Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
Respiratory and Sleep Medicine
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
Last year I was asked you give a lecture at Kirby Institute at the University of NSW (Prif. Raina McIntyre's Group). I was the warm-up act for David Tuller from Berkley
I spoke for 30 minutes on the "Costs of doing nothing"
My slides already need updating 😬
I spoke for 30 minutes on the "Costs of doing nothing"
My slides already need updating 😬
Not a back pat but i debated this general idea in 2020 with a maga jerk whose answer to the “what if” was “it’s too early to worry about that.”
What if even 1% of the pop cant work or has long term complex health care needs - or worse?
What if even 1% of the pop cant work or has long term complex health care needs - or worse?
January 1, 2026 at 6:25 PM
Last year I was asked you give a lecture at Kirby Institute at the University of NSW (Prif. Raina McIntyre's Group). I was the warm-up act for David Tuller from Berkley
I spoke for 30 minutes on the "Costs of doing nothing"
My slides already need updating 😬
I spoke for 30 minutes on the "Costs of doing nothing"
My slides already need updating 😬
Humour Segue
January 1, 2026 at 1:34 PM
Humour Segue
January 1, 2026 at 10:43 AM
My response
"It's ironic that the brain injury is manifest as loss of insight and impulse control. And and irrational outbursts.
Perhaps, Anthony, we shouldn't ask what drives these narratives, but rather, how many infections get you to this place?"
We are shit shape and sinking
"It's ironic that the brain injury is manifest as loss of insight and impulse control. And and irrational outbursts.
Perhaps, Anthony, we shouldn't ask what drives these narratives, but rather, how many infections get you to this place?"
We are shit shape and sinking
Oh yes, how disgusting was that. Just when I was appreciating the guy for taking a swing at Rump.
December 31, 2025 at 12:45 PM
My response
"It's ironic that the brain injury is manifest as loss of insight and impulse control. And and irrational outbursts.
Perhaps, Anthony, we shouldn't ask what drives these narratives, but rather, how many infections get you to this place?"
We are shit shape and sinking
"It's ironic that the brain injury is manifest as loss of insight and impulse control. And and irrational outbursts.
Perhaps, Anthony, we shouldn't ask what drives these narratives, but rather, how many infections get you to this place?"
We are shit shape and sinking
The importance of Sleep in metabolomics and, of course, Long C-19 should be considered by everyone
Yes COI Disclaimer:
I'm a Sleep Dude 🤷🏻♂️🤷🏻♂️
www.nature.com/articles/s42...
Yes COI Disclaimer:
I'm a Sleep Dude 🤷🏻♂️🤷🏻♂️
www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
www.nature.com
December 30, 2025 at 8:53 PM
The importance of Sleep in metabolomics and, of course, Long C-19 should be considered by everyone
Yes COI Disclaimer:
I'm a Sleep Dude 🤷🏻♂️🤷🏻♂️
www.nature.com/articles/s42...
Yes COI Disclaimer:
I'm a Sleep Dude 🤷🏻♂️🤷🏻♂️
www.nature.com/articles/s42...
December 30, 2025 at 4:39 PM
🧠 Daily Feed of Brain Damage 🧠
Paediatric Version
@atranscendedman.bsky.social 🤬🤬
www.mdpi.com/2227-9067/12...
Paediatric Version
@atranscendedman.bsky.social 🤬🤬
www.mdpi.com/2227-9067/12...
www.mdpi.com
December 30, 2025 at 4:10 PM
🧠 Daily Feed of Brain Damage 🧠
Paediatric Version
@atranscendedman.bsky.social 🤬🤬
www.mdpi.com/2227-9067/12...
Paediatric Version
@atranscendedman.bsky.social 🤬🤬
www.mdpi.com/2227-9067/12...
Fascinating twist 🧐
Auto-immune diseases are more common in those "recovered" versus those with Long C-19
There's so much about immune dysregulation were simply don't understand 😔
doi.org/10.3389/fimm...
Auto-immune diseases are more common in those "recovered" versus those with Long C-19
There's so much about immune dysregulation were simply don't understand 😔
doi.org/10.3389/fimm...
Frontiers | Autoantibodies in long COVID in a black/mixed population compared with recovered and pre-pandemic controls
IntroductionLong COVID (LC), a clinical condition marked by persistent and new symptoms after infection with severe acute respiratory syndrome coronavirus 2 ...
doi.org
December 30, 2025 at 7:17 AM
Fascinating twist 🧐
Auto-immune diseases are more common in those "recovered" versus those with Long C-19
There's so much about immune dysregulation were simply don't understand 😔
doi.org/10.3389/fimm...
Auto-immune diseases are more common in those "recovered" versus those with Long C-19
There's so much about immune dysregulation were simply don't understand 😔
doi.org/10.3389/fimm...
Cövid related interstitial lung disease is a nasty complication of an avoidable infection
😷😷😷
doi.org/10.3390/medi...
😷😷😷
doi.org/10.3390/medi...
doi.org
December 28, 2025 at 1:17 PM
Cövid related interstitial lung disease is a nasty complication of an avoidable infection
😷😷😷
doi.org/10.3390/medi...
😷😷😷
doi.org/10.3390/medi...
🔥🔥🔥
Suffice to say"
The dildo of Karma comes with lube
Suffice to say"
The dildo of Karma comes with lube
Maybe Jon Stewart should invite a credible scientist who follows the latest studies regarding the potential impacts of covid on the body and brain.
bsky.app/profile/davi...
bsky.app/profile/davi...
🧠 Daily Feed of Brain Damage 🧠
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
December 28, 2025 at 12:40 PM
🔥🔥🔥
Suffice to say"
The dildo of Karma comes with lube
Suffice to say"
The dildo of Karma comes with lube
🧠 Daily Feed of Brain Damage 🧠
Needless to say, biomarkers are not merely CSF, blood urine etc...
www.mdpi.com/2035-8377/18...
Needless to say, biomarkers are not merely CSF, blood urine etc...
www.mdpi.com/2035-8377/18...
December 27, 2025 at 2:31 PM
🧠 Daily Feed of Brain Damage 🧠
Needless to say, biomarkers are not merely CSF, blood urine etc...
www.mdpi.com/2035-8377/18...
Needless to say, biomarkers are not merely CSF, blood urine etc...
www.mdpi.com/2035-8377/18...
This is the primary paper
Rob has also shown us some seriously good science in our WHN Long Cövid Group... Sitting with the grownups is a great privilege 😊
www.cell.com/trends/endoc...
Rob has also shown us some seriously good science in our WHN Long Cövid Group... Sitting with the grownups is a great privilege 😊
www.cell.com/trends/endoc...
December 27, 2025 at 2:14 AM
This is the primary paper
Rob has also shown us some seriously good science in our WHN Long Cövid Group... Sitting with the grownups is a great privilege 😊
www.cell.com/trends/endoc...
Rob has also shown us some seriously good science in our WHN Long Cövid Group... Sitting with the grownups is a great privilege 😊
www.cell.com/trends/endoc...
Latest pre-print from Amsterdam's wonderful Rob Wust and friends
I guess your LC PEMS isn't psychosomatic🤦🏻♂️
doi.org/10.1101/2025...
I guess your LC PEMS isn't psychosomatic🤦🏻♂️
doi.org/10.1101/2025...
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...
doi.org
December 26, 2025 at 10:30 PM
Latest pre-print from Amsterdam's wonderful Rob Wust and friends
I guess your LC PEMS isn't psychosomatic🤦🏻♂️
doi.org/10.1101/2025...
I guess your LC PEMS isn't psychosomatic🤦🏻♂️
doi.org/10.1101/2025...
In the setting of Cövid with repeated infections, how on earth can you tell the difference?
We will need to rewrite much of current Medicine. I would suggest we start with this article🙏🏻
We will need to rewrite much of current Medicine. I would suggest we start with this article🙏🏻
December 25, 2025 at 7:16 PM
In the setting of Cövid with repeated infections, how on earth can you tell the difference?
We will need to rewrite much of current Medicine. I would suggest we start with this article🙏🏻
We will need to rewrite much of current Medicine. I would suggest we start with this article🙏🏻
🧠 Daily Feed of Brain Damage 🧠
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
COVID-19-associated neurological and psychological manifestations - Nature Reviews Disease Primers
This Primer by Wilson and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of neurological and psychiatric manifestations of COVID-19.
www.nature.com
December 24, 2025 at 8:05 PM
🧠 Daily Feed of Brain Damage 🧠
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
With thanks to @atranscendedman.bsky.social
Santa Edition
www.nature.com/articles/s41...
👍🏻👍🏻
We can only remain hopeful... Nothing else seems to work!!
We can only remain hopeful... Nothing else seems to work!!
Merry Festivities whatever your illness, disability, religion or mobility aid choice! 💙💙💙
#ME #LongCovid #Lyme #POTS #PEM #LivesWeCannotLive
@meassociation.org.uk
@longcovidsupport.bsky.social
#Justice4ME
@ashleydaltonmp.bsky.social
@davidjoffe64.bsky.social
#ME #LongCovid #Lyme #POTS #PEM #LivesWeCannotLive
@meassociation.org.uk
@longcovidsupport.bsky.social
#Justice4ME
@ashleydaltonmp.bsky.social
@davidjoffe64.bsky.social
December 23, 2025 at 4:11 PM
👍🏻👍🏻
We can only remain hopeful... Nothing else seems to work!!
We can only remain hopeful... Nothing else seems to work!!
December 22, 2025 at 9:14 PM
Linking nocturnal blood oxygen, sleep spindles, and dementia: A retrospective cohort mediation analysis in middle-aged and older adults url: academic.oup.com/sleep/articl...
Linking nocturnal blood oxygen, sleep spindles, and dementia: A retrospective cohort mediation analysis in middle-aged and older adults
Statement of Significance Sleep spindles and nocturnal hypoxia are each linked to dementia. However, prior work has not examined the mechanistic link betwe
academic.oup.com
December 22, 2025 at 7:05 PM
Linking nocturnal blood oxygen, sleep spindles, and dementia: A retrospective cohort mediation analysis in middle-aged and older adults url: academic.oup.com/sleep/articl...
Even more shit news for your heart...
Animal model
@atranscendedman.bsky.social 🙏🏻
insight.jci.org/articles/vie...
Animal model
@atranscendedman.bsky.social 🙏🏻
insight.jci.org/articles/vie...
JCI Insight -
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19
insight.jci.org
December 22, 2025 at 7:03 PM
Even more shit news for your heart...
Animal model
@atranscendedman.bsky.social 🙏🏻
insight.jci.org/articles/vie...
Animal model
@atranscendedman.bsky.social 🙏🏻
insight.jci.org/articles/vie...
Things that may very well require many previous studies to be re-evaluated 🧐
If science were simple, we would deny the value of vaccines.....
Oh Yeah🙄... America's already there🔥
doi.org/10.1038/s415...
If science were simple, we would deny the value of vaccines.....
Oh Yeah🙄... America's already there🔥
doi.org/10.1038/s415...
BOLD signal changes can oppose oxygen metabolism across the human cortex - Nature Neuroscience
Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the canonical interpretatio...
doi.org
December 22, 2025 at 12:16 PM
Things that may very well require many previous studies to be re-evaluated 🧐
If science were simple, we would deny the value of vaccines.....
Oh Yeah🙄... America's already there🔥
doi.org/10.1038/s415...
If science were simple, we would deny the value of vaccines.....
Oh Yeah🙄... America's already there🔥
doi.org/10.1038/s415...