Aleksandra Deczkowska
@adeczkowska.bsky.social
Busy @aleksdelab.bsky.social @pasteur.fr || single cells and neuro-immune stuff II #firstgen #ally🏳️🌈🏳️⚧️
Pinned
Local B cell maturation and mast cell regulation of choroid plexus function in early life.
Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...
www.biorxiv.org
Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social
"Explaining something with the wrong model can be worse than not explaining it at all."
www.nature.com/articles/s41...
www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 9, 2026 at 11:11 AM
"Explaining something with the wrong model can be worse than not explaining it at all."
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aleksandra Deczkowska
🎙️ Morgane THION, Collège de France, will talk about "microglia in the developing brain: from colonization to functions" on Monday, 9 February, at 11am at Paris Brain Institute.
👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion
👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion
Scientific lectures: Morgane THION | Paris Brain Institute
Speaker : Morgane THION, College de France"Microglia in the developing brain: from colonization to functions"
parisbraininstitute.org
February 5, 2026 at 5:05 PM
🎙️ Morgane THION, Collège de France, will talk about "microglia in the developing brain: from colonization to functions" on Monday, 9 February, at 11am at Paris Brain Institute.
👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion
👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion
Reposted by Aleksandra Deczkowska
What if the immune system held a key to brain health ? 🧠
Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.
Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.
January 30, 2026 at 4:16 PM
What if the immune system held a key to brain health ? 🧠
Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.
Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.
Reposted by Aleksandra Deczkowska
Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
January 26, 2026 at 8:31 PM
Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Aleksandra Deczkowska
Why do so few cancer cells manage to form metastases - and what helps the rare ones succeed?
Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬
www.cell.com/cell-reports...
Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬
www.cell.com/cell-reports...
January 22, 2026 at 1:56 PM
Why do so few cancer cells manage to form metastases - and what helps the rare ones succeed?
Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬
www.cell.com/cell-reports...
Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬
www.cell.com/cell-reports...
Reposted by Aleksandra Deczkowska
A researchers’ propensity for risky projects is passed down to their doctoral students — and stays with trainees after they leave the laboratory
go.nature.com/4qvaffO
go.nature.com/4qvaffO
PhD students’ taste for risk mirrors their supervisors’
Nature - Learned risk-taking behaviours can persist for years after leaving the lab — and even after taking on a new research topic.
go.nature.com
January 18, 2026 at 1:45 PM
A researchers’ propensity for risky projects is passed down to their doctoral students — and stays with trainees after they leave the laboratory
go.nature.com/4qvaffO
go.nature.com/4qvaffO
Reposted by Aleksandra Deczkowska
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Aleksandra Deczkowska
Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
www.nature.com
December 19, 2025 at 3:03 PM
Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aleksandra Deczkowska
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
PD-L2 Regulates Natural Antibody and IL-10 Secretion by B-1 cells
B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...
www.biorxiv.org
December 15, 2025 at 6:03 AM
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
Reposted by Aleksandra Deczkowska
When your PI presents your work
December 15, 2025 at 12:00 PM
When your PI presents your work
Reposted by Aleksandra Deczkowska
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
December 9, 2025 at 12:05 PM
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Aleksandra Deczkowska
Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 10:56 AM
Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?
Reposted by Aleksandra Deczkowska
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Reposted by Aleksandra Deczkowska
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
www.nature.com
December 7, 2025 at 3:18 AM
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social
Local B cell maturation and mast cell regulation of choroid plexus function in early life.
Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...
www.biorxiv.org
December 3, 2025 at 9:29 AM
Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social
Reposted by Aleksandra Deczkowska
These are the 10 art classroom rules of Corita Kent (artist, teacher, social justice advocate and nun). They are true for any creative process, especially Rule 8: DON’T TRY TO CREATE AND ANALYZE AT THE SAME TIME. THEY’RE DIFFERENT PROCESSES. (i.e. night science / day science).
December 2, 2025 at 1:50 AM
These are the 10 art classroom rules of Corita Kent (artist, teacher, social justice advocate and nun). They are true for any creative process, especially Rule 8: DON’T TRY TO CREATE AND ANALYZE AT THE SAME TIME. THEY’RE DIFFERENT PROCESSES. (i.e. night science / day science).
Reposted by Aleksandra Deczkowska
Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders https://www.biorxiv.org/content/10.1101/2025.11.27.690844v1
November 30, 2025 at 8:16 AM
Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders https://www.biorxiv.org/content/10.1101/2025.11.27.690844v1
Reposted by Aleksandra Deczkowska
Nature research paper: iHALT unlocks liver functionality as a surrogate secondary lymphoid organ
go.nature.com/3M7ctmb
go.nature.com/3M7ctmb
iHALT unlocks liver functionality as a surrogate secondary lymphoid organ - Nature
Liver-restricted viral infection in mice results in secondary lymphoid organ dormancy and the compensatory induction of specialized lymphoid tissue in the liver, the structural features and functional outputs of which are closely mirrored in humans.
go.nature.com
November 28, 2025 at 5:59 PM
Nature research paper: iHALT unlocks liver functionality as a surrogate secondary lymphoid organ
go.nature.com/3M7ctmb
go.nature.com/3M7ctmb
Reposted by Aleksandra Deczkowska
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
@alzdemjournals.bsky.social
@alzdemjournals.bsky.social
November 28, 2025 at 6:00 PM
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
@alzdemjournals.bsky.social
@alzdemjournals.bsky.social
Reposted by Aleksandra Deczkowska
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
November 23, 2025 at 12:27 AM
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
Reposted by Aleksandra Deczkowska
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
November 20, 2025 at 1:23 PM
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Reposted by Aleksandra Deczkowska
November 13, 2025 at 6:44 PM
Reposted by Aleksandra Deczkowska
A study with data from ~14 million children shows that COVID19 infection is significantly more harmful to kids’ hearts than the vaccine.
Marty Makary falsely alleged that “children died” because from COVID19 vaccine. Whomever told him that failed to account for SARS-CoV-2 infections.
Link below.
Marty Makary falsely alleged that “children died” because from COVID19 vaccine. Whomever told him that failed to account for SARS-CoV-2 infections.
Link below.
November 10, 2025 at 3:12 PM
A study with data from ~14 million children shows that COVID19 infection is significantly more harmful to kids’ hearts than the vaccine.
Marty Makary falsely alleged that “children died” because from COVID19 vaccine. Whomever told him that failed to account for SARS-CoV-2 infections.
Link below.
Marty Makary falsely alleged that “children died” because from COVID19 vaccine. Whomever told him that failed to account for SARS-CoV-2 infections.
Link below.
Reposted by Aleksandra Deczkowska
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November 10, 2025 at 7:27 AM
You and the text you need to trim in order to meet the word limit
Reposted by Aleksandra Deczkowska
Evidence continues to accumulate that mRNA can deliver immunostimulatory innate proteins.
www.pnas.org/doi/suppl/10...
www.pnas.org/doi/suppl/10...
November 4, 2025 at 3:31 PM
Evidence continues to accumulate that mRNA can deliver immunostimulatory innate proteins.
www.pnas.org/doi/suppl/10...
www.pnas.org/doi/suppl/10...