https://mecfsscience.org/
Severeijns et al. 2005. The causal status of pain catastrophizing: an experimental test with healthy participants.
onlinelibrary.wiley....
Discussion on S4ME:
www.s4me.info/thread...
Severeijns et al. 2005. The causal status of pain catastrophizing: an experimental test with healthy participants.
onlinelibrary.wiley....
Discussion on S4ME:
www.s4me.info/thread...
We wrote a detailed article about catastrophizing here:
We wrote a detailed article about catastrophizing here:
In other words, catastrophizing didn't have an effect on pain experience and behavior.
In other words, catastrophizing didn't have an effect on pain experience and behavior.
The experiment successfully increase the PCS score in the catastrophizing group.
The experiment successfully increase the PCS score in the catastrophizing group.
Catastrophizing didn't have any influence on pain.
Catastrophizing didn't have any influence on pain.
Strom et al. 2026. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
www.nature.com/artic...
Discussion on S4ME:
www.s4me.info/thread...
Strom et al. 2026. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
www.nature.com/artic...
Discussion on S4ME:
www.s4me.info/thread...
The genetic data for anxiety did correlate strongly with those for depression (rg = 0.9) and was associated with GABAergic neurons.
The genetic data for anxiety did correlate strongly with those for depression (rg = 0.9) and was associated with GABAergic neurons.
link.springer.com/ar...
www.nature.com/artic...
link.springer.com/ar...
www.nature.com/artic...
- Neuronal growth regulator 1 (NEGR1) on chromosome 1
- BTN3A2 of the butyrophilin family of genes on chromosome 6
- Neuronal growth regulator 1 (NEGR1) on chromosome 1
- BTN3A2 of the butyrophilin family of genes on chromosome 6
In this new thread, we made a brief summary of his presentation.
www.youtube.com/watch?v=30Dk...
www.youtube.com/watch?v=30Dk...
They got another grant for single cell transcriptomics (snRNA-seq) of 3 regions: the hypothalamus, frontal cortex and hippocampus.
They got another grant for single cell transcriptomics (snRNA-seq) of 3 regions: the hypothalamus, frontal cortex and hippocampus.
CD68 is a protein found on the membrane of lysosomes so this points to increased phagocytosis (clean-up) and possibly micro-enviromental injury.
CD68 is a protein found on the membrane of lysosomes so this points to increased phagocytosis (clean-up) and possibly micro-enviromental injury.
"So in the patients that donate their brains, possibly endstage patients, we do not see signs of classical neuro-inflammation, but we see dystrophic, rather senescent microglia."
"So in the patients that donate their brains, possibly endstage patients, we do not see signs of classical neuro-inflammation, but we see dystrophic, rather senescent microglia."
They also found no evidence of abnormal T (CD3) or B (CD79a) cell presence in the central nervous system of ME/CFS patients.
They also found no evidence of abnormal T (CD3) or B (CD79a) cell presence in the central nervous system of ME/CFS patients.
There’s no harmonized system to quantify this yet but they certainly see it in the brains of ME/CFS patients.
There’s no harmonized system to quantify this yet but they certainly see it in the brains of ME/CFS patients.