Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
Respiratory and Sleep Medicine
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
"Complaints like dyspnoea or chest pain may be an early indicator of lung function impairment, suggesting that further diagnostic tests for treatable post-COVID-19 complications may be needed."
doi.org/10.1186/s128...
doi.org/10.1186/s128...
Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study - BMC Pulmonary Medicine
Background Although the majority of patients suffering from COVID-19 (coronavirus disease 2019) did not require hospitalization, data on the persistence of pulmonary sequelae after a mild SARS-CoV-2 (...
doi.org
November 10, 2025 at 3:02 AM
"Complaints like dyspnoea or chest pain may be an early indicator of lung function impairment, suggesting that further diagnostic tests for treatable post-COVID-19 complications may be needed."
doi.org/10.1186/s128...
doi.org/10.1186/s128...
Yep‼️
Killing the elderly is politically convenient... They are expensive 🤬
Crippling the tax payers...
That's quite another problem ☠️
Killing the elderly is politically convenient... They are expensive 🤬
Crippling the tax payers...
That's quite another problem ☠️
‘..serious difficulty concentrating, remembering, or making decisions because of a physical, mental, or emotional condition—has become the most commonly reported disability among US adults’
Driven by disproportionate growth in cognitive disability in 18-39 group
(data from CDC Health Data System)
Driven by disproportionate growth in cognitive disability in 18-39 group
(data from CDC Health Data System)
November 8, 2025 at 12:18 AM
Yep‼️
Killing the elderly is politically convenient... They are expensive 🤬
Crippling the tax payers...
That's quite another problem ☠️
Killing the elderly is politically convenient... They are expensive 🤬
Crippling the tax payers...
That's quite another problem ☠️
Precisely‼️
Now consider kids ☠️🤦🏻♂️
Now consider kids ☠️🤦🏻♂️
🍵😷 ... "The disproportionate growth in cognitive disability among younger adults seems to be the primary driver of the overall national trend."
#CovidIsNotOver #Covid19
#CovidIsNotOver #Covid19
November 7, 2025 at 8:26 PM
Precisely‼️
Now consider kids ☠️🤦🏻♂️
Now consider kids ☠️🤦🏻♂️
For those up the back who are yet to fully understand the implications of Cøvid related immune dysregulation
Here's a clue
The #Leonardi_Effect is alive and very busy‼️
www.frontiersin.org/articles/10....
Here's a clue
The #Leonardi_Effect is alive and very busy‼️
www.frontiersin.org/articles/10....
Frontiers | Transcriptome analysis of classical blood cells reveals downregulation of pro-inflammatory genes in the classical monocytes of long COVID patients
IntroductionDespite extensive research, the pathogenesis and predispositions underlying long COVID (long-term coronavirus disease 2019) remain poorly underst...
www.frontiersin.org
November 7, 2025 at 11:36 AM
For those up the back who are yet to fully understand the implications of Cøvid related immune dysregulation
Here's a clue
The #Leonardi_Effect is alive and very busy‼️
www.frontiersin.org/articles/10....
Here's a clue
The #Leonardi_Effect is alive and very busy‼️
www.frontiersin.org/articles/10....
🧠 Daily Feed of Brain Damage 🧠
Your anxiety isn't psychosomatic🤬
@atranscendedman.bsky.social 🙏🏻
www.sciencedirect.com/science/arti...
Your anxiety isn't psychosomatic🤬
@atranscendedman.bsky.social 🙏🏻
www.sciencedirect.com/science/arti...
Early life ACE2 inhibition leads to long term anxiety-like behaviour in rats by disrupting the amygdala
Angiotensin-converting enzyme 2 (ACE2) is important for cardiac and renal development as well as appropriate perinatal growth. In addition, ACE2 has r…
www.sciencedirect.com
November 7, 2025 at 4:27 AM
🧠 Daily Feed of Brain Damage 🧠
Your anxiety isn't psychosomatic🤬
@atranscendedman.bsky.social 🙏🏻
www.sciencedirect.com/science/arti...
Your anxiety isn't psychosomatic🤬
@atranscendedman.bsky.social 🙏🏻
www.sciencedirect.com/science/arti...
EBM 😂😂
Everyone Bullshits Mightly ♨️♨️
Everyone Bullshits Mightly ♨️♨️
The result is that everything in ARIC has an asterisk next to it - because if they'll protect laughable-but-deadly bullshit like that to shield a colleague from accountability, you can't trust anything in the journal.
It also emphasizes that EBM/GRADE etc just do not cut it. Cargo cult science.
It also emphasizes that EBM/GRADE etc just do not cut it. Cargo cult science.
🧵 of 🧵s @ukhadds.bsky.social RE "straw man" papers, there are a bunch but IMO a lot of it comes back to the Evidence Based Medicine idea that a checklist can substitute for expertise.
The result is junk trials compiled into junk reviews and guidance, just from ignorance, hubris and cherry picking.
The result is junk trials compiled into junk reviews and guidance, just from ignorance, hubris and cherry picking.
November 5, 2025 at 4:03 PM
EBM 😂😂
Everyone Bullshits Mightly ♨️♨️
Everyone Bullshits Mightly ♨️♨️
The depths of the perversion of science have reached a new nadir, Mark 🤬
We have always had a small element of Bullshitologists, but now it's become a professional standard ☠️☠️
We have always had a small element of Bullshitologists, but now it's become a professional standard ☠️☠️
Whenever I see one of these stories I am reminded that Antimicrobial Resistance and Infection Control is shielding a study claiming N95s interfere with breathing in pregnancy that tested subjects in the equivalent of 10 N95s at once *by mistake* (and which CAN-PCC thinks is valid).
Cosplay science.
Cosplay science.
The 3rd annual Canadian Long COVID symposium wrapped up yesterday. It was a great meeting, and I got some nice news at the end!
PDF of the poster is here: www.dropbox.com/scl/fi/e8wh6...
MP3 of a 5-minute verbal overview is here: www.dropbox.com/scl/fi/ej0lw...
PDF of the poster is here: www.dropbox.com/scl/fi/e8wh6...
MP3 of a 5-minute verbal overview is here: www.dropbox.com/scl/fi/ej0lw...
November 5, 2025 at 4:01 PM
The depths of the perversion of science have reached a new nadir, Mark 🤬
We have always had a small element of Bullshitologists, but now it's become a professional standard ☠️☠️
We have always had a small element of Bullshitologists, but now it's become a professional standard ☠️☠️
So much truth 😔😔💔
November 5, 2025 at 10:44 AM
So much truth 😔😔💔
Noor,
We have continued to fail each other.
Bullying... Work hours.... Poor supervision... Appalling behaviour from our Colleges
An endless list of issues that have been ever present for the entirety of my almost 40 years of Public Hospital service
"Failure by Design"
😔😔💔
We have continued to fail each other.
Bullying... Work hours.... Poor supervision... Appalling behaviour from our Colleges
An endless list of issues that have been ever present for the entirety of my almost 40 years of Public Hospital service
"Failure by Design"
😔😔💔
I posted only a very short time ago about the personal cost.
Very sad to read this story.
www.abc.net.au/news/2025-10...
Very sad to read this story.
www.abc.net.au/news/2025-10...
Grieving father calls for inquiry after whistleblower doctor's death
There are calls for a Senate inquiry into the suicide deaths of Australian doctors amid allegations of untenable rosters and payback for whistleblowers.
www.abc.net.au
November 5, 2025 at 10:19 AM
Noor,
We have continued to fail each other.
Bullying... Work hours.... Poor supervision... Appalling behaviour from our Colleges
An endless list of issues that have been ever present for the entirety of my almost 40 years of Public Hospital service
"Failure by Design"
😔😔💔
We have continued to fail each other.
Bullying... Work hours.... Poor supervision... Appalling behaviour from our Colleges
An endless list of issues that have been ever present for the entirety of my almost 40 years of Public Hospital service
"Failure by Design"
😔😔💔
Sleep and the gut biome.
Both are problematic in Long C-19
genomicpress.kglmeridian.com/view/journal...
Both are problematic in Long C-19
genomicpress.kglmeridian.com/view/journal...
genomicpress.kglmeridian.com
November 4, 2025 at 4:16 PM
Sleep and the gut biome.
Both are problematic in Long C-19
genomicpress.kglmeridian.com/view/journal...
Both are problematic in Long C-19
genomicpress.kglmeridian.com/view/journal...
Pity it's Telehealth, Brendan...
A thorough history and examination are required for this disorder.
It takes me 90 minutes to see a new Long Cövid patient.
A thorough history and examination are required for this disorder.
It takes me 90 minutes to see a new Long Cövid patient.
In awe of the team at Clinic Nineteen treating adults & children for long COVID & related diseases. COVID infection is commonplace in the community & repeat infections increase your chances of getting LC so do your best to avoid infection. Indoor air quality is key.
www.abc.net.au/news/2025-11...
www.abc.net.au/news/2025-11...
Long COVID patients seeking help 'let down by the system'
Patients are calling for better access to long COVID care after the closure of one of the country's last public clinics.
www.abc.net.au
October 31, 2025 at 9:00 PM
Pity it's Telehealth, Brendan...
A thorough history and examination are required for this disorder.
It takes me 90 minutes to see a new Long Cövid patient.
A thorough history and examination are required for this disorder.
It takes me 90 minutes to see a new Long Cövid patient.
