ME/CFS Science
@mecfsskeptic.bsky.social
In-depth analysis of research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Formerly known as ME/CFS Skeptic.
https://mecfsscience.org/
https://mecfsscience.org/
Reposted by ME/CFS Science
I was just clearing out some files and came across this set of treatment survey results from the CFIDS Association of America in 1999 which I thought might be of interest to the odd person.
Pacing came out on top
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Pacing came out on top
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
November 15, 2025 at 6:37 PM
I was just clearing out some files and came across this set of treatment survey results from the CFIDS Association of America in 1999 which I thought might be of interest to the odd person.
Pacing came out on top
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Pacing came out on top
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
1) This study from Cornell University tested more than 6000 proteins before and after two exercise tests.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
November 15, 2025 at 8:21 AM
1) This study from Cornell University tested more than 6000 proteins before and after two exercise tests.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
It found altered patterns in ME/CFS patients compared to controls, particularly in proteins involved in the immune system, signal transduction, and muscle contraction.
Reposted by ME/CFS Science
Well deserved strategic funding - €50 million *per year* for a decade - on ME/CFS and Long Covid research. Spent wisely this could be a game changer. Germany now leads & other countries need to follow. Goal to “decipher the causes and mechanisms and develop new treatments”. #MEcfs #longcovid
November 14, 2025 at 11:15 AM
Well deserved strategic funding - €50 million *per year* for a decade - on ME/CFS and Long Covid research. Spent wisely this could be a game changer. Germany now leads & other countries need to follow. Goal to “decipher the causes and mechanisms and develop new treatments”. #MEcfs #longcovid
Reposted by ME/CFS Science
Surprised but elated to see Germany make good on its word to fund research into post-infectious diseases.
Beyond post-viral diseases like ME/CFS and Long COVID — for which effective therapy is urgently needed — viral infections are also implicated in diseases like MS, rheumatoid arthritis,
...
Beyond post-viral diseases like ME/CFS and Long COVID — for which effective therapy is urgently needed — viral infections are also implicated in diseases like MS, rheumatoid arthritis,
...
1) 🇩🇪 Some really good news! Germany plans to invest half a billion euros in research on diseases such as ME/CFS and Long Covid.
They are calling it "The National Decade Against Post-Infectious Diseases"
They are calling it "The National Decade Against Post-Infectious Diseases"
November 14, 2025 at 3:17 PM
Surprised but elated to see Germany make good on its word to fund research into post-infectious diseases.
Beyond post-viral diseases like ME/CFS and Long COVID — for which effective therapy is urgently needed — viral infections are also implicated in diseases like MS, rheumatoid arthritis,
...
Beyond post-viral diseases like ME/CFS and Long COVID — for which effective therapy is urgently needed — viral infections are also implicated in diseases like MS, rheumatoid arthritis,
...
1) 🇩🇪 Some really good news! Germany plans to invest half a billion euros in research on diseases such as ME/CFS and Long Covid.
They are calling it "The National Decade Against Post-Infectious Diseases"
They are calling it "The National Decade Against Post-Infectious Diseases"
November 14, 2025 at 8:30 AM
1) 🇩🇪 Some really good news! Germany plans to invest half a billion euros in research on diseases such as ME/CFS and Long Covid.
They are calling it "The National Decade Against Post-Infectious Diseases"
They are calling it "The National Decade Against Post-Infectious Diseases"
1) Had a look at this paper on 'The clinical relevance of Mast Cell Activation in ME/CFS'.
Unfortunately, it's almost fully based on self-reported data and questionnaires.
There are still almost no studies that looked deeper into MCAS in ME/CFS using proper biological tests.
Unfortunately, it's almost fully based on self-reported data and questionnaires.
There are still almost no studies that looked deeper into MCAS in ME/CFS using proper biological tests.
November 13, 2025 at 8:55 AM
1) Had a look at this paper on 'The clinical relevance of Mast Cell Activation in ME/CFS'.
Unfortunately, it's almost fully based on self-reported data and questionnaires.
There are still almost no studies that looked deeper into MCAS in ME/CFS using proper biological tests.
Unfortunately, it's almost fully based on self-reported data and questionnaires.
There are still almost no studies that looked deeper into MCAS in ME/CFS using proper biological tests.
Reposted by ME/CFS Science
1) In-depth Canadian study on 78 Long Covid patients with ME/CFS. They compared these to 62 controls who were infected by SARS-CoV-2 but did not develop complications.
Too many findings to mention them all, but here are some interesting results...
Too many findings to mention them all, but here are some interesting results...
November 12, 2025 at 5:13 PM
Interesting that this Canadian study found upregulated genes involved in neuronal differentiation and development.
DecodeME and the Snyder preprint also pointed in that direction (although using other genes and approaches).
DecodeME and the Snyder preprint also pointed in that direction (although using other genes and approaches).
5) The researchers also did RNA-sequencing to see which genes are upregulated.
In female patients, these were genes involved in neuronal differentiation and development such as ZNF469, BRINP2, and FEZF2.
In female patients, these were genes involved in neuronal differentiation and development such as ZNF469, BRINP2, and FEZF2.
November 12, 2025 at 10:22 AM
Interesting that this Canadian study found upregulated genes involved in neuronal differentiation and development.
DecodeME and the Snyder preprint also pointed in that direction (although using other genes and approaches).
DecodeME and the Snyder preprint also pointed in that direction (although using other genes and approaches).
1) In-depth Canadian study on 78 Long Covid patients with ME/CFS. They compared these to 62 controls who were infected by SARS-CoV-2 but did not develop complications.
Too many findings to mention them all, but here are some interesting results...
Too many findings to mention them all, but here are some interesting results...
November 12, 2025 at 10:07 AM
1) In-depth Canadian study on 78 Long Covid patients with ME/CFS. They compared these to 62 controls who were infected by SARS-CoV-2 but did not develop complications.
Too many findings to mention them all, but here are some interesting results...
Too many findings to mention them all, but here are some interesting results...
1) The results of RECOVER-NEURO are in!
It tested:
- computerized cognitive training
- cognitive-behavioral rehabilitation
- transcranial direct current stimulation
but no intervention showed significant improvement compared to a control group that did video puzzles and games.
It tested:
- computerized cognitive training
- cognitive-behavioral rehabilitation
- transcranial direct current stimulation
but no intervention showed significant improvement compared to a control group that did video puzzles and games.
November 11, 2025 at 9:25 AM
1) The results of RECOVER-NEURO are in!
It tested:
- computerized cognitive training
- cognitive-behavioral rehabilitation
- transcranial direct current stimulation
but no intervention showed significant improvement compared to a control group that did video puzzles and games.
It tested:
- computerized cognitive training
- cognitive-behavioral rehabilitation
- transcranial direct current stimulation
but no intervention showed significant improvement compared to a control group that did video puzzles and games.
Reposted by ME/CFS Science
Some in mental health are really bending backwards to dig up myths and pseudoscience to discredit complex physical illness and to claim it is, actually, psychological.
1) 🇨🇦 Problematic letter in the Canadian journal BCMJ, stating:
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
November 10, 2025 at 5:34 PM
Some in mental health are really bending backwards to dig up myths and pseudoscience to discredit complex physical illness and to claim it is, actually, psychological.
1) A new study by the group of Benjamin Natelson reports abnormal breathing patterns in ME/CFS patients during an exercise test.
42% met the criteria for dysfunctional breathing compared to 16% in controls.
42% met the criteria for dysfunctional breathing compared to 16% in controls.
November 10, 2025 at 9:08 AM
1) A new study by the group of Benjamin Natelson reports abnormal breathing patterns in ME/CFS patients during an exercise test.
42% met the criteria for dysfunctional breathing compared to 16% in controls.
42% met the criteria for dysfunctional breathing compared to 16% in controls.
1) Interesting letter in the Lancet Infectious Diseases.
It argues that Long Covid is a heterogeneous disease, so we need outcome measures that can assess multiple aspects reliably.
Otherwise, we risk falsely concluding that a treatment didn't work.
It argues that Long Covid is a heterogeneous disease, so we need outcome measures that can assess multiple aspects reliably.
Otherwise, we risk falsely concluding that a treatment didn't work.
November 9, 2025 at 2:30 PM
1) Interesting letter in the Lancet Infectious Diseases.
It argues that Long Covid is a heterogeneous disease, so we need outcome measures that can assess multiple aspects reliably.
Otherwise, we risk falsely concluding that a treatment didn't work.
It argues that Long Covid is a heterogeneous disease, so we need outcome measures that can assess multiple aspects reliably.
Otherwise, we risk falsely concluding that a treatment didn't work.
Reposted by ME/CFS Science
This is a very deft thread. A concise precis of our conversation on conservatism, capitalism, and disability
Thank you @mecfsskeptic.bsky.social
#MECFS #LongCovid @davetuller1.bsky.social
Thank you @mecfsskeptic.bsky.social
#MECFS #LongCovid @davetuller1.bsky.social
1) Interesting interview of Prof. Brian Hughes by David Tuller.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
November 7, 2025 at 10:18 PM
This is a very deft thread. A concise precis of our conversation on conservatism, capitalism, and disability
Thank you @mecfsskeptic.bsky.social
#MECFS #LongCovid @davetuller1.bsky.social
Thank you @mecfsskeptic.bsky.social
#MECFS #LongCovid @davetuller1.bsky.social
1) 🇨🇦 Problematic letter in the Canadian journal BCMJ, stating:
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
November 9, 2025 at 8:34 AM
1) 🇨🇦 Problematic letter in the Canadian journal BCMJ, stating:
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
"Patients with fibromyalgia and ME/CFS have a high proportion of childhood physical abuse, emotional neglect, and sexual trauma. This trauma contributes to profound attachment disruptions..."
Reposted by ME/CFS Science
Some psychobabble that we haven't recently seen in the ME/CFS field, in a Canadian medical journal:
bcmj.org/sites/defaul...
Again claims therapies can lead to recovery, like from CBT/GET proponents, without solid evidence they even lead to objective improvement!
#MEcfs #CFS #PwME
bcmj.org/sites/defaul...
Again claims therapies can lead to recovery, like from CBT/GET proponents, without solid evidence they even lead to objective improvement!
#MEcfs #CFS #PwME
November 7, 2025 at 9:31 PM
Some psychobabble that we haven't recently seen in the ME/CFS field, in a Canadian medical journal:
bcmj.org/sites/defaul...
Again claims therapies can lead to recovery, like from CBT/GET proponents, without solid evidence they even lead to objective improvement!
#MEcfs #CFS #PwME
bcmj.org/sites/defaul...
Again claims therapies can lead to recovery, like from CBT/GET proponents, without solid evidence they even lead to objective improvement!
#MEcfs #CFS #PwME
1) New preprint from the Stanford group of Ron Davis.
They looked for 185 human viruses, and found traces of 17 viruses in patients or controls. "Surprisingly", the authors write "more viruses were found in the healthy controls than in the ME/CFS patients."
They looked for 185 human viruses, and found traces of 17 viruses in patients or controls. "Surprisingly", the authors write "more viruses were found in the healthy controls than in the ME/CFS patients."
November 8, 2025 at 3:06 PM
1) New preprint from the Stanford group of Ron Davis.
They looked for 185 human viruses, and found traces of 17 viruses in patients or controls. "Surprisingly", the authors write "more viruses were found in the healthy controls than in the ME/CFS patients."
They looked for 185 human viruses, and found traces of 17 viruses in patients or controls. "Surprisingly", the authors write "more viruses were found in the healthy controls than in the ME/CFS patients."
1) There's a new Medscape article on the ME/CFS treatment trials discussed at the IACFS/ME conference.
- Nacul is testing LDN in Canada
- Scheibenbogen is pursuing immunoadsorption in Germany
- Fluge is trialing daratumumab in Norway
- Sato is testing rituximab again in Japan
- Nacul is testing LDN in Canada
- Scheibenbogen is pursuing immunoadsorption in Germany
- Fluge is trialing daratumumab in Norway
- Sato is testing rituximab again in Japan
November 8, 2025 at 8:36 AM
1) There's a new Medscape article on the ME/CFS treatment trials discussed at the IACFS/ME conference.
- Nacul is testing LDN in Canada
- Scheibenbogen is pursuing immunoadsorption in Germany
- Fluge is trialing daratumumab in Norway
- Sato is testing rituximab again in Japan
- Nacul is testing LDN in Canada
- Scheibenbogen is pursuing immunoadsorption in Germany
- Fluge is trialing daratumumab in Norway
- Sato is testing rituximab again in Japan
Reposted by ME/CFS Science
for those interested in immune diseases, this is a super interesting diagram (see post below)
source : pmc.ncbi.nlm.nih.gov/articles/PMC...
source : pmc.ncbi.nlm.nih.gov/articles/PMC...
1) Interesting figure showing where immune cells are located in the human body (mostly in the bone marrow and lymphatic system).
November 7, 2025 at 8:39 AM
for those interested in immune diseases, this is a super interesting diagram (see post below)
source : pmc.ncbi.nlm.nih.gov/articles/PMC...
source : pmc.ncbi.nlm.nih.gov/articles/PMC...
1) Interesting figure showing where immune cells are located in the human body (mostly in the bone marrow and lymphatic system).
November 7, 2025 at 8:31 AM
1) Interesting figure showing where immune cells are located in the human body (mostly in the bone marrow and lymphatic system).
1) Interesting interview of Prof. Brian Hughes by David Tuller.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
November 6, 2025 at 8:29 AM
1) Interesting interview of Prof. Brian Hughes by David Tuller.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and ignores social context.
1) A new study looked at symptom exacerbations for 8 days after a 20-minute sub-maximal exercise test and compared ME/CFS and Long Covid patients with controls.
Changes were greatest in ME/CFS patients and in the first 3 days after exercise.
Changes were greatest in ME/CFS patients and in the first 3 days after exercise.
November 5, 2025 at 10:55 AM
1) A new study looked at symptom exacerbations for 8 days after a 20-minute sub-maximal exercise test and compared ME/CFS and Long Covid patients with controls.
Changes were greatest in ME/CFS patients and in the first 3 days after exercise.
Changes were greatest in ME/CFS patients and in the first 3 days after exercise.
1) Slide from Maya Dusenbery's presentation at the Canadian ME/CFS Conference yesterday.
She is the author of 'Doing Harm', a book that explores how women’s health has long been overlooked and dismissed within the medical system.
She is the author of 'Doing Harm', a book that explores how women’s health has long been overlooked and dismissed within the medical system.
November 5, 2025 at 8:22 AM
1) Slide from Maya Dusenbery's presentation at the Canadian ME/CFS Conference yesterday.
She is the author of 'Doing Harm', a book that explores how women’s health has long been overlooked and dismissed within the medical system.
She is the author of 'Doing Harm', a book that explores how women’s health has long been overlooked and dismissed within the medical system.
1) 🇦🇺 Interesting interview with molecular biologist Dr Daniel Missailidis.
He has been conducting ME/CFS research since 2016 at at La Trobe University, focusing on the intersection of energy metabolism and immune dysfunction.
He has been conducting ME/CFS research since 2016 at at La Trobe University, focusing on the intersection of energy metabolism and immune dysfunction.
November 3, 2025 at 9:20 AM
1) 🇦🇺 Interesting interview with molecular biologist Dr Daniel Missailidis.
He has been conducting ME/CFS research since 2016 at at La Trobe University, focusing on the intersection of energy metabolism and immune dysfunction.
He has been conducting ME/CFS research since 2016 at at La Trobe University, focusing on the intersection of energy metabolism and immune dysfunction.
For patients with Long Covid: you can now participate in a remote treatment trial of tirzepatide (a GLP-1 inhibitor also known as zepbound).
The study is organized by Scripps Research and aims to enroll 1000 participants.
The study is organized by Scripps Research and aims to enroll 1000 participants.
November 3, 2025 at 8:15 AM
For patients with Long Covid: you can now participate in a remote treatment trial of tirzepatide (a GLP-1 inhibitor also known as zepbound).
The study is organized by Scripps Research and aims to enroll 1000 participants.
The study is organized by Scripps Research and aims to enroll 1000 participants.