Reposted by True_North
Long COVID involves activation of proinflammatory and immune exhaustion pathways
www.nature.com/artic...
1/7
www.nature.com/artic...
1/7
Long COVID involves activation of proinflammatory and immune exhaustion pathways
Nature Immunology - Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC...
www.nature.com
December 12, 2025 at 7:25 PM
Long COVID involves activation of proinflammatory and immune exhaustion pathways
www.nature.com/artic...
1/7
www.nature.com/artic...
1/7
Reposted by True_North
Reposted by True_North
Herausragendes Interview von @ninaweber.bsky.social mit
@bettinagrande.bsky.social über #MECFS. Leseempfehlung!
»Es ist unfassbar, welche Demütigungen diese Menschen ertragen müssen«
Eine fachkundige Schilderung der Realität - ohne Übertreibung, ohne Beschönigung.
www.spiegel.de/gesundheit/d...
@bettinagrande.bsky.social über #MECFS. Leseempfehlung!
»Es ist unfassbar, welche Demütigungen diese Menschen ertragen müssen«
Eine fachkundige Schilderung der Realität - ohne Übertreibung, ohne Beschönigung.
www.spiegel.de/gesundheit/d...
(S+) ME/CFS: Eine Psychotherapeutin erklärt, weshalb die Krankheit so oft verkannt wird
Manche Betroffene können nicht mal mehr das Bett verlassen: Doch die Ursachen der Krankheit ME/CFS sind kaum erforscht, es gibt viele Falschannahmen. Eine Psychotherapeutin sagt, was sie über Patiente...
www.spiegel.de
August 12, 2025 at 1:46 PM
Herausragendes Interview von @ninaweber.bsky.social mit
@bettinagrande.bsky.social über #MECFS. Leseempfehlung!
»Es ist unfassbar, welche Demütigungen diese Menschen ertragen müssen«
Eine fachkundige Schilderung der Realität - ohne Übertreibung, ohne Beschönigung.
www.spiegel.de/gesundheit/d...
@bettinagrande.bsky.social über #MECFS. Leseempfehlung!
»Es ist unfassbar, welche Demütigungen diese Menschen ertragen müssen«
Eine fachkundige Schilderung der Realität - ohne Übertreibung, ohne Beschönigung.
www.spiegel.de/gesundheit/d...
Reposted by True_North
(1/2) Key genetic differences found in people with ME/CFS > Swipe to find out more.
These findings reflect the lived experience of thousands of #pwME.
Thanks to all our participants & supporters who made this possible!
Read a summary of our results: shorturl.at/pgsjk
These findings reflect the lived experience of thousands of #pwME.
Thanks to all our participants & supporters who made this possible!
Read a summary of our results: shorturl.at/pgsjk
August 6, 2025 at 7:03 PM
(1/2) Key genetic differences found in people with ME/CFS > Swipe to find out more.
These findings reflect the lived experience of thousands of #pwME.
Thanks to all our participants & supporters who made this possible!
Read a summary of our results: shorturl.at/pgsjk
These findings reflect the lived experience of thousands of #pwME.
Thanks to all our participants & supporters who made this possible!
Read a summary of our results: shorturl.at/pgsjk
Reposted by True_North
1) Hilda Bastian wrote a new article on the Cochrane review for ME/CFS.
"There are many people who care about the harm this outdated review can do, and won’t let it go – myself included."
"Not retiring influential out-of-date reviews is a ticking time bomb."
"There are many people who care about the harm this outdated review can do, and won’t let it go – myself included."
"Not retiring influential out-of-date reviews is a ticking time bomb."
August 1, 2025 at 9:35 AM
1) Hilda Bastian wrote a new article on the Cochrane review for ME/CFS.
"There are many people who care about the harm this outdated review can do, and won’t let it go – myself included."
"Not retiring influential out-of-date reviews is a ticking time bomb."
"There are many people who care about the harm this outdated review can do, and won’t let it go – myself included."
"Not retiring influential out-of-date reviews is a ticking time bomb."
Reposted by True_North
I did my safeguarding level 3 mandatory training this week on FII (Fabricated or induced illness - seen as a form of child abuse) and PP (perplexing presentations) i.e. symptoms that don’t make sense to paediatricians.
Look at the symptoms that these ‘abusive’ parents may report.
Look at the symptoms that these ‘abusive’ parents may report.
July 15, 2025 at 8:13 AM
I did my safeguarding level 3 mandatory training this week on FII (Fabricated or induced illness - seen as a form of child abuse) and PP (perplexing presentations) i.e. symptoms that don’t make sense to paediatricians.
Look at the symptoms that these ‘abusive’ parents may report.
Look at the symptoms that these ‘abusive’ parents may report.
Reposted by True_North
1) In a large international sample of more than 2000 ME/CFS patients, researchers found that neurocognitive complaints consists of two factors:
- one involving classical memory and concentration symptoms
- the other involving sensory overload phenomena
- one involving classical memory and concentration symptoms
- the other involving sensory overload phenomena
July 31, 2025 at 2:36 PM
1) In a large international sample of more than 2000 ME/CFS patients, researchers found that neurocognitive complaints consists of two factors:
- one involving classical memory and concentration symptoms
- the other involving sensory overload phenomena
- one involving classical memory and concentration symptoms
- the other involving sensory overload phenomena
Reposted by True_North
My rapid response at BMJ is online now. I joined the chorus of protest about an opinion piece claiming people with severe ME/CFS can recover by "reframing their beliefs" &c. People with ME/CFS deserve so much better than that:
www.bmj.com/content/389/...
#MECFS
www.bmj.com/content/389/...
#MECFS
Patients with severe ME/CFS deserve better than unproven theories
www.bmj.com
July 25, 2025 at 1:03 PM
My rapid response at BMJ is online now. I joined the chorus of protest about an opinion piece claiming people with severe ME/CFS can recover by "reframing their beliefs" &c. People with ME/CFS deserve so much better than that:
www.bmj.com/content/389/...
#MECFS
www.bmj.com/content/389/...
#MECFS
Reposted by True_North
📢 Now published:
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
June 20, 2025 at 5:44 AM
📢 Now published:
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
www.embopress.org/doi/full/10.....
Since the preprint, we replicated 9 of 14 traits in All of Us & showed that #pwME with PEM-like symptoms have stronger biomarker differences.
bsky.app/profile/cgat...
Reposted by True_North
I've been thinking about how to explain the challenge of living with ME/CFS and created this cartoon visualization.
Imagine the life of someone without ME is a rainbow of activities that each take a certain amount of energy.
ME limits your energy, and thereby the vibrancy of your life.
Imagine the life of someone without ME is a rainbow of activities that each take a certain amount of energy.
ME limits your energy, and thereby the vibrancy of your life.
February 23, 2025 at 7:35 PM
I've been thinking about how to explain the challenge of living with ME/CFS and created this cartoon visualization.
Imagine the life of someone without ME is a rainbow of activities that each take a certain amount of energy.
ME limits your energy, and thereby the vibrancy of your life.
Imagine the life of someone without ME is a rainbow of activities that each take a certain amount of energy.
ME limits your energy, and thereby the vibrancy of your life.
Reposted by True_North
It is sad to see @bmj.com platforming quack therapies in 2025
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affects around 250 000 people in the UK.
Reframing beliefs about illness, along with specialist rehabilitation, can help recovery in people with severe ME/CFS, @paulgarnerwoof.bsky.social and colleagues
www.bmj.com/content/389/...
Reframing beliefs about illness, along with specialist rehabilitation, can help recovery in people with severe ME/CFS, @paulgarnerwoof.bsky.social and colleagues
www.bmj.com/content/389/...
May 14, 2025 at 4:32 PM
It is sad to see @bmj.com platforming quack therapies in 2025
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
The mind-over-matter approach to #MECFS has been debunked for years, but a cadre of psych devotees in the UK persist in peddling evidence-free miracle cures
Pure and utter pseudoscience
#pwME #LongCovid @georgemonbiot.bsky.social
Reposted by True_North
Thank you @rollingstone.com for the front page coverage
Make the invisible visible. Long Covid is REAL and a growing crisis
Make the invisible visible. Long Covid is REAL and a growing crisis
March 15, 2025 at 10:09 PM
Thank you @rollingstone.com for the front page coverage
Make the invisible visible. Long Covid is REAL and a growing crisis
Make the invisible visible. Long Covid is REAL and a growing crisis
Reposted by True_North
Media pieces that present "think yourself better" as revolutionary secret knowledge as if it is not both the first thing that everyone who gets Long Covid tries, and the first, middle and last thing that everyone who gets Long Covid is told
March 1, 2025 at 12:20 PM
Media pieces that present "think yourself better" as revolutionary secret knowledge as if it is not both the first thing that everyone who gets Long Covid tries, and the first, middle and last thing that everyone who gets Long Covid is told
Reposted by True_North
Another study pointing to reduced information processing speed in ME/CFS.
The large MCAM study from last year found similar results:
www.frontiersin.org/journals/neu...
The large MCAM study from last year found similar results:
www.frontiersin.org/journals/neu...
Cognitive functioning in chronic fatigue syndrome: Slowed information processing or a deficit in attentional selectivity?
psycnet.apa.org/doiLanding?d...
"attentional selectivity is not impaired in #CFS patients & their cognitive dysfunction is restricted to slowed information processing"
#MEcfs
psycnet.apa.org/doiLanding?d...
"attentional selectivity is not impaired in #CFS patients & their cognitive dysfunction is restricted to slowed information processing"
#MEcfs
February 14, 2025 at 3:11 PM
Another study pointing to reduced information processing speed in ME/CFS.
The large MCAM study from last year found similar results:
www.frontiersin.org/journals/neu...
The large MCAM study from last year found similar results:
www.frontiersin.org/journals/neu...
Reposted by True_North
1) Zeraatkar and colleagues (including Paul Garner) have responded to criticism of their review on Long Covid treatments.
Their response is very brief and fails to address most of the issues raised.
Their response is very brief and fails to address most of the issues raised.
January 28, 2025 at 6:00 PM
1) Zeraatkar and colleagues (including Paul Garner) have responded to criticism of their review on Long Covid treatments.
Their response is very brief and fails to address most of the issues raised.
Their response is very brief and fails to address most of the issues raised.
Reposted by True_North
I never thought a day would come when I would write a post this critical about the Cochrane Collaboration. But today was that day:
absolutelymaybe.plos.org/2025/01/24/w...
#mecfs
absolutelymaybe.plos.org/2025/01/24/w...
#mecfs
When Journal, Scientific Society, and Community Values Clash - Absolutely Maybe
A process I’ve been involved with at a journal recently exploded. It was meant to resolve a controversy about a publication, not…
absolutelymaybe.plos.org
January 24, 2025 at 5:17 AM
I never thought a day would come when I would write a post this critical about the Cochrane Collaboration. But today was that day:
absolutelymaybe.plos.org/2025/01/24/w...
#mecfs
absolutelymaybe.plos.org/2025/01/24/w...
#mecfs
Reposted by True_North
“It’s hard to find a word to describe how badly they [Cochrane] treated everybody involved in this,” she said. “It’s been pretty appalling behavior.”
Hilda Bastian...a founding member of the Cochrane Collaboration.
retractionwatch.com/2025/01/23/t...
Hilda Bastian...a founding member of the Cochrane Collaboration.
retractionwatch.com/2025/01/23/t...
Thousands demand withdrawal of review article recommending exercise therapy for chronic fatigue syndrome
The decision to abandon a process to re-evaluate a review recommending exercise therapy for chronic fatigue syndrome (ME/CFS) has reignited calls for the article to be withdrawn. The 2019 ver…
retractionwatch.com
January 23, 2025 at 4:24 PM
“It’s hard to find a word to describe how badly they [Cochrane] treated everybody involved in this,” she said. “It’s been pretty appalling behavior.”
Hilda Bastian...a founding member of the Cochrane Collaboration.
retractionwatch.com/2025/01/23/t...
Hilda Bastian...a founding member of the Cochrane Collaboration.
retractionwatch.com/2025/01/23/t...
Reposted by True_North
Loads of spelling mistakes in this.
January 23, 2025 at 4:52 PM
Loads of spelling mistakes in this.
Reposted by True_North
On the #NIH advocacy call right now.
Koroshetz on, discussing the new Vernon et al. paper distinguishing between #pwME post-COVID versus those we cannot PROVE had COVID.
~ 0.9% in those we can't prove had COVID
vs
~4.5% in those who were in the post-COVID group
met dx criteria for #MECFS. 🧪🧵
Koroshetz on, discussing the new Vernon et al. paper distinguishing between #pwME post-COVID versus those we cannot PROVE had COVID.
~ 0.9% in those we can't prove had COVID
vs
~4.5% in those who were in the post-COVID group
met dx criteria for #MECFS. 🧪🧵
January 14, 2025 at 7:43 PM
Reposted by True_North
Like, PEM isn’t a feature of other conditions. It’s something we see in ME. That’s basically it. People may *screen positive for bits and pieces* of PEM in other conditions. People may have ME *and* another condition, but it’s very important we’re clear that PEM isn’t a part of other conditions.
December 19, 2024 at 3:26 AM
Like, PEM isn’t a feature of other conditions. It’s something we see in ME. That’s basically it. People may *screen positive for bits and pieces* of PEM in other conditions. People may have ME *and* another condition, but it’s very important we’re clear that PEM isn’t a part of other conditions.
Reposted by True_North
Symptoms of #LongCovid should not be equated with direct viral damage.
Symptoms of LC have a cause in the body's response to an infection. That is not the same as that infection having damaged the tissue. That may be hard to understand.
1/5
Symptoms of LC have a cause in the body's response to an infection. That is not the same as that infection having damaged the tissue. That may be hard to understand.
1/5
December 13, 2024 at 4:23 PM
Symptoms of #LongCovid should not be equated with direct viral damage.
Symptoms of LC have a cause in the body's response to an infection. That is not the same as that infection having damaged the tissue. That may be hard to understand.
1/5
Symptoms of LC have a cause in the body's response to an infection. That is not the same as that infection having damaged the tissue. That may be hard to understand.
1/5
Reposted by True_North
Noteworthy that coverage somehow latched onto CBT and rehab sometimes being better than nothing (notwithstanding the potential to exacerbate).
Surely the real take-home was that >4y on, we have nothing substantive to offer some 400 million people globally. We should be able to do better than this..
Surely the real take-home was that >4y on, we have nothing substantive to offer some 400 million people globally. We should be able to do better than this..
A systematic review of 24 randomized trials for #LongCovid
www.bmj.com/content/387/... open-access
No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty).
We're still in desperate need for a validated treatment!
www.bmj.com/content/387/... open-access
No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty).
We're still in desperate need for a validated treatment!
November 28, 2024 at 4:46 PM
Noteworthy that coverage somehow latched onto CBT and rehab sometimes being better than nothing (notwithstanding the potential to exacerbate).
Surely the real take-home was that >4y on, we have nothing substantive to offer some 400 million people globally. We should be able to do better than this..
Surely the real take-home was that >4y on, we have nothing substantive to offer some 400 million people globally. We should be able to do better than this..
Reposted by True_North
🧠 Daily Feed of Brain Damage 🧠
Cøvid isn't your friend.
And WTAF are we doing to developing children's brains??
@daniellebeckman.bsky.social
🙏🏻💖
Cøvid isn't your friend.
And WTAF are we doing to developing children's brains??
@daniellebeckman.bsky.social
🙏🏻💖
A lot of people don't realize that many patients with #LongCovid are now often being treated in Brain Injury Clinics, together with patients recovering from traumatic brain injury after a concussion. It's been hard to keep up with the literature, but here is a new one published yesterday #NeuroCovid
November 27, 2024 at 12:18 AM
🧠 Daily Feed of Brain Damage 🧠
Cøvid isn't your friend.
And WTAF are we doing to developing children's brains??
@daniellebeckman.bsky.social
🙏🏻💖
Cøvid isn't your friend.
And WTAF are we doing to developing children's brains??
@daniellebeckman.bsky.social
🙏🏻💖
Reposted by True_North
🔍 Understanding ME/CFS: It's a complex illness with no clear cause or diagnostic marker, making diagnosis challenging and often based on exclusion. Symptoms vary widely, but persistent fatigue and post-exertional malaise are common. #MECFS #ChronicIllness
November 22, 2024 at 12:16 PM
🔍 Understanding ME/CFS: It's a complex illness with no clear cause or diagnostic marker, making diagnosis challenging and often based on exclusion. Symptoms vary widely, but persistent fatigue and post-exertional malaise are common. #MECFS #ChronicIllness