cells inspired by Xinzhong Dong and @jonykipnis.bsky.social recent (and AWESOME) papers. Lead: @fakesamir.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Reposted by Jonathan Kipnis
📅 Save the Date: Oxford 2026 Glymphatic Research Symposium!
• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow
Looking forward to seeing you there! 🧠
• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow
Looking forward to seeing you there! 🧠
September 12, 2025 at 2:59 PM
📅 Save the Date: Oxford 2026 Glymphatic Research Symposium!
• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow
Looking forward to seeing you there! 🧠
• Dates: March 30th, March 31st, April 1st 2026.
• Keynote speakers: Maiken Nedergaard & Jonathan Kipnis.
• Venue: Keble College, Oxford, UK.
• Registration link to follow
Looking forward to seeing you there! 🧠
Reposted by Jonathan Kipnis
#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
August 25, 2025 at 10:21 PM
#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Reposted by Jonathan Kipnis
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
August 22, 2025 at 10:15 PM
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Reposted by Jonathan Kipnis
In his “Neuroimmunology” lecture, @jonykipnis.bsky.social (@washumedicine.bsky.social) questioned what makes the CNS “immune privileged” if its antigens reach T cells via lymphatics and meningeal APCs—reshaping how we think about brain-immune interactions. #AAIcourses
July 31, 2025 at 5:48 PM
In his “Neuroimmunology” lecture, @jonykipnis.bsky.social (@washumedicine.bsky.social) questioned what makes the CNS “immune privileged” if its antigens reach T cells via lymphatics and meningeal APCs—reshaping how we think about brain-immune interactions. #AAIcourses
Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...
Mast cells regulate the brain-dura interface and CSF dynamics
Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces,
specifically arachnoid cuff exit points. Their activation limits pathogen brain entry
via histamine-induced vas...
www.cell.com
July 24, 2025 at 8:10 PM
Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...
Brilliant BIG center seminar by ex-postdoc fellow, now associate professor @MayoClinic, @da-mesquita.bsky.social, who was our student-invited speaker. 👏👏👏
June 28, 2025 at 5:16 AM
Brilliant BIG center seminar by ex-postdoc fellow, now associate professor @MayoClinic, @da-mesquita.bsky.social, who was our student-invited speaker. 👏👏👏
Here is another reason to come back to Twitter 😂
June 19, 2025 at 12:31 AM
Here is another reason to come back to Twitter 😂
Reposted by Jonathan Kipnis
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience
The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...
www.nature.com
June 16, 2025 at 3:56 PM
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Reposted by Jonathan Kipnis
🔗 By @leonsmyth.bsky.social & @jonykipnis.bsky.social at Nature Reviews Immunology: www.nature.com/articles/s41...
(10/11)
(10/11)
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
June 10, 2025 at 3:14 PM
🔗 By @leonsmyth.bsky.social & @jonykipnis.bsky.social at Nature Reviews Immunology: www.nature.com/articles/s41...
(10/11)
(10/11)
Dear all, come back to Twitter. It’s more exciting there!
June 6, 2025 at 5:31 AM
Dear all, come back to Twitter. It’s more exciting there!
Reposted by Jonathan Kipnis
Check out our special issue! The beautiful cover was designed by @ella-maru.bsky.social, working with @jonykipnis.bsky.social & Mitchell (Min Woo) Kim. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
May 20, 2025 at 5:03 PM
Check out our special issue! The beautiful cover was designed by @ella-maru.bsky.social, working with @jonykipnis.bsky.social & Mitchell (Min Woo) Kim. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
What’s better than The Great Nerve by the amazing Kevin Tracey? Two copies of The Great Nerve 🤩 One for home and one for the lab! Amazing read and truly incredible science!
May 18, 2025 at 9:48 PM
What’s better than The Great Nerve by the amazing Kevin Tracey? Two copies of The Great Nerve 🤩 One for home and one for the lab! Amazing read and truly incredible science!
Reposted by Jonathan Kipnis
and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner
www.cell.com/cell/fulltex... @jonykipnis.bsky.social
www.cell.com/cell/fulltex... @jonykipnis.bsky.social
Meningeal lymphatics-microglia axis regulates synaptic physiology
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and
disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent
manner. Enhancing the funct...
www.cell.com
May 16, 2025 at 10:00 AM
and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner
www.cell.com/cell/fulltex... @jonykipnis.bsky.social
www.cell.com/cell/fulltex... @jonykipnis.bsky.social
Reposted by Jonathan Kipnis
The new issue is out! 👉 cell.com/cell/current
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
May 16, 2025 at 10:00 AM
The new issue is out! 👉 cell.com/cell/current
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
Reposted by Jonathan Kipnis
May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
May 13, 2025 at 4:56 PM
May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
Reposted by Jonathan Kipnis
Review @cp-immunity.bsky.social @jonykipnis.bsky.social
Glymphatics and meningeal lymphatics unlock the brain-immune code
www.cell.com/immunity/ful...
Glymphatics and meningeal lymphatics unlock the brain-immune code
www.cell.com/immunity/ful...
Glymphatics and meningeal lymphatics unlock the brain-immune code
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding
of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived
antigens creates an ...
www.cell.com
May 5, 2025 at 8:01 PM
Review @cp-immunity.bsky.social @jonykipnis.bsky.social
Glymphatics and meningeal lymphatics unlock the brain-immune code
www.cell.com/immunity/ful...
Glymphatics and meningeal lymphatics unlock the brain-immune code
www.cell.com/immunity/ful...
Reposted by Jonathan Kipnis
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
May 6, 2025 at 9:40 PM
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.
Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code
Glymphatics and meningeal lymphatics unlock the brain-immune code
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.
dlvr.it
May 4, 2025 at 10:41 PM
Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.
Reposted by Jonathan Kipnis
Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code
Glymphatics and meningeal lymphatics unlock the brain-immune code
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.
dlvr.it
May 4, 2025 at 2:48 PM
Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code
Reposted by Jonathan Kipnis
The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social
May 4, 2025 at 3:39 PM
The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social
A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social
Reposted by Jonathan Kipnis
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
May 2, 2025 at 8:05 PM
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...